Chercheur(e)

Dr Patrick Mathieu

Cardiologie

Y2186

patrick.mathieu@criucpq.ulaval.ca

Domaine de recherche

Notre laboratoire s'intéresse à élucider les mécanismes de la calcification cardiovasculaire et de leurs liens avec le métabolisme. Plus particulièrement, nous tentons d'établir les mécanismes impliqués dans la calcification de la valve aortique native et des bioprothèses.

Description des travaux

Le laboratoire d'Études Moléculaires des Valvulopathies (LEMV) s'intéresse à expliquer les mécanismes de calcification de la valve aortique. En effet, la sténose aortique est la pathologie des valves cardiaques la plus fréquente, caractérisée par une calcification progressive des tissus et pour laquelle aucun traitement médical n'est actuellement disponible. Nous avons identifié récemment que le développement et la progression de la sténose aortique sont influencés par des facteurs métaboliques reliés à l'obésité viscérale. Une partie de nos travaux est donc dédiée à l'étude des mécanismes métaboliques favorisant la calcification de la valve aortique. Entre autres, nous avons récemment identifié que l'accumulation de lipide oxydé à l'intérieur de la valve aortique est un des processus clé favorisant l'inflammation et la progression de cette maladie. Par ailleurs, étant donné que la sténose aortique affecte une population vieillissante, nous investiguons les mécanismes de sénescence en relation avec la calcification cardiovasculaire. Particulièrement, nous nous intéressons au processus de rétention lipidique et au contrôle de la calcification au niveau moléculaire. De plus, considérant que le seul traitement de la sténose aortique est actuellement un remplacement valvulaire, une portion de nos travaux se concentre aussi sur la calcification et la détérioration des bioprothèses. Notre équipe s'intéresse particulièrement aux mécanismes métaboliques associés à la calcification des tissus biologiques prothétiques. Parmi les découvertes intéressantes dans ce domaine, notons que notre laboratoire a été le premier à identifier que la détérioration des bioprothèses était associée à des mécanismes s'apparentant à l'athérosclérose. Ces travaux de recherche ont pour but de découvrir de nouvelles cibles thérapeutiques afin de prévenir la calcification des valves cardiaques. Il s'agit donc de travaux mécanistiques qui pourraient un jour prévenir le développement des calcifications cardiovasculaires.

Publications

254

Trier par année :

Bouche D, Chauveau C, Roussel JC, Mathieu P, Braudeau C, Tesson L, Soulillou JP, Iyer S, Buelow R, Anegon I. Inhibition of graft arteriosclerosis development in rat aortas following heme oxygenase-1 gene transfer.. Transpl Immunol 2002; 9(2):235-8.
Chauveau C, Bouchet D, Roussel JC, Mathieu P, Braudeau C, Renaudin K, Tesson L, Soulillou JP, Iyer S, Buelow R, Anegon I. Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection.. Am J Transplant 2002; 2(7):581-92.
Mathieu P, Chauveau C, Bouchet D, Guillot C, Tesson L, Anegon I. Genetic engineering in allotransplantation of vascularized organs.. Curr Gene Ther 2002; 2(1):9-21.
Mathieu P, Guillot C, Gerdes C, Buzelin F, Lowenstein P, Castro M, Soulillou JP, Anegon I. Adenovirus-mediated CD40Ig expression attenuates chronic vascular rejection lesions in an aorta allotransplantation model.. Transplant Proc 2002; 34(3):743-4.
Guillot C, Guillonneau C, Mathieu P, Gerdes CA, Ménoret S, Braudeau C, Tesson L, Renaudin K, Castro MG, Löwenstein PR, Anegon I. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejecti. J Immunol 2002; 168(4):1600-9.
Bouchet D, Tesson L, Ménoret S, Charreau B, Mathieu P, Yagita H, Duisit G, Anegon I. Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels.. Mol Med 2002; 8(10):612-23.
D'Ancona G, Baillot R, Poirier B, Dagenais F, Saez de Ibarra JI, Bauset R, Mathieu P, Doyle D. Determinants of gastrointestinal complications in cardiac surgery. Tex Heart Inst J 2003; 30(4):280-5.
D'Ancona G, Saez de Ibarra JI, Baillot R, Mathieu P, Doyle D, Métras J, Desaulniers D, Dagenais F. Determinants of stroke after coronary artery bypass grafting. Eur J Cardiothorac Surg 2003; 24(4):552-6.
Absil B, Dagenais F, Mathieu P, Métras J, Perron J, Baillot R, Bauset R, Doyle D. Does moderate mitral regurgitation impact early or mid-term clinical outcome in patients undergoing isolated aortic valve replacement for aortic stenosis?. Eur J Cardiothorac Surg 2003; 24(2):217-22; di.
Poirier B, Baillot R, Bauset R, Dagenais F, Mathieu P, Simard S, Dionne B, Caouette M, Hould FS, Doyle D, Poirier P. [Abdominal complications associated with cardiac surgery. Review of a contemporary surgical experience and of a series done without extracorporeal circulation]. Can J Surg 2003; 46(3):176-82.
Turgeon AF, Dagenais F, Poirier P, Bauset R, Mathieu P. Myocardial infarction in a young woman secondary to a rupture of a noncoronary sinus of Valsalva aneurysm without coronary artery disease.. Can J Cardiol 2003; 19(6):723-4.
Mathieu P, Dagenais F, Saez De Ibarra JI, Baillot R. Surgical treatment of commissural prolapse: case report and review of the options.. J Heart Valve Dis 2004; 13(1):142-4.
Saez de Ibarra JI, Mathieu P, Dagenais F, Bauset R, Baillot R, Desaulniers D, Lemieux M, Métras J, Perron J, Raymond G, Doyle D. Cirugìa coronaria en el paciente dializado crònico. Resultado a medio plazo y evaluaciòn de la calidad de vida. Cir Cardiov 2003; 10(2):173-9.
Saez de Ibarra JI, Dagenais F, D'Ancona G, Mathieu P, Dionne B, Simard S, Bauset R, Desaulniers D, Lemieux M, Métras J, Perron J, Raymond G, Doyle D, Baillot R. La cirugìca coronaria sin bomba disminuye la morbilidad y la mortalidad en el paceinte anoso. Estudio de caso.. Cir Cardiov 2004; 11(1):51-7.
Mathieu P, Roussel JC, Dagenais F, Anegon I. Cartilaginous metaplasia and calcification in aortic allograft is associated with transforming growth factor beta 1 expression.. J Thorac Cardiovasc Surg 2003; 126(5):1449-54.
Dagenais F, Mathieu P. Rescue therapy with methylene blue in systemic inflammatory response syndrome after cardiac surgery.. Can J Cardiol 2003; 19(2):167-9.
Pibarot P, Blais C, Baillot R, Mathieu P, Doyle D, Métras J, Desaulniers D, Dagenais F. Patient-prostesis mismatch in a independent predictor of operative mortality. Circulation 2003; 108(0):993-98.
Saez de Barra JI, Baillot R, Dagenais F, Mathieu P, Dionne B, Raymond G, Bauset R, Doyle D. Cirugia coronaria en octogenarios. Evolution y resultados. Cirugia Cardiovascular 2002; 9(1):24.
Saez de Ibarra JI, Dagenais F, Mathieu P, Cartier PC, Dumesnil JG, Lemieux M, Métras J, Raymond G, Desaulniers D,Perron J, Bauset R, Baillot R, Doyle D. Ocho anos de experienca con la protesis Freestyle Medtronic. Cirugia Cardiovascular 2002; 9(1):37.
Saez de Ibarra JI, Mathieu P, Dagenais F, Darveau S, Bauset R, Baillot R, Doyle D. Resultados precoces y a medio plazo de la cirugua coronaria en el dializado cronico. Cirugia Cardiovascular 2002; 9(1):62.
Dagenais F, Cartier P, Voisine P, Desaulniers D, Perron J, Baillot R, Raymond G, Métras J, Doyle D, Mathieu P. Which biologic valve should we select for the 45- to 65-year-old age group requiring aortic valve replacement?. J Thorac Cardiovasc Surg 2005; 129(5):1041-9.
Dagenais F, Bauset R, Mathieu P. Aortic valve-sparing procedure with cusp elongation and free edge reinforcement for bicuspid aortic valve.. Ann Thorac Surg 2005; 79(4):1393-5.
Dagenais F, Normand JP, Turcotte R, Mathieu P. Changing trends in management of thoracic aortic disease: where do we stand with thoracic endovascular stent grafts?. Can J Cardiol 2005; 21(2):173-8.
Li M, Dumesnil JG, Mathieu P, Pibarot P. Impact of valve prosthesis-patient mismatch on pulmonary arterial pressure after mitral valve replacement.. J Am Coll Cardiol 2005; 45(7):1034-40.
