Chercheur(e)

Dr Nicolas Flamand

Pneumologie

A3140

nicolas.flamand@criucpq.ulaval.ca

Publications

Trier par année :

Coffey MJ, Serezani CH, Phare SM, Flamand N, Peters-Golden M. NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.. J Leukoc Biol 2007; 82(6):1585-91.
Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions.. J Immunol 2007; 179(8):5454-61.
St-Onge M, Flamand N, Biarc J, Picard S, Bouchard L, Dussault AA, Laflamme C, James MJ, Caughey GE, Cleland LG, Borgeat P, Pouliot M. Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.. Biochim Biophys Acta 2007; 1771(9):1235-45.
Flamand N, Mancuso P, Serezani CH, Brock TG. Leukotrienes: mediators that have been typecast as villains.. Cell Mol Life Sci 2007; 64(19):2657-70.
Aronoff DM, Hao Y, Chung J, Coleman N, Lewis C, Peres CM, Serezani CH, Chen GH, Flamand N, Brock TG, Peters-Golden M. Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.. J Immunol 2008; 180(12):8222-30.
Flamand N, Luo M, Peters-Golden M, Brock TG. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.. J Biol Chem 2009; 284(1):306-13.
Langlois A, Chouinard F, Flamand N, Ferland C, Rola-Pleszczynski M, Laviolette M. Crucial implication of protein kinase C (PKC)-delta, PKC-zeta, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils.. J Leukoc Biol 2009; 85(4):656-63.
Chakravarti A, Rusu D, Flamand N, Borgeat P, Poubelle PE. Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.. Lab Invest 2009; 89(10):1084-99.
Lefebvre JS, Marleau S, Milot V, Lévesque T, Picard S, Flamand N, Borgeat P. Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.. FASEB J 2010; 24(2):637-47.
Chouinard F, Lefebvre JS, Navarro P, Bouchard L, Ferland C, Lalancette-Hébert M, Marsolais D, Laviolette M, Flamand N. The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis.. J Immunol 2011; 186(5):3188-96.
Boudreau LH, Bertin J, Robichaud PP, Laflamme M, Ouellette RJ, Flamand N, Surette ME. Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products.. FASEB J 2011; 25(3):1097-105.
Boudreau LH, Maillet J, LeBlanc LM, Jean-François J, Touaibia M, Flamand N, Surette ME. Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.. PLoS One 2012; 7(2):e31833.
Provost V, Larose MC, Langlois A, Rola-Pleszczynski M, Flamand N, Laviolette M. CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2.. J Leukoc Biol 2013; 94(2):213-22.
Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N. 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.. J Leukoc Biol 2013; 93(2):267-76.
Provost V, Langlois A, Chouinard F, Rola-Pleszczynski M, Chakir J, Flamand N, Laviolette M. Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.. PLoS One 2012; 7(8):e43544.
Turcotte C, Chouinard F, Lefebvre JS, Flamand N. Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.. J Leukoc Biol 2015; 97(6):1049-70.
Larose MC, Turcotte C, Chouinard F, Ferland C, Martin C, Provost V, Laviolette M, Flamand N.. Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol.. J Allergy Clin Immunol 2014; 133(5):1480-2.
Larose MC, Chakir J, Archambault AS, Joubert P, Provost V, Laviolette M, Flamand N.. Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma.. J Allergy Clin Immunol 2015; 136(4):904-13.
Gendron D, Lemay AM, Tremblay C, Lai L, Langlois A, Bernatchez É, Flamand N, Blanchet MR, Don AS, Bossé Y, Bissonnette É, Marsolais D.. Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.. Respir Res 2015; 16(1):7.
Bernatchez E, Gold MJ, Langlois A, Lemay AM, Brassard J, Flamand N, Marsolais D, McNagny KM, Blanchet MR. Pulmonary CD103 expression regulates airway inflammation in asthma.. Am J Physiol Lung Cell Mol Physiol 2015; 308(8):L816-26.
Sylvain-Prévost S, Ear T, Simard FA, Fortin CF, Dubois CM, Flamand N, McDonald PP. Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses.. J Immunol 2015; 195(11):5393-403.
