Chercheur(e)

Dr Roxane Paulin

Pneumologie

A2118

roxane.paulin@criucpq.ulaval.ca

Description des travaux

Orienté vers le développement de solutions thérapeutiques plus efficaces, le programme de recherche de la Dre Paulin porte sur les liens qui existent entre les désordres du métabolisme cellulaire et mitochondrial et l'inflammation qui accompagnent les maladies vasculaires pulmonaires ainsi que les implications cliniques et thérapeutiques que ces interactions cellulaires pourraient avoir.

Publications

Trier par année :

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED. A miR-208-Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension.. Circ Res 2015; 116(1):56-69.
Potus F, Ruffenach G, Dahou A, Thebault C, Breuils-Bonnet S, Tremblay È, Nadeau V, Paradis R, Graydon C, Wong R, Johnson I, Paulin R, Lajoie AC, Perron J, Charbonneau E, Joubert P, Pibarot P, Michelakis ED, Provencher S, Bonnet S. Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension.. Circulation 2015; 132(10):932-43.
Luc JG, Paulin R, Zhao JY, Freed DH, Michelakis ED, Nagendran J. 2-Methoxyestradiol: A Hormonal Metabolite Modulates Stimulated T-Cells Function and proliferation.. Transplant Proc 2015; 47(6):2057-66.
Paulin R, Michelakis ED. Addressing Complexity in Pulmonary Hypertension: The FoxO1 Case.. Circ Res 2015; 116(11):1732-5.
Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD. Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.. PLoS One 2015; 10(3):e0120257.
Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.. Eur Urol 2016; 69(4):734-44.
Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.. Sci Rep 2017; 7(1):4546.
Meloche J, Lampron MC, Nadeau V, Maltais M, Potus F, Lambert C, Tremblay E, Vitry G, Breuils-Bonnet S, Boucherat O, Charbonneau E, Provencher S, Paulin R, Bonnet S. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol 2017; 37(8):1513-23.
Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S, Bonnet S. The cancer theory of Pulmonary Arterial Hypertension.. Pulm Circ 2017; 7(2):285-99.
Paulin R, Bonnet S. Epigenetics, Inflammation and Metabolism in Right Heart Failure Associated with Pulmonary Hypertension.. Pulm Circ 2017; 7(3):572-87.
Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S. Dual ET_A/ET_B blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension.. Pulm Circ 2018; 8(1):204589321774142.
Brittain EL, Thenappan T, Maron BA, Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C, Paulin R, Machado RF, Yu PB. Update in Pulmonary Vascular Disease 2016 and 2017.. Am J Respir Crit Care Med 2018; 198(1):13-23.
Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet S. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2018; 198(1):90-103.
Bourgeois A, Lambert C, Habbout K, Ranchoux B, Paquet-Marceau S, Trinh I, Breuils-Bonnet S, Paradis R, Nadeau V, Paulin R, Provencher S, Bonnet S, Boucherat O. FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.. J Mol Med (Berl) 2018; 96(2):223-235.
Ruffenach G, Chabot S, Tanguay VF, Courboulin A, Boucherat O, Potus F, Meloche J, Pflieger A, Breuils-Bonnet S, Nadeau V, Paradis R, Tremblay E, Girerd B, Hautefort A, Montani D, Fadel E, Dorfmuller P, Humbert M, Perros F, Paulin R, Provencher S, Bonnet S. Role for RUNX2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2016; 194(10):1273-85.
Boucherat O, Bonnet S, Paulin R. The HIPPO-Thesis of Pulmonary HYPERtension.. Am J Respir Crit Care Med 2016; 194(7):787-789.
Ranchoux B, Meloche J, Paulin R, Boucherat O, Provencher S, Bonnet S. DNA Damage and Pulmonary Hypertension.. Int J Mol Sci 2016; 17(6):E990.
Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S.. Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.. Circ Res 2018; 122(7):1021-32.
Bonnet S, Paulin R, Provencher S, Boucherat O. Small SeP or Giant Leap for Pulmonary Hypertension Research?. Circulation 2018; 138(6):624-626.
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O. Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(8):1667-1681.
Nadeau V, Bonnet S, Paulin R. Letter by Nadeau et al Regarding Article, "Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension".. Circulation 2019; 140(7):e286-e287.
Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2019; 200(7):910-920.
Bonnet S, Boucherat O, Provencher S, Paulin R. Early Evidence for the Role of lncRNA TUG1 in Vascular Remodelling in Pulmonary Hypertension.. Can J Cardiol 2019; 35(11):1433-1434.
Boucherat O, Paulin R, Provencher S, Bonnet S. New Insights Into HIMF (Hypoxia-Induced Mitogenic Factor)-Mediated Signaling Pathways in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(12):2451-2453.
Bonnet S, Paulin R. Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?. Am J Respir Crit Care Med 2019; 200(5):532-534.
Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F.. Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.. Circ Res 2019; 125(4):449-466.
Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB, Provencher S, Zhang L, Uchida S. Clinical Value of Non-Coding RNAs in Cardiovascular, Pulmonary, and Muscle Diseases.. Am J Physiol Cell Physiol 2020; 318(1):C1-C28.
Lampron MC, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, Tremblay È, Boucherat O, Meloche J, Bonnet S, Provencher S, Potus F, Paulin R. PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2020; 40(3):783-801.
Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in PAH.. Am J Respir Crit Care Med 2021; 203(5):614-627.
Omura J, Habbout K, Shimauchi T, Wu WH, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F, Perron J, Potus F, Lin JH, Zafar H, Kiely DG, Lawrie A, Archer SL, Paulin R, Provencher S, Boucherat O, Bonnet S. Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.. Circulation 2020; 142(15):1464-1484.
Shimauchi T, Potus F, Bonnet S, Provencher S, Paulin R, Boucherat O.. Limitations and Flaws of Preclinical Pulmonary Hypertension Studies.. Adv Pulm Hypertens 2020; 19(2):47-54.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O. Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.. Int J Mol Sci 2021; 22(6):2957.
Grobs Y, Awada C, Lemay SE, Romanet C, Bourgeois A, Toro V, Nadeau V, Shimauchi K, Orcholski M, Breuils-Bonnet S, Tremblay E, Provencher S, Paulin R, Boucherat O, Bonnet S. Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.. Int J Mol Sci 2021; 22(6):2919.
Malenfant S, Lebret M, Breton-Gagnon É, Potus F, Paulin R, Bonnet S, Provencher S. Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms.. Eur Respir Rev 2021; 30(160):200284.
Awada C, Grobs Y, Wu WH, Habbout K, Romanet C, Breuils-Bonnet S, Tremblay E, Martineau S, Paulin R, Bonnet S, Provencher S, Potus F, Boucherat O. (R)-Crizotinib Predisposes To and Exacerbates Pulmonary Arterial Hypertension in Animal Models.. Eur Respir J 2021; 57(5):2003271.
Wu WH, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, Nadeau V, Orcholski M, Breuils-Bonnet S, Martineau S, Ferraro P, Potus F, Paulin R, Provencher S, Boucherat O. Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension.. Thorax 2022; 77(3):247-258.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.. JACC Basic Transl Sci 2022; 7(4):384-403.
Jutras-Beaudoin N, Toro V, Lajoie AC, Breuils-Bonnet S, Paulin R, Potus F. Neutrophil-Lymphocyte Ratio as an Independent Predictor of Survival in Pulmonary Arterial Hypertension: An Exploratory Study.. CJC Open 2022; 4(4):357-363.

Dr Roxane Paulin

Description des travaux

Publications

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