Chercheur(e)

Dr Vincenzo Di Marzo

Obésité-Métabolisme

A3128

vincenzo.dimarzo@criucpq.ulaval.ca

Domaine de recherche

Etude du rôle de l'axe microbiome intestinal / endocannabinoidome dans la santé métabolique et le risque cardiométabolique.

Description des travaux

La capacité des endocannabinoïdes de l'hôte et des médiateurs apparentés à moduler l'activité ou à être modulée par certaines bactéries commensales, et la capacité potentielle de certaines espèces bactériennes intestinales à produire des molécules capables d'interagir avec les mêmes cibles moléculaires des endocannabinoïdes et des médiateurs apparentés, sont en cours d'investigation dans le contexte des troubles métaboliques et du risque cardiométabolique associé.

Prix et distinctions

Human Frontier Science Program research grant to study the biosynthesis, metabolism, and structure-activity relationships of anandamide.
Merkator Fellowship for Foreign Scientists by the Deutsche Forschungsgemeinshaft.
Mechoulam Award for his outstanding contributions to cannabinoid research.
Luigi Tartufari award for Chemistry from the Italian Academy of Sciences (Accademia dei Lincei).
Ester Fride Award for Basic Science from the International Association for Cannabinoid Medicines.
International Award Guido Dorso for Research.
Medal of the Italian Accademia delle Scienze, or of the XL, for Physical and Natural Sciences.

Publications

196

Trier par année :

