Clinicien(ne) chercheur(e)

Dr François Maltais

Pneumologie

U2760

francois.maltais@criucpq.ulaval.ca

Domaine de recherche

Intolérance à l'effort dans la MPOC. Réadaptation respiratoire. Dysfonction musculaire dans la MPOC.

Description des travaux

Le thème général de mon équipe de recherche est l'intolérance à l'exercice dans la maladie pulmonaire obstructive chronique (MPOC). Plus spécifiquement, nous étudions les effets de la réadaptation pulmonaire et la dysfonction musculaire périphérique dans la MPOC. Plusieurs étudiants (tes) gradués (ée) de la maîtrise au post-doctorat participent à ma recherche. Nous pouvons recevoir des étudiants (tes) intéressés (ées) aux sciences fondamentales (mécanismes de la cachexie musculaire) et/ou à la recherche clinique (physiologie à l'effort).

Recherche fondamentale. l'atrophie musculaire dans la MPOC est en fait un état cachexique et non simplement un déséquilibre nutritionnel. Nous suggérons qu'il y ait une activation de la protéolyse musculaire qui est elle-même due à un déséquilibre catabolique/anabolique. Nous investiguons les voies de signalisation intracellulaire qui régulent la synthèse et la dégradation protéique musculaire chez des patients atteints de la MPOC chez qui nous réalisons une biopsie à l'aiguille du vaste externe de la cuisse.

Recherche clinique. Nous poursuivons également un programme de recherche clinique en investiguant le rôle de la fatigue musculaire périphérique dans l'intolérance à l'effort dans la MPOC. Nous utilisons la stimulation nerveuse magnétique du nerf fémoral pour obtenir une mesure de la force musculaire qui est indépendante de la volonté. Ce faisant, nous sommes en mesure de détecter la présence de fatigue musculaire après un exercice global sur ergocycle qui est définie comme une diminution réversible de la force musculaire après l'exercice. Nous investiguons présentement comment l'apparition de fatigue musculaire influence la tolérance à l'effort dans la MPOC. Différentes études de physiologie à l'effort sont également réalisées afin de mieux comprendre les mécanismes de l'intolérance à l'effort dans cette maladie.

Prix et distinctions

2004-2009 Fonds de la Recherche en Santé du Québec (FRSQ) Chercheur National.
2006- 2006 European Respiratory Society Romain Pauwels Research Award (50 000 EUR) récompensant un chercheur de moins de 46 ans ayant eu une contribution significative dans le domaine de la MPOC.
2006 Institute of Circulatory and Respiratory distinguished lecture in respiratory sciences.

Publications

346

Trier par année :

