Clinicien(ne) chercheur(e)

Dr Steeve Provencher

Pneumologie

A2118

steeve.provencher@criucpq.ulaval.ca

Domaine de recherche

Mécanismes impliqués dans l'intolérance à l'effort en hypertension artérielle pulmonaire (HTAP); Mécanismes cellulaires et moléculaires impliqués dans le développement de l'HTAP et la dysfonction cardiaque; Identification et validation de biomarqueurs en HTAP; Remodelage cellulaire; Épidémiologie

Description des travaux

Le Dr Provencher fait partie du Groupe de Recherche en Hypertension Pulmonaire (www.hypertensionarteriellepulmonaire.ca). Le Groupe est composé de chercheurs oeuvrant selon un programme de recherche translationnel-clinique, basé à la fois sur l'investigation clinique et la recherche fondamentale qui fait du groupe une équipe de recherche unique en son genre au Canada.

Le programme de recherche du Dr Provencher est orienté sur la physiopathologie de l'exercice, ainsi que les mécanismes cellulaires conduisant au développement de l'hypertension artérielle pulmonaire (HTAP). Il s'intéresse également à la validation clinique de biomarqueurs de cette maladie. Ses intérêts l'ont également conduit à la réalisation de travaux sur l'embolie pulmonaire et la maladie pulmonaire obstructive chronique(MPOC).

Son programme vise à améliorer la prise en charge des patients, leur qualité de vie et leur survie. Il s'intéresse notamment :

1) au développement anormal de nouveaux vaisseaux (angiogenèse);

2) au dérèglement des mécanismes influençant l'expression des gènes (lecteur épigénétique BRD4);

3) à la capacité de nouveaux marqueurs sanguins à détecter l'HTAP et à prédire la réponse subséquente aux traitements;

4) à explorer de nouveaux mécanismes de l'intolérance à l'effort;

5) à valider de nouveaux outils évaluatifs de la qualité de vie qui, par leur utilisation dans les essais cliniques, permettront de soutenir le développement de nouveaux médicaments.

Ultimement, la réalisation de ce programme inspirera de nouvelles pistes de recherche et potentiellement de nouvelles thérapies pour cette maladie encore mortelle.

Prix et distinctions

2011 : Prix Jacques Leblanc (nominé), décerné au directeur de recherche s’étant le plus illustré par l’excellence de la formation offerte aux étudiants.
2011 : Prix reconnaissance Marc Julien, décerné par les résidents en médecine interne de l’Université Laval. En reconnaissance du travail remarquable fait au sein des hôpitaux d’enseignement auprès des résidents, du dévouement à ses patients, des compétences cliniques et la qualité des soins.
2004 : Prix François Brenot de l’European Respiratory Society, récompensant le jeune investigateur le plus prometteur dans le domaine des sciences pulmonaires vasculaires.

Publications

203

Trier par année :