Petrosino S, Di Marzo V. The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations.. Br J Pharmacol 2017; 174(11):1349-1365.
Saravia R, Flores Á, Plaza-Zabala A, Busquets-Garcia A, Pastor A, de la Torre R, Di Marzo V, Marsicano G, Ozaita A, Maldonado R, Berrendero F. CB₁ Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.. Biol Psychiatry 2017; 81(7):625-634.
Pagano E, Orlando P, Finizio S, Rossi A, Buono L, Iannotti FA, Piscitelli F, Izzo AA, Di Marzo V, Borrelli F. Role of the endocannabinoid system in the control of mouse myometrium contractility during the menstrual cycle.. Biochem Pharmacol 2017; 124(0):83-93.
Quercioli A, Carbone F, Bonaventura A, Liberale L, Pataky Z, Thomas A, Lenglet S, Lauer E, Golay A, Dallegri F, Di Marzo V, Schindler TH, Montecucco F. Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function.. Int J Cardiol 2017; 231(0):1-5.
Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Cannabinoid CB₂ receptor ligand profiling reveals biased signalling and off-target activity.. Nat Commun 2017; 8(0):13958.
Hals PA, Wang X, Piscitelli F, Di Marzo V, Xiao YF. The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil.. Lipids Health Dis 2017; 16(1):16.
Romero-Parra J, Chung H, Tapia RA, Faúndez M, Morales-Verdejo C, Lorca M, Lagos CF, Di Marzo V, David Pessoa-Mahana C, Mella J. Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.. Eur J Pharm Sci 2017; 101(0):1-10.
Cremon C, Stanghellini V, Barbaro MR, Cogliandro RF, Bellacosa L, Santos J, Vicario M, Pigrau M, Alonso Cotoner C, Lobo B, Azpiroz F, Bruley des Varannes S, Neunlist M, DeFilippis D, Iuvone T, Petrosino S, Di Marzo V, Barbara G. Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.. Aliment Pharmacol Ther 2017; 45(7):909-922.
Pagano E, Borrelli F, Orlando P, Romano B, Monti M, Morbidelli L, Aviello G, Imperatore R, Capasso R, Piscitelli F, Buono L, Di Marzo V, Izzo AA. Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis.. Pharmacol Res 2017; 119(0):227-236.
Luongo L, Starowicz K, Maione S, Di Marzo V. Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).. Pharmacol Res 2017; 119(0):272-277.
Guida F, Luongo L, Boccella S, Giordano ME, Romano R, Bellini G, Manzo I, Furiano A, Rizzo A, Imperatore R, Iannotti FA, D'Aniello E, Piscitelli F, Sca Rossi F, Cristino L, Di Marzo V, de Novellis V, Maione S. Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.. Sci Rep 2017; 7(1):375.
Piscitelli F, Pagano E, Lauritano A, Izzo AA, Di Marzo V. Development of a Rapid LC-MS/MS Method for the Quantification of Cannabidiol, Cannabidivarin, ?⁹-Tetrahydrocannabivarin, and Cannabigerol in Mouse Peripheral Tissues.. Anal Chem 2017; 89(8):4749-4755.
Barutta F, Grimaldi S, Gambino R, Vemuri K, Makriyannis A, Annaratone L, di Marzo V, Bruno G, Gruden G. Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy.. Nephrol Dial Transplant 2017; 32(10):1655-65.
Carta G, Melis M, Pintus S, Pintus P, Piras CA, Muredda L, Demurtas D, Di Marzo V, Banni S, Barbarossa IT. Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids.. Sci Rep 2017; 7(1):1361.
Becker TM, Favero M, Di Marzo V, Cristino L, Busetto G. Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice.. Mol Metab 2017; 6(6):594-601.
van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.. Science 2017; 356(6342):1084-1087.
Murillo-Rodríguez E, Di Marzo V, Machado S, Rocha NB, Veras AB, Neto GAM, Budde H, Arias-Carrión O, Arankowsky-Sandoval G. Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation.. Front Mol Neurosci 2017; 10(0):152.
Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S. 2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation.. Front Pharmacol 2017; 8(0):308.
Rigamonti AE, Bini S, Piscitelli F, Lauritano A, Di Marzo V, Vanetti C, Agosti F, De Col A, Lucchetti E, Grugni G, Sartorio A. Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion.. Food Nutr Res 2017; 61(1):1297553.
Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T. A TRPV1-to-secretagogin regulatory axis controls pancreatic ?-cell survival by modulating protein turnover.. EMBO J 2017; 36(14):2107-2125.
Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M. Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).. Neurogastroenterol Motil 2017; 29(12):13148.
Cristino L, Imperatore R, Di Marzo V. Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain.. Methods Enzymol 2017; 593(0):61-98.
Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S. Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice.. Brain Behav Immun 2018; 67(0):230-245.
Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L. Effects of curcumin and curcumin analogues on TRP channels.. Fitoterapia 2017; 122(0):126-131.
Forner-Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish.. Endocrinology 2017; 158(10):3462-3476.
Valastro C, Campanile D, Marinaro M, Franchini D, Piscitelli F, Verde R, Di Marzo V, Di Bello A. Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study.. BMC Vet Res 2017; 13(1):309.
Monteleone AM, Piscitelli F, Dalle Grave R, El Ghoch M, Di Marzo V, Maj M, Monteleone P. Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder.. Nutrients 2017; 9(12):E1377.
Ferreira RCM, Castor MGM, Piscitelli F, Di Marzo V, Duarte IDG, Romero TRL. The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.. J Pain 2018; 19(5):487-495.
Melis M, Carta G, Pintus S, Pintus P, Piras CA, Murru E, Manca C, Di Marzo V, Banni S, Tomassini Barbarossa I. Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects.. Front Physiol 2017; 8(0):1006.
Roviezzo F, Rossi A, Caiazzo E, Orlando P, Riemma MA, Iacono VM, Guarino A, Ialenti A, Cicala C, Peritore A, Capasso R, Di Marzo V, Izzo AA. Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse.. Front Pharmacol 2017; 8(0):857.
Mela V, Piscitelli F, Berzal AL, Chowen J, Silvestri C, Viveros MP, Di Marzo V.. Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet.. J Physiol Biochem 2017; 0(0):Epub.