Allain EP, Boudreau LH, Flamand N, Surette ME. The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase ?13 Isoform Differs from That of Its Full Length Counterpart.. PLoS One 2015; 10(7):e0132607.
Galvão AF, Petta T, Flamand N, Bollela VR, Silva CL, Jarduli LR, Malmegrim KC, Simões BP, de Moraes LA, Faccioli LH. Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment.. Anal Bioanal Chem 2016; 408(13):3613-23.
Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, Flamand N, Weigert A, Stark H, Steinhilber D, Kahnt AS. Cellular analysis of the histamine H4 receptor in human myeloid cells.. Biochem Pharmacol 2016; 103(0):74-84.
Ball AK, Beilstein K, Wittmann S, Sürün D, Saul MJ, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber D. Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LO?13, 5-LO?4 and 5-LOp12.. Biochim Biophys Acta Mol Cell Biol Lipids 2017; 1862(5):561-571.
Larose MC, Archambault AS, Provost V, Laviolette M, Flamand N. Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma.. Front Med (Lausanne) 2017; 4(0):136.
Sorgi CA, Zarini S, Martin SA, Sanchez RL, Scandiuzzi RF, Gijón MA, Guijas C, Flamand N, Murphy RC, Faccioli LH. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid.. Sci Rep 2017; 7(1):10981.
Mailhot-Larouche S, Lortie K, Marsolais D, Flamand N, Bossé Y. An in vitro study examining the duration between deep inspirations on the rate of renarrowing.. Respir Physiol Neurobiol 2017; 243(0):13-19.
Bernatchez E, Langlois A, Brassard J, Flamand N, Marsolais D, Blanchet MR. Hypersensitivity pneumonitis onset and severity is regulated by CD103 dendritic cell expression.. PLoS One 2017; 12(6):e0179678.
Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppé CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette É, Blanchet MR, Laplante M, Bourgoin SG, Bossé Y, Marsolais D. A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.. Front Pharmacol 2017; 8(0):78.
Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Marsolais D, Laviolette M, Blanchet MR, Flamand N. The Endocannabinoid Metabolite Prostaglandin E₂ (PGE₂)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE₂ and EP Receptors.. J Immunol 2017; 198(8):3255-3263.
Archambault AS, Turcotte C, Martin C, Lefebvre JS, Provost V, Laviolette M, Flamand N. Leukotriene B? Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ?-Oxidation of Leukotriene B? In Vitro and In Cellulo.. PLoS One 2017; 12(1):e0169804.
Archambault AS, Turcotte C, Martin C, Provost V, Larose MC, Laprise C, Chakir J, Bissonnette É, Laviolette M, Bossé Y, Flamand N. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils.. PLoS One 2018; 13(8):e0202424.
Larouche M, Gagné-Ouellet V, Boucher-Lafleur AM, Larose MC, Plante S, Madore AM, Laviolette M, Flamand N, Chakir J, Laprise C. Methylation profiles of IL33 and CCL26 in bronchial epithelial cells are associated with asthma.. Epigenomics 2018; 10(12):1555-1568.
Brassard J, Maheux C, Langlois A, Bernatchez E, Marsolais D, Flamand N, Blanchet MR. Lipopolysaccharide impacts murine CD103⁺ DC differentiation, altering the lung DC population balance.. Eur J Immunol 2019; 49(4):638-652.
Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD. Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.. Nat Commun 2019; 10(1):457.
Archambault AS, Poirier S, Lefebvre JS, Robichaud PP, Larose MC, Turcotte C, Martin C, Provost V, Boudreau LH, McDonald PP, Laviolette M, Surette ME, Flamand N. 20-Hydroxy- and 20-carboxy-leukotriene (LT) B₄ downregulate LTB₄ -mediated responses of human neutrophils and eosinophils.. J Leukoc Biol 2019; 105(6):1131-1142.
Turcotte C, Dumais É, Archambault AS, Martin C, Blanchet MR, Bissonnette É, Boulet LP, Laviolette M, Di Marzo V, Flamand N. Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways.. J Leukoc Biol 2019; 106(6):1337-1347.
