Domaine de recherche
Mécanismes d'adaptation du coeur aux surcharges hémodynamiques. hypertrophie cardiaque gauche et insuffisance cardiaque, métabolisme énergétique cardiaque.
Description des travaux
Pour compenser une surcharge, le coeur met en marche une série de mécanismes pour s'adapter à ce surcroît de travail. Une hypertension artérielle mal contrôlée, les sténose ou régurgitations valvulaires significatives, le coeur en post-infarctus ou plus positivement, celui de l'athlète de haut niveau sont différents types de surcharge associés à un remodelage compensatoire du myocarde. Le coeur cherchera à produire de façon plus efficace l'énergie nécessaire pour continuer à assurer sa fonction de pompe. Souvent, le muscle cardiaque devra gagner de la masse pour continuer à remplir son rôle correctement. On nomme ce processus l'hypertrophie cardiaque.
Notre équipe s'intéresse depuis plusieurs années aux adaptations cardiaques dans les cas d'une surcharge de volume sanguin à pomper. Nous avons remarqué que la dilatation du coeur causée par le surplus de volume s'accompagne par un remodelage du métabolisme énergétique favorisant à court terme le glucose. De plus, nous avons démontré que, paradoxalement, ce mécanisme de compensation à la surcharge a intérêt à être ralenti le plus possible pour aider le coeur à maintenir sa fonction.
Nous sommes à mieux caractériser les mécanismes prenant place dans l'hypertrophie cardiaque et à identifier de nouveaux intervenants dans ce processus.
Prix et distinctions
4- 2006 à 2009: Chercheur-boursier senior du FRSQ
- 2004 à 2006: Chercheur-boursier Junior 2 du FRSQ
- 1999 à 2004: Chercheur boursier du CRM/Soc. rech. cancer inc.
- 1998 à 1999: Chercheur-boursier Junior 1 du FRSQ
Publications
55- Arsenault M, Plante E, Drolet MC, Couet J. Experimental aortic regurgitation in rats under echocardiographic guidance. J Heart Valve Dis 2002; 11(1):128-34.
- Plante E, Lachance D, Gaudreau M, Drolet MC, Roussel E, Arsenault M, Couet J. Effectiveness of beta-blockade in experimental chronic aortic regurgitation.. Circulation 2004; 110(11):1477-83.
- Drolet MC, Plante E, Battistini B, Couet J, Arsenault M. Early endothelial dysfunction in cholesterol-fed rabbits: a non-invasive in vivo ultrasound study.. Cardiovasc Ultrasound 2004; 2(1):10.
- Plante E, Gaudreau M, Lachance D, Drolet MC, Roussel E, Gauthier C, Lapointe E, Arsenault M, Couet J. Angiotensin-converting enzyme inhibitor captopril prevents volume overload cardiomyopathy in experimental chronic aortic valve regurgitation.. Can J Physiol Pharmacol 2004; 82(3):191-9.
- Roussel E, Bélanger MM, Couet J. G2/M blockade by paclitaxel induces caveolin-1 expression in A549 lung cancer cells: caveolin-1 as a marker of cytotoxicity.. Anticancer Drugs 2004; 15(10):961-7.
- Bélanger MM, Gaudreau M, Roussel E, Couet J. Role of caveolin-1 in Etoposide resistance development in a549 lung cancer cells.. Cancer Biol Ther 2004; 3(10):954-9.
- Drolet MC, Arsenault M, Couet J. Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 2003; 41(7):1211-7.
- Bélanger MM, Roussel E, Couet J. Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells.. Anticancer Drugs 2003; 14(4):281-7.
- Plante E, Couet J, Gaudreau M, Dumas MP, Drolet MC, Arsenault M. Left ventricular response to sustained volume overload from chronic aortic valve regurgitation in rats. J Card Fail 2003; 9(2):128-40.
- Drolet MC, Roussel E, Deshaies Y, Couet J, Arsenault M. A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice.. J Am Coll Cardiol 2006; 47(4):850-5.
- Plante E, Lachance D, Drolet MC, Roussel E, Couet J, Arsenault M. Dobutamine stress echocardiography in healthy adult male rats.. Cardiovasc Ultrasound 2005; 3(0):34.
- Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Després JP, Arsenault M, Couet J, Pibarot P. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis.. J Am Coll Cardiol 2006; 47(11):2229-36.
- Plante E, Lachance D, Roussel E, Drolet MC, Arsenault M, Couet J. Impact of anesthesia on echocardiographic evaluation of systolic and diastolic function in rats.. J Am Soc Echocardiogr 2006; 19(12):1520-5.
- Couet J, Gaudreau M, Lachance D, Plante E, Roussel E, Drolet MC, Arsenault M. Treatment of combined aortic regurgitation and systemic hypertension: Insights from an animal model study.. Am J Hypertens 2006; 19(8):843-50.