Shetty R, Voisine P, Mathieu P, Dagenais F. Recannulation of the right axillary for complex aortic surgeries.. Tex Heart Inst J 2005; 32(0):194-7.
Voisine P, Mathieu P, Doyle D, Perron J, Baillot R, Raymond G, Métras J, Dagenais F. Influence of time elapsed between myocardial infarction and coronary artery bypass grafting surgery on operative mortality.. Eur J Cardiothorac Surg 2006; 29(3):319-23.
Plante I, Fournier D, Ricard G, Drolet B, O'Hara G, Champagne J, Mathieu P, Baillot R, Daleau P. Electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (R87Q, A251T, and P307S) found in hKv1.5.. Pflugers Arch 2006; 452(3):316-23.
Shetty R, Pépin A, Charest A, Perron J, Doyle D, Voisine P, Dagenais F, Pibarot P, Mathieu P. Expression of bone-regulatory proteins in human valve allografts.. Heart 2006; 92(9):1303-8.
Dagenais F, Voisine P, Mathieu P. Giant pseudoaneurysm after proximal aortic surgery treated by means of redo axillary artery cannulation and use of an Endoclamp device.. J Thorac Cardiovasc Surg 2005; 130(1):208-9.
Mathieu P, Pépin A, Shetty R, Savard N, Perron J, Dagenais F, Baillot R. Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity.. J Heart Valve Dis 2005; 14(3):353-7.
Briand M, Pibarot P, Després JP, Voisine P, Dumesnil JG, Dagenais F, Mathieu P. Metabolic syndrome is associated with faster degeneration of bioprosthetic valves.. Circulation 2006; 141(1):I512-7.
Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Després JP, Arsenault M, Couet J, Pibarot P. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis.. J Am Coll Cardiol 2006; 47(11):2229-36.
Mohammadi S, Baillot R, Voisine P, Mathieu P, Dagenais F. Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms.. J Thorac Cardiovasc Surg 2006; 132(2):401-6.
Dagenais F, Shetty R, Normand JP, Turcotte R, Mathieu P, Voisine P. Extended applications of thoracic aortic stent grafts.. Ann Thorac Surg 2006; 82(2):567-72.
Charest A, Pépin A, Shetty R, Côté C, Voisine P, Dagenais F, Pibarot P, Mathieu P. Distribution of SPARC during neovascularisation of degenerative aortic stenosis.. Heart 2006; 92(12):1844-9.
Mathieu P, Pibarot P, Després JP. Metabolic syndrome: The danger signal in atherosclerosis.. Vasc Health Risk Manag 2006; 2(3):285-302.
Mohammadi S, Voisine P, Mathieu P, Dagenais F. Use of the endoclamp device in a patient with a native mitrial valve endocarditis and a previous arch replacement with a modified Griepp technique.. J Thorac Cardiovasc Surg 2006; 131(5):1188-90.
Mohammadi S, Normand JP, Turcotte R, Voisine P, Mathieu P, Dagenais F. Management of a right aberrant subclavian artery during complex hybrid stent graft procedures: A rare and complex issue.. Innovations 2007; 2(1):45-50.
Magne J, Mathieu P, Dumesnil JG, Tanné D, Dagenais F, Doyle D, Pibarot P. Impact of prosthesis-patient mismatch on survival after mitral valve replacement.. Circulation 2007; 115(11):1417-25.
Pibarot P, Dumesnil JG, Mathieu P. [New insight into the treatment of aortic stenosis]. Med Sci (Paris) 2007; 23(1):81-7.
Mathieu P, Després JP, Pibarot P. The "valvulo-metabolic" risk in calcific aortic valve disease.. Can J Cardiol 2007; 23(0):32-9B.
Magne J, Sénéchal M, Mathieu P, Dumesnil JG, Dagenais F, Pibarot P. Restrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosis.. J Am Coll Cardiol 2008; 51(17):1692-701.
Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodés-Cabau J, Bertrand OF, Poirier P. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk.. Arterioscler Thromb Vasc Biol 2008; 28(6):1039-49.
Bossé Y, Mathieu P, Pibarot P. Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis.. J Am Coll Cardiol 2008; 51(14):1327-36.
Plante I, Fournier D, Mathieu P, Daleau P. A pilot study to estimate the feasibility of assessing the relationships between polymorphisms in hKv1.5 and atrial fibrillation in patients following coronary artery bypass graft surgery.. Can J Cardiol 2008; 24(1):41-4.
Mathieu P, Pibarot P, Larose E, Poirier P, Marette A, Després JP. Visceral obesity and the heart.. Int J Biochem Cell Biol 2008; 40(5):821-36.
Mohty D, Pibarot P, Després JP, Côté C, Arsenault B, Cartier A, Cosnay P, Couture C, Mathieu P. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis.. Arterioscler Thromb Vasc Biol 2008; 28(1):187-93.
Echahidi N, Pibarot P, O'Hara G, Mathieu P. Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery.. J Am Coll Cardiol 2008; 51(8):793-801.
Echahidi N, Pibarot P, Després JP, Daigle JM, Mohty D, Voisine P, Baillot R, Mathieu P. Metabolic syndrome increases operative mortality in patients undergoing coronary artery bypass grafting surgery.. J Am Coll Cardiol 2007; 50(9):843-51.
Mohammadi S, Dagenais F, Mathieu P, Kingma JG, Doyle D, Lopez S, Baillot R, Perron J, Charbonneau E, Dumont E, Metras J, Desaulniers D, Voisine P. Long-term impact of diabetes and its comorbidities in patients undergoing isolated primary coronary artery bypass graft surgery.. Circulation 2007; 116(11):I220-5.
Lopez S, Mathieu P, Pibarot P, Mohammadi S, Dagenais F, Voisine P, Dumesnil JG, Doyle D. Does the use of stentless aortic valves in a subcoronary position prevent patient-prosthesis mismatch for small aortic annulus?. J Card Surg 2008; 23(4):331-5.
Echahidi N, Mohty D, Pibarot P, Després JP, O'Hara G, Champagne J, Philippon F, Daleau P, Voisine P, Mathieu P. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation after coronary artery bypass graft surgery.. Circulation 2007; 116(11):I213-9.
Mohammadi S, Voisine P, Mathieu P, Dagenais F. Complete aortic obstruction owing to a proximal dehiscence of a free-style root bioprosthesis.. Can J Cardiol 2007; 23(8):633.
Côté C, Pibarot P, Despres JP, Mohty D, Cartier A, Arsenault B, Couture C, Mathieu P. Association between circulating oxidized low-density lipoprotein and fibro-calcific remodeling of the aortic valve in aortic stenosis.. Heart 2007; 0(0):Epub.
Dagenais F, Dumont E, Mathieu P, Voisine P. Advances in thoracic aortic surgery: arch replacement with axillary cannulation and thoracic stent grafts.. Can J Cardiol 2007; 23(0):76-9B.
Dagenais F, Nadeau G, Normand JP, Turcotte R, Mathieu P, Voisine P. Endovascular treatment of a blunt thoracic aortic laceration owing to a thoracolombar spine fractures.. Techno Tech Cardiothor Vasc Surg 2007; 0(0):(sous-presse).
Côté C, Pibarot P, Després JP, Mohty D, Cartier A, Arsenault BJ, Couture C, Mathieu P. Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis.. Heart 2008; 94(9):1175-80.
Bossé Y, Mathieu P, Pibarot P. Reply to a letter to the editor re: genomics of aortic valve disease.. J Am Coll Cardiol 2008; 52(0):498-9.
Rodés-Cabau J, Deblois J, Bertrand OF, Mohammadi S, Courtis J, Larose E, Dagenais F, Déry JP, Mathieu P, Rousseau M, Barbeau G, Baillot R, Gleeton O, Perron J, Nguyen CM, Roy L, Doyle D, De Larochellière R, Bogaty P, Voisine P. Nonrandomized comparison of coronary artery bypass surgery and percutaneous coronary intervention for the treatment of unprotected left main coronary artery disease in octogenarians.. Circulation 2008; 118(23):2374-81.
Mohammadi S, Dagenais F, Doyle D, Mathieu P, Baillot R, Charbonneau E, Perron J, Voisine P. Age cut-off for the loss of benefit from bilateral internal thoracic artery grafting.. Eur J Cardiothorac Surg 2008; 33(6):977-82.
Mathieu P. Abdominal obesity and the metabolic syndrome: a surgeon's perspective.. Can J Cardiol 2008; 24(0):19D-23D.
Clavel MA, Fuchs C, Burwash IG, Mundigler G, Dumesnil JG, Baumgartner H, Bergler-Klein J, Beanlands RS, Mathieu P, Magne J, Pibarot P. Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study.. Circulation 2008; 118(14):S234-42.
Mohty D, Dumesnil JG, Echahidi N, Mathieu P, Dagenais F, Voisine P, Pibarot P. Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: influence of age, obesity, and left ventricular dysfunction.. J Am Coll Cardiol 2009; 53(1):39-47.
