Chercheur(e)

Dr Olivier Boucherat

Pneumologie

A2138

olivier.boucherat@criucpq.ulaval.ca

Publications

Trier par année :

Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S, Bonnet S. The cancer theory of Pulmonary Arterial Hypertension.. Pulm Circ 2017; 7(2):285-99.
Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M. Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2017; 195(5):583-595.
Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.. Sci Rep 2017; 7(1):4546.
Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L. HOXA5 plays tissue-specific roles in the developing respiratory system.. Development 2017; 144(19):3547-61.
Boucherat O, Landry-Truchon K, Aoidi R, Houde N, Nadeau V, Charron J, Jeannotte L. Lung development requires an active ERK/MAPK pathway in the lung mesenchyme.. Dev Dyn 2017; 246(1):72-82.
Boucherat O, Jeannotte L, Hadchouel A, Delacourt C, Benachi A. Pathomechanisms of Congenital Cystic Lung Diseases: Focus on Congenital Cystic Adenomatoid Malformation and Pleuropulmonary Blastoma.. Paediatr Respir Rev 2016; 19(0):62-8.
Boucherat O, Provencher S, Bonnet S. Therapeutic value of ASK1 inhibition in pulmonary arterial hypertension.. Am J Respir Crit Care Med 2018; 197(3):284-6.
Meloche J, Lampron MC, Nadeau V, Maltais M, Potus F, Lambert C, Tremblay E, Vitry G, Breuils-Bonnet S, Boucherat O, Charbonneau E, Provencher S, Paulin R, Bonnet S. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol 2017; 37(8):1513-23.
Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S. Dual ET_A/ET_B blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension.. Pulm Circ 2018; 8(1):204589321774142.
Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet S. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2018; 198(1):90-103.
Bonnet S, Boucherat O. The ROS controversy in hypoxic pulmonary hypertension revisited.. Eur Respir J 2018; 51(3):1800276.
Bourgeois A, Lambert C, Habbout K, Ranchoux B, Paquet-Marceau S, Trinh I, Breuils-Bonnet S, Paradis R, Nadeau V, Paulin R, Provencher S, Bonnet S, Boucherat O. FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.. J Mol Med (Berl) 2018; 96(2):223-235.
Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S.. Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.. Circ Res 2018; 122(7):1021-32.
Boucherat O, Morissette MC, Provencher S, Bonnet S, Maltais F. Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.. Am J Respir Crit Care Med 2016; 193(4):362-75.
Ruffenach G, Chabot S, Tanguay VF, Courboulin A, Boucherat O, Potus F, Meloche J, Pflieger A, Breuils-Bonnet S, Nadeau V, Paradis R, Tremblay E, Girerd B, Hautefort A, Montani D, Fadel E, Dorfmuller P, Humbert M, Perros F, Paulin R, Provencher S, Bonnet S. Role for RUNX2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2016; 194(10):1273-85.
Boucherat O, Bonnet S, Paulin R. The HIPPO-Thesis of Pulmonary HYPERtension.. Am J Respir Crit Care Med 2016; 194(7):787-789.
Ranchoux B, Meloche J, Paulin R, Boucherat O, Provencher S, Bonnet S. DNA Damage and Pulmonary Hypertension.. Int J Mol Sci 2016; 17(6):E990.
Boucherat O, Bonnet S. MicroRNA signature of end-stage idiopathic pulmonary arterial hypertension: clinical correlations and regulation of WNT signaling.. J Mol Med (Berl) 2016; 94(8):849-51.
Bonnet S, Paulin R, Provencher S, Boucherat O. Small SeP or Giant Leap for Pulmonary Hypertension Research?. Circulation 2018; 138(6):624-626.
Bourgeois A, Omura J, Habbout K, Bonnet S, Boucherat O. Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets.. Int J Biochem Cell Biol 2018; 104(0):9-13.
Clemenceau A, Boucherat O, Landry-Truchon K, Lamontagne M, Biardel S, Joubert P, Gobeil S, Secco B, Laplante M, Morissette M, Obeidat M, Timens W, Jeannotte L, Bossé Y.. Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.. Int J Dev Biol 2018; 62(11):857-864.
Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB, Provencher S, Zhang L, Uchida S. Clinical Value of Non-Coding RNAs in Cardiovascular, Pulmonary, and Muscle Diseases.. Am J Physiol Cell Physiol 2020; 318(1):C1-C28.
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O. Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(8):1667-1681.
Kurakula K, Boucherat O, Van der Feen DE, Bogaard HJ, Kulikowski E, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez.. Am J Respir Crit Care Med 2019; 200(9):1190-1191.
Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2019; 200(7):910-920.
Bonnet S, Boucherat O, Provencher S, Paulin R. Early Evidence for the Role of lncRNA TUG1 in Vascular Remodelling in Pulmonary Hypertension.. Can J Cardiol 2019; 35(11):1433-1434.
Boucherat O, Paulin R, Provencher S, Bonnet S. New Insights Into HIMF (Hypoxia-Induced Mitogenic Factor)-Mediated Signaling Pathways in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2019; 39(12):2451-2453.
Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F.. Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.. Circ Res 2019; 125(4):449-466.
Chelladurai P, Boucherat O, Stenmark K, Kracht M, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS. Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy.. Br J Pharmacol 2021; 178(1):54-71.
Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L. Correction: HOXA5 plays tissue-specific roles in the developing respiratory system (doi: 10.1242/dev.152686).. Development 2019; 146(18):dev184697.
Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S. Reply to Ning et al.: More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension.. Am J Respir Crit Care Med 2020; 201(3):389-391.
Lampron MC, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, Tremblay È, Boucherat O, Meloche J, Bonnet S, Provencher S, Potus F, Paulin R. PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension.. Arterioscler Thromb Vasc Biol 2020; 40(3):783-801.
Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in PAH.. Am J Respir Crit Care Med 2021; 203(5):614-627.
Provencher S, Boucherat O, Potus F, Bonnet S. Pulmonary hypertension thresholds: time to lower further?. Lancet Respir Med 2020; 8(9):834-836.
Boucherat O, Austin ED, Bonnet S. Revisiting the Role for HIF Stabilizers in Bronchopulmonary Dysplasia.. Am J Respir Crit Care Med 2020; 202(8):1075-1077.
Omura J, Habbout K, Shimauchi T, Wu WH, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F, Perron J, Potus F, Lin JH, Zafar H, Kiely DG, Lawrie A, Archer SL, Paulin R, Provencher S, Boucherat O, Bonnet S. Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.. Circulation 2020; 142(15):1464-1484.
Potus F, Mai V, Lebret M, Malenfant S, Breton-Gagnon E, Lajoie AC, Boucherat O, Bonnet S, Provencher S. Novel insights on the pulmonary vascular consequences of COVID-19.. Am J Physiol Lung Cell Mol Physiol 2020; 319(2):L277-L288.
Provencher S, Boucherat O, Berger RMF, Goumans MJ, Bonnet S. Reply to Chen et al.: BET Signaling: A Novel Therapeutic Target for Pulmonary Hypertension?. Am J Respir Crit Care Med 2020; 201(10):1313-1314.
Shimauchi T, Potus F, Bonnet S, Provencher S, Paulin R, Boucherat O.. Limitations and Flaws of Preclinical Pulmonary Hypertension Studies.. Adv Pulm Hypertens 2020; 19(2):47-54.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O. Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.. Int J Mol Sci 2021; 22(6):2957.
Grobs Y, Awada C, Lemay SE, Romanet C, Bourgeois A, Toro V, Nadeau V, Shimauchi K, Orcholski M, Breuils-Bonnet S, Tremblay E, Provencher S, Paulin R, Boucherat O, Bonnet S. Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.. Int J Mol Sci 2021; 22(6):2919.