- Drolet MC, Lachance D, Plante E, Roussel E, Couet J, Arsenault M. Gender-related differences in left ventricular remodeling in chronic severe aortic valve regurgitation in rats.. J Heart Valve Dis 2006; 15(3):345-51.
- Roussel E, Gaudreau M, Plante E, Drolet MC, Breault C, Couet J, Arsenault M. Early responses of the left ventricle to pressure overload in Wistar rats.. Life Sci 2008; 82(5):265-72.
- Plante E, Lachance D, Champetier S, Drolet MC, Roussel E, Arsenault M, Couet J. Benefits of long-term beta-blockade in experimental chronic aortic regurgitation.. Am J Physiol Heart Circ Physiol 2008; 294(4):H1888-95.
- Drolet MC, Couet J, Arsenault M. Development of aortic valve sclerosis or stenosis in rabbits: role of cholesterol and calcium.. J Heart Valve Dis 2008; 17(0):381-387.
- Lachance D, Plante E, Gaudreau M, Roussel E, Drolet MC, Couet J, Arsenault M. Early left ventricular remodeling in acute severe aortic regurgitation: insights from an animal model.. J Heart Valve Dis 2008; 17(0):300-8.
- Champetier S, Bojmehrani A, Beaudoin J, Lachance D, Plante E, Roussel E, Couet J, Arsenault M. Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems.. Am J Physiol Heart Circ Physiol 2008; 0(0):Epub.
- Champetier S, Bojmehrani A, Beaudoin J, Lachance D, Plante E, Roussel E, Couet J, Arsenault M. Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems.. Am J Physiol Heart Circ Physiol 2009; 296(3):H669-77.
- Hermawan H, Purnama A, Dube D, Couet J, Mantovani D. Fe-Mn alloys for metallic biodegradable stents: Degradation and cell viability studies.. Acta Biomater 2010; 6(5):1800-7.
- Festuccia WT, Laplante M, Brûlé S, Houde VP, Achouba A, Lachance D, Pedrosa ML, Silva ME, Guerra-Sá R, Couet J, Arsenault M, Marette A, Deshaies Y. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.. J Mol Cell Cardiol 2009; 47(1):85-95.
- Lachance D, Champetier S, Plante E, Bouchard-Thomassin AA, Roussel E, Couet J, Arsenault M. Effects of exercise in volume overload: insights from a model of aortic regurgitation.. Med Sci Sports Exerc 2009; 41(6):1230-8.
- Plante E, Lachance D, Beaudoin J, Champetier S, Roussel E, Arsenault M, Couet J. Comparative study of vasodilators in an animal model of chronic volume overload caused by severe aortic regurgitation.. Circ Heart Fail 2009; 2(1):25-32.
- Lachance D, Plante E, Bouchard-Thomassin AA, Champetier S, Roussel E, Drolet MC, Arsenault M, Couet J. Moderate exercise training improves survival and ventricular remodeling in an animal model of left ventricular volume overload.. Circ Heart Fail 2009; 2(5):437-45.
- Bouchard-Martel J, Roussel E, Drolet MC, Arsenault M, Couet J. Interstitial cells from left-sided heart valves display more calcification potential than from right-sided valves: an in-vitro study of porcine valves.. J Heart Valve Dis 2009; 18(4):421-8.
- Moravej M, Purnama A, Fiset M, Couet J, Mantovani D. Electroformed pure iron as a new biomaterial for degradable stents: In vitro degradation and preliminary cell viability studies.. Acta Biomater 2010; 6(5):1843-51.
- Zendaoui A, Lachance D, Roussel E, Couet J, Arsenault M. Usefulness of carvedilol in the treatment of chronic aortic valve regurgitation.. Circ Heart Fail 2011; 4(2):207-13.
- Bouchard-Thomassin AA, Lachance D, Drolet MC, Couet J, Arsenault M. A high-fructose diet worsens eccentric left ventricular hypertrophy in experimental volume overload.. Am J Physiol Heart Circ Physiol 2011; 300(1):H125-34.
- Zendaoui A, Lachance D, Drolet MC, Couet J, Arsenault M. Usefulness of spironolactone in the treatment of chronic aortic valve regurgitation.. J Heart Valve Dis 2011; 4(2):207-13.
- Purnama A, Hermawan H, Champetier S, Mantovani D, Couet J. Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.. Acta Biomater 2013; 9(10):8746-53.
- Dhahri W, Couet J, Roussel É, Drolet MC, Arsenault M. Fenofibrate reduces cardiac remodeling and improves cardiac function in a rat model of severe left ventricle volume overload.. Life Sci 2013; 92(1):26-34.
- Zendaoui A, Lachance D, Roussel E, Couet J, Arsenault M. Effects of spironolactone treatment on an experimental model of chronic aortic valve regurgitation.. J Heart Valve Dis 2012; 21(4):478-86.