Mathieu P, Poirier P, Pibarot P, Lemieux I, Després JP. Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease.. Hypertension 2009; 53(4):577-84.
Mohty D, Pibarot P, Després JP, Cartier A, Arsenault B, Picard F, Mathieu P. Age-related differences in the pathogenesis of calcific aortic stenosis: the potential role of resistin.. Int J Cardiol 2009; 0(0):Epub (20 janv.).
Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodès JC, Bertrand P, Poirier P. From insulin resitance syndrome (x) to metabolic syndrome to visceral obesity/ectopic fat: introducing the notion of global cardiometabolik risk.. Arterioscler Thromb Vasc Biol 2008; 28(0):1039-49.
Mathieu P, Després JP, Pibarot P. Response to the letter to the editor re: the "valvulo-metabolic" risk in calcific aortic valve disease.. Can J Cardiol 2008; 24(0):521.
Echahidi N, Pibarot P, O'Hara G, Mathieu P. Response to the Editor re: combination prophylactic therapy for postoperative atrial fibrillation.. J Am Coll Cardiol 2008; 52(0):397-398.
Mathieu P, Pibarot P, Després JP. Response to the Editior re: relationship between serum high density lipoprotein levels and the progression of aortic valvular disease.. Heart 2009; 95(0):938-9.
Mathieu P. A special case of fatty heart, not a so rare condition after all.. Obesity Management 2008; 138(0):70-72.
Girerd N, Pibarot P, Fournier D, Daleau P, Voisine P, O'Hara G, Després JP, Mathieu P. Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery.. Eur Heart J 2009; 30(10):1270-8.
Shetty R, Pibarot P, Audet A, Janvier R, Dagenais F, Perron J, Couture C, Voisine P, Després JP, Mathieu P. Lipid-mediated inflammation and degeneration of bioprosthetic heart valves.. Eur J Clin Invest 2009; 39(6):471-80.
Magne J, Girerd N, Sénéchal M, Mathieu P, Dagenais F, Dumesnil JG, Charbonneau E, Voisine P, Pibarot P. Mitral repair versus replacement for ischemic mitral regurgitation: comparison of short-term and long-term survival.. Circulation 2009; 120(11):S104-11.
Bossé Y, Miqdad A, Fournier D, Pépin A, Pibarot P, Mathieu P. Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves.. Circ Cardiovasc Genet 2009; 2(5):489-98.
Derbali H, Bossé Y, Pibarot P, Audet A, Pépin A, Arsenault B, Couture C, Després JP, Mathieu P. Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2.. Am J Pathol 2010; 176(6):2638-45.
Mathieu P, Lemieux I, Després JP. Obesity, inflammation, and cardiovascular risk.. Clin Pharmacol Ther 2010; 87(4):407-16.
Clavel MA, Burwash IG, Mundigler G, Dumesnil JG, Baumgartner H, Bergler-Klein J, Sénéchal M, Mathieu P, Couture C, Beanlands R, Pibarot P. Validation of conventional and simplified methods to calculate projected valve area at normal flow rate in patients with low flow, low gradient aortic stenosis: the multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) study.. J Am Soc Echocardiogr 2010; 23(4):380-6.
Côté N, Pibarot P, Pépin A, Fournier D, Audet A, Arsenault B, Couture C, Poirier P, Després JP, Mathieu P. Oxidized low-density lipoprotein, angiotensin II and increased waist circumference are associated with valve inflammation in prehypertensive patients with aortic stenosis.. J Cardiol 2009; 0(0):Epub (12 juin).
Daleau P, Comeau G, Fournier D, Patoine D, Mathieu P and Poirier P. Higher expression of connexion 40 in human atrial tissue of patients with type 2 diabetes who have undergone a coronary artery bypass graft surgery.. Health (London) 2010; 2(0):271-7.
Mohty D, Coté N, Pibarot p, Fournier D, Pépin A, Audet A, Després JP, Mathieu P.. Reduced fetuin A plasma level is associated with faster stenosis progression increased valvular calcification in elderly patients with aortic stenosis.. J Clin Exp Cardiolog 2011; 2(0):147.
Côté N, Pibarot P, Pépin A, Fournier D, Audet A, Arsenault B, Couture C, Poirier P, Després JP, Mathieu P. Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis.. Int J Cardiol 2010; 145(3):444-9.
Mohty D, Pibarot P, Després JP, Cartier A, Arsenault B, Picard F, Mathieu P. Age-related differences in the pathogenesis of calcific aortic stenosis: the potential role of resistin.. Int J Cardiol 2010; 142(2):126-32.
Pagé A, Dumesnil JG, Clavel MA, Chan KL, Teo KK, Tam JW, Mathieu P, Després JP, Pibarot P, . Metabolic syndrome is associated with more pronounced impairment of left ventricle geometry and function in patients with calcific aortic stenosis: a substudy of the ASTRONOMER (Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin).. J Am Coll Cardiol 2010; 55(17):1867-74.
Clavel MA, Webb JG, Rodés-Cabau J, Masson JB, Dumont E, De Larochellière R, Doyle D, Bergeron S, Baumgartner H, Burwash IG, Dumesnil JG, Mundigler G, Moss R, Kempny A, Bagur R, Bergler-Klein J, Gurvitch R, Mathieu P, Pibarot P. Comparison between transcatheter and surgical prosthetic valve implantation in patients with severe aortic stenosis and reduced left ventricular ejection fraction.. Circulation 2010; 122(19):1928-36.
Dagenais F, Mathieu P, Doyle D, Dumont É, Voisine P. Moderate aortic stenosis in coronary artery bypass grafting patients more than 70 years of age: to replace or not to replace?. Ann Thorac Surg 2010; 90(5):1495-9; discussion.
Picichè M, Kingma JJ, Fadel E, Dagenais F, Mathieu P, Simard D, Demaria RG, Voisine P. Enhancement of non-coronary collateral blood flow from the internal thoracic arteries: the theoretical and practical basis of an alternative method of myocardial blood supply.. J Cardiovasc Surg (Torino) 2011; 52(1):127-31.
Guauque-Olarte S, Gaudreault N, Piché ME, Fournier D, Mauriège P, Mathieu P, Bossé Y. The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease.. PLoS One 2011; 6(5):e19908.
Mothy D, Pibarot P, Cartier A, Côté M, Côté C, Després JP, Cosnay P, Mathieu P. Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis.. Cardiology 2011; 118(2):140-6.
Girerd N, Pibarot P, Mathieu P. Predictors of atrial fibrillation following coronary artery bypass surgery: increased waist circumference rather than increased body mass index?. Med Sci Monit 2011; 17(3):LE3.
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.. Circulation 2011; 124(16):1783-91.
Gaudreault N, Ducharme V, Lamontagne M, Guauque-Olarte S, Mathieu P, Pibarot P, Bossé Y. Replication of genetic association studies in aortic stenosis in adults.. Am J Cardiol 2011; 108(9):1305-10.
Bagur R, Manazzoni JM, Dumont É, Doyle D, Perron J, Dagenais F, Mathieu P, Baillot R, Charbonneau E, Métras J, Mohammadi S, Côté M, Philippon F, Voisine P, Rodés-Cabau J. Permanent pacemaker implantation following isolated aortic valve replacement in a large cohort of elderly patients with severe aortic stenosis.. Heart 2011; 97(20):1687-94.
Girerd N, Magne J, Pibarot P, Voisine P, Dagenais F, Mathieu P. Postoperative atrial fibrillation predicts long-term survival after aortic-valve surgery but not after mitral-valve surgery: a retrospective study.. BMJ Open 2011; 1(2):e000385.
Côté N, Couture C, Pibarot P, Després JP, Mathieu P. Angiotensin receptor blockers are associated with a lower remodelling score of stenotic aortic valves.. Eur J Clin Invest 2011; 41(11):1172-9.
Kulik A, Voisine P, Mathieu P, Masters RG, Mesana TG, Le May MR, Ruel M. Statin therapy and saphenous vein graft disease after coronary bypass surgery: analysis from the CASCADE randomized trial.. Ann Thorac Surg 2011; 92(4):1284-90; discussio.
Côté N, El Husseini D, Pépin A, Guauque-Olarte S, Ducharme V, Bouchard-Cannon P, Audet A, Fournier D, Gaudreault N, Derbali H, McKee MD, Simard C, Després JP, Pibarot P, Bossé Y, Mathieu P. ATP acts as a survival signal and prevents the mineralization of aortic valve.. J Mol Cell Cardiol 2012; 52(5):1191-202.
Girerd N, Mathieu P, Dumesnil JG, Magne J, Charbonneau É, Dagenais F, Dumont É, Voisine P, Baillot R, Pibarot P. Impact of aortic stenosis severity and its interaction with prosthesis-patient mismatch on operative mortality following aortic valve replacement.. J Heart Valve Dis 2012; 21(2):158-67.