Tomas-Roig J, Piscitelli F, Gil V, Quintana E, Ramió-Torrentà LL, Del Río JA, Moore TP, Agbemenyah H, Salinas G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U. Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.. CNS Neurosci Ther 2018; 24(6):528-538.
Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T. Endocannabinoid tone regulates human sebocyte biology.. J Invest Dermatol 2018; 138(8):1699-1706.
Forner-Piquer I, Mylonas CC, Calduch-Giner J, Maradonna F, Gioacchini G, Allarà M, Piscitelli F, Di Marzo V, Pérez-Sánchez J, Carnevali O. Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A.. Environ Int 2018; 119(0):54-65.
Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.. Front Pharmacol 2018; 9(0):249.
Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.. N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.. Neuropharmacology 2019; 148(0):320-331.
Tomas-Roig J, Benito E, Agis-Balboa RC, Piscitelli F, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.. Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice.. Addict Biol 2017; 22(6):1778-89.
Gamelin FX, Aucouturier J, Iannotti FA, Piscitelli F, Mazzarella E, Aveta T, Leriche M, Dupont E, Cieniewski-Bernard C, Leclair E, Bastide B, Di Marzo V, Heyman E.. Exercise training and high-fat diet elicit endocannabinoid system modifications in the rat hypothalamus and hippocampus.. J Physiol Biochem 2017; 0(0):Epub.
Sampaio LS, Iannotti FA, Veneziani L, Borelli-Tôrres RT, De Maio F, Piscitelli F, Reis RAM, Di Marzo V, Einicker-Lamas M. Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na⁺/K⁺ ATPase expression and activity in kidney proximal tubule cells.. Biochem Pharmacol 2018; 154(0):482-491.
Hegyi Z, Oláh T, K?szeghy Á, Pisticelli F, Holló K, Pál B, Csernoch L, Di Marzo V, Antal M. CB₁ receptor activation induces intracellular Ca²⁺ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes.. Sci Rep 2018; 8(1):10562.
Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V. Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.. Br J Pharmacol 2019; 176(10):1568-1584.
Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.. ChemMedChem 2018; 13(19):2090-2103.
Forner-Piquer I, Santangeli S, Maradonna F, Rabbito A, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.. Environ Pollut 2018; 241(0):1-8.
Forner-Piquer I, Santangeli S, Maradonna F, Verde R, Piscitelli F, di Marzo V, Habibi HR, Carnevali O.. Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish.. Chemosphere 2018; 205(0):118-25.
Imperatore R, D'Angelo L, Safari O, Motlagh HA, Piscitelli F, de Girolamo P, Cristino L, Varricchio E, di Marzo V, Paolucci M. Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish.. Front Neuroanat 2018; 12(0):62.
Di Marzo V. New approaches and challenges to targeting the endocannabinoid system.. Nat Rev Drug Discov 2018; 17(9):623-639.
Janssens A, Silvestri C, Martella A, Vanoevelen JM, Di Marzo V, Voets T. Delta9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6.. Pharmacol Res 2018; 136(0):83-89.
Schiano Moriello A, López Chinarro S, Novo Fernández O, Eras J, Amodeo P, Canela-Garayoa R, Vitale RM, Di Marzo V, De Petrocellis L. Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.. J Med Chem 2018; 61(18):8255-8281.
Barutta F, Bellini S, Mastrocola R, Gambino R, Piscitelli F, di Marzo V, Corbetta B, Vemuri K, Makriyannis A, Annaratone L, Bruno G, Gruden G. Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy. Br J Pharmacol 2018; 175(23):4371-4385.
Ligresti A, Silvestri C, Vitale RM, Martos J, Piscitelli F, Wang J, Allarà M, Carling R, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward D, Di Marzo V, Marino G. FAAH-catalyzed C-C bond cleavage of a new multi-target analgesic drug.. ACS Chem Neurosci 2019; 10(1):424-437.
Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V. Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.. J Pharmacol Exp Ther 2018; 365(3):652-663.
Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, Piscitelli F, Gazzerro E, Busetto G, Carrella D, Capasso R, Puri PL, Minchiotti G, Di Marzo V.. Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy.. Nat Commun 2018; 9(1):3950.
Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD. Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.. Nat Commun 2019; 10(1):457.
Vitale RM, D'Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani ME, Fellous T, Gentile A, Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D'Aniello B, Defranoux F, Felline S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E. Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.. Mar Drugs 2018; 16(11):E431.
Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, Cygankiewicz AI, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J.. Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.. Biochem Pharmacol 2019; 161(0):37-51.
Forner-Piquer I, Mylonas CC, Fakriadis I, Papadaki M, Piscitelli F, Di Marzo V, Calduch-Giner J, Pérez-Sánchez J, Carnevali O.. Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season.. Arch Toxicol 2019; 93(3):727-741.
D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V.. Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.. Biochim Biophys Acta Gen Subj 2019; 1863(3):586-597.
D'Aniello E, Iannotti FA, Falkenberg LG, Martella A, Gentile A, De Maio F, Ciavatta ML, Gavagnin M, Waxman JS, Di Marzo V, Amodeo P, Vitale RM.. In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.. Mar Drugs 2019; 17(2):E110.
Guida F, Boccella S, Belardo C, Iannotta M, Piscitelli F, De Filippis F, Paino S, Ricciardi F, Siniscalco D, Marabese I, Luongo L, Ercolini D, Di Marzo V, Maione S. Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain.. Brain Behav Immun 2020; 85(0):128-141.
Turcotte C, Dumais É, Archambault AS, Martin C, Blanchet MR, Bissonnette É, Boulet LP, Laviolette M, Di Marzo V, Flamand N. Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways.. J Leukoc Biol 2019; 106(6):1337-1347.
Petrosino S, Schiano Moriello A, Verde R, Allarà M, Imperatore R, Ligresti A, Mahmoud AM, Peritore AF, Iannotti FA, Di Marzo V. Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity.. J Neuroinflammation 2019; 16(1):274.