Lacroix S, Pechereau F, Leblanc N, Boubertakh B, Houde A, Martin C, Flamand N, Silvestri C, Raymond F, Di Marzo V, Veilleux A. Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice.. mSystems 2019; 4(6):e00407-19..
Manca C, Boubertakh B, Leblanc N, Deschênes T, Lacroix S, Martin C, Houde A, Veilleux A, Flamand N, Muccioli GG, Raymond F, Cani PD, Di Marzo V, Silvestri C. Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling.. J Lipid Res 2020; 61(1):70-85.
Turcotte C, Archambault AS, Dumais É, Martin C, Blanchet MR, Bissonnette E, Ohashi N, Yamamoto K, Itoh T, Laviolette M, Veilleux A, Boulet LP, Di Marzo V, Flamand N. Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes.. FASEB J 2020; 34(3):4253-4265.
Castonguay-Paradis S, Lacroix S, Rochefort G, Parent L, Perron J, Martin C, Lamarche B, Raymond F, Flamand N, Di Marzo V, Veilleux A. Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.. Sci Rep 2020; 10(1):15975.
Manca C, Shen M, Boubertakh B, Martin C, Flamand N, Silvestri C, Di Marzo V. Alterations of brain endocannabinoidome signaling in germ-free mice.. Biochim Biophys Acta Mol Cell Biol Lipids 2020; 1865(12):158786.
Lefort C, Roumain M, Van Hul M, Rastelli M, Manco R, Leclercq I, Delzenne NM, Di Marzo V, Flamand N, Luquet S, Silvestri C, Muccioli GG, Cani PD. Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism.. Cells 2020; 9(5):1247.
Wong GS, Redes JL, Balenga N, McCullough M, Fuentes N, Gokhale A, Koziol-White C, Jude JA, Madigan LA, Chan EC, Jester WH, Biardel S, Flamand N, Panettieri RA Jr, Druey KM. RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.. J Allergy Clin Immunol 2020; 146(5):1152-1164.e13.
Poirier SJ, Boudreau LH, Flamand N, Surette ME. LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells.. Prostaglandins Leukot Essent Fatty Acids 2020; 154(0):102078.
Rochefort G, Provencher V, Castonguay-Paradis S, Perron J, Lacroix S, Martin C, Flamand N, Di Marzo V, Veilleux A.. Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators.. Appetite 2021; 156(0):104973.
Gazzola M, Flamand N, Bossé Y.. La contractilité du muscle lisse des voies respiratoires est régulée par de nombreuses molécules extracellulaires qui pourraient contribuer à l'hyperréactivité bronchique [Extracellular molecules controlling the contraction of airway smooth muscle and their potential contribution to bronchial hyperresponsiveness].. Rev Mal Respir 2020; 34(0):462-473.
Suriano F, Manca C, Flamand N, Depommier C, Van Hul M, Delzenne NM, Silvestri C, Cani PD, Di Marzo V.. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1867(1):159056.
Depommier C, Flamand N, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Everard A, Delzenne NM, Di Marzo V, Cani PD. Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models.. Cells 2021; 10(1):71.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD. Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPAR? Agonists.. Cells 2021; 10(1):185.
Archambault AS, Zaid Y, Rakotoarivelo V, Turcotte C, Doré É, Dubuc I, Martin C, Flamand O, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Côté A, Laviolette M, Boilard É, Flamand L, Flamand N. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients.. FASEB J 2021; 35(6):e21666.
Tinto F, Archambault AS, Dumais É, Rakotoarivelo V, Kostrzewa M, Martin C, Plante PL, Desjardins Y, Simard M, Pouliot R, De Petrocellis L, Ligresti A, Di Marzo V, Flamand N. Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva.. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1866(8):158954.
Morin S, Simard M, Flamand N, Pouliot R. Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway.. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1866(12):159032.