Provencher S, Sitbon O, Humbert M, Cabrol S, Jaïs X, Simonneau G. Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension.. Eur Heart J 2006; 27(5):589-95.
Provencher S, Herve P, Jais X, Lebrec D, Humbert M, Simonneau G, Sitbon O. Deleterious effects of beta-blockers on exercise capacity and hemodynamics in patients with portopulmonary hypertension.. Gastroenterology 2006; 130(1):120-6.
Provencher S, Martel S, Jais X, Sitbon O, Humbert M, Simonneau G. [Diagnosis and classification of pulmonary arterial hypertension]. Presse Med 2005; 34(19):1435-44.
Provencher S, Jais X, Yaici A, Sitbon O, Humbert M, Simonneau G. Clinical challenges in pulmonary hypertension: Roger S. Mitchell lecture.. Chest 2005; 128(6):622S-628S.
Provencher S, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension with bosentan: from pathophysiology to clinical evidence.. Expert Opin Pharmacother 2005; 6(8):1337-48.
Sitbon O, Humbert M, Jaïs X, Ioos V, Hamid AM, Provencher S, Garcia G, Parent F, Hervé P, Simonneau G. Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension.. Circulation 2005; 111(23):3105-11.
Provencher S, Chemla D, Hervé P, Sitbon O, Humbert M, Simonneau G. Heart rate responses during the 6-minute walk test in pulmonary arterial hypertension.. Eur Respir J 2006; 27(1):114-20.
Provencher S, Jaïs X, Sitbon O. Bosentan therapy for pulmonary arterial hypertension.. Future Cardiol 2005; 1(3):299-309.
Provencher S. Long-term treprostinil in pulmonary arterial hypertension: is the glass half full or half empty?. Eur Respir J 2006; 28(6):1073-5.
Provencher S, Poirier C, Mainguy V, Humbert M, Simonneau G. Le test de marche de six minutes en pneumologie. Encyclopédie médico-chirurgicale (Elsevier Masson SAS, Paris). Pneumologie 2007; 0(0):6-000-N-95.
Lafleur A, Provencher S. Stratification du risque de lembolie pulmonaire.. Le clinicien 2008; 23(3):81-5.
Provencher S, Hervé P, Sitbon O, Humbert M, Simonneau G, Chemla D. Changes in Exercise hemodynamics during treatment in Pulmonary Arterial Hypertension.. Eur Respir J 2008; 32(2):393-8.
Chemla D, Castelain V, Provencher S, Humbert M, Simonneau G, Hervé P. Evaluation of various empirical formulas for estimating mean pulmonary artery pressure by using systolic pulmonary artery pressure in adults.. Chest 2009; 135(3):760-8.
Grünig E, Weissmann S, Ehlken N, Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani A, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G. Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia.. Circulation 2009; 119(13):1747-57.
Ugalde P, Miro S, Provencher S, Quevillon M, Chau L, Deslauriers DR, Lacasse Y, Ferland S, Simard S, Deslauriers J. Ipsilateral diaphragmatic motion and lung function in long-term pneumonectomy patients.. Ann Thorac Surg 2008; 86(6):1745-51.
Provencher S, Sitbon O. Intravenous iloprost for pulmonary arterial hypertension: still waiting for evidence.. Eur Respir J 2009; 34(1):7-9.
McLaughlin VV, Badesch DB, Delcroix M, Fleming TR, Gaine SP, Galiè N, Gibbs JS, Kim NH, Oudiz RJ, Peacock A, Provencher S, Sitbon O, Tapson VF, Seeger W. End points and clinical trial design in pulmonary arterial hypertension.. J Am Coll Cardiol 2009; 54(1):S97-107.
Gagnon P, Saey D, Vivodtzev I, Laviolette L, Mainguy V, Milot J, Provencher S, Maltais F. Impact of preinduced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjects.. J Appl Physiol 2009; 107(3):832-40.
Lega JC, Lacasse Y, Lakhal L, Provencher S. Natriuretic peptides and troponins in pulmonary embolism: a meta-analysis.. Thorax 2009; 64(10):869-75.
Laviolette L, Lands LC, Dauletbaev N, Saey D, Milot J, Provencher S, LeBlanc P, Maltais F. Combined effect of dietary supplementation with pressurized whey and exercise training in COPD: a randomized controlled double-blind pilot study.. J Med Food 2010; 13(3):589-98.
Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension.. J Cardiopulm Rehabil Prev 2010; 30(5):319-23.
Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension.. Thorax 2010; 65(2):113-7.
Provencher S, Souza R. Predicting survival in pulmonary arterial hypertension: time to move forward.. Eur Respir J 2010; 35(5):958-9.
Provencher S. Assessment and Treatment of Pulmonary Hypertension in COPD and Other Lung Diseases.. Can J Cardiol 2010; 17(0):31A-32A.
Provencher S. Nouveautés en hypertension pulmonaire.. Rev Mal Respir 2009; 2(0):S75-7.
Provencher S. La stratification du risque de lembolie pulmonaire : à faire systématiquement.. L'inhalo 2009; 26(1):14-6.
Bédard ME, Marquis K, Poirier P, Provencher S. Reduced heart rate variability in patients with chronic obstructive pulmonary disease independent of anticholinergic or ?-agonist medications.. COPD 2010; 7(6):391-7.
Deslauriers J, Ugalde P, Miro S, Ferland S, Bergeron S, Lacasse Y, Provencher S. Adjustments in cardiorespiratory function after pneumonectomy: results of the pneumonectomy project.. J Thorac Cardiovasc Surg 2011; 141(1):7-15.
Paulin R, Courboulin A, Meloche J, Mainguy V, Dumas de la Roque E, Saksouk N, Côté J, Provencher S, Sussman MA, Bonnet S. Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension.. Circulation 2011; 123(11):1205-15.
Courboulin A, Paulin R, Giguère NJ, Saksouk N, Perreault T, Meloche J, Paquet ER, Biardel S, Provencher S, Côté J, Simard MJ, Bonnet S. Role for miR-204 in human pulmonary arterial hypertension.. J Exp Med 2011; 208(3):535-48.
Mehta S, Helmersen D, Provencher S, Hirani N, Rubens FD, De Perrot M, Blostein M, Boutet K, Chandy G, Dennie C, Granton J, Hernandez P, Hirsch AM, Laframboise K, Levy RD, Lien D, Martel S, Shoemaker G, Swiston J, Weinkauf J; for the Canadian Thoracic Society Pulmonary Vascular Disease - CTEPH CPG Development Committee; and the Canadian Thoracic Society Canadian Respiratory Guidelines Committee.. Diagnostic evaluation and management of chronic thromboembolic pulmonary hypertension: A clinical practice guideline.. Can Respir J 2010; 17(6):301-34.
Deslauriers J, Ugalde P, Miro S, Deslauriers DR, Ferland S, Bergeron S, Lacasse Y, Provencher S. Long-term physiological consequences of pneumonectomy.. Semin Thorac Cardiovasc Surg 2011; 23(3):196-202.
Mainguy V, Provencher S, Maltais F, Malenfant S, Saey D. Assessment of daily life physical activities in pulmonary arterial hypertension.. PLoS One 2011; 6(11):e27993.
Provencher S, Chemla D, Hervé P. [Resting and exercise hemodynamics in pulmonary arterial hypertension].. Presse Med 2011; 40(1):S28-38.
Deschênes D, Provencher S, Cormier Y. Farmer's lung-induced hypersensitivity pneumonitis complicated by shock.. Respir Care 2012; 57(3):464-6.
Barrier M, Meloche J, Jacob MH, Courboulin A, Provencher S, Bonnet S. Today's and tomorrow's imaging and circulating biomarkers for pulmonary arterial hypertension.. Cell Mol Life Sci 2012; 69(17):2805-31.