Lacroix S, Pechereau F, Leblanc N, Boubertakh B, Houde A, Martin C, Flamand N, Silvestri C, Raymond F, Di Marzo V, Veilleux A. Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice.. mSystems 2019; 4(6):e00407-19..
Rock EM, Ayoub SM, Limebeer CL, Gene A, Wills KL, DeVuono MV, Smoum R, Di Marzo V, Lichtman AH, Mechoulam R, Parker LA. Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.. Psychopharmacology (Berl) 2020; 237(2):375-384.
Veilleux A, Di Marzo V, Silvestri C. The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus.. Curr Diab Rep 2019; 19(11):117.
Forner-Piquer I, Fakriadis I, Mylonas CC, Piscitelli F, Di Marzo V, Maradonna F, Calduch-Giner J, Pérez-Sánchez J, Carnevali O. Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes.. Int J Mol Sci 2019; 20(20):E5003.
Pagano E, Romano B, Iannotti FA, Parisi OA, D'Armiento M, Pignatiello S, Coretti L, Lucafò M, Venneri T, Stocco G, Lembo F, Orlando P, Capasso R, Di Marzo V, Izzo AA, Borrelli F. The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients.. Pharmacol Res 2019; 149(0):104464.
Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, Cygankiewicz AI, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J. Corrigendum to "Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system" [Biochem. Pharmacol. 161 (2019) 37-51].. Biochem Pharmacol 2019; 169(0):113636.
Capasso A, Benigni A, Capitanio U, Danesh FR, Di Marzo V, Gesualdo L, Grandaliano G, Jaimes EA, Malyszko J, Perazella MA, Qian Q, Ronco P, Rosner MH, Trepiccione F, Viggiano D, Zoccali C, Capasso G. Summary of the International Conference on Onco-Nephrology: an emerging field in medicine.. Kidney Int 2019; 96(3):555-567.
Di Marzo V, Silvestri C. Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome.. Nutrients 2019; 11(8):E1956.
Ferrara AL, Piscitelli F, Petraroli A, Parente R, Galdiero MR, Varricchi G, Marone G, Triggiani M, Di Marzo V, Loffredo S. Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis.. J Immunol Res 2019; 2019(0):5836476.
Alalawi A, Dodu JC, Woolley-Roberts M, Brodie J, Di Marzo V, Soderstrom K. Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model.. Neuropharmacology 2019; 158(0):107716.
Ghonim AE, Ligresti A, Rabbito A, Mahmoud AM, Di Marzo V, Osman NA, Abadi AH. Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties.. Eur J Med Chem 2019; 180(0):154-170.
Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, Ligresti A, Rampa A. Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.. Eur J Med Chem 2019; 178(0):243-258.
Zamberletti E, Gabaglio M, Piscitelli F, Brodie JS, Woolley-Roberts M, Barbiero I, Tramarin M, Binelli G, Landsberger N, Kilstrup-Nielsen C, Rubino T, Di Marzo V, Parolaro D. Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.. J Psychopharmacol 2019; 33(7):894-907.
Tunisi L, Forte N, Fernández-Rilo AC, Mavaro I, Capasso R, D'Angelo L, Mili? N, Cristino L, Di Marzo V, Palomba L. Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier.. Front Endocrinol (Lausanne) 2019; 10(0):219.
Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM, Humphrey AE, Sheppard-Perkins M, Lichtman AH, Mechoulam R, Di Marzo V, Parker LA. Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.. Psychopharmacology (Berl) 2019; 236(9):2623-2633.
Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia.. Neuropharmacology 2019; 146(0):212-221.
Mugnaini C, Rabbito A, Brizzi A, Palombi N, Petrosino S, Verde R, Di Marzo V, Ligresti A, Corelli F. Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease.. Eur J Med Chem 2019; 161(0):239-251.
Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L. Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.. Neurobiol Dis 2019; 121(0):106-119.
Cristino L, Bisogno T, Di Marzo V. Cannabinoids and the expanded endocannabinoid system in neurological disorders.. Nat Rev Neurol 2020; 16(1):9-29.
Cinquina V, Calvigioni D, Farlik M, Halbritter F, Fife-Gernedl V, Shirran SL, Fuszard MA, Botting CH, Poullet P, Piscitelli F, Máté Z, Szabó G, Yanagawa Y, Kasper S, Di Marzo V, Mackie K, McBain CJ, Bock C, Keimpema E, Harkany T. Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy.. Mol Psychiatry 2020; 25(1):22-36.
Manca C, Boubertakh B, Leblanc N, Deschênes T, Lacroix S, Martin C, Houde A, Veilleux A, Flamand N, Muccioli GG, Raymond F, Cani PD, Di Marzo V, Silvestri C. Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling.. J Lipid Res 2020; 61(1):70-85.
Turcotte C, Archambault AS, Dumais É, Martin C, Blanchet MR, Bissonnette E, Ohashi N, Yamamoto K, Itoh T, Laviolette M, Veilleux A, Boulet LP, Di Marzo V, Flamand N. Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes.. FASEB J 2020; 34(3):4253-4265.
Silvestri C, Pagano E, Lacroix S, Venneri T, Cristiano C, Calignano A, Parisi OA, Izzo AA, Di Marzo V, Borrelli F. Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis.. Front Pharmacol 2020; 11(0):585096.
Di Marzo V. The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders?.. Dialogues Clin Neurosci 2020; 22(3):259-269.
Beiersdorf J, Hevesi Z, Calvigioni D, Pyszkowski J, Romanov R, Szodorai E, Lubec G, Shirran S, Botting CH, Kasper S, Guy GW, Gray R, Di Marzo V, Harkany T, Keimpema E. Adverse effects of ?9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development.. JCI Insight 2020; 5(23):e135418.
Mazzotta S, Carullo G, Schiano Moriello A, Amodeo P, Di Marzo V, Vega-Holm M, Vitale RM, Aiello F, Brizzi A, De Petrocellis L. Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes.. Mar Drugs 2020; 18(10):519.
Pagano E, Iannotti FA, Piscitelli F, Romano B, Lucariello G, Venneri T, Di Marzo V, Izzo AA, Borrelli F. Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation.. Phytother Res 2021; 35(1):517-529.
Castonguay-Paradis S, Lacroix S, Rochefort G, Parent L, Perron J, Martin C, Lamarche B, Raymond F, Flamand N, Di Marzo V, Veilleux A. Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.. Sci Rep 2020; 10(1):15975.
Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F. Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.. J Med Chem 2020; 63(19):11303.
Manca C, Shen M, Boubertakh B, Martin C, Flamand N, Silvestri C, Di Marzo V. Alterations of brain endocannabinoidome signaling in germ-free mice.. Biochim Biophys Acta Mol Cell Biol Lipids 2020; 1865(12):158786.
Ruocco C, Ragni M, Rossi F, Carullo P, Ghini V, Piscitelli F, Cutignano A, Manzo E, Ioris RM, Bontems F, Tedesco L, Greco CM, Pino A, Severi I, Liu D, Ceddia RP, Ponzoni L, Tenori L, Rizzetto L, Scholz M, Tuohy K, Bifari F, Di Marzo V, Luchinat C, Carruba MO, Cinti S, Decimo I, Condorelli G, Coppari R, Collins S, Valerio A, Nisoli E. Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis.. Diabetes 2020; 69(11):2324-2339.
Gray RA, Stott CG, Jones NA, Di Marzo V, Whalley BJ. Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent.. Cannabis Cannabinoid Res 2020; 5(2):145-149.
Palomba L, Motta A, Imperatore R, Piscitelli F, Capasso R, Mastroiacovo F, Battaglia G, Bruno V, Cristino L, Di Marzo V. Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen-Glucose Deprivation-Induced Neuronal Injury.. Cells 2020; 9(6):1507.
Ayoub SM, Smoum R, Farag M, Atwal H, Collins SA, Rock EM, Limebeer CL, Piscitelli F, Iannotti FA, Lichtman AH, Leri F, Di Marzo V, Mechoulam R, Parker LA. Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats.. Psychopharmacology (Berl) 2020; 237(9):2753-2765.
Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F. Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.. J Med Chem 2020; 63(13):7369-7391.
Forner-Piquer I, Beato S, Piscitelli F, Santangeli S, Di Marzo V, Habibi HR, Maradonna F, Carnevali O. Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system.. Environ Pollut 2020; 264(0):114710.
Stark T, Di Bartolomeo M, Di Marco R, Drazanova E, Platania CBM, Iannotti FA, Ruda-Kucerova J, D'Addario C, Kratka L, Pekarik V, Piscitelli F, Babinska Z, Fedotova J, Giurdanella G, Salomone S, Sulcova A, Bucolo C, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment.. Biochem Pharmacol 2020; 177(0):114004.
Brizzi A, Aiello F, Boccella S, Cascio MG, De Petrocellis L, Frosini M, Gado F, Ligresti A, Luongo L, Marini P, Mugnaini C, Pessina F, Corelli F, Maione S, Manera C, Pertwee RG, Di Marzo V. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.. Bioorg Med Chem 2020; 28(11):115513.
Gamelin FX, Cuvelier G, Mendes A, Aucouturier J, Berthoin S, Di Marzo V, Heyman E. Cannabidiol in sport: Ergogenic or else?. Pharmacol Res 2020; 156(0):104764.
Boccella S, Iannotta M, Cristiano C, Iannotti FA, Bello FD, Guida F, Belardo C, Infantino R, Ricciardi F, Giannella M, Calignano A, Di Marzo V, Maione S, Luongo L. Treatment With 2-Pentadecyl-2-Oxazoline Restores Mild Traumatic Brain Injury-Induced Sensorial and Neuropsychiatric Dysfunctions.. Front Pharmacol 2020; 11(0):91.
Forte N, Fernández-Rilo AC, Palomba L, Di Marzo V, Cristino L. Obesity Affects the Microbiota-Gut-Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators.. Int J Mol Sci 2020; 21(5):1554.
Forner-Piquer I, Santangeli S, Maradonna F, Rabbito A, Piscitelli F, Habibi HR, di Marzo V, Carnevali O. Comments on Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate - Forner-Piquer et al. (2018)": rebuttal to Prosser CM.. Environ Pollut 2020; 261(0):114028.
Fellous T, De Maio F, Kalkan H, Carannante B, Boccella S, Petrosino S, Maione S, Di Marzo V, Iannotti FA. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets.. Biochem Pharmacol 2020; 175(0):113859.
Piscitelli F, Guida F, Luongo L, Iannotti FA, Boccella S, Verde R, Lauritano A, Imperatore R, Smoum R, Cristino L, Lichtman AH, Parker LA, Mechoulam R, Maione S, Di Marzo V. Protective Effects of N-Oleoylglycine in a Mouse Model of Mild Traumatic Brain Injury.. ACS Chem Neurosci 2020; 11(8):1117-1128.
Romero TRL, Miranda E Castor MG, Parrella C, Piscitelli F, Di Marzo V, Duarte IDG. ?₂-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system.. Pharmacol Rep 2020; 72(1):96-103.
Szymaszkiewicz A, W?odarczyk J, Wasilewski A, Di Marzo V, Storr M, Fichna J, Zieli?ska M. Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract.. Naunyn Schmiedebergs Arch Pharmacol 2020; 393(8):1357-1364.
Suriano F, Manca C, Flamand N, Depommier C, Van Hul M, Delzenne NM, Silvestri C, Cani PD, Di Marzo V.. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1867(1):159056.
Iannotti FA, Di Marzo V. The gut microbiome, endocannabinoids and metabolic disorders.. J Endocrinol 2021; 248(2):R83-R97.
Dione N, Lacroix S, Taschler U, Deschênes T, Abolghasemi A, Leblanc N, Di Marzo V, Silvestri C. Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.. Cells 2020; 9(12):2705.
Rochefort G, Provencher V, Castonguay-Paradis S, Perron J, Lacroix S, Martin C, Flamand N, Di Marzo V, Veilleux A.. Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators.. Appetite 2021; 156(0):104973.
Lefort C, Roumain M, Van Hul M, Rastelli M, Manco R, Leclercq I, Delzenne NM, Di Marzo V, Flamand N, Luquet S, Silvestri C, Muccioli GG, Cani PD. Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism.. Cells 2020; 9(5):1247.
Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N.. Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.. Cells 2021; 10(9):2322.
Romano B, Pagano E, Iannotti FA, Piscitelli F, Brancaleone V, Lucariello G, Nanì MF, Fiorino F, Sparaco R, Vanacore G, Di Tella F, Cicia D, Lionetti R, Makriyannis A, Malamas M, De Luca M, Aprea G, D'Armiento M, Capasso R, Sbarro B, Venneri T, Di Marzo V, Borrelli F, Izzo AA. N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth.. Br J Pharmacol 2022; 179(8):1679-1694.
Keimpema E, Di Marzo V, Harkany T. Biological basis of cannabinoid medicines.. Science 2021; 374(6574):1449-1450.
Lamontagne-Proulx J, Coulombe K, Dahhani F, Côté M, Guyaz C, Tremblay C, Di Marzo V, Flamand N, Calon F, Soulet D. Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model.. Nutrients 2021; 13(12):4218.