Zaid Y, Doré É, Dubuc I, Archambault AS, Flamand O, Laviolette M, Flamand N, Boilard É, Flamand L. Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19.. J Allergy Clin Immunol 2021; 148(2):368-380.e3.
Rakotoarivelo V, Sihag J, Flamand N. Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism.. Cells 2021; 10(6):1279.
Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N.. Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.. Cells 2021; 10(9):2322.
Lamontagne-Proulx J, Coulombe K, Dahhani F, Côté M, Guyaz C, Tremblay C, Di Marzo V, Flamand N, Calon F, Soulet D. Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model.. Nutrients 2021; 13(12):4218.
Abolghasemi A, Manca C, Iannotti FA, Shen M, Leblanc N, Lacroix S, Martin C, Flamand N, Di Marzo V, Silvestri C. Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis.. Int J Mol Sci 2021; 22(22):12361.
Manca C, Lacroix S, Pérusse F, Flamand N, Chagnon Y, Drapeau V, Tremblay A, Di Marzo V, Silvestri C. Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity.. Biomedicines 2021; 9(9):1246.
Simard M, Tremblay A, Morin S, Martin C, Julien P, Fradette J, Flamand N, Pouliot R. a-linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model.. Acta Biomater 2022; 140(0):261-274.
Simard M, Rioux G, Morin S, Martin C, Guérin SL, Flamand N, Julien P, Fradette J, Pouliot R. Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.. J Invest Dermatol 2021; 141(10):2391-2401.e13.
Shen M, Manca C, Suriano F, Nallabelli N, Pechereau F, Allam-Ndoul B, Iannotti FA, Flamand N, Veilleux A, Cani PD, Silvestri C, Di Marzo V. Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.. Molecules 2021; 27(1):1.
Archambault AS, Brassard J, Bernatchez É, Martin C, Di Marzo V, Laviolette M, Boulet LP, Blanchet MR, Flamand N. Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners.. Cells 2022; 11(1):141.
Suriano F, Manca C, Flamand N, Depommier C, Van Hul M, Delzenne NM, Silvestri C, Cani PD, Di Marzo V. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.. Biochim Biophys Acta Mol Cell Biol Lipids 2022; 1867(1):159056.
Schebb NH, Kühn H, Kahnt AS, Rund KM, O'Donnell VB, Flamand N, Peters-Golden M, Jakobsson PJ, Weylandt KH, Rohwer N, Murphy RC, Geisslinger G, FitzGerald GA, Hanson J, Dahlgren C, Alnouri MW, Offermanns S, Steinhilber D. Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?. Front Pharmacol 2022; 13(0):838782.
Doré E, Joly-Beauparlant C, Morozumi S, Mathieu A, Lévesque T, Allaeys I, Duchez AC, Cloutier N, Leclercq M, Bodein A, Payré C, Martin C, Petit-Paitel A, Gelb MH, Rangachari M, Murakami M, Davidovic L, Flamand N, Arita M, Lambeau G, Droit A, Boilard E. The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.. JCI Insight 2022; 7(2):152638.
Forteza F, Bourdeau-Julien I, Nguyen GQ, Guevara Agudelo FA, Rochefort G, Parent L, Rakotoarivelo V, Feutry P, Martin C, Perron J, Lamarche B, Flamand N, Veilleux A, Billaut F, Di Marzo V, Raymond F. Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study.. Sci Rep 2022; 12(1):8568.
Archambault AS, Zaid Y, Rakotoarivelo V, Doré É, Dubuc I, Martin C, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Laviolette M, Boilard É, Flamand N.. Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites.. medRxiv 2020; 0(0):Epub.
Ben Necib R, Manca C, Lacroix S, Martin C, Flamand N, Di Marzo V, Silvestri C. Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed.. Front Immunol 2022; 13(0):882455.
Simard M, Archambault AS, Lavoie JC, Dumais É, Di Marzo V, Flamand N. Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families.. Biochem Pharmacol 2022; 205(0):115261.
Dubuc I, Prunier J, Lacasse É, Gravel A, Puhm F, Allaeys I, Archambault AS, Gudimard L, Villano R, Droit A, Flamand N, Boilard É, Flamand L. Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice.. Front Immunol 2022; 13(0):893792.