Courboulin A, Barrier M, Perreault T, Bonnet P, Tremblay VL, Paulin R, Tremblay E, Lambert C, Jacob MH, Bonnet SN, Provencher S, Bonnet S. Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH.. Eur Respir J 2012; 40(3):618-29.
Bédard ME, Brouillard C, Pepin V, Provencher S, Milot J, Lacasse Y, Leblanc P, Maltais F. Tiotropium improves walking endurance in COPD.. Eur Respir J 2012; 39(2):265-71.
Mainguy V, Girard D, Maltais F, Saey D, Milot J, Sénéchal M, Poirier P, Provencher S. Effect of Bisoprolol on Respiratory Function and Exercise Capacity in Chronic Obstructive Pulmonary Disease.. Am J Cardiol 2012; 110(2):258-63.
Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, Bisserier M, Paulin R, Lambert C, Provencher S, Bonnet S.. Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension.. Respir Res 2011; 12(1):128.
Mainguy V, Malenfant S, Neyron AS, Bonnet S, Maltais F, Saey D, Provencher S. Repeatability and responsiveness of exercise tests in pulmonary arterial hypertension.. Eur Respir J 2013; 42(2):425-34.
Gagnon P, Saey D, Provencher S, Milot J, Bourbeau J, Tan WC, Martel S, Maltais F. Walking exercise response to bronchodilation in mild COPD: a randomized trial.. Respir Med 2012; 106(12):1695-705.
Gagnon P, Bussières JS, Ribeiro F, Gagnon SL, Saey D, Gagné N, Provencher S, Maltais F. Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2012; 186(7):606-15.
Meloche J, Paulin R, Provencher S, Bonnet S. Therapeutic potential of microRNA modulation in pulmonary arterial hypertension.. Curr Vasc Pharmacol 2013; 0(0):Epub.
Renard S, Paulin R, Breuils-Bonnet S, Simard S, Pibarot P, Bonnet S, Provencher S. Pim-1: a new biomarker in pulmonary arterial hypertension.. Pulm Circ 2013; 3(1):74-81.
Provencher S, Bonnet S. Pulmonary arterial hypertension research : Why does it take so long? How can I contribute?. Connect (Tor) 2012; 3(2):26-27.
Mainguy V, Provencher S.. Le test de marche : un outil essentiel en pneumologie.. La lettre du pneumologue 2012; 6(0):162-6.
Malenfant S, Margaillan G, Loehr JE, Bonnet S, Provencher S. The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to the near future.. Expert Rev Respir Med 2013; 7(1):43-55.
Borel B, Provencher S, Saey D, Maltais F. Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD.. Pulm Med 2013; 2013(0):410748.
Coates AL, Graham BL, McFadden RG, McParland C, Moosa D, Provencher S, Road J. Spirometry in primary care.. Can Respir J 2013; 20(1):13-21.
Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay E, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S. Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.. J Am Heart Assoc 2013; 2(1):e005157.
Malenfant S, Neyron AS, Potus F, Provencher S, Bonnet S. Signal transduction pathways in the development of pulmonary arterial hypertension.. Pulm Circ 2013; 3(2):278-93.
Paulin R, Meloche J, Courboulin A, Lambert C, Haromy A, Courchesne A, Bonnet P, Provencher S, Michelakis ED, Bonnet S.. Targeting cell motility in pulmonary arterial hypertension.. Eur Respir J 2014; 43(2):531-44.
Chemla D, Castelain V, Hoette S, Creuze N, Provencher S, Zhu K, Humbert M, Herve P.. Strong linear relationship between heart rate and mean pulmonary artery pressure in exercising patients with severe precapillary pulmonary hypertension.. Am J Physiol Heart Circ Physiol 2013; 305(5):H769-77.
Vonk Noordegraaf A, Chin KM, Forfia PR, Haddad F, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel N, Hassoun PM.. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.. J Am Coll Cardiol 2013; 62(25):D22-33.
Potus F, Graydon C, Provencher S, Bonnet S.. Vascular remodeling process in pulmonary arterial hypertension, with focus on miR-204 and miR-126 (2013 Grover Conference series).. Pulm Circ 2014; 4(2):175-84.
Ruffenach G, Chabot S, Tanguay VF, Courboulin A, Boucherat O, Potus F, Meloche J, Pflieger A, Breuils-Bonnet S, Nadeau V, Paradis R, Tremblay E, Girerd B, Hautefort A, Montani D, Fadel E, Dorfmuller P, Humbert M, Perros F, Paulin R, Provencher S, Bonnet S. Role for RUNX2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2016; 194(10):1273-85.
Fortin M, Turgeon PY, Nadreau E, Grégoire P, Maltais LG, Sénéchal M, Provencher S, Maltais F. Prognostic value of oxygen kinetics during recovery from cardiopulmonary exercise testing in patients with chronic heart failure.. Am J Cardiol 2015; 31(10):1259-65.
Meloche J, Renard S, Provencher S, Bonnet S. Anti-inflammatory and Immunosuppressive Agents in PAH.. Handb Exp Pharmacol 2013; 218(0):437-76.
Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulos S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S. Role for DNA damage signaling in pulmonary arterial hypertension.. Circulation 2013; 0(0):Epub.
Gagnon P, Lemire BB, Dubé A, Saey D, Porlier A, Croteau M, Provencher S, Debigaré R, Maltais F. Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD.. Respir Res 2014; 15(0):4.
Vivodtzev I, Devost AA, Saey D, Villeneuve S, Boilard G, Gagnon P, Provencher S, Simon M, Baillot R, Maltais F, Lellouche F. Severe and early quadriceps weakness in mechanically ventilated patients.. Crit Care 2014; 18(3):431.
Chaouat A, Sitbon O, Mercy M, Ponçot-Mongars R, Provencher S, Guillaumot A, Gomez E, Selton-Suty C, Malvestio P, Regent D, Paris C, Hervé P, Chabot F.. Prognostic value of exercise pulmonary haemodynamics in pulmonary arterial hypertension.. Eur Respir J 2014; 44(3):704-13.
Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED. A miR-208-Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension.. Circ Res 2015; 116(1):56-69.
Meloche J, Paulin R, Provencher S, Bonnet S.. Therapeutic Potential of microRNA Modulation in Pulmonary Arterial Hypertension.. Curr Vasc Pharmacol 2015; 13(3):331-40.
Malenfant S, Potus F, Fournier F, Breuils-Bonnet S, Pflieger A, Bourassa S, Tremblay È, Nehmé B, Droit A, Bonnet S, Provencher S. Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension.. J Mol Med (Berl) 2015; 93(5):573-84.
Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED. Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.. Cell Metab 2014; 20(5):827-39.
Mainguy V, Malenfant S, Neyron AS, Saey D, Maltais F, Bonnet S, Provencher S. Alternatives to the six-minute walk test in pulmonary arterial hypertension.. PLoS One 2014; 9(8):e103626.
Potus F, Malenfant S, Graydon C, Mainguy V, Tremblay È, Breuils-Bonnet S, Ribeiro F, Porlier A, Maltais F, Bonnet S, Provencher S. Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension.. Am J Respir Crit Care Med 2014; 190(3):318-28.
Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M. Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.. Circulation 2014; 130(9):776-85.