Depommier C, Flamand N, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Everard A, Delzenne NM, Di Marzo V, Cani PD. Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models.. Cells 2021; 10(1):71.
Tunisi L, D'Angelo L, Fernández-Rilo AC, Forte N, Piscitelli F, Imperatore R, de Girolamo P, Di Marzo V, Cristino L. Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice.. Front Synaptic Neurosci 2021; 13(0):622405.
Manzo E, Schiano Moriello A, Tinto F, Verde R, Allarà M, De Petrocellis L, Pagano E, Izzo AA, Di Marzo V, Petrosino S. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator.. Cells 2021; 10(2):450.
Di Bartolomeo M, Stark T, Maurel OM, Iannotti FA, Kuchar M, Ruda-Kucerova J, Piscitelli F, Laudani S, Pekarik V, Salomone S, Arosio B, Mechoulam R, Maccarrone M, Drago F, Wotjak CT, Di Marzo V, Vismara M, Dell'Osso B, D'Addario C, Micale V. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal ?9-tetrahydrocannabinol-exposed rats.. Pharmacol Res 2021; 164(0):105357.
Boccella S, Guida F, Iannotta M, Iannotti FA, Infantino R, Ricciardi F, Cristiano C, Vitale RM, Amodeo P, Marabese I, Belardo C, de Novellis V, Paino S, Palazzo E, Calignano A, Di Marzo V, Maione S, Luongo L. 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.. Mol Brain 2021; 14(1):28.
Iannotta M, Belardo C, Trotta MC, Iannotti FA, Vitale RM, Maisto R, Boccella S, Infantino R, Ricciardi F, Mirto BF, Ferraraccio F, Panarese I, Amodeo P, Tunisi L, Cristino L, D'Amico M, Di Marzo V, Luongo L, Maione S, Guida F. N-palmitoyl-D-glucosamine, a Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice.. Int J Mol Sci 2021; 22(3):1491.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD. Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPAR? Agonists.. Cells 2021; 10(1):185.
Rock EM, Limebeer CL, Sullivan MT, DeVuono MV, Lichtman AH, Di Marzo V, Mechoulam R, Parker LA. N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine.. Front Synaptic Neurosci 2021; 13(0):620145.
Boccella S, Guida F, Iannotta M, Iannotti FA, Infantino R, Ricciardi F, Cristiano C, Vitale RM, Amodeo P, Marabese I, Belardo C, de Novellis V, Paino S, Palazzo E, Calignano A, Di Marzo V, Maione S, Luongo L. Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.. Mol Brain 2021; 14(1):64.
Vitale RM, Iannotti FA, Schiano Moriello A, Tunisi L, Piscitelli F, Savopoulos R, Cristino L, De Petrocellis L, Amodeo P, Gray R, Di Marzo V. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.. Biomolecules 2021; 11(8):1134.
Isaac AR, de Velasco PC, Fraga KYD, Tavares-do-Carmo MDG, Campos RMP, Iannotti FA, Verde R, Martins DBG, Santos TA, Ferreira BK, de Mello FG, Di Marzo V, Andrade-da-Costa BLDS, de Melo Reis RA. Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers.. J Nutr Biochem 2021; 96(0):108782.
Tinto F, Archambault AS, Dumais É, Rakotoarivelo V, Kostrzewa M, Martin C, Plante PL, Desjardins Y, Simard M, Pouliot R, De Petrocellis L, Ligresti A, Di Marzo V, Flamand N. Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva.. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1866(8):158954.
Tortoriello G, Beiersdorf J, Romani S, Williams G, Cameron GA, Mackie K, Williams MJ, Di Marzo V, Keimpema E, Doherty P, Harkany T. Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB₁ Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster.. Cannabis Cannabinoid Res 2021; 6(2):119-136.
Shen M, Manca C, Suriano F, Nallabelli N, Pechereau F, Allam-Ndoul B, Iannotti FA, Flamand N, Veilleux A, Cani PD, Silvestri C, Di Marzo V. Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.. Molecules 2021; 27(1):1.
Le Bacquer O, Salles J, Piscitelli F, Sanchez P, Martin V, Montaurier C, Di Marzo V, Walrand S. Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats.. J Cachexia Sarcopenia Muscle 2022; 13(1):662-676.
Abolghasemi A, Manca C, Iannotti FA, Shen M, Leblanc N, Lacroix S, Martin C, Flamand N, Di Marzo V, Silvestri C. Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis.. Int J Mol Sci 2021; 22(22):12361.
Forte N, Boccella S, Tunisi L, Fernández-Rilo AC, Imperatore R, Iannotti FA, De Risi M, Iannotta M, Piscitelli F, Capasso R, De Girolamo P, De Leonibus E, Maione S, Di Marzo V, Cristino L. Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.. Nat Commun 2021; 12(1):6137.
Ayoub SM, Piscitelli F, Silvestri C, Limebeer CL, Rock EM, Smoum R, Farag M, de Almeida H, Sullivan MT, Lacroix S, Boubertakh B, Nallabelli N, Lichtman AH, Leri F, Mechoulam R, Di Marzo V, Parker LA. Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators.. Front Pharmacol 2021; 12(0):706703.
Manca C, Lacroix S, Pérusse F, Flamand N, Chagnon Y, Drapeau V, Tremblay A, Di Marzo V, Silvestri C. Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity.. Biomedicines 2021; 9(9):1246.
Guevara Agudelo FA, Leblanc N, Bourdeau-Julien I, St-Arnaud G, Lacroix S, Martin C, Flamand N, Veilleux A, Di Marzo V, Raymond F. Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice.. Front Immunol 2022; 13(0):1028412.
Guzzo LS, Oliveira CC, Ferreira RCM, Machado DPD, Castor MGM, Perez AC, Piscitelli F, Di Marzo V, Romero TRL, Duarte IDG.. Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation. Braz J Med Biol Res 2021; 54(12):e11071.
Bertrand JA, Woodward DF, Sherwood JM, Spenlehauer A, Silvestri C, Piscitelli F, Di Marzo V, Yamazaki M, Sakimura K, Inoue Y, Watanabe K, Overby DR.. Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.. Prostaglandins Leukot Essent Fatty Acids 2021; 165(0):102235.
Archambault AS, Brassard J, Bernatchez É, Martin C, Di Marzo V, Laviolette M, Boulet LP, Blanchet MR, Flamand N. Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners.. Cells 2022; 11(1):141.
Suriano F, Manca C, Flamand N, Depommier C, Van Hul M, Delzenne NM, Silvestri C, Cani PD, Di Marzo V. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.. Biochim Biophys Acta Mol Cell Biol Lipids 2022; 1867(1):159056.