Sénéchal M, Michaud N, Machaalany J, Bernier M, Dubois M, Magne J, Couture C, Mathieu P, Bertrand OF, Voisine P. Relation of mitral valve morphology and motion to mitral regurgitation severity in patients with mitral valve prolapse.. Cardiovasc Ultrasound 2012; 10(0):3.
Girerd N, Pibarot P, Daleau P, Voisine P, O'Hara G, Després JP, Mathieu P. Statins Reduce Short- and Long-Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival.. Clin Cardiol 2012; 35(7):430-6.
Chechi K, Gelinas Y, Mathieu P, Deshaies Y, Richard D. Validation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue.. PLoS One 2012; 7(4):e32265.
Shetty R, Girerd N, Côté N, Arsenault B, Després JP, Pibarot P, Mathieu P. Elevated proportion of small, dense low-density lipoprotein particles and lower adiponectin blood levels predict early structural valve degeneration of bioprostheses.. Cardiology 2012; 121(1):20-6.
Carter S, Miard S, Roy-Bellavance C, Boivin L, Li Z, Pibarot P, Mathieu P, Picard F. Sirt1 inhibits resistin expression in aortic stenosis.. PLoS One 2012; 7(4):e35110.
Clavel MA, Webb J, Rodés-Cabau J, Masson JB, Dumont É, De Larochelière R, Doyle D, Bergeron S, Baumgartner H, Burwash I, Dumesnil JG, Mundigler G, Bergler-Klein J, Gurwitch R, Mathieu P, Pibarot P.. Response to letters from Ranucci and colleagues and Subramanian and colleagues.. Circulation 2011; 124(0):e207-8.
Gilard M, Eltchaninoff H, Iung B, Donzeau-Gouge P, Chevreul K, Fajadet J, Leprince P, Leguerrier A, Lievre M, Prat A, Teiger E, Lefevre T, Himbert D, Tchetche D, Carrié D, Albat B, Cribier A, Rioufol G, Sudre A, Blanchard D, Collet F, Dos Santos P, Meneveau N, Tirouvanziam A, Caussin C, Guyon P, Boschat J, Le Breton H, Collart F, Houel R, Delpine S, Souteyrand G, Favereau X, Ohlmann P, Doisy V, Grollier G, Gommeaux A, Claudel JP, Bourlon F, Bertrand B, Van Belle E, Laskar M; FRANCE 2 Investigators (Gilard M, Laskar M, Eltchaninoff H, Fajadet J, Iung B, Teiger E, Donzeau-Gouge P, Leprince P, Leguerrier A, Prat A, Chevreul K, Lievre M, Bertrand M, Cassagne J, Mathieu P, Logeais Y, Lefevre T, Chevalier B, Farge A, Garot P, Hovasse T, Morice MC, Romano M, Donzeau Gouge P, Tchetche D, Vahdat O, Farah B, Fajadet J, Himbert D, Nataf P, Vahanian A, Carrie D, Dumonteil N, Fournial G, Marcheix B, Albat B, Leclercq F, Piot C, Schmutz L, Aubas P, Du Cailar A, Dubar A, Durrleman N, Fargosz F, Levy G, Maupas E, Rivalland F, Robert G, Eltchaninoff H, Bessou JP, Cribier A, Tron C, Rioufol G, Cao D, Dauphin R, Durand De Gevigney G, Finet G, Jegaden O, Obadia JF, Sudre A, Juthier F, Modine T, Van Belle E, Banfi C, Blanchard D, Sallerin T, Bar O, Barbey C, Chassaing S, Chatel D, Le Page O, Tauran A, Leprince P, Beygui F, Collet JP, Pavie A, Teiger E, Couetil JP, Dubois Rande JL, Hayat D, Fougeres E, Monin JL, Mouillet G, Collet F, Pecheux, Bayet, Vaillant A, Vicat J, Wittenberg O, Dos Santos P, Arsac F, Choukroun E, Dijos M, Guibaud JP, Leroux L, Elia N, Meneveau N, Genon D, Chocron S, Schiele F, Tirouvanziam A, Crochet D, Gaudin R, Roussel JC, Caussin C, Azmoun A, Ghostine S, Nottin R, Guyon P, Bonnet N, Digne F, Mesnidrey P, Royer T, Stratiev V, Gilard M, Bezon E, Boschat J, Choplain JN, Le Breton H, Abouliatim I, Bedossa M, Boulmier D, Verhoye JP, Collart F, Bonnet JL, Cuisset T, Grisoli D, Houel R, Joly P, Rosario R, Bergeron P, Bille J, Gelisse R, Delepine S, Debrux JL, Furber A, Pinaud F, Lusson JR, Azarnouch K, Durel N, Innorta A, Souteyrand G, Favereau X, Bical O, Dambrin G, Deleuze P, Jegou A, Ohlmann P, Kindo M, Mazzucotelli JP, Zupan M, Doisy V, Lienhart Y, Roriz R, Staat P, Blanchard D, Fabiani JN, Lafont A, Zegdi R, Heudes D, Grollier G, Ivascau C, Lognone T, Massetti M, Sabatier R, Huret B, Gommeaux A, Hochart P, Pecheux, Claudel JP, Bouchayer D, Gabrielle F, Pelissier F, Tremeau G, Bourlon F, Dreyfus G, Eker A, Habib Y, Hugues N, Mialhe C, Bertrand B, Chavanon O, Porcu P, Vanzetto G.). Registry of transcatheter aortic-valve implantation in high-risk patients.. N Engl J Med 2012; 366(18):1705-15.
Laflamme C, Simard JR, Buteau S, Lahaie P, Nadeau D, Déry B, Houle O, Mathieu P, Roy G, Ho J, Duchaine C.. Effect of growth media and washing on the spectral signatures of aerosolized biological simulants.. Appl Opt 2011; 50(6):788-96.
Ducharme V, Guauque-Olarte S, Gaudreault N, Pibarot P, Mathieu P, Bossé Y. NOTCH1 genetic variants in patients with tricuspid calcific aortic valve stenosis.. J Heart Valve Dis 2013; 22(2):142-9.
Coté N, Mahmut A, Bosse Y, Couture C, Pagé S, Trahan S, Boulanger MC, Fournier D, Pibarot P, Mathieu P. Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease.. Inflammation 2013; 36(3):573-81.
Audet A, Côté N, Couture C, Bossé Y, Després JP, Pibarot P, Mathieu P. Amyloid substance within stenotic aortic valves promotes mineralization.. Histopathology 2012; 61(4):610-619.
Chechi K, Blanchard PG, Mathieu P, Deshaies Y, Richard D. Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease.. Int J Cardiol 2013; 167(5):2264-70.
Capoulade R, Clavel MA, Dumesnil JG, Chan KL, Teo KK, Tam JW, Côté N, Mathieu P, Després JP, Pibarot P. Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy.. J Am Coll Cardiol 2012; 60(3):216-23.
Mathieu P. Pharmacology of ectonucleotidases: relevance for the treatment of cardiovascular disorders.. Eur J Pharmacol 2012; 696(1):1-4.
Côté N, El Husseini D, Pépin A, Bouvet C, Gilbert LA, Audet A, Fournier D, Pibarot P, Moreau P, Mathieu P. Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats.. Eur J Pharmacol 2012; 689(1):139-46.
Clavel MA, Dumesnil JG, Capoulade R, Mathieu P, Sénéchal M, Pibarot P. Outcome of patients with aortic stenosis, small valve area, and low-flow, low-gradient despite preserved left ventricular ejection fraction.. J Am Coll Cardiol 2012; 60(14):1259-67.
Girerd N, Magne J, Rabilloud M, Charbonneau E, Mohamadi S, Pibarot P, Voisine P, Baillot R, Doyle D, Dumont E, Dagenais F, Mathieu P. The impact of complete revascularization on long-term survival is strongly dependent on age.. Ann Thorac Surg 2012; 94(4):1166-72.
El Husseini D, Boulanger MC, Fournier D, Mahmut A, Bossé Y, Pibarot P, Mathieu P. High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1.. PLoS One 2013; 8(1):e53393.
Mahmut A, Boulanger MC, Fournier D, Couture C, Trahan S, Pagé S, Arsenault B, Després JP, Pibarot P, Mathieu P. Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling.. Eur J Clin Invest 2013; 43(6):570-8.
Capoulade R, Clavel MA, Dumesnil JG, Chan KL, Teo KK, Tam JW, Côté N, Mathieu P, Després JP, Pibarot P. Insulin Resistance and LVH Progression in Patients With Calcific Aortic Stenosis: A Substudy of the ASTRONOMER Trial.. JACC Cardiovasc Imaging 2013; 6(2):165-74.
Mahjoub H, Mathieu P, Sénéchal M, Larose E, Dumesnil J, Després JP, Pibarot P. ApoB/ApoA-I ratio is associated with increased risk of bioprosthetic valve degeneration.. J Am Coll Cardiol 2013; 61(7):752-61.