Meloche J, Pflieger A, Vaillancourt M, Graydon C, Provencher S, Bonnet S. miRNAs in PAH: biomarker, therapeutic target or both?. Drug Discov Today 2014; 19(8):1264-9.
Rival G, Lacasse Y, Martin S, Bonnet S, Provencher S. Effect of pulmonary arterial hypertension-specific therapies on health-related quality of life: a systematic review.. Chest 2014; 146(3):686-708.
Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulos S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S. Role for DNA damage signaling in pulmonary arterial hypertension.. Circulation 2014; 129(7):786-97.
Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM. [Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology].. Turk Kardiyol Dern Ars 2014; 42(0):29-44.
Provencher S, Granton JT. Current Treatment Approaches to Pulmonary Arterial Hypertension.. Can J Cardiol 2015; 31(4):460-477.
Ferland N, Couture C, Provencher S. Near-fatal haemoptysis as presentation of a giant intralobar pulmonary sequestration.. Eur Respir Rev 2015; 24(135):155-6.
Provencher S, Paruchuru P, Spezzi A, Waterhouse B, Gomberg-Maitland M. Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterial hypertension.. PLoS One 2015; 10(3):e0120657.
Potus F, LeGuen M, Provencher S, Meloche J, Bonnet S.. DNA damage at the dawn of micro-RNA pathway impairment in pulmonary arterial hypertension. RNA Dis 2015; 2(4):e810.
Gagnon P, Casaburi R, Saey D, Porszasz J, Provencher S, Milot J, Bourbeau J, O'Donnell DE, Maltais F.. Cluster Analysis in Patients with GOLD 1 Chronic Obstructive Pulmonary Disease.. PLoS One 2015; 10(4):e0123626.
Malenfant S, Potus F, Mainguy V, Leblanc È, Malenfant M, Ribeiro F, Saey D, Maltais F, Bonnet S, Provencher S. Impaired Skeletal Muscle Oxygenation and Exercise Tolerance in Pulmonary Hypertension.. Med Sci Sports Exerc 2015; 47(11):2273-82.
Boucherat O, Chabot S, Antigny F, Perros F, Provencher S, Bonnet S. Potassium channels in pulmonary arterial hypertension.. Eur Respir J 2015; 46(4):1167-77.
Meloche J, Potus F, Vaillancourt M, Bourgeois A, Johnson I, Deschamps L, Chabot S, Ruffenach G, Henry S, Breuils-Bonnet S, Tremblay È, Nadeau V, Lambert C, Paradis R, Provencher S, Bonnet S. Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension.. Circ Res 2015; 117(6):525-35.
Potus F, Ruffenach G, Dahou A, Thebault C, Breuils-Bonnet S, Tremblay È, Nadeau V, Paradis R, Graydon C, Wong R, Johnson I, Paulin R, Lajoie AC, Perron J, Charbonneau E, Joubert P, Pibarot P, Michelakis ED, Provencher S, Bonnet S. Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension.. Circulation 2015; 132(10):932-43.
Meloche J, Le Guen M, Potus F, Vinck J, Ranchoux B, Johnson I, Antigny F, Tremblay E, Breuils-Bonnet S, Perros F, Provencher S, Bonnet S. miR-223 reverses experimental pulmonary arterial hypertension.. Am J Physiol Cell Physiol 2015; 309(6):C363-72.
Labbé C, Beaudoin S, Martel S, Delage A, Joubert P, Drapeau C, Provencher S. Diagnostic yield of non-guided flexible bronchoscopy for peripheral pulmonary neoplasia.. Thorac Cancer 2015; 6(4):517-23.
Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, Péchoux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfmüller P, Breuils-Bonnet S, Fadel E, Ranchoux B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simonneau G, Humbert M, Perros F. Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.. Circulation 2016; 133(14):1371-85.
Lajoie AC, Lauzière G, Lega JC, Lacasse Y, Martin S, Simard S, Bonnet S, Provencher S. Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis.. Lancet Respir Med 2016; 4(4):291-305.
Boucherat O, Morissette MC, Provencher S, Bonnet S, Maltais F. Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.. Am J Respir Crit Care Med 2016; 193(4):362-75.
Provencher S. Evolution in management of pulmonary arterial hypertension (PAH): Targeting of the Prostacyclin Pathway in PAH.. Med Options 2016; 40011(0):3-8.
Ranchoux B, Meloche J, Paulin R, Boucherat O, Provencher S, Bonnet S. DNA Damage and Pulmonary Hypertension.. Int J Mol Sci 2016; 17(6):E990.
Bonnet S, Provencher S. Shear Stress Maladaptation in Pulmonary Arterial Hypertension. An Ageless Concept.. Am J Respir Crit Care Med 2016; 193(12):1331-2.
Ryerson CJ, Camp PG, Eves ND, Schaeffer M, Syed N, Dhillon S, Jensen D, Maltais F, O'Donnell DE, Raghavan N, Roman M, Stickland MK, Assayag D, Bourbeau J, Dion G, Fell CD, Hambly N, Johannson KA, Kalluri M, Khalil N, Kolb M, Manganas H, Morán-Mendoza O, Provencher S, Ramesh W, Rolf JD, Wilcox PG, Guenette JA. High Oxygen Delivery to Preserve Exercise Capacity in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib. Methodology of the HOPE-IPF Study.. Ann Am Thorac Soc 2016; 13(9):1640-7.
Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M. Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2017; 195(5):583-595.
Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.. Am J Respir Crit Care Med 2017; 195(4):515-529.
Harel F, Langleben D, Provencher S, Fournier A, Finnerty V, Nguyen QT, Letourneau M, Levac X, Abikhzer G, Guimond J, Mansour A, Guertin MC, Dupuis J. Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principle trial.. Eur J Nucl Med Mol Imaging 2017; 44(7):1136-44.
Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S, Bonnet S. The cancer theory of Pulmonary Arterial Hypertension.. Pulm Circ 2017; 7(2):285-99.
Provencher S, Mainguy V. Exercise testing in Pulmonary Arterial Hypertension.. Karger Kompass Pneumoligie 2016; 4(2):64-76.
Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM1; APEX Investigators (Bello F, Ferrari AE, Jure H, Macin S, Oliva M, Parody M, Poy C, Baker R, Colquhoun D, Coughlin P, Finfer S, Rubinfeld A, Huber K, König J, Mathies R, Pilger E, Schoenerr H, Adzerikho I, Koryk V, Mikhailova E, Mitkovskaya N, Pimanov S, Polonetsy L, Soroka N, Blockmans D, Delforge M, Dive A, Lienart F, Motte S, Bizzacchi J, Fiss E, Freire A, Manenti E, Ramacciotti E, Raymuno S, Rocha A, Saraiva JF, Dimov B, Grigorov M, Kalpachki R, Kamenova Z, Kostadinova M, Milanova M, Mincheva V, Pencheva G, Raev D, Runev N, Stoeva N, Stoyanov M, Syulemzova S, Todorov G, Tokmakova M, Dhar A, Douketis J, Kahn S, Le Gal G, Pearce M, Provencher S, Verreault S, Alarcon M, Cañon C, Lazcano M, Cardenas S, Butkovic-Soldo S, Car S, Ciglenecki N, Francetic I, Jakopovic M, Kalinic-Grgorinic H, Knezevic A, Malojcic B, Marusic S, Vagic J, Skerk V, Cermak O, Chlumsky J, Chochola J, Cizek V, Dunaj M, Dusek J, Francek L, Havelka J, Herold M, Holaj R, Horny I, Hubac J, Jajtner P, Kolman P, Lang P, Mayer O, Mikulova J, Podpera I, Reiterer P, Spacek R, Vejvoda J, Vyhnanek M, Christensen H, Lassen M, Storgaard M, Tuxen C, Urhammer S, Lember M, Marandi T, Uuetoa T, Airaksinen J, Honkaniemi J, Kaaja R, Lassila