- Purnama A, Mantovani D, Couet J. Caveolin: A possible biomarker of degradable metallic materials toxicity in vascular cells.. Acta Biomater 2013; 9(10):8754-60.
- Dhahri W, Roussel É, Drolet MC, Gascon S, Sarrhini O, Rousseau JA, Lecomte R, Couet J, Arsenault M. Metformin Reduces Left Ventricular Eccentric Re-modeling In Experimental volume Overload in the Rat. J Clin Exp Cardiolog 2012; 3(11):217.
- Purnama A, Hermawan H, Couet J, Mantovani D. Assessing the biocompatibility of degradable metallic materials: state-of-the-art and focus on the potential of genetic regulation.. Acta Biomater 2010; 6(5):1800-7.
- Dhahri W, Drolet MC, Roussel E, Couet J, Arsenault M.. Chronic high-fat diet-induced obesity decreased survival and increased hypertrophy of rats with experimental eccentric hypertrophy from chronic aortic regurgitation.. BMC Cardiovasc Disord 2014; 14(0):123.
- Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP. An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models.. Mol Ther Methods Clin Dev 2014; 1(0):14044.
- Lachance D, Dhahri W, Drolet MC, Roussel É, Gascon S, Sarrhini O, Rousseau JA, Lecomte R, Arsenault M, Couet J.. Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload.. BMC Cardiovasc Disord 2014; 14(0):190.
- Roussel E, Drolet MC, Walsh-Wilkinson E, Dhahri W, Lachance D, Gascon S, Sarrhini O, Rousseau JA, Lecomte R, Couet J, Arsenault M. Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism.. Biomed Res Int 2015; 2015(0):949624.
- Drolet MC, Desbiens-Brassard V, Roussel E, Tu V, Couet J, Arsenault M. Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation.. Springerplus 2015; 4(0):435.
- Beaumont C, Walsh-Wilkinson É, Drolet MC, Roussel É, Arsenault M, Couet J. Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males.. Sci Rep 2017; 7(1):729.
- Garneau AP, Marcoux AA, Noël M, Frenette-Cotton R, Drolet MC, Couet J, Larivière R, Isenring P. Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria.. PLoS One 2016; 11(5):e0154398.
- Marsit O, Royer O, Drolet MC, Arsenault M, Couet J, Morin S, Levine RA, Pibarot P, Beaudoin J. Early Activation of Growth Pathways in Mitral Leaflets Exposed to Aortic Regurgitation: New Insights from an Animal Model.. J Heart Valve Dis 2017; 26(3):281-289.
- Carter S, Miard S, Caron A, Sallé-Lefort S, St-Pierre P, Anhê FF, Lavoie-Charland E, Blais-Lecours P, Drolet MC, Lefebvre JS, Lacombe J, Deshaies Y, Couet J, Laplante M, Ferron M, Bossé Y, Marette A, Richard D, Marsolais D, Picard F. Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure.. Diabetes 2018; 67(7):1285-1296.
- Roussel E, Drolet MC, Lavigne AM, Arsenault M, Couet J. Multiple short-chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy.. FEBS Open Bio 2018; 8(10):1624-1635.
- Walsh-Wilkinson É, Drolet MC, Le Houillier C, Roy ÈM, Arsenault M, Couet J. Sex differences in the response to angiotensin II receptor blockade in a rat model of eccentric cardiac hypertrophy.. PeerJ 2019; 7(0):e7461.
- Walsh-Wilkinson E, Beaumont C, Drolet MC, Roy ÈM, Le Houillier C, Beaudoin J, Arsenault M, Couet J. Effects of the loss of estrogen on the heart's hypertrophic response to chronic left ventricle volume overload in rats.. PeerJ 2019; 7(0):e7924.
- Beaumont C, Walsh-Wilkinson É, Drolet MC, Roussel É, Melançon N, Fortier É, Harpin G, Beaudoin J, Arsenault M, Couet J. Testosterone deficiency reduces cardiac hypertrophy in a rat model of severe volume overload.. Physiol Rep 2019; 7(9):e14088.
- Walsh-Wilkinson E, Drolet MC, Arsenault M, Couet J. Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload.. BMC Cardiovasc Disord 2020; 20(1):51.
- Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.. J Am Coll Cardiol 2020; 75(4):395-405.
- Walsh-Wilkinson E, Arsenault M, Couet J. Segmental analysis by speckle-tracking echocardiography of the left ventricle response to isoproterenol in male and female mice.. PeerJ 2021; 9(0):e11085.
- Walsh-Wilkinson É, Aidara ML, Morin-Grandmont A, Thibodeau SÈ, Gagnon J, Genest M, Arsenault M, Couet J. Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice.. Am J Physiol Heart Circ Physiol 2022; 323(4):H643-H658.
- Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J. Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.. J Am Coll Cardiol 2022; 80(5):500-510.