Clavel MA, Dumesnil JG, Capoulade R, Mathieu P, Sénéchal M, Pibarot P. Outcome of Patients with Aortic Stenosis, Small Valve Area and Low-Flow, Low-Gradient despite Preserved Left Ventricular Ejection Fraction - Reply.. J Am Coll Cardiol 2013; 61(17):1833-4.
Doyon M, Mathieu P, Moreau P. Decreased expression of gamma-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.. Cardiovasc Res 2013; 97(2):331-8.
Clavel MA, Ennezat PV, Maréchaux S, Dumesnil JG, Capoulade R, Hachicha Z, Mathieu P, Bellouin A, Bergeron S, Meimoun P, Arsenault M, Le Tourneau T, Pasquet A, Couture C, Pibarot P. Stress Echocardiography to Assess Stenosis Severity and Predict Outcome in Patients With Paradoxical Low-Flow, Low-Gradient Aortic Stenosis and Preserved LVEF.. JACC Cardiovasc Imaging 2013; 6(2):175-83.
Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Yla-Herttuala S, Laakso M, Despres JP, Deshaies Y, Sweeney G, Mathieu P, Marette A.. Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.. Am J Physiol Endocrinol Metab 2013; 305(5):E573-84.
Abete P, Adlbrecht C, Assimakopoulos SF, Côté N, Dullaart RP, Evsyukova HV, Fang TC, Goswami N, Hinghofer-Szalkay H, Ho YL, Hoebaus C, Hülsmann M, Indridason OS, Kholová I, Lin YH, Maniscalco M, Mathieu P, Mizukami H, Ndrepepa G, Roessler A, Sánchez-Ramón S, Santamaria F, Schernthaner GH, Scopa CD, Sharp KM, Skuladottir GV, Steichen O, Stenvinkel P, Tejera-Alhambra M, Testa G, Visseren FL, Westerink J, Witasp A, Yagihashi S, Ylä-Herttuala S.. Research update for articles published in EJCI in 2011.. Eur J Clin Invest 2013; 43(10):1097-110.
Capoulade R, Clavel MA, Mathieu P, Côté N, Dumesnil JG, Arsenault M, Bédard E, Pibarot P. Impact of hypertension and renin angiotensin system inhibitors in aprtic stenosis.. Eur J Clin Invest 2013; 43(12):1262-72.
Arsenault BJ, Dubé MP, Brodeur MR, de Oliveira Moraes AB, Lavoie V, Kernaleguen AE, Guauque-Olarte S, Mathieu P, Pibarot P, Messika-Zeitoun D, Bossé Y, Rhainds D, Rhéaume E, Tardif JC. Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.. Arterioscler Thromb Vasc Biol 2014; 34(2):457-62.
Michelena HI, Prakash SK, Della Corte A, Bissell M, Anavekar N, Mathieu P, Bossé Y, Limongelli G, Bossone E, Benson DW, Lancellotti P, Isselbacher EM, Enriquez-Sarano M, Sundt TM, Pibarot P, Evangelista A, Milewicz DM, Body SC. Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon).. Circulation 2014; 129(25):2691-704.
Côté N, Mahmut A, Fournier D, Boulanger MC, Couture C, Després JP, Trahan S, Bossé Y, Pagé S, Pibarot P, Mathieu P. Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease.. Pathobiology 2014; 81(1):15-24.
Capoulade R, Larose E, Mathieu P, Clavel MA, Dahou A, Arsenault M, Bédard E, Larue-Grondin S, Le Ven F, Dumesnil JG, Després JP, Pibarot P.. Visceral adiposity and left ventricular mass and function in patients with aortic stenosis: The PROGRESSA Study.. Can J Cardiol 2014; 30(9):1080-7.
Bouchareb R, Boulanger MC, Fournier D, Pibarot P, Messaddeq Y, Mathieu P. Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism.. J Mol Cell Cardiol 2014; 67(0):49-59.
El Husseini D, Boulanger MC, Mahmut A, Bouchareb R, Laflamme MH, Fournier D, Pibarot P, Bossé Y, Mathieu P. P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease.. J Mol Cell Cardiol 2014; 72(0):146-156.
Clavel MA, Côté N, Mathieu P, Dumesnil JG, Audet A, Pépin A, Couture C, Fournier D, Trahan S, Pagé S, Pibarot P. Paradoxical low-flow, low-gradient aortic stenosis despite preserved left ventricular ejection fraction: new insights from weights of operatively excised aortic valves.. Eur Heart J 2014; 35(38):2655-62.
Della Corte A, Body SC, Booher AM, Schaefers HJ, Milewski RK, Michelena HI, Evangelista A, Pibarot P, Mathieu P, Limongelli G, Shekar PS, Aranki SF, Ballotta A, Di Benedetto G, Sakalihasan N, Nappi G, Eagle KA, Bavaria JE, Frigiola A, Sundt TM (Collaborateurs: Body SC, Isselbacher EM, Muehlschlegel JD, Schoen FJ, Levine RA, Seidman C, Seidman J, Sundt TM, MacRae CA, Shekar P, Aranki SF, Eagle KA, Kroner BL, Asch F, Michelena HI, Enriquez-Sarano M, Anavekar N, Giuseppe L, Russo MG, Fratta F, Sarubbi B, D'Andrea A, Pacileo G, Di Salvo G, Scognamiglio G, Esposito R, Carrozza M, Morelli M, Rea A, Ricci C, Nemer M, Bissell MM, Bossone E, Citro R, Di Benedetto G, Ferrara F, Frigiola A, Ballotta A, Pluchinotta F, Varrica A, Della Corte A, De Feo M, Bancone C, Dialetto G, Covino FE, Manduca S, Buonocore M, Nappi G, Huggins G, Lancelotti P, Sakalihasan N, Bossé Y, Mathieu P, Pibarot P, Boulanger MC, Booher AM, Milewski RK, Bavaria J, Milewicz DM, Prakash S, Evangelista A, Rodriguez-Palomares J, Tura GT, Denny JC, Weeke P). Surgical treatment of bicuspid aortic valve disease: Knowledge gaps and research perspectives.. J Thorac Cardiovasc Surg 2014; 147(6):1749-57.
Mathieu P, Bouchareb R, Boulanger MC. Innate and adaptive immunity in calcific aortic valve disease.. J Immunol Res 2015; 2015(0):851945.
Mathieu P, Bossé Y, Huggins GS, Della Corte A, Pibarot P, Michelena HI, Limongelli G, Boulanger MC, Evangelista A, Bédard E, Citro R, Body SC, Nemer M, Schoen FJ. Pathology and pathobiology of bicuspid aortic valve: state of the art and novel research perspectives - A report from the International Bicuspid Aortic Valve Consortium (BAVCon).. J Pathol 2015; 1(4):195-206.
Mahmut A, Boulanger MC, Bouchareb R, Hadji F, Mathieu P. Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.. Cardiovasc Res 2015; 106(1):109-20.
Mahjoub H, Mathieu P, Larose É, Dahou A, Sénéchal M, Dumesnil JG, Després JP, Pibarot P. Determinants of aortic bioprosthetic valve calcification assessed by multidetector CT.. Heart 2015; 101(6):472-7.
Capoulade R, Mahmut A, Tastet L, Arsenault M, Bédard É, Dumesnil JG, Després JP, Larose É, Arsenault BJ, Bossé Y, Mathieu P, Pibarot P. Impact of Plasma Lp-PLA2 Activity on the Progression of Aortic Stenosis: The PROGRESSA Study.. JACC Cardiovasc Imaging 2015; 8(1):26-33.
Mahmut A, Mahjoub H, Boulanger MC, Fournier D, Després JP, Pibarot P, Mathieu P. Lp-PLA2 is associated with structural valve degeneration of bioprostheses.. Eur J Clin Invest 2014; 44(2):136-45.
Le Quang K, Bouchareb R, Lachance D, Laplante MA, El Husseini D, Boulanger MC, Fournier D, Fang XP, Avramoglu RK, Pibarot P, Deshaies Y, Sweeney G, Mathieu P, Marette A.. Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.. Arterioscler Thromb Vasc Biol 2014; 34(10):2283-91.
Laflamme MH, Mahjoub H, Mahmut A, Boulanger MC, Larose E, Pibarot P, Mathieu P. Parathyroid hormone is associated with the LV mass after aortic valve replacement.. Heart 2014; 100(23):1859-64.
Guay SP, Légaré C, Houde AA, Mathieu P, Bossé Y, Bouchard L. Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.. Clin Epigenetics 2014; 6(1):14.
Mahmut A, Boulanger MC, El Husseini D, Fournier D, Bouchareb R, Després JP, Pibarot P, Bossé Y, Mathieu P. Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization.. J Am Coll Cardiol 2014; 63(5):460-9.