R, Saarinen J, Tatlisumak T, Vikman S, Agraou B, Aquilanti S, Belhassane A, Brisot D, De Geeter G, Debourdeau P, Decoulx E, El Kouri D, Falvo N, Grange C, Lacroix P, Messas E, Mismetti P, Montaclair K, Mottier D, Paleiron N, Payot L, Pernod G, Pottier P, Proust A, Quere I, Roy PM, Schmidt J, Simoneau G, Datikashvili-David I, Khabeishvili G, Khintibidze I, Kobulia B, Megreladze I, Pagava Z, Paposhvili K, Shaburishvili T, Amann B, Berrouschot J, Beyer-Westendorf J, Blessing E, Bott M, Dengler T, Dziewas R, Genth-Zotz S, Hamann F, Horacek T, Klimpe S, Kröning R, Lapp H, Lawall H, Licka M, Rizos T, Schellong S, Tiefenbacher C, Weimar C, Zeymer U, Alkonyi B, Faluközy J, Futo L, Katona A, Kirschner R, Kristóf P, Lakatos F, Laszlo Z, Lupkovics G, Merkely B, András C, Németh L, Papp A, Soltesz P, Sudár Z, Szabo G, Szegedi N, Tímár G, Valcó J, Vertes A, Efrati S, Elias M, Gafter A, Hayek T, Hussein O, Lishner M, Lugassy G, Zeltser D, Ageno W, Cerveri I, D'Angelo A, De Pellegrin A, Imberti D, Landolfi R, Lembo G, Lodigiani C, Moia M, Molteni M, Mumoli N, Novo S, Orlandini F, Parisi R, Pizzini A, Pomero F, Salvi A, Schenone A, Visonà A, Krievins D, Martinova V, Pontaga N, Rozitis V, Stukena I, Alekniene B, Bagdonas A, Basijokiene V, Butkiene Z, Griskeviciene V, Naudziunas A, Norvaisiene R, Norviliene R, Petrauskiene R, Poskiene R, Susinskiene D, Valavicius A, Leon R, Pereyra R, Karlo L, Horna M, Osores J, Salas M, Yañez L, Fryze W, Gaciong Z, Gniot J, Gorecka D, Gruenpeter P, Grzelakowski P, Jastrzebski D, Kucharski L, Mirek-Bryniarska E, Pulkowski G, Sobkowicz B, Sulik P, Tomkowski W, Walasek L, Waldemar K, Wrzesinski K, Balogh ZE, Bojinca M, Marin I, Mot S, Musetescu R, Podoleanu C, Popescu M, Stamate S, Stanciulescu G, Vida-Simiti L, Abashev A, Andreev D, Apartsin K, Arkhipov M, Averkov O, Barbarash O, Belskaya G, Bogdanov E, Boldueva S, Chefranova Z, Dovgalevskiy Y, Ershova O, Goloshchekin B, Khachatryan N, Klein G, Kobalava Z, Kosmacheva E, Kostenko V, Malygin A, Martynenko T, Martynenko V, Maslova N, Mordovin V, Nikolaev K, Nilk R, Panchenko E, Popov D, Privalova E, Reshetko O, Sergeeva E, Shapovalova Y, Shpagina L, Shvarts Y, Simanenkov V, Solovyov O, Vishneva E, Vishnevskiy A, Apostolovic S, Celic V, Ilic S, Kovacevic-Kuzmanovic A, Miloradovic V, Tan RS, Bodikova S, Cervenakova A, Dvorak M, Gaspar L, Herman O, Hrubon A, Kokles M, Krastev G, Payer J, Prokop D, Spisakova M, Adler D, Basson M, Breedt J, Engelbrecht J, Jacobson B, Mitha I, Van Dyk C, Sala LA, López C, Bisbe J, Guardiola A, Cepeda JM, Cereto F, Santos E, Ferrer R, Cerezo J, Gonzales-Porras JR, Grandes J, Jiménez D, Mellibovsky L, Richart C, Riera A, Trujillo J, Nunez JA, Villalta J, Akgul O, Guneri S, Kilichesmez K, Kırma C, Kutluk H, Nazliel B, Okumus G, Ongen G, Tigen K, Topcuoglu M, Tuncay E, Abrahamovych O, Batushkin V, Brozhyk J, Burmak I, Godlevska O, Goloborodko A, Goloborodko B, Goncharova Y, Gryb V, Karpenko O, Kopytsya M, Koshlia V, Krakhmalova O, Kyrychenko I, Legkonogov O, Malynovsky Y, Maslovaskyi V, Nikonov V, Parkhomenko O, Perepeliuk M, Reshotko D, Rudenko L, Ryabichenko T, Svyridova I, Svyshchenko Y, Tseluyko V, Ursol G, Vakaliuk I, Vishnivestsky I, Voronkov L, Yagensky A, Body R, Davis M, MacCallum P, McCollum C, Natarajan I, Almasri E, Amin M, Anderson C, Baker S, Barney J, Bastani A, Bercz P, Bidair M, Carman T, Chang H, Clark C, Concha M, Cornell J, Dhingra R, Doshi A, Farley B, Fermann G, Fraiz J, Fulmer J, Gaggin H, Goytia-Leos D, Hahn B, Haidar A, Hamad A, Hazelrigg M, Ioachimescu O, Kabler H, Kao CK, Kazimir M, Koura F, Kung M, Lerner R, Lopez J, Macchiavelli A, Mahal S, Margolis B, McLaren G, Milling T Jr, Mittal M, Nadar V, Ohaju V, Ortel T, Overcash J, Parthiban K, Pearl R, Pineda L, Pratt R, Pullman J, Quintana O, Rajan R, Rastogi P, Rees C, Rodriguez W, Saba F, Shammas N, Sharma S, Sokol S, Stoltz S, Tuck M, Updegrove J, Warner A, Welch M, Welker J, Whitman B, Wichman T, Yousef K, Yusen R, Zakai N). Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients.. N Engl J Med 2016; 375(6):534-44.
Perros F, de Man FS, Bogaard HJ, Antigny F, Simonneau G, Bonnet S, Provencher S, Galiè N, Humbert M. Use of ?-Blockers in Pulmonary Hypertension.. Circ Heart Fail 2017; 10(4):e003703.
Lajoie AC, Bonnet S, Provencher S. Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges.. Pulm Circ 2017; 7(2):312-325.
Lajoie AC, Bonnet S, Provencher S. Clinical trial research in focus: improving drug development and trial design in pulmonary arterial hypertension.. Lancet Respir Med 2017; 5(7):544-546.
Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.. Sci Rep 2017; 7(1):4546.
Meloche J, Lampron MC, Nadeau V, Maltais M, Potus F, Lambert C, Tremblay E, Vitry G, Breuils-Bonnet S, Boucherat O, Charbonneau E, Provencher S, Paulin R, Bonnet S. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol 2017; 37(8):1513-23.
Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Nadeau V, Allan PD, Tzeng YC, Simard S, Bonnet S, Provencher S. Compromised Cerebrovascular Regulation and Cerebral Oxygenation in Pulmonary Arterial Hypertension.. J Am Heart Assoc 2017; 6(10):e006126.
Lajoie AC, Guay CA, Lega JC, Lauzière G, Simard S, Lambert C, Lacasse Y, Bonnet S, Provencher S. Trial Duration and Risk Reduction in Combination Therapy Trials for Pulmonary Arterial Hypertension: A Systematic Review.. Chest 2018; 153(5):1142-1152.
Boucherat O, Provencher S, Bonnet S. Therapeutic value of ASK1 inhibition in pulmonary arterial hypertension.. Am J Respir Crit Care Med 2018; 197(3):284-6.
Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S. Dual ET_A/ET_B blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension.. Pulm Circ 2018; 8(1):204589321774142.
Couture EJ, Provencher S, Somma J, Lellouche F, Marceau S, Bussières JS. Effect of position and positive pressure ventilation on functional residual capacity in morbidly obese patients: a randomized trial.. Can J Anaesth 2018; 65(5):522-8.
Morin-Thibault LV, Wiseman D, Fortin M, Couture C, Provencher S. Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report.. Pulm Circ 2018; 8(2):2045893218754853.
Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM. Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.. Am J Respir Crit Care Med 2018; 197(2):244-260.
Ruffenach G, Bonnet S, Rousseaux S, Khochbin S, Provencher S, Perros F. Identity crisis in pulmonary arterial hypertension.. Pulm Circ 2018; 8(1):2045893217746054.
Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet S. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2018; 198(1):90-103.
Bourgeois A, Lambert C, Habbout K, Ranchoux B, Paquet-Marceau S, Trinh I, Breuils-Bonnet S, Paradis R, Nadeau V, Paulin R, Provencher S, Bonnet S, Boucherat O. FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.. J Mol Med (Berl) 2018; 96(2):223-235.
Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S.. Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.. Circ Res 2018; 122(7):1021-32.
Rival G, Provencher S. Méthodes dinvestigation: Exploration pulmonaire par cathétérisme droit. EMC Pneumologie 2017; 0(0):Epub.
Adão R, Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Pimentel L, Pinto C, Mulvaney EP, Reid HM, Kinsella BT, Potus F, Breuils-Bonnet S, Rademaker MT, Provencher S, Bonnet S, Leite-Moreira A, Brás-Silva C.. Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.. Cardiovasc Res 2018; 114(8):1165-1177.
Bonnet S, Paulin R, Provencher S, Boucherat O. Small SeP or Giant Leap for Pulmonary Hypertension Research?. Circulation 2018; 138(6):624-626.
Lajoie AC, Bonnet S, Lacasse Y, Provencher S.. Interpreting risk reduction in clinical trials for pulmonary arterial hypertension.. Eur Respir Rev 2018; 27(148):180020.
Belzile D, Jacquet S, Bertoletti L, Lacasse Y, Lambert C, Lega JC, Provencher S.. Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: A meta-analysis of the management outcome studies.. J Thromb Haemost 2018; 16(6):1107-1120.
Couture EJ, Provencher S, Denault AY. Management of Severe Pulmonary Hypertensive Disease for Surgical and Nonsurgical Procedures.. Int Anesthesiol Clin 2018; 56(4):e28-e55.
Nathan SD, Barbera JA, Gaine SP, Harari S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Seeger W. Pulmonary hypertension in chronic lung disease and hypoxia.. Eur Respir J 2019; 53(1):1801914.
Barba T, Fort R, Cottin V, Provencher S, Durieu I, Jardel S, Hot A, Reynaud Q, Lega JC. Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis.. Autoimmun Rev 2019; 18(2):113-122.
Guay CA, Morin-Thibault LV, Bonnet S, Lacasse Y, Lambert C, Lega JC, Provencher S. Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.. PLoS One 2018; 13(10):e0204610.
Lai YC, Provencher S, Goncharova EA. TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet?. Thorax 2019; 74(2):103-105.
Bussières JS, Moreault O, Couture EJ, Provencher S. Optimizing Lung Collapse With a Bronchial Blocker: It's Not What You Use, but How You Use It, Part II.. J Cardiothorac Vasc Anesth 2019; 33(1):255.
Tanguay VF, Babin C, Giardetti G, Sohier-Poirier C, Ménard-Cholette V, Ranchoux B, Ruffenach G, Montani D, Bonnet S, Provencher S. Enhanced Pulmonary Artery Radiodensity in Pulmonary Arterial Hypertension: A Sign of Early Calcification?. Am J Respir Crit Care Med 2019; 199(6):799-802.
Mai V, Bertoletti L, Cucherat M, Jardel S, Grange C, Provencher S, Lega JC.. Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis.. PLoS One 2019; 14(4):e0214134.
Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S. Reply to Ning et al.: More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2020; 201(3):389-391.
Bonnet S, Boucherat O, Provencher S, Paulin R. Early Evidence for the Role of lncRNA TUG1 in Vascular Remodelling in Pulmonary Hypertension.. Can J Cardiol 2019; 35(11):1433-1434.
Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2019; 200(7):910-920.
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O. Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(8):1667-1681.
Mai V, Guay CA, Perreault L, Bonnet S, Bertoletti L, Lacasse Y, Jardel S, Lega JC, Provencher S. Extended Anticoagulation for VTE: A Systematic Review and Meta-Analysis.. Chest 2019; 155(6):1199-1216.
Kurakula K, Boucherat O, Van der Feen DE, Bogaard HJ, Kulikowski E, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez.. Am J Respir Crit Care Med 2019; 200(9):1190-1191.
Guimaraes L, Lindenfeld J, Sandoval J, Bayés-Genis A, Bernier M, Provencher S, Rodés-Cabau J. Interatrial shunting for heart failure: current evidence and future perspectives.. EuroIntervention 2019; 15(2):164-171.
Boucherat O, Paulin R, Provencher S, Bonnet S. New Insights Into HIMF (Hypoxia-Induced Mitogenic Factor)-Mediated Signaling Pathways in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(12):2451-2453.
Jelmersen D, Provencher S, Hirsch AM, Dennie C, De Perrot M, Mielniczuk L Hirani N, Chandy G, Swiston J, Lien D, Kim NH, Delcroix M, Mehta S.. Diagnosis of Chronic Thromboembolic Pulmonary Hypertension: A Canadian Thoracic Society Clinical Practice Guideline.. Can J Respir Crit Care Sleep Med 2019; 3(4):177-198.
Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F.. Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.. Circ Res 2019; 125(4):449-466.
Elia D, Caminati A, Zompatori M, Cassandro R, Lonati C, Luisi F, Pelosi G, Provencher S, Harari S. Pulmonary hypertension and chronic lung disease: where are we headed?. Eur Respir Rev 2019; 28(153):190065.
Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard LS, Johnson M, Kiely DG, Lawrie A, Lordan J, MacKenzie Ross RV, Martin JM, Moledina S, Newnham M, Peacock AJ, Price LC, Rhodes CJ, Suntharalingam J, Swietlik EM, Toshner MR, Wharton J, Wilkins MR, Wort SJ, Pepke-Zaba J, Condliffe R, Corris PA, Di Angelantonio E, Provencher S, Morrell NW. Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.. Eur Respir J 2019; 53(5):1801429.
Nickel NP, Yuan K, Dorfmuller P, Provencher S, Lai YC, Bonnet S, Austin ED, Koch CD, Morris A, Perros F, Montani D, Zamanian RT, de Jesus Perez VA. Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2020; 201(2):148-157.
Ramirez FD, Jung RG, Motazedian P, Perry-Nguyen D, Di Santo P, MacDonald Z, Clancy AA, Labinaz A, Promislow S, Simard T, Provencher S, Bonnet S, Graham ID, Wells GA, Hibbert B. Journal Initiatives to Enhance Preclinical Research: Analyses of Stroke, Nature Medicine, Science Translational Medicine.. Stroke 2020; 51(1):291-299.
Lampron MC, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, Tremblay È, Boucherat O, Meloche J, Bonnet S, Provencher S, Potus F, Paulin R. PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2020; 40(3):783-801.
Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB, Provencher S, Zhang L, Uchida S. Clinical Value of Non-Coding RNAs in Cardiovascular, Pulmonary, and Muscle Diseases.. Am J Physiol Cell Physiol 2020; 318(1):C1-C28.
Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in PAH.. Am J Respir Crit Care Med 2021; 203(5):614-627.
Provencher S, Boucherat O, Potus F, Bonnet S. Pulmonary hypertension thresholds: time to lower further?. Lancet Respir Med 2020; 8(9):834-836.
Omura J, Habbout K, Shimauchi T, Wu WH, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F, Perron J, Potus F, Lin JH, Zafar H, Kiely DG, Lawrie A, Archer SL, Paulin R, Provencher S, Boucherat O, Bonnet S. Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.. Circulation 2020; 142(15):1464-1484.