Simard M, Grenier A, Rioux G, Tremblay A, Blais I, Flamand N, Pouliot R. Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids.. Biomedicines 2022; 10(5):1078.
Guevara Agudelo FA, Leblanc N, Bourdeau-Julien I, St-Arnaud G, Lacroix S, Martin C, Flamand N, Veilleux A, Di Marzo V, Raymond F. Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice.. Front Immunol 2022; 13(0):1028412.
Simard M, Rakotoarivelo V, Di Marzo V, Flamand N. Expression and Functions of the CB(2) Receptor in Human Leukocytes.. Front Pharmacol 2022; 13(0):826400.
Murru A, Vadeboncoeur N, Therrien AA, Coderre L, Vaillancourt M, Labrecque MM, Berthiaume Y, Damien A, Brochiero E, Lessage S, Flamand N, Bilodeau L, Fernandes M.. Association of low-density neutrophils with lung function and disease progression in adult cystic fibrosis.. J Cyst Fibros 2023; 22(6):1080-1084.
Daniel N, Le Barz M, Mitchell P, Varin TV, Boudreau Julien I, Pilon G, Gauthier J, Garofalo C, Kang JX, Trottier J, Barbier O, Roy D, Chassaing B, Levy E, Raymond F, Flamand N, Silvestri C, Jobin C, Di Marzo V, Marette A.. Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.. Function (Oxf) 2022; 4(2):zqac069.
Bourdeau-Julien I, Castonguay-Paradis S, Rochefort G, Perron J, Lamarche B, Flamand N, Di Marzo V, Veilleux A, Raymond F.. The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population.. Microbiome 2023; 11(1):26.
Suriano F, Manca C, Flamand N, Van Hul M, Delzenne NM, Silvestri C,Cani PD, Di Marzo V.. A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese ( ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota. Cells 2023; 12(3):411.
Mukorako P, St-Pierre DH, Flamand N, Biertho L, Lebel S, Lemoine N, Plamondon J, Roy MC, Tchernof A, Varin TV, Marette A, Silvestri C, Di Marzo V, Richard D. Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects.. Int J Obes (Lond) 2023; 47(7):630-641.
Lacroix S, Leblanc N, Abolghasemi A, Paris-Robidas S, Martin C, Frappier M, Flamand N, Silvestri C, Raymond F, Millette M, Di Marzo V, Veilleux A. Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations.. Benef Microbes 2023; 0(0):1-16.
Venneri T, Giorgini G, Leblanc N, Flamand N, Borrelli F, Silvestri C, Di Marzo V. Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice.. Lipids Health Dis 2023; 22(1):63.
Daniel N, Le Barz M, Mitchell PL, Varin TV, Julien IB, Farabos D, Pilon G, Gauthier J, Garofalo C, Kang JX, Trottier J, Barbier O, Roy D, Chassaing B, Levy E, Raymond F, Lamaziere A, Flamand N, Silvestri C, Jobin C, Di Marzo V, Marette A. Comparing Transgenic Production to Supplementation of ?-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.. Function (Oxf) 2023; 4(2):zqac069.
Inserra A, Giorgini G, Lacroix S, Bertazzo A, Choo J, Markopolous A, Grant E, Abolghasemi A, De Gregorio D, Flamand N, Rogers G, Comai S, Silvestri C, Gobbi G, Di Marzo V. Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome.. Br J Pharmacol 2023; 180(6):721-739.
Castonguay-Paradis S, Perron J, Flamand N, Lamarche B, Raymond F, Di Marzo V, Veilleux A. Dietary food patterns as determinants of the gut microbiome-endocannabinoidome axis in humans.. Sci Rep 2023; 13(1):15702.
Simard M, Tremblay A, Morin S, Rioux G, Flamand N, Pouliot R. N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model.. Sci Rep 2023; 13(1):12113.
Morissette A, André DM, Agrinier AL, Varin TV, Pilon G, Flamand N, Houde VP, Marette A. The metabolic benefits of substituting sucrose for maple syrup are associated with a shift in carbohydrate digestion and gut microbiota composition in high-fat high-sucrose diet-fed mice.. Am J Physiol Endocrinol Metab 2023; 325(6):E661-E671.
Morin S, Tremblay A, Dumais E, Julien P, Flamand N, Pouliot R. Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.. Biomolecules 2023; 13(9):1413.

Dr Nicolas Flamand

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