Capoulade R, Côté N, Mathieu P, Chan KL, Clavel MA, Dumesnil JG, Teo KK, Tam JW, Fournier D, Després JP, Pibarot P. Circulating levels of matrix gla protein and progression of aortic stenosis: a substudy of the Aortic Stenosis Progression Observation: Measuring Effects of rosuvastatin (ASTRONOMER) trial.. Can J Cardiol 2014; 30(9):1088-95.
Mathieu P, Boulanger MC, Després JP. Ectopic visceral fat: a clinical and molecular perspective on the cardiometabolic risk.. Rev Endocr Metab Disord 2014; 15(4):289-98.
Le Ven F, Tizón-Marcos H, Fuchs C, Mathieu P, Pibarot P, Larose E. Valve tissue characterization by magnetic resonance imaging in calcific aortic valve disease.. Can J Cardiol 2014; 30(12):1676-83.
Asselin J, Roy C, Boudreau D, Messaddeq Y, Bouchareb R, Mathieu P. Supported core-shell nanobiosensors for quantitative fluorescence imaging of extracellular pH.. Chem Commun (Camb) 2014; 50(89):13746-9.
Mathieu P, Boulanger MC. Basic mechanisms of calcific aortic valve disease.. Can J Cardiol 2014; 30(9):982-93.
Mathieu P, Boulanger MC, Bouchareb R. Molecular biology of calcific aortic valve disease: towards new pharmacological therapies.. Expert Rev Cardiovasc Ther 2014; 12(7):851-62.
Guay SP, Brisson D, Mathieu P, Bossé Y, Gaudet D, Bouchard L.. A study in familial hypercholesterolemia suggests reduced methylomic plasticity in men with coronary artery disease.. Epigenomics 2015; 7(1):17-34.
Bouchareb R, Côté N, Boulanger MC, Le Quang K, El Husseini D, Asselin J, Hadji F, Lachance D, Shayhidin EE, Mahmut A, Pibarot P, Bossé Y, Messaddeq Y, Boudreau D, Marette A, Mathieu P.. Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis.. J Mol Cell Cardiol 2015; 82(0):104-15.
Clavel MA, Berthelot-Richer M, Le Ven F, Capoulade R, Dahou A, Dumesnil JG, Mathieu P, Pibarot P.. Impact of classic and paradoxical low flow on survival after aortic valve replacement for severe aortic stenosis.. J Am Coll Cardiol 2015; 65(7):645-53.
Carter S, Capoulade R, Arsenault M, Bédard É, Dumesnil JG, Mathieu P, Pibarot P, Picard F. Relationship Between Insulin-Like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients With Aortic Stenosis.. Can J Cardiol 2015; 31(12):1447-54.
Dahou A, Magne J, Clavel MA, Capoulade R, Bartko PE, Bergler-Klein J, Sénéchal M, Mundigler G, Burwash I, Ribeiro HB, O'Connor K, Mathieu P, Baumgartner H, Dumesnil JG, Rosenhek R, Larose É, Rodés-Cabau J, Pibarot P. Tricuspid Regurgitation Is Associated With Increased Risk of Mortality in Patients With Low-Flow Low-Gradient Aortic Stenosis and Reduced Ejection Fraction: Results of the Multicenter TOPAS Study (True or Pseudo-Severe Aortic Stenosis).. JACC Cardiovasc Interv 2015; 8(4):588-96.
Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.. J Am Coll Cardiol 2015; 66(11):1236-46.
Bouchareb R, Mahmut A, Nsaibia MJ, Boulanger MC, Dahou A, Lépine JL, Laflamme MH, Hadji F, Couture C, Trahan S, Pagé S, Bossé Y, Pibarot P, Scipione CA, Romagnuolo R, Koschinsky ML, Arsenault BJ, Marette A, Mathieu P. Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.. Circulation 2015; 132(8):677-90.
Shayhidin EE, Forcellini E, Boulanger MC, Mahmut A, Dautrey S, Barbeau X, Lagüe P, Sévigny J, Paquin JF, Mathieu P. Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells.. Br J Pharmacol 2015; 172(16):4189-99.
Guauque-Olarte S, Messika-Zeitoun D, Droit A, Lamontagne M, Tremblay-Marchand J, Lavoie-Charland E, Gaudreault N, Arsenault BJ, Dubé MP, Tardif JC, Body SC, Seidman JG, Boileau C, Mathieu P, Pibarot P, Bossé Y. Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.. Circ Cardiovasc Genet 2015; 8(6):812-22.
Chassé M, Mathieu P, Voisine P, Després JP, Pibarot P, Baillot R, Lellouche F, Poirier P. The Underestimated Belly Factor: Waist Circumference Is Linked to Significant Morbidity Following Isolated Coronary Artery Bypass Grafting.. Can J Cardiol 2016; 32(3):327-35.
Tastet L, Capoulade R, Clavel MA, Larose É, Shen M, Dahou A, Arsenault M, Mathieu P, Bédard É, Dumesnil JG, Tremblay A, Bossé Y, Després JP, Pibarot P. Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study.. Eur Heart J Cardiovasc Imaging 2017; 18(1):70-78.
Guay SP, Légaré C, Brisson D, Mathieu P, Bossé Y, Gaudet D, Bouchard L. Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.. Epigenomics 2016; 8(3):359-71.
Mahmut A, Mahjoub H, Boulanger MC, Dahou A, Bouchareb R, Capoulade R, Arsenault BJ, Larose E, Bossé Y, Pibarot P, Mathieu P. Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses.. Clin Chim Acta 2016; 455(0):20-5.
Dargis N, Lamontagne M, Gaudreault N, Sbarra L, Henry C, Pibarot P, Mathieu P, Bossé Y. Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.. Am J Cardiol 2016; 117(3):420-6.
Dahou A, Clavel MA, Capoulade R, Bartko PE, Magne J, Mundigler G, Bergler-Klein J, Burwash I, Mascherbauer J, Ribeiro HB, O'Connor K, Baumgartner H, Sénéchal M, Dumesnil JG, Rosenhek R, Mathieu P, Larose E, Rodés-Cabau J, Pibarot P. Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction.. Heart 2016; 102(7):548-54.
Girerd N, Rabilloud M, Pibarot P, Mathieu P, Roy P. Quantification of Treatment Effect Modification on Both an Additive and Multiplicative Scale.. PLoS One 2016; 11(4):e0153010.
Simard L, Côté N, Mathieu P, Clavel MA. Response by Simard et al to Letter Regarding Article, "Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?". Circ Res 2017; 120(5):e26.
Lefebvre CA, Forcellini E, Boutin S, Côté MF, C-Gaudreault R, Mathieu P, Lagüe P, Paquin JF. Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.. Bioorg Med Chem Lett 2017; 27(2):299-302.
Mohamed N, Mahmut A, Boulanger MC, Arsenault BJ, Bouchareb R, Simard S, Witztum JL, Clavel MA, Pibarot P, Bossé Y, Tsimikas S, Mathieu P. Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.. J Int Med Res 2016; 280(5):509-17.
Dahou A, Toubal O, Clavel MA, Beaudoin J, Magne J, Mathieu P, Philippon F, Dumesnil JG, Puri R, Ribeiro HB, Larose É, Rodés-Cabau J, Pibarot P. Relationship Between QT Interval and Outcome in Low-Flow Low-Gradient Aortic Stenosis With Low Left Ventricular Ejection Fraction.. J Am Heart Assoc 2016; 5(10):e003980.
Hadji F, Boulanger MC, Guay SP, Gaudreault N, Amellah S, Mkannez G, Bouchareb R, Marchand JT, Nsaibia MJ, Guauque-Olarte S, Pibarot P, Bouchard L, Bossé Y, Mathieu P. Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.. Circulation 2016; 134(23):1848-1862.
Guauque-Olarte S, Droit A, Tremblay-Marchand J, Gaudreault N, Kalavrouziotis D, Dagenais F, Seidman JG, Body SC, Pibarot P, Mathieu P, Bossé Y. RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.. Physiol Genomics 2016; 48(10):749-761.
Nsaibia MJ, Mahmut A, Mahjoub H, Dahou A, Bouchareb R, Boulanger MC, Després JP, Bossé Y, Arsenault BJ, Larose E, Pibarot P, Mathieu P. Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration.. Heart 2016; 102(23):1915-1921.
Unger P, Clavel MA, Lindman BR, Mathieu P, Pibarot P. Pathophysiology and management of multivalvular disease.. Nat Rev Cardiol 2016; 13(7):429-40.
Boyer M, Lévesque V, Poirier P, Marette A, Mathieu P, Després JP, Larose É, Arsenault BJ. Impact of a 1-year lifestyle modification program on plasma lipoprotein and PCSK9 concentrations in patients with coronary artery disease.. J Clin Lipidol 2016; 10(6):1353-1361.