Vilela VR, Samson N, Nachbar R, Perazza LR, Lachance G, Rokatoarivelo V, Centano-Baez C, Zancan P, Sola-Penna M, Bellmann K, Di Marzo V, Laplante M, Marette A. Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice.. Mol Metab 2022; 0(0):101437.
Sihag J, Di Marzo V. (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders.. Lipids Health Dis 2022; 21(1):9.
Villano R, Tinto F, Di Marzo V. Facile and Sustainable Synthesis of Commendamide and its Analogues.. Front Chem 2022; 10(0):858854.
Forte N, Fernández-Rilo AC, Palomba L, Marfella B, Piscitelli F, De Girolamo P, Di Costanzo A, Di Marzo V, Cristino L. Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer's disease.. Front Aging Neurosci 2022; 14(0):1004002.
Schiano Moriello A, Di Marzo V, Petrosino S. Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint.. Animals (Basel) 2022; 12(3):348.
Stark T, Iannotti FA, Di Martino S, Di Bartolomeo M, Ruda-Kucerova J, Piscitelli F, Wotjak CT, D'Addario C, Drago F, Di Marzo V, Micale V. Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia.. Biomolecules 2022; 12(1):108.
Forteza F, Bourdeau-Julien I, Nguyen GQ, Guevara Agudelo FA, Rochefort G, Parent L, Rakotoarivelo V, Feutry P, Martin C, Perron J, Lamarche B, Flamand N, Veilleux A, Billaut F, Di Marzo V, Raymond F. Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study.. Sci Rep 2022; 12(1):8568.
Ben Necib R, Manca C, Lacroix S, Martin C, Flamand N, Di Marzo V, Silvestri C. Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed.. Front Immunol 2022; 13(0):882455.
Simard M, Archambault AS, Lavoie JC, Dumais É, Di Marzo V, Flamand N. Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families.. Biochem Pharmacol 2022; 205(0):115261.
Roussel C, Anunciação Braga Guebara S, Plante PL, Desjardins Y, Di Marzo V, Silvestri C. Short-term supplementation with ?-3 polyunsaturated fatty acids modulates primarily mucolytic species from the gut luminal mucin niche in a human fermentation system.. Gut Microbes 2022; 14(1):2120344.
Mboumba Bouassa RS, Sebastiani G, Di Marzo V, Jenabian MA, Costiniuk CT. Cannabinoids and Chronic Liver Diseases.. Int J Mol Sci 2022; 23(16):9423.
Boubertakh B, Silvestri C, Di Marzo V. Obesity: The Fat Tissue Disease Version of Cancer.. Cells 2022; 11(12):1872.
Ten-Blanco M, Flores Á, Pereda-Pérez I, Piscitelli F, Izquierdo-Luengo C, Cristino L, Romero J, Hillard CJ, Maldonado R, Di Marzo V, Berrendero F. Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1.. Biomed Pharmacother 2022; 149(0):112925.
Boubertakh B, Courtemanche O, Marsolais D, Di Marzo V, Silvestri C.. New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation.. J Lipid Res 2023; 64(11):100444.
Lauritano A, Cipollone I, Verde R, Kalkan H, Moriello C, Iannotti FA, Di Marzo V, Piscitelli F. The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity.. Front Aging Neurosci 2022; 14(0):926634.
Simard M, Rakotoarivelo V, Di Marzo V, Flamand N. Expression and Functions of the CB(2) Receptor in Human Leukocytes.. Front Pharmacol 2022; 13(0):826400.
Bertrand JA, Woodward DF, Sherwood JM, Spenlehauer A, Silvestri C, Piscitelli F, Di Marzo V, Yamazaki M, Sakimura K, Watanabe K, Overby DR.. Gene deletion studies reveal a critical role for prostamide/prostaglandin F2α synthase in prostamide F2α formation.. bioRxiv 2020; 0(0):Epub.
Forte N, Roussel C, Marfella B, Lauritano A, Villano R, De Leonibus E, Salviati E, Khalilzadehsabet T, Giorgini G, Silvestri C, Piscitelli F, Pina Mollica M, Di Marzo V, Cristino L.. Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity.. Commun Biol 2023; 6(1):959.
Schiano Moriello A, Roviezzo F, Iannotti FA, Rea G, Allarà M, Camerlingo R, Verde R, Di Marzo V, Petrosino S. First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury.. Biomolecules 2022; 13(1):33.
Falascina G, Bindels LB, Di Marzo V, Cutignano A. Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples.. J Pharm Biomed Anal 2023; 226(0):115252.
Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, Piscitelli F, Abolghasemi A, Gazzerro E, Silvestri C, Capasso R, Motta A, Russo R, Di Marzo V, Iannotti FA. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.. EMBO Mol Med 2023; 0(0):e16225.
Daniel N, Le Barz M, Mitchell P, Varin TV, Boudreau Julien I, Pilon G, Gauthier J, Garofalo C, Kang JX, Trottier J, Barbier O, Roy D, Chassaing B, Levy E, Raymond F, Flamand N, Silvestri C, Jobin C, Di Marzo V, Marette A.. Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.. Function (Oxf) 2022; 4(2):zqac069.
Pagano E, Romano B, Cicia D, Iannotti FA, Venneri T, Lucariello G, Nanì MF, Cattaneo F, De Cicco P, D'Armiento M, De Luca M, Lionetti R, Lama S, Stiuso P, Zoppoli P, Falco G, Marchianò S, Fiorucci S, Capasso R, Di Marzo V, Borrelli F, Izzo AA. TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/?-catenin signalling.. Br J Pharmacol 2023; 180(2):235-251.
Dugas C, Laberee L, Perron J, St-Arnaud G, Richard V, Perreault V, Leblanc N, Marc I, Di Marzo V, Doyen A, Veilleux A, Robitaille J. Gestational Diabetes Mellitus, Human Milk Composition, and Infant Growth.. Breastfeed Med 2023; 18(1):14-22.
Barré T, Di Marzo V, Marcellin F, Burra P, Carrieri P. Expanding Research on Cannabis-Based Medicines for Liver Steatosis: A Low-Risk High-Reward Way Out of the Present Deadlock?. Cannabis Cannabinoid Res 2023; 8(1):5-11.
Bourdeau-Julien I, Castonguay-Paradis S, Rochefort G, Perron J, Lamarche B, Flamand N, Di Marzo V, Veilleux A, Raymond F.. The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population.. Microbiome 2023; 11(1):26.
Suriano F, Manca C, Flamand N, Van Hul M, Delzenne NM, Silvestri C,Cani PD, Di Marzo V.. A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese ( ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota. Cells 2023; 12(3):411.
Mukorako P, St-Pierre DH, Flamand N, Biertho L, Lebel S, Lemoine N, Plamondon J, Roy MC, Tchernof A, Varin TV, Marette A, Silvestri C, Di Marzo V, Richard D. Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects.. Int J Obes (Lond) 2023; 47(7):630-641.