Allaire J, Maltais F, LeBlanc P, Simard PM, Whittom F, Doyon JF, Simard C, Jobin J. Lipofuscin accumulation in the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Muscle Nerve 2002; 25(3):383-9.
Marquis K, Debigaré R, Lacasse Y, LeBlanc P, Jobin J, Carrier G, Maltais F. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2002; 166(6):809-13.
Maltais F, Leblanc P, Jobin J, Casaburi R. [Peripheral muscle dysfunction in chronic obstructive pulmonary disease]. Rev Mal Respir 2002; 19(4):444-53.
Lacasse Y, Maltais F, Goldstein RS. Smoking cessation in pulmonary rehabilitation: goal or prerequisite?. J Cardiopulm Rehabil 2002; 22(3):148-53.
Maltais F, Ostinelli J, Bourbeau J, Tonnel AB, Jacquemet N, Haddon J, Rouleau M, Boukhana M, Martinot JB, Duroux P. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial.. Am J Respir Crit Care Med 2002; 165(5):698-703.
Maltais F, Debigaré R. Biology of muscle impairment in COPD.. Monaldi Arch Chest Dis 2003; 59(4):338-41.
Saey D, Debigaré R, LeBlanc P, Mador MJ, Côté CH, Jobin J, Maltais F. Contractile leg fatigue after cycle exercise: a factor limiting exercise in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2003; 168(4):425-30.
Couillard A, Maltais F, Saey D, Debigaré R, Michaud A, Koechlin C, LeBlanc P, Préfaut C. Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2003; 167(12):1664-9.
Debigaré R, Côté CH, Hould FS, LeBlanc P, Maltais F. In vitro and in vivo contractile properties of the vastus lateralis muscle in males with COPD.. Eur Respir J 2003; 21(2):273-8.
Goldstein RS, Todd TR, Guyatt G, Keshavjee S, Dolmage TE, van Rooy S, Krip B, Maltais F, LeBlanc P, Pakhale S, Waddell TK. Influence of lung volume reduction surgery (LVRS) on health related quality of life in patients with chronic obstructive pulmonary disease.. Thorax 2003; 58(5):405-10.
Maltais F. Skeletal muscles in chronic airflow obstruction: why bother?. Am J Respir Crit Care Med 2003; 168(8):916-7.
O'Donnell DE, Hernandez P, Aaron S, Bourbeau J, Marciniuk D, Hodder R, Balter M, Ford G, Gervais A, Goldstein R, Maltais F, Road J, McKay V, Schenkel J. Canadian Thoracic Society COPD Guidelines: summary of highlights for family doctors.. Can Respir J 2003; 10(4):183-5.
Bourbeau J, Julien M, Maltais F, Rouleau M, Beaupré A, Bégin R, Renzi P, Nault D, Borycki E, Schwartzman K, Singh R, Collet JP. Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention.. Arch Intern Med 2003; 163(5):585-91.
Russell AP, Somm E, Debigaré R, Hartley O, Richard D, Gastaldi G, Melotti A, Michaud A, Giacobino JP, Muzzin P, LeBlanc P, Maltais F. COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers.. J Cardiopulm Rehabil 2004; 24(5):332-9.
Doucet M, Debigaré R, Joanisse DR, Côté C, LeBlanc P, Gregoire J, Deslauriers J, Vaillancourt R, Maltais F. Adaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPD.. Eur Respir J 2004; 24(6):971-9.
Allaire J, Maltais F, Doyon JF, Noël M, LeBlanc P, Carrier G, Simard C, Jobin J. Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD.. Thorax 2004; 59(8):673-8.
Lacasse Y, Beaudoin L, Rousseau L, Maltais F. Randomized trial of paroxetine in end-stage COPD.. Monaldi Arch Chest Dis 2004; 61(3):140-7.
Lacasse Y, Maltais F, Goldstein RS. Pulmonary rehabilitation: an integral part of the long-term management of COPD.. Swiss Med Wkly 2004; 134(41):601-5.
Dolmage TE, Waddell TK, Maltais F, Guyatt GH, Todd TR, Keshavjee S, Van Rooy S, Krip B, LeBlanc P, Goldstein RS. The influence of lung volume reduction surgery on exercise in patients with COPD.. Eur Respir J 2004; 23(2):269-74.
Aaron SD, Vandemheen K, Fergusson D, Fitzgerald M, Maltais F, Bourbeau J, Goldstein R, McIvor A, Balter M, O'Donnell D. The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment.. Can Respir J 2004; 11(8):581-5.
Bourbeau J, Maltais F, Rouleau M, Guimont C. French-Canadian version of the Chronic Respiratory and St George's Respiratory questionnaires: an assessment of their psychometric properties in patients with chronic obstructive pulmonary disease.. Can Respir J 2004; 11(7):480-6.
Debigaré R, Marquis K, Côté CH, Tremblay RR, Michaud A, LeBlanc P, Maltais F. Catabolic/anabolic balance and muscle wasting in patients with COPD.. Chest 2003; 124(1):83-9.
O'Donnell DE, Maltais F, Frith P, Southcott A, Kesten S, Hamilton A.. Perceived locus of symptom limitation during constant work rate cycle ergometry in COPD patients treated with Tiotropium.. Chest 2004; 126(0):838s.
Lacasse Y, Maltais F, Goldstein RS. Smoking cessation in pulmonary rehabilitation: goal or prerequisite?. J Cardiopulm Rehabil 2002; 22(0):148-153.
Marquis K, Debigaré R, Lacasse Y, Leblanc P, Jobin J, Maltais F. Mid-thigh cross-sectional area is a better predictor of mortality than a body mass index in patients with COPD.. Am J Respir Crit Care Med 2002; 166(0):809-813.
Debigaré R, Milot J, Côté CH, Michaud A, Leblanc P, Maltais F. Blood and peripheral muscle pro-inflamatory cytokines in patients with COPD.. Am J Respir Crit Care Med 2002; 163(5):A287.
O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk D, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Maltais F, Road J,. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003.. Can Respir J 2003; 10(0):11A-65A.
Debigaré R, LeBlanc P, Maltais F. Exercise training and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease. Am J Sports Med 2003; 5(0):48-53.
O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk D, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Maltais F, Road J. State of the Art Compendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease.. Can Respir J 2004; 11(0):7B-59B.
Jobin J, Maltais F, Poirier P, LeBlanc P, Franklin B. Proceedings of the third Québec International Symposium on cardiopulmonary rehabilitation.. Am J Sports Med 2004; 6(0):1-6.
Saey D, Michaud A, Couillard A, Côté CH, Mador MJ, Leblanc P, Jobin J, Maltais F. Contractile fatigue, muscle morphometry, and blood lactate in chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2005; 171(10):1109-15.
Brassard P, Maltais F, Noël M, Doyon JF, LeBlanc P, Allaire J, Simard C, LeBlanc MH, Poirier P, Jobin J. Skeletal muscle endurance in patients with chronic heart failure: relation to metabolism.. Can J Cardiol 2006; 22(5):387-92.
Lacasse Y, Lecours R, Pelletier C, Bégin R, Maltais F. Randomized trial of ambulatory oxygen in oxygen-dependent chronic obstructive pulmonary disease.. Eur Respir J 2005; 25(0):1032-8.
Hayot M, Michaud A, Koechlin K, Caron MA, LeBlanc P, Préfaut C, Maltais F. Muscle microbiopsy: a validation study of a minimally invasive technique to assess the skeletal muscles.. Eur Respir J 2005; 25(0):431-40.
Saey D, Pepin V, Brodeur J, Lizotte J, Gagnon P, Laviolette L, Nadreau E, LeBlanc P, Jobin J, Maltais F. Use of facemask and mouthpiece to assess constant-workrate exercise capacity in COPD.. Med Sci Sports Exerc 2006; 38(2):223-30.
Lacasse Y, LaForge J, Maltais F. Got a match? Home oxygen therapy in current smokers.. Thorax 2006; 61(0):374-5.
Saey D, Côté CH, Mador MJ, Laviolette L, Leblanc P, Jobin J, Maltais F. Assessment of muscle fatigue during exercise in chronic obstructive pulmonary disease.. Muscle Nerve 2006; 34(1):62-71.
Leigh R, Pizzichini MM, Morris M, Maltais F, Hargreave FE, Pizzichini E. Stable COPD: predicting benefit from high dose inhaled corticosteroid treatment.. Eur Respir J 2006; 27(5):964-71.
Marquis K, Maltais F, Duguay V, Bezeau AM, LeBlanc P, Jobin J, Poirier P. The metabolic syndrome in patients with chronic obstructive pulmonary disease.. J Cardiopulm Rehabil 2005; 25(4):226-32.
Lacasse M, Maltais F, Poirier P, Lacasse Y, Marquis K, Jobin J, LeBlanc P. Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease.. Respir Med 2005; 99(7):877-86.
Lacasse Y, Montori VM, Lanthier C, Maltais F. The validity of diagnosing chronic obstructive pulmonary disease from a large administrative database.. Can Respir J 2005; 12(5):251-6.
Maltais F, Bourbeau J, Lacasse Y, Shapiro S, Perrault H, Penrod JR, Baltzan M, Rouleau M, Julien M, Paradis B, Audet R, Hernandez P, Levy RD, Camp P, Lecours R, Picard D, Bernard S. A Canadian, multicentre, randomized clinical trial of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease: rationale and methods.. Can Respir J 2005; 12(4):193-8.
Pepin V, Saey D, Whittom F, Leblanc P, Maltais F. Walking versus Cycling: Sensitivity to Bronchodilation in Chronic Obstructive Pulmonary Disease.. Am J Respir Crit Care Med 2005; 172(12):1517-22.
Koechlin C, Maltais F, Saey D, Michaud A, LeBlanc P, Hayot M, Préfaut C. Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease.. Thorax 2005; 60(10):834-41.