Shen M, Tastet L, Capoulade R, Larose É, Bédard É, Arsenault M, Chetaille P, Dumesnil JG, Mathieu P, Clavel MA, Pibarot P. Effect of age and aortic valve anatomy on calcification and haemodynamic severity of aortic stenosis.. Heart 2017; 103(1):32-39.
Dahou A, Clavel MA, Dumesnil JG, Capoulade R, Ribeiro HB, O'Connor K, Mathieu P, Beaudoin J, Larose É, Rodés-Cabau J, Pibarot P. Impact of AVR on LV Remodeling and Function in Paradoxical Low-Flow, Low-Gradient Aortic Stenosis With Preserved LVEF.. JACC Cardiovasc Imaging 2017; 10(1):88-89.
Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial.. Atherosclerosis 2017; 260(0):1-7.
Simard L, Côté N, Dagenais F, Mathieu P, Couture C, Trahan S, Bossé Y, Mohammadi S, Pagé S, Joubert P, Clavel MA. Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?. Circ Res 2017; 120(4):681-691.
Mathieu P, Arsenault BJ. CAVD: Civilization Aortic Valve Disease.. Eur Heart J 2017; 38(28):2198-200.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancelloti P, Otto CM, Pibarot P. Calcific aortic stenosis.. Nat Rev Dis Primers 2016; 2(0):1-28.
Barbeau X, Mathieu P, Paquin JF, Lague P. Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling.. Mol Biosyst 2017; 13(6):1058-69.
Dahou A, Clavel MA, Capoulade R, O'Connor K, Ribeiro HB, Côté N, Le Ven F, Rodés-Cabau J, Dumesnil JG, Mathieu P, Pibarot P. B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin for Risk Stratification in Low-Flow, Low-Gradient Aortic Stenosis: A Substudy of the TOPAS Study.. JACC Cardiovasc Imaging 2018; 11(7):939-947.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Le Quang K, Hadji F, Argaud D, Dahou A, Bossé Y, Koschinsky ML, Pibarot P, Arsenault BJ, Marette A, Mathieu P. OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-KB pathway.. Cardiovasc Res 2017; 113(11):1351-1363.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML. Pathobiology of Lp(a) in calcific aortic valve disease.. Expert Rev Cardiovasc Ther 2017; 15(10):797-807.
Boekholdt SM, Arsenault BJ, Mathieu P. Coronary Artery Disease Affects Symptomatology of Aortic Valve Stenosis.. J Am Coll Cardiol 2017; 70(8):1103-1104.
Kim S, Paget-Bailly S, Messager M, Nguyen T, Mathieu P, Lamfichekh N, Fein F, Fratté S, Cléau D, Lakkis Z, Jary M, Sakek N, Jacquin M, Foubert A, Bonnetain F, Mariette C, Fiteni F, Borg C. Perioperative docetaxel, cisplatin, and 5-fluorouracil compared to standard chemotherapy for resectable gastroesophageal adenocarcinoma.. Eur J Surg Oncol 2017; 43(1):218-225.
Arsenault BJ, Bourgeois R, Mathieu P. Do Oxidized Lipoproteins Cause Atherosclerotic Cardiovascular Diseases?. Can J Cardiol 2017; 33(12):1513-1516.
Chechi K, Voisine P, Mathieu P, Laplante M, Bonnet S, Picard F, Joubert P, Richard D. Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.. Sci Rep 2017; 7(1):15566.
Forcellini E, Boutin S, Lefebvre CA, Shayhidin EE, Boulanger MC, Rhéaume G, Barbeau X, Lagüe P, Mathieu P, Paquin JF. Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.. Eur J Med Chem 2018; 147(0):130-149.
Clemenceau A, Bérubé JC, Bélanger P, Gaudreault N, Lamontagne M, Toubal O, Clavel MA, Capoulade R, Mathieu P, Pibarot P, Bosse Y. Deleterious variants in DCHS1 are prevalent in sporadic cases of mitral valve prolapse.. Mol Genet Genomic Med 2018; 6(1):114-120.
Thériault S, Gaudreault N, Lamontagne M, Rosa M, Boulanger MC, Messika-Zeitoun D, Clavel MA, Capoulade R, Dagenais F, Pibarot P, Mathieu P, Bossé Y. A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.. Nat Commun 2018; 9(1):988.
Tastet L, Capoulade R, Shen M, Clavel MA, Côté N, Mathieu P, Arsenault M, Bédard É, Tremblay A, Samson M, Bossé Y, Dumesnil JG, Arsenault BJ, Beaudoin J, Bernier M, Després JP, Pibarot P. ApoB/ApoA-I Ratio is Associated With Faster Hemodynamic Progression of Aortic Stenosis: Results From the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) Study.. J Am Heart Assoc 2018; 7(4):e007980.
Gharibeh L, Komati H, Bossé Y, Boodhwani M, Heydarpour M, Fortier M, Hassandazeh R, Ngu J, Mathieu P, Body S, Nemer M; Bicuspid Aortic Valve Consortium.. GATA6 Regulates Aortic Valve Remodeling and its Haploinsufficiency Leads to RL-Type Bicuspid Aortic Valve.. Circulation 2018; 138(10):1025-1038.
Mkannez G, Gagné-Ouellet V, Jalloul Nsaibia M, Boulanger MC, Rosa M, Argaud D, Hadji F, Gaudreault N, Rhéaume G, Bouchard L, Bossé Y, Mathieu P. DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.. Cardiovasc Res 2018; 114(11):1525-1535.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Dahou A, Salaun E, Bossé Y, Clavel MA, Arsenault BJ, Pibarot P, Mathieu P. Soluble CD14 is associated with the structural failure of bioprostheses.. Clin Chim Acta 2018; 485(0):173-177.
Salaun E, Mahjoub H, Dahou A, Mathieu P, Larose E, Després JP, Rodés-Cabau J, Arsenault BJ, Puri R, Clavel MA, Pibarot P. Hemodynamic Deterioration of Surgically Implanted Bioprosthetic Aortic Valves.. J Am Coll Cardiol 2018; 72(3):241-251.
Boyer M, Lévesque V, Poirier P, Marette A, Mitchell PL, Mora S, Mathieu P, Després JP, Larose E, Arsenault BJ. Longitudinal Changes in Cholesterol Efflux Capacities in Patients With Coronary Artery Disease Undergoing Lifestyle Modification Therapy.. J Am Heart Assoc 2018; 7(11):e008681.
Perrot N, Boekholdt SM, Mathieu P, Wareham NJ, Khaw KT, Arsenault BJ. Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.. Int J Cardiol 2018; 269(0):226-228.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ. Acute and chronic effect of bariatric surgery on circulating autotaxin levels.. Physiol Rep 2019; 7(5):e14004.
Salaun E, Mahjoub H, Girerd N, Dagenais F, Voisine P, Mohammadi S, Yanagawa B, Kalavrouziotis D, Juni P, Verma S, Puri R, Coté N, Rodés-Cabau J, Mathieu P, Clavel MA, Pibarot P.. Rate, Timing, Correlates, and Outcomes of Hemodynamic Valve Deterioration After Bioprosthetic Surgical Aortic Valve Replacement.. Circulation 2018; 138(10):971-985.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P. Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.. Eur Heart J 2019; 40(17):1362-1373.
Lindman BR, Clavel MA, Abu-Alhayja'a R, Côté N, Dagenais F, Novak E, Voisine P, Poulin A, Arsenault BJ, Desmeules P, Dahou A, Taster L, Aldahoun K, Bossé Y, Mathieu P, Pibarot P. Multimarker Approach to Identify Patients With Higher Mortality and Rehospitalization Rate After Surgical Aortic Valve Replacement for Aortic Stenosis.. JACC Cardiovasc Interv 2018; 11(21):2172-2181.
Piché ME, Poirier P, Marette A, Mathieu P, Lévesque V, Bibeau K, Larose E, Després JP. Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 Diabetes.. Metab Syndr Relat Disord 2019; 17(3):149-159.
Bossé Y, Mathieu P, Thériault S.. PALMD as a novel target for calcific aortic valve stenosis.. Curr Opin Cardiol 2019; 34(2):105-111.
Mathieu P, Boulanger MC.. Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease.. Front Cardiovasc Med 2019; 6(0):18.
Chechi K, Vijay J, Voisine P, Mathieu P, Bossé Y, Tchernof A, Grundberg E, Richard D.. UCP1 expression-associated gene signatures of human epicardial adipose tissue.. J Clin Invest 2019; 4(8):123618.
Perrot N, Thériault S, Dina S, Chen HY, Boekholdt SM, Rigade S, Després MA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert J, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.. Variation in LPA and calcific aortic valve stenosis in patients undergoing cardiac surgery and familial risk of aortic valve microcalcification.. JAMA Cardiol 2019; 4(7):620-627.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Bourgeois R, Trottier M, Tessier M, Guimont J, Nadeau M, Thériault S, Bossé Y. Witzum JL, Couture P, Mathieu P, Dweck M, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.. Lipoprotein(a), oxidized phospholipids and aortic valve microcalcification assessed by 18-NaF PET/CT.. CJC Open 2019; 1(3):131-140.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P. A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.. NPJ Genom Med 2019; 4(0):23.
Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P. Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.. Nucleic Acids Res 2019; 47(16):8424-8438.
Thériault S, Dina C, Messika-Zitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Verhoye JP, Baufreton C, Probst V, Roussel R, the D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.. Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis. Circ Genom Precis Med 2019; 12(10):e002617.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.. Heart 2020; 106(10):738-745.
Chartrand DJ, Larose E, Poirier P, Mathieu P, Alméras N, Pibarot P, Lamarche B, Rhéaume C, Després JP. Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis.. Am J Physiol Endocrinol Metab 2020; 319(3):E548-E556.
Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ. Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.. JACC Basic Transl Sci 2020; 5(7):649-661.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA.. Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.. J Am Coll Cardiol 2020; 76(15):1737-1748.
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.. J Am Coll Cardiol 2020; 75(4):395-405.
Perrot N, Thériault S, Rigade S, Chen HY, Dina C, Martinsson A, Boekholdt M, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Engert JC, Wareham NJ, Clavel MA, Pibarot P, Smith G, Schott JJ, Mathieu P, Bossé Y, Thanassoulis G, Arsenault BJ. Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.. Heart 2020; 106(18):1407-1412.
Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, Bossé Y, Mathieu P, Côté N, Clavel MA.. Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve.. J Am Heart Assoc 2020; 9(10):e015610.
Després AA, Piché ME, Auclair A, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Poirier P, Arsenault BJ. Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.. Obes Surg 2020; 30(10):3714-3720.
Li Z, Gaudreault N, Arsenault BJ, Mathieu P, Bossé Y, Thériault S. Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.. Commun Biol 2020; 3(1):477.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P. Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.. Commun Biol 2020; 3(1):206.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G. Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.. JAMA Cardiol 2020; 5(6):694-702.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM. Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.. JAMA Netw Open 2020; 3(2):e200129.
Perazza LR, Mitchell PL, Jensen BAH, Daniel N, Boyer M, Varin TV, Bouchareb R, Nachbar RT, Bouchard M, Blais M, Gagné A, Joubert P, Sweeney G, Roy D, Arsenault BJ, Mathieu P, Marette A. Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr^-/-ApoB^100/100 mice.. Atherosclerosis 2020; 304(0):9-21.
Bourgeois R, Devillers R, Perrot N, Després AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ. Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.. JACC Basic Transl Sci 2020; 5(9):888-897.
Bon-Baret V, Chignon A, Boulanger MC, Mathieu P. Warning AlarmIn Diabetes Mellitus: A Balancing Act Between Inflammation and Redox Signaling in Vascular Mineralization.. Arterioscler Thromb Vasc Biol 2020; 40(8):1804-1807.
Chignon A, Bon-Baret V, Boulanger MC, Bossé Y, Mathieu P. Oxyphospholipids in Cardiovascular Calcification.. Arterioscler Thromb Vasc Biol 2021; 41(1):11-19.
Perazza LR, Mitchell PL, Lizotte F, Jensen BAH, St-Pierre P, Trottier J, Barbier O, Mathieu P, Geraldes PM, Marette A. Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice.. FASEB J 2021; 35(5):e21559.
Bon-Baret V, Chignon A, Boulanger MC, Li Z, Argaud D, Arsenault BJ, Thériault S, Bossé Y, Mathieu P. System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan.. Circ Genom Precis Med 2021; 14(2):e003196.
Chignon A, Rosa M, Boulanger MC, Argaud D, Devillers R, Bon-Baret V, Mkannez G, Li Z, Rufiange A, Gaudreault N, Gosselin D, Thériault S, Bossé Y, Mathieu P. Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.. iScience 2021; 24(3):102241.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ. Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.. Metabolites 2021; 11(7):459.
Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ. Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.. Circ Genom Precis Med 2021; 14(4):e003271.
Valette K, Li Z, Bon-Baret V, Chignon A, Bérubé JC, Eslami A, Lamothe J, Gaudreault N, Joubert P, Obeidat M, van den Berge M, Timens W, Sin DD, Nickle DC, Hao K, Labbé C, Godbout K, Côté A, Laviolette M, Boulet LP, Mathieu P, Thériault S, Bossé Y. Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.. Commun Biol 2021; 4(1):700.
Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ. A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.. CJC Open 2020; 3(4):450-459.
Arnaud C, Mathieu P. A Role for Heme and Iron in Calcific Aortic Valve Disease?. Can J Cardiol 2021; 37(9):1310-1311.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ. Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.. Cell Rep Med 2021; 2(11):100437.
Perrot N, Pelletier W, Bourgault J, Couture C, Li Z, Mitchell PL, Ghodsian N, Bossé Y, Thériault S, Mathieu P, Arsenault BJ. A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.. Aging Cell 2021; 20(11):e13497.
Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S. Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.. Circ Genom Precis Med 2021; 14(6):e003452.
Chignon A, Argaud D, Boulanger MC, Mkannez G, Bon-Baret V, Li Z, Thériault S, Bossé Y, Mathieu P. Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.. PLoS Genet 2022; 18(1):e1010010.
Chignon A, Mathieu S, Rufiange A, Argaud D, Voisine P, Bossé Y, Arsenault BJ, Thériault S, Mathieu P. Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease.. Hum Genomics 2022; 16(1):8.
Mathieu S, Briend M, Abner E, Couture C, Li Z, Bossé Y, Thériault S, Esko T, Arsenault BJ, Mathieu P. Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.. iScience 2022; 25(9):104992.
Moncla LM, Mathieu S, Sylla MS, Bossé Y, Thériault S, Arsenault BJ, Mathieu P. Mendelian randomization of circulating proteome identifies actionable targets in heart failure.. BMC Genomics 2022; 23(1):588.
Gobeil É, Maltais-Payette I, Taba N, Brière F, Ghodsian N, Abner E, Bourgault J, Gagnon E, Manikpurage HD, Couture C, Mitchell PL, Mathieu P, Julien F, Corbeil J, Vohl MC, Thériault S, Esko T, Tchernof A, Arsenault BJ. Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease.. Metabolites 2022; 12(5):440.
Labbé P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin É. Angiopoietin-like 2 is essential to aortic valve development in mice.. Commun Biol 2022; 5(1):1277.
Gagnon E, Mitchell PL, Manikpurage HD, Abner E, Taba N, Esko T, Ghodsian N, Thériault S, Mathieu P, Arsenault BJ. Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study.. J Transl Med 2023; 21(1):60.
Minvielle Moncla LH, Briend M, Bossé Y, Mathieu P.. Calcific aortic valve disease: mechanisms, prevention and treatment.. Nat Rev Cardiol 2023; 20(8):546-559.
Gagnon E, Girard A, Gobeil E, Bourgault J, Couture C, Mitchell PL, Bouchard C, Tremblay A, Mathieu P, Michaud A, Pérusse L, Arsenault BJ.. Genetic control of body weight by the human brain proteome. iScience 2023; 26(4):106376.
Bourgault J, Abner E, Manikpurage HD, Pujol-Gualdo N, Laisk T, Estonian Biobank Research Team, Gobeil E, Gagnon E, Girard A, Mitchell PL, Thériault S, Esko T, Mathieu P, Arsenault BJ.. Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.. Gastroenterology 2023; 164(6):953-965.e3.
Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ.. Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.. Eur Heart J Open 2023; 3(2):oead032.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F. Associations of insulin-like growth factor binding protein-2 (IGFBP-2) with metabolic profile and hepatic fat deposition in asymptomatic men and women.. Am J Physiol Endocrinol Metab 2023; 325(1):E99-E105.
Thériault S, Mathieu P, Bossé Y. The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis.. Eur Heart J 2023; 44(21):1940-1942.
Briend M, Rufiange A, Moncla LM, Mathieu S, Bossé Y, Mathieu P. Connectome and regulatory hubs of CAGE highly active enhancers.. Sci Rep 2023; 13(1):5594.
Li Z, Zhang B, Salaun E, Côté N, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Xu Y, Pibarot P, Wu Y, Clavel MA. Association Between Remnant Cholesterol and Progression of Bioprosthetic Valve Degeneration.. Eur Heart J Cardiovasc Imaging 2023; 24(12):1690-1699.
Rauzier C, Chartrand DJ, Alméras N, Lemieux I, Larose E, Mathieu P, Pibarot P, Lamarche B, Rhéaume C, Poirier P, Després JP, Picard F. Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.. Front Endocrinol (Lausanne) 2023; 14(0):1222101.
Manikpurage HD, Paulin A, Girard A, Eslami A, Mathieu P, Thériault S, Arsenault BJ. Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.. Circ Genom Precis Med 2023; 16(5):470-477.

Dr Patrick Mathieu

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