Provencher S, Potus F, Bonnet S. COVID-19 and the pulmonary vasculature.. Pulm Circ 2020; 10(3):2045894020933088.
Veeroju S, Mamazhakypov A, Rai N, Kojonazarov B, Nadeau V, Breuils-Bonnet S, Li L, Weissmann N, Rohrbach S, Provencher S, Bonnet S, Seeger W, Schermuly R, Novoyatleva T. Effect of p53 activation on experimental right ventricular hypertrophy.. PLoS One 2020; 15(6):e0234872.
Potus F, Mai V, Lebret M, Malenfant S, Breton-Gagnon E, Lajoie AC, Boucherat O, Bonnet S, Provencher S. Novel insights on the pulmonary vascular consequences of COVID-19.. Am J Physiol Lung Cell Mol Physiol 2020; 319(2):L277-L288.
Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PDA, Hong Z, Zhao YY, Hindmarch CCT, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL. Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.. Circ Res 2020; 126(12):1723-1745.
Malenfant S, Brassard P, Paquette M, Le Blanc O, Chouinard A, Bonnet S, Provencher S. Continuous reduction in cerebral oxygenation during endurance exercise in patients with pulmonary arterial hypertension.. Physiol Rep 2020; 8(6):e14389.
Sommer N, Ghofrani HA, Pak O, Bonnet S, Provencher S, Sitbon O, Rosenkranz S, Hoeper MM, Kiely DG. Current and future treatments of pulmonary arterial hypertension.. Br J Pharmacol 2021; 178(1):6-30.
Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S. Reply to Chen et al.: BET Signaling: A Novel Therapeutic Target for Pulmonary Hypertension?. Am J Respir Crit Care Med 2020; 201(10):1313-1314.
Mai V, Tanguay VF, Guay CA, Bertoletti L, Magnan S, Turgeon AF, Lacasse Y, Lega JC, Provencher S. DOAC compared to LMWH in the treatment of cancer related-venous thromboembolism: a systematic review and meta-analysis.. J Thromb Thrombolysis 2020; 50(3):661-667.
Gupta S, Batt J, Bourbeau J, Chapman KR, Gershon A, Granton J, Hambly N, Hernandez P, Kolb M, Mehta S, Mielniczuk L, Provencher S, Stephenson AL, Swiston J, Tullis DE, Vozoris NT, Wald J, Weatherald J, Bhutani M. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement.. Chest 2020; 158(6):2270-2274.
Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner NK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I, Kim S, Chan SY.. Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.. Sci Adv 2021; 7(43):eabh3794.
Shimauchi T, Potus F, Bonnet S, Provencher S, Paulin R, Boucherat O.. Limitations and Flaws of Preclinical Pulmonary Hypertension Studies.. Adv Pulm Hypertens 2020; 19(2):47-54.
Lobbes H, Mainbourg S, Mai V, Douplat M, Provencher S, Lega JC. Risk Factors for Venous Thromboembolism in Severe COVID-19: A Study-Level Meta-Analysis of 21 Studies.. Int J Environ Res Public Health 2021; 18(24):12944.
Weatherald J, Mai V, Provencher S.. Clinical Year in Review Pulmonary Vascular Diseases.. Can J Respir Crit Care Sleep Med 2020; 4(1):2-5.
Gupta S, Batt Jane, Bourbeau J, Chapman KR, Gershon A, Granton J, Hambly N, Hernandez P, Kolb M, Mehta S, Mielniczuk L, Provencher S, Stephenson A, Swiston J, Tullis D, Vozoris N, Wald J, Weatherald J, Bhutani M.. Position statement from the Canadian Thoracic Society (CTS) on clinical triage thresholds in respiratory disease patients in the event of a major surge during the COVID-19 pandemic.. Can J Respir Crit Care Sleep Med 2020; 4(4):214-225.
Moreault O, Couture EJ, Provencher S, Somma J, Lohser J, Ugalde Figueroa PA, Lemieux J, Lellouche F, Bussières JS. Double-lumen endotracheal tubes and bronchial blockers exhibit similar lung collapse physiology during lung isolation.. Can J Anaesth 2021; 68(6):791-800.
Dore M, Provencher S, Poirier P, Gélinas C, Stoller JK, de Oliveira EM, Gallani MC. Validity of the Modified Dyspnea Index for the French-Canadian Population.. J Nurs Meas 2021; 29(1):121-139.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O. Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.. Int J Mol Sci 2021; 22(6):2957.
Grobs Y, Awada C, Lemay SE, Romanet C, Bourgeois A, Toro V, Nadeau V, Shimauchi K, Orcholski M, Breuils-Bonnet S, Tremblay E, Provencher S, Paulin R, Boucherat O, Bonnet S. Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.. Int J Mol Sci 2021; 22(6):2919.
Malenfant S, Lebret M, Breton-Gagnon É, Potus F, Paulin R, Bonnet S, Provencher S. Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms.. Eur Respir Rev 2021; 30(160):200284.
Mai V, Marceau-Ferron E, Bertoletti L, Lacasse Y, Bonnet S, Lega JC, Provencher S. Direct oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis.. Pharmacol Res 2021; 163(0):105317.
Awada C, Grobs Y, Wu WH, Habbout K, Romanet C, Breuils-Bonnet S, Tremblay E, Martineau S, Paulin R, Bonnet S, Provencher S, Potus F, Boucherat O. (R)-Crizotinib Predisposes To and Exacerbates Pulmonary Arterial Hypertension in Animal Models.. Eur Respir J 2021; 57(5):2003271.
Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17?-Estradiol and estrogen receptor ? protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.. J Clin Invest 2021; 131(6):e129433.
Mainbourg S, Cucherat M, Provencher S, Bertoletti L, Nony P, Gueyffier F, Mismetti P, Grange C, Durieu I, Kilo R, Laporte S, Grenet G, Lega JC. Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis.. Thromb Res 2021; 197(0):24-32.
Lemieux S, Kim T, Pothier-Piccinin O, Racine LC, Firoozi F, Drolet M, Pasian S, Kennedy KF, Provencher S, Ugalde Figueroa PA. Ultrasound-guided transthoracic needle biopsy of the lung: sensitivity and safety variables.. Eur Radiol 2021; 31(11):8272-8281.
Nathan SD, Barnett SD, King CS, Provencher S, Barbera JA, Pastre J, Shlobin OA, Seeger W. Impact of the new definition for pulmonary hypertension in patients with lung disease: an analysis of the United Network for Organ Sharing database.. Pulm Circ 2021; 11(2):2045894021999960.
Mai V, Mainbourg S, Tan BK, Lega JC, Provencher S. Significant major bleeding in hospitalized patients with COVID-19 receiving thromboprophylaxis.. Thromb Haemost 2021; 121(12):1670-1673.
Somma J, Couture ÉJ, Pelletier S, Provencher S, Moreault O, Lohser J, Ugalde Figueroa PA, Vigneault L, Lemieux J, Somma A, Guay SE, Bussières JS. Non-ventilated lung deflation during one-lung ventilation with a double-lumen endotracheal tube: a randomized-controlled trial of occluding the non-ventilated endobronchial lumen before pleural opening.. Can J Anaesth 2021; 68(6):801-811.
Lemieux S, Buies A, F Turgeon A, Hallet J, Daigle G, Côté F, Provencher S. Effect of Yttrium-90 transarterial radioembolization in patients with non-surgical hepatocellular carcinoma: A systematic review and meta-analysis.. PLoS One 2021; 16(3):e0247958.
Tan BK, Mainbourg S, Friggeri A, Bertoletti L, Douplat M, Dargaud Y, Grange C, Lobbes H, Provencher S, Lega JC. Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis.. Thorax 2021; 76(10):970-979.