Gadoury MA, Schwartzman K, Rouleau M, Maltais F, Julien M, Beaupré A, Renzi P, Bégin R, Nault D, Bourbeau J,. Self-management reduces both short- and long-term hospitalisation in COPD.. Eur Respir J 2005; 26(5):853-7.
Maltais F, Hamilton A, Marciniuk D, Hernandez P, Sciurba FC, Richter K, Kesten S, O'Donnell D. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD.. Chest 2005; 128(3):1168-78.
Maltais F. Les muscles locomoteurs dans les pathologies respiratoires chroniques : exemple de la BPCO.[Loco-motor muscles in chronic respiratory diseases: the example of COPD]. Rev Mal Respir 2005; 22(1):2S53-61.
Poulain M, Doucet M, Major G, Drapeau V, Sériès F, Boulet LP, Tremblay A, Maltais F. The effect of obesity on chronic respiratory diseases: a review of the pathophysiology and therapeutic strategies.. CMAJ 2006; 174(9):1293-9.
Marciniuk DD, Aaron S, Maltais F, Moqbel R. 12th Annual Canadian Resident-Fellow Competition in Respiratory Research.. Can Respir J 2005; 12(1):46.
Deschênes D, Pepin V, Saey D, Leblanc P, Maltais F. Locus of Symptom Limitation and Exercise Response to Bronchodilation in Chronic Obstructive Pulmonary Disease.. J Cardiopulm Rehabil 2008; 28(3):208-14.
Pepin V, Brodeur J, Lacasse Y, Milot J, Leblanc P, Whittom F, Maltais F. Six-minute walking versus shuttle walking: responsiveness to bronchodilation in chronic obstructive pulmonary disease.. Thorax 2007; 62(4):291-8.
Laviolette L, Lacasse Y, Doucet M, Lacasse M, Marquis K, Saey D, Leblanc P, Maltais F. Chronic obstructive pulmonary disease in women.. Can Respir J 2007; 14(2):93-8.
Manganas H, Lacasse Y, Bourgeois S, Perron J, Dagenais F, Maltais F. Postoperative outcome after coronary artery bypass grafting in chronic obstructive pulmonary disease.. Can Respir J 2007; 14(1):19-24.
Lacasse Y, Sériès F, Martin S, Maltais F. Nocturnal oxygen therapy in patients with COPD: A survey of Canadian pulmonologists.. Can Respir J 2007; 14(6):343-8.
Pepin V, Laviolette L, Saey D, Maltais F. Synergetic interactions between rehabilitation and pharmacotherapy in COPD.. Clin Invest Med 2006; 29(3):170-7.
Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Tr. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation.. Am J Respir Crit Care Med 2006; 173(12):1390-413.
Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O'donnell D, McIvor A, Sharma S, Bishop G, Anthony J, Cowie R, Field S, Hirsch A, Hernandez P, Rivington R, Road J, Hoffstein V, Hodder R, Marciniuk D, McCormack D, Fox G,. Tiotropium in Combination with Placebo, Salmeterol, or Fluticasone-Salmeterol for Treatment of Chronic Obstructive Pulmonary Disease: A Randomized Trial.. Ann Intern Med 2007; 146(8):545-5.
Pepin V, Saey D, Laviolette L, Maltais F. Exercise capacity in chronic obstructive pulmonary disease: Mechanisms of limitation.. Int J Chron Obstruct Pulmon Dis 2007; 4(3):195-204.
Marquis K, Maltais F, Poirier P. Les manifestations cardiovasculaires chez les patients atteints d'une BPCO.. Rev Mal Respir 2008; 25(0):663-673.
Lessard A, Maltais F, Boulet LP. Clinical management of chronic obstructive pulmonary disease and asthma in an obese patient.. Expert Opin Pharmacother 2008; 9(1):83-93.
Aliverti A, Macklem PT, Debigare R, Maltais F, O'Donnell DE, Webb KA. Point: Counterpoint - The major limitations to exercise performance in COPD.. J Appl Physiol 2008; 105(0):751-753.
Brouillard C, Pepin V, Milot J, Lacasse Y, Maltais F. Endurance shuttle walking test: responsiveness to salmeterol in COPD.. Eur Respir J 2008; 31(3):579-84.
Laviolette L, Bourbeau J, Bernard S, Lacasse Y, Pepin V, Breton MJ, Baltzan M, Rouleau M, Maltais F. Assessing the impact of pulmonary rehabilitation on functional status in COPD.. Thorax 2008; 63(2):115-21.
Doucet M, Russell AP, Léger B, Debigaré R, Joanisse DR, Caron MA, LeBlanc P, Maltais F. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2007; 176(3):261-9.
Poulain M, Doucet M, Drapeau V, Fournier G, Tremblay A, Poirier P, Maltais F. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease.. Chron Respir Dis 2008; 5(1):35-41.
Brassard P, Ferland A, Marquis K, Maltais F, Jobin J, Poirier P. Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses.. Can J Cardiol 2007; 23(0):89-96B.
Aaron SD, Fergusson D, Marks GB, Suissa S, Vandemheen KL, Doucette S, Maltais F, Bourbeau JF, Goldstein RS, Balter M, O'Donnell D, Fitzgerald M. Counting, analysing and reporting exacerbations of COPD in randomised controlled trials.. Thorax 2008; 63(2):122-8.
Vivodtzev I, Lacasse Y, Maltais F. Neuromuscular Electrical Stimulation of the Lower Limbs in Patients With Chronic Obstructive Pulmonary Disease.. J Cardiopulm Rehabil 2008; 28(2):79-91.
O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk DD, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin D, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update.. Can Respir J 2007; 14(0):5B-32B.
Beaulieu-Genest L, Chrétien D, Maltais F, Pelletier K, Parent JG, Lacasse Y. Self-administered prescriptions of oral steroids and antibiotics in chronic obstructive pulmonary disease: are we doing more harm than good?. Chron Respir Dis 2007; 4(3):143-7.
Chan CK, Maltais F, Sigouin C, Haddon JM, Ford GT. A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease.. Can Respir J 2007; 14(8):465-72.
Bourbeau J, Christodoulopoulos P, Maltais F, Yamauchi Y, Olivenstein R, Hamid Q. Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial.. Thorax 2007; 62(11):938-43.
Maltais F, Saey D, Debigaré R. Enhancing the benefits of pulmonary rehabilitation: doing more for a few or doing a little less for many?. Am J Respir Crit Care Med 2008; 178(3):215-6.
Maltais F, Bourbeau J, Shapiro S, Lacasse Y, Perrault H, Baltzan M, Hernandez P, Rouleau M, Julien M, Parenteau S, Paradis B, Levy RD, Camp P, Lecours R, Audet R, Hutton B, Penrod JR, Picard D, Bernard S. Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial.. Ann Intern Med 2008; 149(12):869-78.
Marquis K, Maltais F, Lacasse Y, Lacourciere Y, Fortin C, Poirier P. Effects of aerobic exercise training and irbesartan on blood pressure and heart rate variability in patients with chronic obstructive pulmonary disease.. Can Respir J 2008; 15(7):355-60.
O'Donnell DE, Travers J, Webb KA, He Z, Lam YM, Hamilton A, Kesten S, Maltais F, Magnussen H. Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD.. Eur Respir J 2009; 34(4):866-74.
Caron MA, Debigaré R, Dekhuikzen PN, Maltais F. Comparative Assessment of the Quadriceps and the Diaphragm in Patients with COPD.. J Appl Physiol 2009; 107(3):952-61.
Nici L, Raskin J, Rochester CL, Bourbeau JC, Carlin BW, Casaburi R, Celli BR, Cote C, Crouch RH, Diez-Morales LF, Donner CF, Fahy BF, Garvey C, Goldstein R, Lane-Reticker A, Lareau SC, Make B, Maltais F, McCormick J, Morgan MD, Ries A, Troosters T, ZuWallack R. Pulmonary rehabilitation: WHAT WE KNOW AND WHAT WE NEED TO KNOW.. J Cardiopulm Rehabil Prev 2009; 29(3):141-51.
Gagnon P, Saey D, Vivodtzev I, Laviolette L, Mainguy V, Milot J, Provencher S, Maltais F. Impact of preinduced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjects.. J Appl Physiol 2009; 107(3):832-40.
O'Donnell DE, Hernandez P, Kaplan A, Aaron S, Bourbeau J, Marciniuk D, Balter M, Ford G, Gervais A, Lacasse Y, Maltais F, Road J, Rocker G, Sin D, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care.. Can Respir J 2008; 15(0):1A-8A.
Seaborn T, St-Amand J, Cloutier M, Tremblay MG, Maltais F, Dinel S, Moulin V, Khan PA, Piedboeuf B. Identification of cellular processes that are rapidly modulated in response to tracheal occlusion within mice lungs.. Pediatr Res 2008; 63(2):124-30.
Cloutier M, Maltais F, Piedboeuf B. Increased distension stimulates distal capillary growth as well as expression of specific angiogenesis genes in fetal mouse lungs.. Exp Lung Res 2008; 34(3):101-13.
Debigaré R, Maltais F. Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation.. J Appl Physiol 2008; 105(2):764.
Marquis K, Maltais F, Poirier P. [Cardiovascular manifestations in patients with COPD]. Rev Mal Respir 2008; 25(6):663-73.
Ahmed S, Bourbeau J, Maltais F, Mansour A. The Oort structural equation modeling approach detected a response shift after a COPD self-management program not detected by the Schmitt technique.. J Clin Epidemiol 2009; 62(11):1165-72.
Saey D, Bernard S, Gagnon P, Laviolette L, Soicher J, Maltais F, Esgagne P, Coats V, Devost AA. Pulmonary rehabilitation in chronic obstructive pulmonary disease.. Panminerva Med 2009; 51(2):95-114.
Perrault H, Baril J, Henophy S, Rycroft A, Bourbeau J, Maltais F. Paced-walk and step tests to assess exertional dyspnea in COPD.. COPD 2009; 6(5):330-9.