Awada C, Grobs Y, Wu WH, Habbout K, Romanet C, Breuils-Bonnet S, Tremblay E, Martineau S, Paulin R, Bonnet S, Provencher S, Potus F, Boucherat O. (R)-Crizotinib Predisposes To and Exacerbates Pulmonary Arterial Hypertension in Animal Models.. Eur Respir J 2021; 57(5):2003271.
Lemay SE, Awada C, Shimauchi T, Wu WH, Bonnet S, Provencher S, Boucherat O. Fetal Gene Reactivation in Pulmonary Arterial Hypertension: GOOD, BAD, or BOTH?. Cells 2021; 10(6):1473.
Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival.. Circ Res 2022; 130(5):760-778.
Wu WH, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, Nadeau V, Orcholski M, Breuils-Bonnet S, Martineau S, Ferraro P, Potus F, Paulin R, Provencher S, Boucherat O. Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension.. Thorax 2022; 77(3):247-258.
Bisserier M, Boucherat O, Bonnet S, Hadri L. Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models.. Methods Mol Biol 2022; 2573(0):263-278.
Lemay SE, Boucherat O, Bonnet S. Reverse Reaction of Nicotinamide Nucleotide Transhydrogenase Promotes ROS Production and Contributes to Right Ventricular Failure.. JACC Basic Transl Sci 2022; 7(7):678-680.
Chelladurai P, Kuenne C, Bourgeois A, Günther S, Valasarajan C, Cherian AV, Rottier RJ, Romanet C, Weigert A, Boucherat O, Eichstaedt CA, Ruppert C, Guenther A, Braun T, Looso M, Savai R, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS. Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension.. Sci Transl Med 2022; 14(648):eabe5407.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.. JACC Basic Transl Sci 2022; 7(4):384-403.
Boucherat O, Agrawal V, Lawrie A, Bonnet S. The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.. Circ Res 2022; 130(9):1466-1486.
Provencher S, Potus F, Blais-Lecours P, Bernard S, Martineau S, Breuils-Bonnet S, Weatherald J, Sweeney M, Kulikowski E, Boucherat O, Bonnet S. BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Trial.. Am J Respir Crit Care Med 2022; 205(11):1357-1360.
Awada C, Bourgeois A, Lemay SE, Grobs Y, Yokokawa T, Breuils-Bonnet S, Martineau S, Krishna V, Potus F, Jeyaseelan J, Provencher S, Bonnet S, Boucherat O. G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.. Am J Respir Cell Mol Biol 2023; 68(5):537-550.
Yamamoto K, Lemay SE, Yokokawa T, Breuils-Bonnet S, Salem M, Potus F, Provencher S, Boucherat O, Bonnet S. DNA-Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension.. Am J Respir Cell Mol Biol 2023; 68(1):116-119.
Boucherat O, Yokokawa T, Krishna V, Kalyana-Sundaram S, Martineau S, Breuils-Bonnet S, Azhar N, Bonilla F, Gutstein D, Potus F, Lawrie A, Jeyaseelan J, Provencher S, Bonnet S.. From heart to blood: LTBP-2 is a promising biomarker for pulmonary arterial hypertension.. Nat Cardiovasc Res 2022; 1(0):804-805.
Lemay SE, Grobs Y, Boucherat O. Right Ventricular Dysfunction in Pulmonary Hypertension: Is Resistin a Promising Target?. J Am Heart Assoc 2023; 12(6):e8285.
Awada C, Boucherat O, Provencher S, Bonnet S, Potus F. The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets.. Vascul Pharmacol 2023; 151(0):107180.
Toro V, Jutras-Beaudoin N, Boucherat O, Bonnet S, Provencher S, Potus F. Right Ventricle and Epigenetics: A Systematic Review.. Cells 2023; 12(23):2693.
Khassafi F, Chelladurai P, Valasarajan C, Nayakanti SR, Martineau S , Sommer N, Yokokawa T, Boucherat O, Kamal A, Kiely DG, Swift AJ, Alabed S, Omura J, Breuils-Bonnet S , Kuenne C, Potus F, Günther S, Savai R, Seeger W, Looso M, Lawrie L, Zaugg JB, Tello K, Provencher S, Bonnet S, Pullamsetti SS.. Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.. Nat Cardiovasc Res 2023; 2(0):917-936.

Dr Olivier Boucherat

Publications

Support tomorrow's medicine, now.