Hiram R, Provencher S. Pulmonary Disease, Pulmonary Hypertension and Atrial Fibrillation.. Card Electrophysiol Clin 2021; 13(1):141-153.
Lemay SE, Awada C, Shimauchi T, Wu WH, Bonnet S, Provencher S, Boucherat O. Fetal Gene Reactivation in Pulmonary Arterial Hypertension: GOOD, BAD, or BOTH?. Cells 2021; 10(6):1473.
Mai V, Tan BK, Mainbourg S, Potus F, Cucherat M, Lega JC, Provencher S. Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis.. Vascul Pharmacol 2021; 139(0):106882.
Kilo R, Laporte S, Arab R, Mainbourg S, Provencher S, Grenet G, Bertoletti L, Villeneuve L, Cucherat M, Lega JC. Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality.. Sci Rep 2021; 11(1):14728.
Saleh D, Fisher JH, Provencher S, Liang Z, Ryerson CJ, Weatherald J. A Systematic Evaluation of Quality, Accuracy, and Reliability of Internet Websites about Pulmonary Arterial Hypertension.. Ann Am Thorac Soc 2022; 19(8):1404-1413.
Morin-Thibault LV, Wiseman D, Joubert P, Paulin R, Bonnet S, Provencher S.. Pulmonary tumor thrombotic microangiopathy: a systematic review of the literature.. Can J Respir Crit Care Sleep Med 2021; 5(1):20-27.
Provencher S.. Les personnes atteintes dhypertension pulmonaire (HTP) et leurs aidants naturels sont appelés à préciser ce quils espèrent des médicaments actuels et futurs.. Revue Liaison 2021; 0(0):En ligne.
Millaire É, Ouellet É, Fortin M, Martel S, Milot J, Bilodeau L, Conti M, Provencher S, Dion G. Outcomes Following Surgical Lung Biopsy for Interstitial Lung Diseases: A Monocenter Experience.. Thorac Cardiovasc Surg 2022; 70(7):583-588.
Wu WH, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, Nadeau V, Orcholski M, Breuils-Bonnet S, Martineau S, Ferraro P, Potus F, Paulin R, Provencher S, Boucherat O. Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension.. Thorax 2022; 77(3):247-258.
Zelt JGE, Cadete V, Deng Y, Godoy R, Cuillerier A, Rowe K, Abdul-Ghani M, Megeney L, Burelle Y, Giulivi A, Stewart AFR, Provencher S, Breuils-Bonnet S, Bonnet S, deKemp R, Beanlands R, Mielniczuk LM, Stewart DJ. Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.. Hypertension 2022; 79(12):2774-2786.
Tremblay É, Gosselin C, Mai V, Lajoie AC, Kilo R, Weatherald J, Lacasse Y, Bonnet S, Lega JC, Provencher S. Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Circulation 2022; 146(8):597-612.
Al-Qazazi R, Lima PDA, Prisco SZ, Potus F, Dasgupta A, Chen KH, Tian L, Bentley RET, Mewburn J, Martin AY, Wu D, Jones O, Maurice DH, Bonnet S, Provencher S, Prins KW, Archer SL. Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2022; 206(5):608-624.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.. JACC Basic Transl Sci 2022; 7(4):384-403.
Provencher S, Potus F, Blais-Lecours P, Bernard S, Martineau S, Breuils-Bonnet S, Weatherald J, Sweeney M, Kulikowski E, Boucherat O, Bonnet S. BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Trial.. Am J Respir Crit Care Med 2022; 205(11):1357-1360.
Toro V, Jutras-Beaudoin N, Boucherat O, Bonnet S, Provencher S, Potus F. Right Ventricle and Epigenetics: A Systematic Review.. Cells 2023; 12(23):2693.
Awada C, Bourgeois A, Lemay SE, Grobs Y, Yokokawa T, Breuils-Bonnet S, Martineau S, Krishna V, Potus F, Jeyaseelan J, Provencher S, Bonnet S, Boucherat O. G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.. Am J Respir Cell Mol Biol 2023; 68(5):537-550.
Yamamoto K, Lemay SE, Yokokawa T, Breuils-Bonnet S, Salem M, Potus F, Provencher S, Boucherat O, Bonnet S. DNA-Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension.. Am J Respir Cell Mol Biol 2023; 68(1):116-119.
Nayakanti SR, Friedrich A, Sarode P, Jafari L, Maroli G, Boehm M, Bourgeois A, Grobs Y, Khassafi F, Kuenne C, Guenther S, Dabral S, Wilhelm J, Weiss A, Wietelmann A, Kojonazarov B, Janssen W, de Man F, Provencher S, Khodr T, Seeger W, Bonnet S, Savai R, Schermuly RT, Pullamsetti SS.. Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. Circ Res 2023; 132(11):1468-1485.
Fortin M, Liberman M, Delage A, Dion G, Rolland F, Soumagne T, Trahan S, Assayagh D, Albert E, Kelly MM, Johannson KA, Guenther Z, Leduc C, Manganas H, Prenovault J, Provencher S.. Transbronchial Lung Cryobiopsy and SurgicAl LuNg Biopsy: A Prospective MultI-CEntre Agreement Study (CAN-ICE).. Am J Respir Crit Care Med 2023; 207(12):1612-1619.
Boucherat O, Yokokawa T, Krishna V, Kalyana-Sundaram S, Martineau S, Breuils-Bonnet S, Azhar N, Bonilla F, Gutstein D, Potus F, Lawrie A, Jeyaseelan J, Provencher S, Bonnet S.. From heart to blood: LTBP-2 is a promising biomarker for pulmonary arterial hypertension.. Nat Cardiovasc Res 2022; 1(0):804-805.
de Perrot M, Donahoe L, McRae K, Thenganatt J, Moric J, Chan J, McInnis M, Jumaa K, Teng Tan K, Mafeld S, Granton J, Canadian CTEPH Working Group (Weatherald J, Hirani N, Thakrar M, Helmersen D, Swiston J, Brunner N, Levy R, Mehta S, Kapasi A, Lien D, Michelakis E, Hernandez P, Kemp K, Hirsch A, Langleben D, Hambly N, Dorasamy P, D'Arsigny C, Chandy G, Mielniczuk LM, Christiansen D, Fox G, Laframbroise K, Provencher S).. Outcome after pulmonary endarterectomy for segmental chronic thromboembolic pulmonary hypertension.. J Thorac Cardiovasc Surg 2022; 164(3):696-707.e4.
Agharazii M, Bujold E, Després JP, Pibarot P, Provencher S, Milot A.. Research at Université Laval. Hypertension News 2022; 0(0):27-31.
Mai V, Gosselin C, Tremblay É, Rompré G, Lajoie AC, Weatherald J, Lega JC, Bonnet S, Provencher S. Patients' perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy.. Thorax 2023; 78(7):721-725.
Weatherald J, Iqbal H, Mielniczuk L, Syed AR, Legkaia L, Howard J, Dempsey N, Rader T, Swiston J, Provencher S. Priorities for pulmonary hypertension research: A James Lind Alliance priority setting partnership.. J Heart Lung Transplant 2023; 42(1):1-6.
Millaire É, Lévesque M, Lemière C, Cartier A, Provencher S, Dion G. Progression of Pulmonary Fibrosis According to Radiological Pattern in Asbestosis.. Ann Am Thorac Soc 2023; 20(2):328-330.
Couture EJ, Carrier-Boucher A, Provencher S, Tanoubi I, Marceau S, Bussières JS. Effect of reverse Trendelenburg position and positive pressure ventilation on safe non-hypoxic apnea period in obese, a randomized-control trial.. BMC Anesthesiol 2023; 23(1):198.
Vézina FA, Bouchard PA, Breton-Gagnon É, Dion G, Viglino D, Roy P, Bilodeau L, Provencher S, Denault MH, Saey D, Lellouche F, Maltais F. Automated O(2) Titration Alone or With High-Flow Nasal Cannula During Walking Exercise in Chronic Lung Diseases.. Respir Care 2023; 0(0):respcare.10810.
Awada C, Boucherat O, Provencher S, Bonnet S, Potus F. The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets.. Vascul Pharmacol 2023; 151(0):107180.

Dr Steeve Provencher

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