Laviolette L, O'Donnell DE, Webb KA, Hamilton AL, Kesten S, Maltais F. Performance during constant workrate cycling exercise in women with COPD and hyperinflation.. COPD 2009; 6(5):340-51.
Caron MA, Thériault ME, Paré ME, Maltais F, Debigaré R. Hypoxia alters contractile protein homeostasis in L6 myotubes.. FEBS Lett 2009; 583(9):1528-34.
Marquis N, Debigaré R, Bouyer L, Saey D, Laviolette L, Brouillard C, Maltais F. Physiology of walking in patients with moderate to severe chronic obstructive pulmonary disease.. Med Sci Sports Exerc 2009; 41(8):1540-8.
Labidi M, Baillot R, Dionne B, Lacasse Y, Maltais F, Boulet LP. Pleural effusions following cardiac surgery: prevalence, risk factors, and clinical features.. Chest 2009; 136(6):1604-11.
Kim HC, Mofarrahi M, Vassilokopoulos T, Maltais F, Sigala I, Debigare R, Bellenis I, Hussain SN. Expression and Functional Significance of Nicotinamide N-methyl Transferase (NNMT) in Skeletal Muscles of Patients with COPD.. Am J Respir Crit Care Med 2010; 181(8):797-805.
Debigaré R, Côté CH, Maltais F. Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease.. Proc Am Thorac Soc 2010; 7(1):84-90.
Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension.. Thorax 2010; 65(2):113-7.
Vieira DS, Maltais F, Bourbeau J. Home-based pulmonary rehabilitation in chronic obstructive pulmonary disease patients.. Curr Opin Pulm Med 2010; 16(2):134-43.
Laviolette L, Lands LC, Dauletbaev N, Saey D, Milot J, Provencher S, LeBlanc P, Maltais F. Combined effect of dietary supplementation with pressurized whey and exercise training in COPD: a randomized controlled double-blind pilot study.. J Med Food 2010; 13(3):589-98.
Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension.. J Cardiopulm Rehabil Prev 2010; 30(5):319-23.
Gagnon P, Saey D, Maltais F. Afferent feedback and psychobiological components: complementary approaches.. J Appl Physiol 2010; 108(2):466.
Doucet M, Dubé A, Joanisse DR, Debigaré R, Michaud A, Paré MÈ, Vaillancourt R, Fréchette E, Maltais F. Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD.. Thorax 2010; 65(11):963-70.
Marciniuk DD, Brooks D, Butcher S, Debigare R, Dechman G, Ford G, Pepin V, Reid D, Sheel AW, Stickland MK, Todd DC, Walker SL, Aaron SD, Balter M, Bourbeau J, Hernandez P, Maltais F, O'Donnell DE, Bleakney D, Carlin B, Goldstein R, Muthuri SK, . Optimizing pulmonary rehabilitation in chronic obstructive pulmonary disease--practical issues: a Canadian Thoracic Society Clinical Practice Guideline.. Can Respir J 2010; 17(4):159-68.
Laviolette L, O'Donnell D, Maltais F. Significance of the endurance time to constant work rate cycling exercise.. COPD 2010; 7(6):443-4; author repl.
Sava F, Laviolette L, Bernard S, Breton MJ, Bourbeau J, Maltais F. The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD.. BMC Pulm Med 2010; 10(0):55.
Hussain SN, Mofarrahi M, Sigala I, Kim HC, Vassilakopoulos T, Maltais F, Bellenis I, Chaturvedi R, Gottfried SB, Metrakos P, Danialou G, Matecki S, Jaber S, Petrof BJ, Goldberg P. Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy.. Am J Respir Crit Care Med 2010; 182(11):1377-86.
Laviolette L, Sava F, O'Donnell DE, Webb KA, Hamilton AL, Kesten S, Maltais F. Effect of obesity on constant workrate exercise in hyperinflated men with COPD.. BMC Pulm Med 2010; 10(0):33.
Saey D, Lemire BB, Gagnon P, Bombardier E, Tupling AR, Debigaré R, Côté CH, Maltais F. Quadriceps metabolism during constant workrate cycling exercise in chronic obstructive pulmonary disease.. J Appl Physiol 2011; 110(1):116-24.
Pepin V, Laviolette L, Brouillard C, Sewell L, Singh SJ, Revill SM, Lacasse Y, Maltais F. Significance of changes in endurance shuttle walking performance.. Thorax 2011; 66(2):115-20.
Marciniuk D, Goodridge D, Hernandez P, Rocker G, Balter M, Bailey P, Ford G, Bourbeau J, O'Donnell DE, Maltais F, Mularski RA, Cave AJ, Mayers I, Kennedy V, Oliver TK, Brown C. Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: A Canadian Thoracic Society clinical practice guideline.. Can Respir J 2011; 18(2):69-78.
Chang Y, Nadigel J, Boulais N, Bourbeau J, Maltais F, Eidelman DH, Hamid Q. CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease.. Respir Res 2011; 12(0):43.
Baltzan MA, Scott AS, Wolkove N, Bailes S, Bernard S, Bourbeau J, Maltais F. Fatigue in COPD: Prevalence and effect on outcomes in pulmonary rehabilitation.. Chron Respir Dis 2011; 8(2):119-28.
Vivodtzev I, Gagnon P, Pepin V, Saey D, Laviolette L, Brouillard C, Maltais F. Physiological correlates of endurance time variability during constant-workrate cycling exercise in patients with COPD.. PLoS One 2011; 6(2):e17007.
Maltais F, Celli B, Casaburi R, Porszasz J, Jarreta D, Seoane B, Caracta C. Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD.. Respir Med 2011; 105(4):580-7.
Bischoff EW, Hamd DH, Sedeno M, Benedetti A, Schermer TR, Bernard S, Maltais F, Bourbeau J. Effects of written action plan adherence on COPD exacerbation recovery.. Thorax 2011; 66(1):26-31.
Maltais F. Glossopharyngeal breathing. (Image in medicine).. Am J Respir Crit Care Med 2011; 184(3):381.
Caron MA, Debigaré R, Dekhuijzen PN, Maltais F. [Diaphragm and skeletal muscle dysfunction in COPD].. Rev Mal Respir 2011; 28(10):1250-64.
Caron MA, Charette SJ, Maltais F, Debigaré R. Variability of protein level and phosphorylation status caused by biopsy protocol design in human skeletal muscle analyses.. BMC Res Notes 2011; 4(0):488.
Shah PL, Slebos DJ, Cardoso PF, Cetti E, Voelker K, Levine B, Russell ME, Goldin J, Brown M, Cooper JD, Sybrecht GW; EASE trial study group (Shah PL, Alexander D, Cuerden E, Dusmet M, Hind M, Hopkinson NS, Kemp S, Kon OM, Polkey MI, Slebos DJ, Douma R, Kerstjens H, Vennik P, Klooster K, Smidt A, Snijders S, Cardoso PF, Rubin A, Berto P, Cavalcanti M, Spilimbergo FB, Frosi F, Schmitt M, Soares PR, Voelker K, Ferreira G, Horiuchi T, Morgan K, Bradley M, Clapp N, Gormley K, Miller A, Pope-Nix K, Levine B, Baratz D, Comp R, Gotfried M, Ross B, DeLaCruz V, Fu L, Harker S, Sybrecht G, Franzen K, Gröschel A, Rentz K, Wilkens H, Schaeck I, Sollgan M, Weingard B, Leeds W, Ludlow L, Malik O, Nicklin S, Griggs D, Maxfield R, Bulman W, DiMango A, Lederer D, Brogan F, Jellen P, Burghuber O, Koller H, Valipour A, Firlinger I, Ruis M, Hazelrigg S, Boley T, Christy J, Leslie C, Ernst A, Michaud G, DeCamp M, Dea A, Carbone C, Kopman D, Mulkern P, Lima M, Cardoso AP, Silva JR, Szlko A, Luduvice M, Rodrigues L, Simoff M, McCann-Swiderek J, Ray C, Tatem G, Almario R, Bibbs W, Dempsey K, Gay S, Bauman K, Chan K, Chang A, Martinez F, Majors C, Musani A, Make B, McPeak K, Rhodes D, McLennan G, Baker K, Ferguson S, Thomas K, Chapman A, Keating J, Pirotte P, Sprenger K, Losso L, Gasques S, Vieira TF, Chan A, Avdalovic M, Albertson T, Allen R, Harper R, Morrissey B, Stollenwerk N, Algaze S, Chaldekas K, Juarez M, Kelly M, Snell G, Keating D, Westall G, Whitford H, Williams T, Dunn T, Fowler S, Holsworth L, Levvey B, Manterfield C, Wahidi M, D'Amico T, Kraft M, Lugogo N, Shofer S, Willis C, Beaver D, Beyea M, Foss C, Hathcock C, Stiles J, Parmar J, Davies M, Wat D, Millington-Parrish H, Mitchell A, Kucharczuk J, Gillepsie C, Haas A, Sterman D, McConville H, Kromplewski M, Riggs J, Thompson S, Tillis W, Whitten PE, Dorrington M, Hartwig KL, Scott AL, Egan J, Adamali H, Bartosik W, Judge E, Tuohy M, Vapra Y, Bolger C, Lawrie I, Murphy L, Winward S, Mosenifar Z, Balfe D, Chaux G, Falk J, Lewis M, Geaga C, Freiler L, Sellman R, Bekemeyer WB, Holle R, Lemire S, Hoffman K, Krininger B, Van Gundy K, Bilello K, Evans T, Joseph J, Peterson M, Blaauw J, Garcia R, Newton J, Brisland C, Fleischer K, Fruci C, Inayat N, Collier M, Connolly M, Holladay M, Pine L, McCormack D, Farquhar D, Halko S, Licskai C, MacBean L, Strapp R, Bechara R, Berkowitz D, Miller D, Parks C, Perez R, Wolfenden L, Guidot J, Perez T, Ross C, Laviolette M, Maltais F, Martel S, Milot J, Belanger M, Breton MJ, Trepanier L, Gildea T, Machuzak M, Mann B, Mason D, Mehta A, Minai O, Murthy S, Krizmanich G, Meli Y, Parambil J, Rice R, Herth F, Eberhardt R, Kappes J, Rump B, Stanzel F, Littersk P, Shen KR, Cassivi S, Edell E, Kaira S, Mithun D, Utz J, Wigle D, Mieras K, Flandes J, Fernandez-Navamuel I, Heili S, Nieto MJ). Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial.. Lancet 2011; 378(9795):997-1005.
Tan WC, Bourbeau J, Hernandez P, Chapman K, Cowie R, FitzGerald MJ, Aaron S, Marciniuk DD, Maltais F, O'Donnell DE, Goldstein R, Sin D, . Canadian prediction equations of spirometric lung function for Caucasian adults 20 to 90 years of age: results from the Canadian Obstructive Lung Disease (COLD) study and the Lung Health Canadian Environment (LHCE) study.. Can Respir J 2011; 18(6):321-6.