Lacroix S, Leblanc N, Abolghasemi A, Paris-Robidas S, Martin C, Frappier M, Flamand N, Silvestri C, Raymond F, Millette M, Di Marzo V, Veilleux A. Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations.. Benef Microbes 2023; 0(0):1-16.
Mir HD, Giorgini G, Di Marzo V. The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders.. Psychoneuroendocrinology 2023; 154(0):106295.
Romeo I, Brizzi A, Pessina F, Ambrosio FA, Aiello F, Belardo C, Carullo G, Costa G, De Petrocellis L, Frosini M, Luongo L, Maramai S, Paolino M, Moriello AS, Mugnaini C, Scorzelli F, Maione S, Corelli F, Di Marzo V, Alcaro S, Artese A. In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.. J Med Chem 2023; 66(10):6994-7015.
Venneri T, Giorgini G, Leblanc N, Flamand N, Borrelli F, Silvestri C, Di Marzo V. Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice.. Lipids Health Dis 2023; 22(1):63.
Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M. Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years.. Pharmacol Rev 2023; 75(5):885-958.
Santos-García I, Rodríguez-Cueto C, Villegas P, Piscitelli F, Lauritano A, Shen CJ, Di Marzo V, Fernández-Ruiz J, de Lago E. Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.. J Neuroinflammation 2023; 20(1):108.
Paes-Colli Y, Trindade PMP, Vitorino LC, Piscitelli F, Iannotti FA, Campos RMP, Isaac AR, de Aguiar AFL, Allodi S, de Mello FG, Einicker-Lamas M, de Siqueira-Santos R, Di Marzo V, Tannous BA, Carvalho LA, De Melo Reis RA, Sampaio LS. Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium.. Front Cell Neurosci 2023; 17(0):1134130.
Maia J, Iannotti FA, Piscitelli F, Fonseca BM, Braga A, Braga J, Teixeira N, Di Marzo V, Correia-da-Silva G. The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia.. Biofactors 2023; 49(4):887-899.
Elisei L, Moraes T, Malta I, Rodríguez J, Di Marzo V, Galdino G. Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review.. Cannabis Cannabinoid Res 2023; 8(3):389-407.
Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L. Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.. Mol Metab 2023; 72(0):101713.
Di Bartolomeo M, Stark T, Di Martino S, Iannotti FA, Ruda-Kucerova J, Romano GL, Kuchar M, Laudani S, Palivec P, Piscitelli F, Wotjak CT, Bucolo C, Drago F, Di Marzo V, D'Addario C, Micale V. The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology.. Int J Mol Sci 2023; 24(4):3907.
Silvestri C, Di Marzo V. The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior.. Function (Oxf) 2023; 4(2):zqad003.
Daniel N, Le Barz M, Mitchell PL, Varin TV, Julien IB, Farabos D, Pilon G, Gauthier J, Garofalo C, Kang JX, Trottier J, Barbier O, Roy D, Chassaing B, Levy E, Raymond F, Lamaziere A, Flamand N, Silvestri C, Jobin C, Di Marzo V, Marette A. Comparing Transgenic Production to Supplementation of ?-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.. Function (Oxf) 2023; 4(2):zqac069.
Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Di Marzo V, Ronca R, Ligresti A. Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer.. Pharmacol Res 2023; 189(0):106683.
Inserra A, Giorgini G, Lacroix S, Bertazzo A, Choo J, Markopolous A, Grant E, Abolghasemi A, De Gregorio D, Flamand N, Rogers G, Comai S, Silvestri C, Gobbi G, Di Marzo V. Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome.. Br J Pharmacol 2023; 180(6):721-739.
Castonguay-Paradis S, Perron J, Flamand N, Lamarche B, Raymond F, Di Marzo V, Veilleux A. Dietary food patterns as determinants of the gut microbiome-endocannabinoidome axis in humans.. Sci Rep 2023; 13(1):15702.
Forte N, Roussel C, Marfella B, Lauritano A, Villano R, De Leonibus E, Salviati E, Khalilzadehsabet T, Giorgini G, Silvestri C, Piscitelli F, Mollica MP, Di Marzo V, Cristino L. Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity.. Commun Biol 2023; 6(1):959.
Boubertakh B, Courtemanche O, Marsolais D, Di Marzo V, Silvestri C. New role for the anandamide metabolite prostaglandin F(2?) ethanolamide: Rolling preadipocyte proliferation.. J Lipid Res 2023; 0(0):100444.
Kalkan H, Panza E, Pagano E, Ercolano G, Moriello C, Piscitelli F, Sztretye M, Capasso R, Di Marzo V, Iannotti FA. Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin.. Cell Death Dis 2023; 14(8):544.
Sierra-Ruelas E, Torres-Castillo N, Vizmanos B, Campos-Pérez W, Lopez-Cortes OD, Di Marzo V, Martínez-López E. FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.. Metab Syndr Relat Disord 2023; 0(0):Epub.
Deschênes T, Tohoundjona FWE, Plante PL, Di Marzo V, Raymond F. Gene-based microbiome representation enhances host phenotype classification.. mSystems 2023; 8(4):e0053123.
Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M. Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.. Pharmacol Rev 2023; 75(5):885-958.
Cinquina V, Calvigioni D, Piscitelli F, Keimpema E, Di Marzo V, Verkhratsky A, Harkany T.. Astrocytes modulate neuronal development by S100A6 signaling.. bioRxiv 2023; 0(0):Epub.
Ruddy S, Di Marzo V, Ngueta G.. Cannabis use in relation to Pulse Pressure and Mean Arterial Pressure in US Adults.. medRxiv 2023; 0(0):Epub.
Villano R, Straker H, Di Marzo V.. Short and efficient synthesis of alkylresorcinols: a route for the preparation of cannabinoids.. New J Chem 2022; 43(0):20664-20668.
Piscitelli F, Di Marzo V.. Cannabinoids: a class of unique natural products with unique pharmacology.. Rendi Lincei Sci Fisiche e Nat 2021; 32(0):5-15.
Di Marzo V, Marino G.. Editorial on Cannabis and cannabinoids: history, practice and socio-economical inferences of a controversial plant.. Rendi Lincei Sci Fisiche e Nat 2021; 32(0):1-4.
Piscitelli F, Coccurello R, Totaro A, Leuti A, Giacovazzo G, Verde R, Rossi E, Podaliri Vulpiani M, Ferri N, Giacominelli Stuffler R, Di Marzo V, Oddi S, Bisogno T, Maccarrone M.. Targeted Lipidomics Investigation of N-acylethanolamines in a Transgenic Mouse Model of AD: A Longitudinal Study.. Eur J Lipid Sci Technol 2019; 121(10):1900015.

Dr Vincenzo Di Marzo

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