Burtin C, Saey D, Saglam M, Langer D, Gosselink R, Janssens W, Decramer M, Maltais F, Troosters T. Effectiveness of exercise training in patients with COPD: the role of muscle fatigue.. Eur Respir J 2012; 40(2):338-44.
Mainguy V, Provencher S, Maltais F, Malenfant S, Saey D. Assessment of daily life physical activities in pulmonary arterial hypertension.. PLoS One 2011; 6(11):e27993.
Nadigel J, Préfontaine D, Baglole CJ, Maltais F, Bourbeau J, Eidelman DH, Hamid Q. Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.. Respir Res 2011; 12(0):149.
McKim DA, Road J, Avendano M, Abdool S, Cote F, Duguid N, Fraser J, Maltais F, Morrison DL, O'Connell C, Petrof BJ, Rimmer K, Skomro R. Home mechanical ventilation: a Canadian Thoracic Society clinical practice guideline.. Can Respir J 2011; 18(4):197-215.
Pakhale S, Wood-Dauphinee S, Spahija J, Collet JP, Maltais F, Bernard S, Baltzan M, Rouleau M, Bourbeau J. Combining both generic and disease-specific properties: development of the McGill COPD quality of life questionnaire.. COPD 2011; 8(4):255-63.
Vivodtzev I, Debigaré R, Gagnon P, Mainguy V, Saey D, Dubé A, Paré MÈ, Bélanger M, Maltais F. Functional and Muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial.. Chest 2012; 141(3):716-25.
Bédard ME, Brouillard C, Pepin V, Provencher S, Milot J, Lacasse Y, Leblanc P, Maltais F. Tiotropium improves walking endurance in COPD.. Eur Respir J 2012; 39(2):265-71.
Sava F, Perrault H, Brouillard C, Darauay C, Hamilton A, Bourbeau J, Maltais F. Detecting Improvements in Dyspnea in COPD Using a Three-Minute Constant Rate Shuttle Walking Protocol.. COPD 2012; 9(4):395-400.
Vadász I, Dada LA, Maltais F. Lord of the RING: Ubiquitination and Directed Degradation of Skeletal Muscle in Acute Lung Injury.. Am J Respir Crit Care Med 2012; 185(8):795-6.
Mainguy V, Girard D, Maltais F, Saey D, Milot J, Sénéchal M, Poirier P, Provencher S. Effect of Bisoprolol on Respiratory Function and Exercise Capacity in Chronic Obstructive Pulmonary Disease.. Am J Cardiol 2012; 110(2):258-63.
Maltais F. Physiology to Assist Bedside Prognostication in Mechanically Ventilated Patients with Chronic Obstructive Pulmonary Disease.. Respiration 2012; 84(1):14-6.
Bourbeau J, Tan WC, Benedetti A, Aaron SD, Chapman KR, Coxson HO, Cowie R, Fitzgerald M, Goldstein R, Hernandez P, Leipsic J, Maltais F, Marciniuk D, O'Donnell D, Sin DD, For The Cancold Study Group. Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the Need for Longitudinal Observational Studies in COPD.. COPD 2012; 0(0):Epub.
Lemay J, Sériès F, Sénéchal M, Maranda B, Maltais F. Unusual respiratory manifestations in two young adults with Duchenne muscular dystrophy.. Can Respir J 2012; 19(1):37-40.
O'Donnell DE, Guenette JA, Maltais F, Webb KA. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise.. Chest 2012; 141(3):753-62.
Soicher JE, Mayo NE, Gauvin L, Hanley JA, Bernard S, Maltais F, Bourbeau J. Trajectories of endurance activity following pulmonary rehabilitation in COPD patients.. Eur Respir J 2012; 39(2):272-8.
Lacasse Y, Sériès F, Vujovic-Zotovic N, Goldstein R, Bourbeau J, Lecours R, Aaron SD, Maltais F.. Evaluating nocturnal oxygen desaturation in COPD--revised.. Respir Med 2011; 105(9):1331-7.
Kuna P, Ivanov Y, Trofimov VI, Saito T, Beckman O, Bengtsson T, Jorup C, Maltais F. Efficacy and safety of AZD3199 versus formoterol in COPD; a randomized, double-blind study.. Respir Res 2013; 14(1):64.
Mainguy V, Malenfant S, Neyron AS, Bonnet S, Maltais F, Saey D, Provencher S. Repeatability and responsiveness of exercise tests in pulmonary arterial hypertension.. Eur Respir J 2013; 42(2):425-34.
Thériault ME, Paré MÈ, Maltais F, Debigaré R. Satellite cells senescence in limb muscle of severe patients with COPD.. PLoS One 2012; 7(6):e39124.
Lemire BB, Debigaré R, Dubé A, Thériault ME, Côté CH, Maltais F. MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease.. J Appl Physiol 2012; 113(1):159-66.
Lacasse Y, Daigle JM, Martin S, Maltais F. Validity of chronic obstructive pulmonary disease diagnoses in a large administrative database.. Can Respir J 2012; 19(2):e5-9.
Pakhale S, Wood-Dauphinee S, Spahija A, Collet JP, Maltais F, Bernard S, Baltzan M, Rouleau M, Bourbeau J. Validation of a new questionnaire with generic and disease-specific qualities: the McGill COPD Quality of Life Questionnaire.. Can Respir J 2012; 19(6):367-72.
Maltais F, Milot J. The potential for aclidinium bromide, a new anticholinergic, in the management of chronic obstructive pulmonary disease.. Ther Adv Respir Dis 2012; 6(6):345-61.
Gagnon P, Saey D, Provencher S, Milot J, Bourbeau J, Tan WC, Martel S, Maltais F. Walking exercise response to bronchodilation in mild COPD: a randomized trial.. Respir Med 2012; 106(12):1695-705.
Gagnon P, Bussières JS, Ribeiro F, Gagnon SL, Saey D, Gagné N, Provencher S, Maltais F. Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2012; 186(7):606-15.
Magnussen H, Paggiaro P, Schmidt H, Kesten S, Metzdorf N, Maltais F. Effect of combination treatment on lung volumes and exercise endurance time in COPD.. Respir Med 2012; 106(10):1413-20.
Marciniuk DD, Hernandez P, Balter M, Bourbeau J, Chapman KR, Ford GT, Lauzon JL, Maltais F, O'Donnell DE, Goodridge D, Strange C, Cave AJ, Curren K, Muthuri S. Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline.. Can Respir J 2012; 19(2):109-16.
Ribeiro F, Thériault ME, Debigare R, Maltais F. Should all patients with COPD be exercise-trained?. J Appl Physiol 2013; 114(9):1300-8.
Mofarrahi M, Sigala I, Vassilakopoulos T, Harel S, Guo Y, Debigare R, Maltais F, Hussain SN. Angiogenesis-related factors in skeletal muscles of COPD patients: roles of angiopoietin-2.. J Appl Physiol 2013; 114(9):1309-18.
Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, Fitzgerald JM, Aaron S, Marciniuk DD, Maltais F, Buist AS, O'Donnell DE, Sin DD. Bronchodilator responsiveness and reported respiratory symptoms in an adult population.. PLoS One 2013; 8(3):e58932.
Gagnon P, Maltais F, Bouyer L, Ribeiro F, Coats V, Brouillard C, Noël M, Rousseau-Gagnon M, Saey D. Distal Leg Muscle Function in Patients with COPD.. COPD 2013; 10(2):235-42.
Maltais F. Exercise and COPD: therapeutic responses, disease-related outcomes, and activity-promotion strategies.. Phys Sportsmed 2013; 41(1):66-80.
Borel B, Provencher S, Saey D, Maltais F. Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD.. Pulm Med 2013; 2013(0):410748.
Maltais F, Dennis N, Chan CK. Rationale for earlier treatment in COPD: a systematic review of published literature in mild-to-moderate COPD.. COPD 2013; 10(1):79-103.
Aaron SD, Vandemheen KL, Maltais F, Field SK, Sin DD, Bourbeau J, Marciniuk DD, FitzGerald JM, Nair P, Mallick R. TNFalpha antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial.. Thorax 2013; 68(2):142-8.
Decramer M, Maltais F, Feldman G, Brooks J, Harris S, Mehta R, Crater G. Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients.. Respir Physiol Neurobiol 2013; 185(2):393-9.
Maltais F, Mahler DA, Pepin V, Nadreau E, Crater GD, Morris AN, Emmett AH, Ferro TJ.. Effect of fluticasone propionate/salmeterol plus tiotropium versus tiotropium on walking endurance in COPD.. Eur Respir J 2013; 42(2):539-41.
Coats V, Maltais F, Simard S, Fréchette E, Tremblay L, Ribeiro F, Saey D.. Feasibility and effectiveness of a home-based exercise training program before lung resection surgery.. Can Respir J 2013; 20(2):e10-6.
Rochester CL, Maltais F.. Innovate to ambulate: creating opportunities for patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2013; 188(3):265-7.
Charususin N, Gosselink R, Decramer M, McConnell A, Saey D, Maltais F, Derom E, Vermeersch S, van Helvoort H, Heijdra Y, Klaassen M, Glöckl R, Kenn K, Langer D.. Inspiratory muscle training protocol for patients with chronic obstructive pulmonary disease (IMTCO study): a multicentre randomised controlled trial.. BMJ Open 2013; 3(8):e003101.
Mok M, Nombela-Franco L, Dumont E, Urena M, De Larochellière R, Doyle D, Villeneuve J, Côté M, Ribeiro HB, Allende R, Laflamme J, De Larochellière H, Laflamme L, Amat-Santos I, Pibarot P, Maltais F, Rodés-Cabau J.. Chronic obstructive pulmonary disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes, prognostic markers and functional status changes.. JACC Cardiovasc Interv 2013; 6(10):1072-84.
Spruit MA, Singh SJ, Garvey C, Zuwallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WD, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FM, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJ, Collins E, Garcia-Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AM, Carlin B, Benzo R, Meek P, Morgan M, Rutten-van Mölken MP, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF, Wouters EF; ATS/ERS Task Force on Pulmonary Rehabilitation.. An official american thoracic society/european respiratory society statement: key concepts and advances in pulmonary rehabilitation.. Am J Respir Crit Care Med 2013; 188(8):e13-64.
Malenfant S, Potus F, Mainguy V, Leblanc È, Malenfant M, Ribeiro F, Saey D, Maltais F, Bonnet S, Provencher S. Impaired Skeletal Muscle Oxygenation and Exercise Tolerance in Pulmonary Hypertension.. Med Sci Sports Exerc 2015; 47(11):2273-82.
Guo Y, Gosker HR, Schols AM, Kapchinsky S, Bourbeau J, Sandri M, Jagoe RT, Debigaré R, Maltais F, Taivassalo T, Hussain SN. Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2013; 188(11):1313-20.
Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigaré R, Dekhuijzen PN, Franssen F, Gayan-Ramirez G, Gea J, Gosker HR, Gosselink R, Hayot M, Hussain SN, Janssens W, Polkey MI, Roca J, Saey D, Schols AM, Spruit MA, Steiner M, Taivassalo T, Troosters T, Vogiatzis I, Wagner PD. An official american thoracic society/european respiratory society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2014; 189(9):e15-62.
Thériault ME, Paré MÈ, Lemire BB, Maltais F, Debigaré R. Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease.. Respir Res 2014; 15(0):35.
Gagnon P, Lemire BB, Dubé A, Saey D, Porlier A, Croteau M, Provencher S, Debigaré R, Maltais F. Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD.. Respir Res 2014; 15(0):4.
Galesanu RG, Bernard S, Marquis K, Lacasse Y, Poirier P, Bourbeau J, Maltais F. Obesity in chronic obstructive pulmonary disease: Is fatter really better?. Can Respir J 2014; 21(5):297-301.
Vivodtzev I, Rivard B, Gagnon P, Mainguy V, Dubé A, Bélanger M, Jean B, Maltais F. Tolerance and Physiological Correlates of Neuromuscular Electrical Stimulation in COPD: A Pilot Study.. PLoS One 2014; 9(5):e94850.
O'Donnell DE, Maltais F, Porszasz J, Webb KA, Albers FC, Deng Q, Iqbal A, Paden HA, Casaburi R. The Continuum of Physiological Impairment during Treadmill Walking in Patients with Mild-to-Moderate COPD: Patient Characterization Phase of a Randomized Clinical Trial.. PLoS One 2014; 9(5):e96574.
Vivodtzev I, Devost AA, Saey D, Villeneuve S, Boilard G, Gagnon P, Provencher S, Simon M, Baillot R, Maltais F, Lellouche F. Severe and early quadriceps weakness in mechanically ventilated patients.. Crit Care 2014; 18(3):431.
Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, Fitzgerald JM, Marciniuk DD, Maltais F, Buist AS, O'Donnell DE, Sin DD, Aaron SD. Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study.. Thorax 2014; 69(8):709-17.
Tan WC, Bourbeau J, O'Donnell D, Aaron S, Maltais F, Marciniuk D, Hernandez P, Cowie R, Chapman K, Sonia Buist A, Sin D, Mark Fitzgerald J. Quality assurance of spirometry in a population-based study -predictors of good outcome in spirometry testing.. COPD 2014; 11(2):143-51.
Gagnon P, Guenette JA, Langer D, Laviolette L, Mainguy V, Maltais F, Ribeiro F, Saey D. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease.. Int J Chron Obstruct Pulmon Dis 2014; 9(0):187-201.
Bernard S, Ribeiro F, Maltais F, Saey D. Prescribing exercise training in pulmonary rehabilitation: a clinical experience.. Rev Port Pneumol 2014; 20(2):92-100.
Maltais F. Body composition in COPD: looking beyond BMI.. Int J Tuberc Lung Dis 2014; 18(1):3-4.
Coats V, Maltais F, Tremblay L, Saey D.. Exercise-Based Rehabilitation for People with Lung Cancer.. J Pulm Respir Med 2015; 4(0):3.
Nyberg A, Saey D, Martin M, Maltais F. Muscular and functional effects of partitioning exercising muscle mass in patients with chronic obstructive pulmonary disease - a study protocol for a randomized controlled trial.. Trials 2015; 16(1):194.
Buhl R, Maltais F, Abrahams R, Bjermer L, Derom E, Ferguson G, Fle?ar M, Hébert J, McGarvey L, Pizzichini E, Reid J, Veale A, Grönke L, Hamilton A, Korducki L, Tetzlaff K, Waitere-Wijker S, Watz H, Bateman E. Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4).. Eur Respir J 2015; 45(4):969-79.
Saunders TJ, Dechman G, Hernandez P, Spence JC, Rhodes RE, McGannon K, Mundle S, Ferguson C, Bourbeau J, Maltais F, Marciniuk DD, Camp PG, Blanchard C.. Distinct Trajectories of Physical Activity Among Patients with COPD During and After Pulmonary Rehabilitation.. COPD 2015; 12(5):539-45.
Gagnon P, Casaburi R, Saey D, Porszasz J, Provencher S, Milot J, Bourbeau J, O'Donnell DE, Maltais F.. Cluster Analysis in Patients with GOLD 1 Chronic Obstructive Pulmonary Disease.. PLoS One 2015; 10(4):e0123626.
Fortin M, Turgeon PY, Nadreau E, Grégoire P, Maltais LG, Sénéchal M, Provencher S, Maltais F. Prognostic value of oxygen kinetics during recovery from cardiopulmonary exercise testing in patients with chronic heart failure.. Am J Cardiol 2015; 31(10):1259-65.
Mainguy V, Malenfant S, Neyron AS, Saey D, Maltais F, Bonnet S, Provencher S. Alternatives to the six-minute walk test in pulmonary arterial hypertension.. PLoS One 2014; 9(8):e103626.
Potus F, Malenfant S, Graydon C, Mainguy V, Tremblay È, Breuils-Bonnet S, Ribeiro F, Porlier A, Maltais F, Bonnet S, Provencher S. Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension.. Am J Respir Crit Care Med 2014; 190(3):318-28.
Maltais F, Singh S, Donald AC, Crater G, Church A, Goh AH, Riley JH. Effects of a combination of umeclidinium/vilanterol on exercise endurance in patients with chronic obstructive pulmonary disease: two randomized, double-blind clinical trials.. Ther Adv Respir Dis 2014; 8(6):169-81.
Casaburi R, Maltais F, Porszasz J, Albers F, Deng Q, Iqbal A, Paden HA, O'Donnell DE. Effects of tiotropium on hyperinflation and treadmill exercise tolerance in mild to moderate chronic obstructive pulmonary disease.. Ann Am Thorac Soc 2014; 11(9):1351-61.
Borel B, Pepin V, Mahler DA, Nadreau É, Maltais F. Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD.. Eur Respir J 2014; 44(5):1166-76.
Diaz AA, Zhou L, Young TP, McDonald ML, Harmouche R, Ross JC, San Jose Estepar R, Wouters EF, Coxson HO, MacNee W, Rennard S, Maltais F, Kinney GL, Hokanson JE, Washko GR. Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers.. Acad Radiol 2014; 21(10):1255-61.
Patel MS, Natanek SA, Stratakos G, Pascual S, Martínez-Llorens J, Disano L, Terzis G, Hopkinson NS, Gea J, Vogiatzis I, Maltais F, Polkey MI. Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2014; 190(3):350-2.
Tan WC, Bourbeau J, Aaron S, FitzGerald JM, Hernandez P, Cowie R, Chapman KR, Marciniuk D, Maltais F, Buist S, O'Donnell D, Sin DD. Exacerbations in non-COPD patients: truth or myth--authors' response.. Thorax 2014; 69(11):1050-1.
Bourbeau J, Tan WC, Benedetti A, Aaron SD, Chapman KR, Coxson HO, Cowie R, Fitzgerald M, Goldstein R, Hernandez P, Leipsic J, Maltais F, Marciniuk D, O'Donnell D, Sin DD, Cancold Study Group. Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the need for longitudinal observational studies in COPD.. COPD 2014; 11(2):125-32.
Lacasse Y, Légaré M, Maltais F. E-cigarette use in patients receiving home oxygen therapy.. Can Respir J 2015; 22(2):83-5.
Lacasse Y, Bernard S, Martin S, Boivin M, Maltais F. Utility Scores In Patients With Oxygen-Dependent COPD: A Case-Control Study.. COPD 2015; 12(5):510-5.
Celli BR, Decramer M, Wedzicha JA, Wilson KC, Agustí A, Criner GJ, MacNee W, Make BJ, Rennard SI, Stockley RA, Vogelmeier C, Anzueto A, Au DH, Barnes PJ, Burgel PR, Calverley PM, Casanova C, Clini EM, Cooper CB, Coxson HO, Dusser DJ, Fabbri LM, Fahy B, Ferguson GT, Fisher A, Fletcher MJ, Hayot M, Hurst JR, Jones PW, Mahler DA, Maltais F, Mannino DM, Martinez FJ, Miravitlles M, Meek PM, Papi A, Rabe KF, Roche N, Sciurba FC, Sethi S, Siafakas N, Sin DD, Soriano JB, Stoller JK, Tashkin DP, Troosters T, Verleden GM, Verschakelen J, Vestbo J, Walsh JW, Washko GR, Wise RA, Wouters EF, ZuWallack RL. An official american thoracic society/european respiratory society statement: research questions in chronic obstructive pulmonary disease.. Am J Respir Crit Care Med 2015; 191(7):e4-e27.
Celli BR, Decramer M, Wedzicha JA, Wilson KC, Agustí A, Criner GJ, MacNee W, Make BJ, Rennard SI, Stockley RA, Vogelmeier C, Anzueto A, Au DH, Barnes PJ, Burgel PR, Calverley PM, Casanova C, Clini EM, Cooper CB, Coxson HO, Dusser DJ, Fabbri LM, Fahy B, Ferguson GT, Fisher A, Fletcher MJ, Hayot M, Hurst JR, Jones PW, Mahler DA, Maltais F, Mannino DM, Martinez FJ, Miravitlles M, Meek PM, Papi A, Rabe KF, Roche N, Sciurba FC, Sethi S, Siafakas N, Sin DD, Soriano JB, Stoller JK, Tashkin DP, Troosters T, Verleden GM, Verschakelen J, Vestbo J, Walsh JW, Washko GR, Wise RA, Wouters EF, ZuWallack RL. An official American Thoracic Society/European Respiratory Society statement: research questions in COPD.. Eur Respir J 2015; 45(4):879-905.
Troosters T, Bourbeau J, Maltais F, Leidy N, Erzen D, De Sousa D, Korducki L, Hamilton A. Enhancing exercise tolerance and physical activity in COPD with combined pharmacological and non-pharmacological interventions: PHYSACTO® randomised, placebo-controlled study design.. BMJ Open 2016; 6(0):e010106.
Clark MP, Ledeboer MW, Davies I, Byrn RA, Jones SM, Perola E, Tsai A, Jacobs M, Nti-Addae K, Bandarage UK, Boyd MJ, Bethiel RS, Court JJ, Deng H, Duffy JP, Dorsch WA, Farmer LJ, Gao H, Gu W, Jackson K, Jacobs DH, Kennedy JM, Ledford B, Liang J, Maltais F, Murcko M, Wang T, Wannamaker MW, Bennett HB, Leeman JR, McNeil C, Taylor WP, Memmott C, Jiang M, Rijnbrand R, Bral C, Germann U, Nezami A, Zhang Y, Salituro FG, Bennani YL, Charifson PS. Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.. J Med Chem 2014; 57(15):6668-78.
Lacasse Y, Bernard S, Maltais F. Eligibility for home oxygen programs and funding across Canada.. Can Respir J 2015; 22(6):324-30.
Nyberg A, Saey D, Maltais F. Why and How Limb Muscle Mass and Function Should Be Measured in Patients with Chronic Obstructive Pulmonary Disease.. Ann Am Thorac Soc 2015; 12(9):1269-77.
Ribeiro F, Lépine PA, Garceau-Bolduc C, Coats V, Allard É, Maltais F, Saey D. Test-retest reliability of lower limb isokinetic endurance in COPD: A comparison of angular velocities.. Int J Chron Obstruct Pulmon Dis 2015; 10(0):1163-72.
Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O'Donnell DE, Aaron SD. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.. Thorax 2015; 70(9):822-9.
Buhl R, Maltais F, Abrahams R, Bjermer L, Derom E, Ferguson G, Fle?ar M, Hébert J, McGarvey L, Pizzichini E, Reid J, Veale A, Grönke L, Hamilton A, Korducki L, Tetzlaff K, Waitere-Wijker S, Watz H, Bateman E. Author correction. Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4).. Eur Respir J 2015; 45(6):1763.
Boucherat O, Morissette MC, Provencher S, Bonnet S, Maltais F. Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.. Am J Respir Crit Care Med 2016; 193(4):362-75.
Labonté LE, Tan WC, Li PZ, Mancino P, Aaron SD, Benedetti A, Chapman KR, Cowie R, FitzGerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Sin D, Bourbeau J. Undiagnosed COPD Contributes to the Burden of Health Care Utilization: Data from the CanCOLD Study.. Am J Respir Crit Care Med 2016; 194(3):285-98.
Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder JA, O'Donnell DE, Onorati P, Porszasz J, Rabinovich R, Rossiter HB, Singh S, Troosters T, Ward S. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement.. Eur Respir J 2016; 47(2):429-60.
Bourbeau J, Lavoie KL, Sedeno M, De Sousa D, Erzen D, Hamilton A, Maltais F, Troosters T, Leidy N. Behaviour-change intervention in a multicentre, randomised, placebo-controlled COPD study: methodological considerations and implementation.. BMJ Open 2016; 6(4):e010109.
Feldman G, Maltais F, Shah P, Khindri S, Vahdati-Bolouri M, Church A, Fahy WA, Trivedi R. A randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5 mcg compared with tiotropium 18 mcg in patients with COPD.. Int J Chron Obstruct Pulmon Dis 2016; 11(0):719-30.
Ryerson CJ, Camp PG, Eves ND, Schaeffer M, Syed N, Dhillon S, Jensen D, Maltais F, O'Donnell DE, Raghavan N, Roman M, Stickland MK, Assayag D, Bourbeau J, Dion G, Fell CD, Hambly N, Johannson KA, Kalluri M, Khalil N, Kolb M, Manganas H, Morán-Mendoza O, Provencher S, Ramesh W, Rolf JD, Wilcox PG, Guenette JA. High Oxygen Delivery to Preserve Exercise Capacity in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib. Methodology of the HOPE-IPF Study.. Ann Am Thorac Soc 2016; 13(9):1640-7.
Lellouche F, Bouchard PA, Roberge M, Simard S, L'Her E, Maltais F, Lacasse Y. Automated oxygen titration and weaning with FreeO2 in patients with acute exacerbation of COPD: a pilot randomized trial.. Int J Chron Obstruct Pulmon Dis 2016; 11(0):1983-90.
Lellouche F, L'Her E, Bouchard PA, Brouillard C, Maltais F. Automatic Oxygen Titration During Walking in Subjects With COPD: A Randomized Crossover Controlled Study.. Respir Care 2016; 61(11):1456-1464.
Borel B, Wilkinson-Maitland CA, Hamilton A, Bourbeau J, Perrault H, Jensen D, Maltais F. Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in COPD.. Int J Chron Obstruct Pulmon Dis 2016; 11(0):2991-3000.
Tan WC, Hague CJ, Leipsic J, Bourbeau J, Zheng L, Li PZ, Sin DD, Coxson HO, Kirby M, Hogg JC, Raju R, Road J, O'Donnell DE, Maltais F, Hernandez P, Cowie R, Chapman KR, Marciniuk DD, FitzGerald JM, Aaron SD. Findings on Thoracic Computed Tomography Scans and Respiratory Outcomes in Persons with and without Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study.. PLoS One 2016; 11(11):e0166745.
Nyberg A, Carvalho J, Bui KL, Saey D, Maltais F. Adaptations in limb muscle function following pulmonary rehabilitation in patients with COPD - a review.. Rev Port Pneumol (2006) 2016; 22(6):342-350.
Maltais F, Kirsten AM, Hamilton A, De Sousa D, Voß F, Decramer M. Evaluation of the effects of olodaterol on exercise endurance in patients with chronic obstructive pulmonary disease: results from two 6-week crossover studies.. Respir Res 2016; 17(1):77.
Gupta N, Pinto L, Benedetti A, Li PZ, Tan WC, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL, Bourbeau J. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?. Chest 2016; 150(5):1069-1079.
Martin M, Almeras N, Després JP, Coxson HO, Washko GR, Vivodtzev I, Wouters EF, Rutten E, Williams MC, Murchison JT, MacNee W, Sin DD, Maltais F. Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy.. Int J Chron Obstruct Pulmon Dis 2017; 12(0):451-460.
Nadeau M, Boulay MÈ, Milot J, Lepage J, Bilodeau L, Maltais F, Boulet LP. Comparative prevalence of co-morbidities in smoking and non-smoking asthma patients with incomplete reversibility of airway obstruction, non-smoking asthma patients with complete reversibility of airway obstruction and COPD patients.. Respir Med 2017; 125(0):82-88.
Lacasse Y, Bernard S, Sériès F, Nguyen VH, Bourbeau J, Aaron S, Maltais F. Multi-center, randomized, placebo-controlled trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease: a study protocol for the INOX trial.. BMC Pulm Med 2017; 17(1):8.
Spina G, Spruit MA, Alison J, Benzo RP, Calverley PM, Clarenbach CF, Costello RW, Donaire-Gonzalez D, Dürr S, Garcia-Aymerich J, van Gestel AJ, Gramm M, Hernandes NA, Hill K, Hopkinson NS, Jarreta D, Kohler M, Kirsten AM, Leuppi JD, Magnussen H, Maltais F, Man WD, McKeough ZJ, Mesquita R, Miedinger D, Pitta F, Singh SJ, Smeenk FW, Tal-Singer R, Vagaggini B, Waschki B, Watz H, Wouters EF, Zogg S, den Brinker AC. Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity.. Thorax 2017; 72(8):694-701.
Vivodtzev I, Mendelson M, Croteau M, Gorain S, Wuyam B, Tamisier R, Lévy P, Maltais F, Pépin JL. Physiological correlates to spontaneous physical activity variability in obese patients with already treated sleep apnea syndrome.. Sleep Breath 2017; 21(1):61-68.
Nyberg A, Saey D, Martin M, Maltais F. Acute Effects of Low-Load/High-Repetition Single-Limb Resistance Training in COPD.. Med Sci Sports Exerc 2016; 48(12):2353-2361.
ODonnell DE, Casaburi R, Frith P, Kirsten A, De Sousa D, Hamilton A, Xue W, Maltais F. Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD.. Eur Respir J 2017; 49(4):1601348.
Bui KL, Nyberg A, Maltais F, Saey D. Functional Tests in Chronic Obstructive Pulmonary Disease, Part 1: Clinical Relevance and Links to the International Classification of Functioning, Disability, and Health.. Ann Am Thorac Soc 2017; 14(5):778-784.
Bui KL, Nyberg A, Maltais F, Saey D. Functional Tests in Chronic Obstructive Pulmonary Disease, Part 2: Measurement Properties.. Ann Am Thorac Soc 2017; 14(5):785-794.
Mesquita R, Spina G, Pitta F, Donaire-Gonzalez D, Deering BM, Patel MS, Mitchell KE, Alison J, van Gestel AJ, Zogg S, Gagnon P, Abascal-Bolado B, Vagaggini B, Garcia-Aymerich J, Jenkins SC, Romme EA, Kon SS, Albert PS, Waschki B, Shrikrishna D, Singh SJ, Hopkinson NS, Miedinger D, Benzo RP, Maltais F, Paggiaro P, McKeough ZJ, Polkey MI, Hill K, Man WD, Clarenbach CF, Hernandes NA, Savi D, Wootton S, Furlanetto KC, Cindy Ng LW, Vaes AW, Jenkins C, Eastwood PR, Jarreta D, Kirsten A, Brooks D, Hillman DR, Sant'Anna T, Meijer K, Dürr S, Rutten EP, Kohler M, Probst VS, Tal-Singer R, Gil EG, den Brinker AC, Leuppi JD, Calverley PM, Smeenk FW, Costello RW, Gramm M, Goldstein R, Groenen MT, Magnussen H, Wouters EF, ZuWallack RL, Amft O, Watz H, Spruit MA. Physical activity patterns and clusters in 1001 patients with COPD.. Chron Respir Dis 2017; 14(3):256-269.
Tan WC, Bourbeau J, Aaron SD, Zhou G, Maltais F, Hernandez P, Fitzgerald JM, Marciniuk DD, Walker BL, Sin DD. Global Initiative for Chronic Obstructive Lung Disease 2017 Classification and Lung Function Decline in Chronic Obstructive Pulmonary Disease.. Am J Respir Crit Care Med 2018; 197(5):670-673.
de Sousa Sena R, Ahmed S, Tan WC, Li PZ, Labonté L, Aaron SD, Benedetti A, Chapman KR, Walker B, Fitzgerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Bourbeau J. Work productivity loss in mild to moderate COPD: lessons learned from the CanCOLD study.. Eur Respir J 2017; 50(3):1701154.
Vivodtzev I, Moncharmont L, Tamisier R, Borel JC, Arbib F, Wuyam B, Lévy P, Maltais F, Ferretti G, Pépin JL. Quadriceps muscle fat infiltration is associated with cardiometabolic risk in COPD.. Clin Physiol Funct Imaging 2018; 38(5):788-797.
Nyberg A, Saey D, Martin M, Maltais F. Cardiorespiratory and muscle oxygenation responses to low-load/high-repetition resistance exercises in COPD and healthy controls.. J Appl Physiol (1985) 2018; 124(4):877-887.
Porszasz J, Carraro N, Cao R, Gore A, Ma S, Jiang T, Maltais F, Ferguson GT, O'Donnell DE, Shaikh A, Rossiter HB, Casaburi R. Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD.. Respir Physiol Neurobiol 2018; 251(0):8-15.
Singh S, Maltais F, Tombs L, Fahy WA, Vahdati-Bolouri M, Locantore N, Riley JH. Relationship between exercise endurance and static hyperinflation in a post hoc analysis of two clinical trials in patients with COPD.. Int J Chron Obstruct Pulmon Dis 2018; 13(0):203-215.
Vivodtzev I, Tamisier R, Croteau M, Borel JC, Grangier A, Wuyam B, Lévy P, Minville C, Sériès F, Maltais F, Pépin JL. Ventilatory support or respiratory muscle training as adjuncts to exercise in obese CPAP-treated patients with obstructive sleep apnoea: a randomised controlled trial.. Thorax 2018; 0(0):Epub.
Maltais F, O'Donnell D, Gáldiz Iturri JB, Kirsten AM, Singh D, Hamilton A, Tetzlaff K, Zhao Y, Casaburi R. Effect of 12 weeks of once-daily tiotropium/olodaterol on exercise endurance during constant work-rate cycling and endurance shuttle walking in chronic obstructive pulmonary disease.. Ther Adv Respir Dis 2018; 12(0):1753465818755091.
Poder TG, Kouakou CRC, Bouchard PA, Tremblay V, Blais S, Maltais F, Lellouche F. Cost-effectiveness of FreeO₂ in patients with chronic obstructive pulmonary disease hospitalised for acute exacerbations: analysis of a pilot study in Quebec.. BMJ Open 2018; 8(1):e018835.
Maltais F, Gaudreault N, Racine C, Thériault S, Bossé Y. Clinical Experience with SERPINA1 DNA Sequencing to Detect Alpha-1 Antitrypsin Deficiency.. Ann Am Thorac Soc 2018; 15(2):266-268.
Bourbeau J, Bhutani M, Hernandez P, Marciniuk DD, Aaron SD, Balter M, Beauchesne MF, D'Urzo A, Goldstein R, Kaplan A, Maltais F, O'Donnell DE, Sin DD. CTS position statement: Pharmacotherapy in patients with COPDAn update. Can J Respir Crit Care Sleep Med 2017; 1(4):222-41.
Maltais F, Buhl R, Koch A, Amatto VC, Reid J, Grönke L, Bothner U, Voß F, McGarvey L, Ferguson GT. Beta-Blockers in COPD: A Cohort Study From the TONADO Research Program.. Chest 2018; 153(6):1315-1325.
Lacasse Y, Tan AM, Maltais F, Krishnan JA. Home Oxygen in Chronic Obstructive Pulmonary Disease.. Am J Respir Crit Care Med 2018; 197(10):1254-64.
Jubinville E, Veillette M, Milot J, Maltais F, Comeau AM, Levesque RC, Duchaine C. Exacerbation induces a microbiota shift in sputa of COPD patients.. PLoS One 2018; 13(3):e0194355.
Charususin N, Gosselink R, Decramer M, Demeyer H, McConnell A, Saey D, Maltais F, Derom E, Vermeersch S, Heijdra YF, van Helvoort H, Garms L, Schneeberger T, Kenn K, Gloeckl R, Langer D. Randomised controlled trial of adjunctive inspiratory muscle training for patients with COPD.. Thorax 2018; 73(10):942-950.
Nyberg A, Saey D, Martin M, Maltais F. Test-re-test reliability of quadriceps muscle strength measures in people with more severe chronic obstructive pulmonary disease.. J Rehabil Med 2018; 50(8):759-764.
Vivodtzev I, L'Her E, Vottero G, Yankoff C, Tamisier R, Maltais F, Lellouche F, Pépin JL. Automated O₂ titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial.. Thorax 2019; 74(3):298-301.
Gauthier A, Bernard S, Bernard E, Simard S, Maltais F, Lacasse Y.. Adherence to long-term oxygen therapy in patients with chronic obstructive pulmonary disease.. Chron Respir Dis 2019; 16(0):147997231876772.
Boulet LP, Boulay MÈ, Dérival JL, Milot J, Lepage J, Bilodeau L, Maltais F.. Asthma-COPD Overlap Phenotypes and Smoking :Comparative features of asthma in smoking or non-smoking patients with an incomplete reversibility of airway obstruction.. COPD 2018; 15(2):130-138.
Troosters T, Maltais F, Leidy N, Lavoie KL, Sedeno M, Janssens W, Garcia-Aymerich J, Erzen D, De Sousa D, Korducki L, Hamilton A, Bourbeau J.. Effect of Bronchodilation and Exercise Training with Behavior Modification on Exercise Tolerance and Downstream Effects on Symptoms and Physical Activity in COPD.. Am J Respir Crit Care Med 2018; 198(8):1021-1032.
Maltais F.. Critically Appraised Papers: In people with chronic obstructive pulmonary disease, home-based pulmonary rehabilitation produces similar results to a hospital-based outpatient program [commentary].. J Physiother 2018; 64(2):122.
Coats V, Després JP, Alméras N, Martin M, Sin DD, Rabasa-Lhoret R, Larose E, Tan WC, Bourbeau J, Maltais F. Ectopic adiposity and cardiometabolic health in COPD.. Int J Chron Obstruct Pulmon Dis 2018; 13(0):3331-3340.
Maltais F, Hamilton A, Voß F, Maleki-Yazdi MR. Dose Determination for a Fixed-Dose Drug Combination: A Phase II Randomized Controlled Trial for Tiotropium/Olodaterol Versus Tiotropium in Patients with COPD.. Adv Ther 2019; 36(4):962-968.
Paine NJ, Bacon SL, Bourbeau J, Tan WC, Lavoie KL, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL. Psychological distress is related to poor health behaviours in COPD and non-COPD patients: Evidence from the CanCOLD study.. Respir Med 2019; 146(0):1-9.
Maltais F, Aumann JL, Kirsten AM, Nadreau E, Macesic H, Jin X, Hamilton A, O'Donnell DE. Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD.. Eur Respir J 2019; 53(3):1802049.
Biardel S, Racine C, Fortier Y, Mogas AK, Maillé É, Brochiero E, Maltais F, Lauzon AM, Tse SM, Laprise C, Joubert P, Rousseau É, Bissonnette É, Laviolette M, Bossé Y, Rousseau S.. The Quebec Respiratory Health Network Biobank. Open J Bioresour 2018; 5(0):53.
Ribeiro F, Oueslati F, Saey D, Lépine PA, Chambah S, Coats V, Maltais F. Cardiorespiratory and Muscle Oxygenation Responses to Isokinetic Test in COPD.. Med Sci Sports Exerc 2019; 51(5):841-849.
Gendron LM, Nyberg A, Saey D, Maltais F, Lacasse Y. Active mind-body movement therapies as an adjunct to or in comparison with pulmonary rehabilitation for people with chronic obstructive pulmonary disease.. Cochrane Database Syst Rev 2018; 10(0):CD012290.
Donner CF, Raskin J, ZuWallack R, Nici L, Ambrosino N, Balbi B, Blackstock F, Casaburi R, Dreher M, Effing T, Goldstein R, Krishnan J, Lareau SC, Make BJ, Maltais F, Meek P, Morgan M, Pépin JL, Rabbito C, Rochester CL, Silverman AR, Singh S, Spruit MA, Vitacca M, Williams L. Incorporating telemedicine into the integrated care of the COPD patient a summary of an interdisciplinary workshop held in Stresa, Italy, 7-8 September 2017.. Respir Med 2018; 143(0):91-102.
Bossé Y, Lamontagne M, Gaudreault N, Racine C, Levesque MH, Smith BM, Auger D, Clemenceau A, Paré MÈ, Laviolette L, Tremblay V, Maranda B, Morissette MC, Maltais F.. Early-onset emphysema in a large French-Canadian family: a genetic investigation.. Lancet Respir Med 2019; 7(5):427-436.
Frykholm E, Géphine S, Saey D, van Hees H, Lemson A, Klijn P, Maltais F, Nyberg A. Inter-day test-retest reliability and feasibility of isokinetic, isometric, and isotonic measurements to assess quadriceps endurance in people with chronic obstructive pulmonary disease: A multicenter study.. Chron Respir Dis 2019; 16(0):1479973118816497.
Frykholm E, Klijn P, Saey D, van Hees HWH, Stål P, Sandström T, Sörlin A, Maltais F, Nyberg A. Effect and feasibility of non-linear periodized resistance training in people with COPD: study protocol for a randomized controlled trial.. Trials 2019; 20(1):6.
Bui K-L, Mathur S, Dechman G., Maltais F, Camp P, Saey D.. Fixed handheld dynamometry provides reliable and valid values for quadriceps isometric strength in patients with COPD: a multicenter study.. Phys Ther 2019; 99(9):1255-1267.
Boulet LP, Boulay ME, Milot J, Lepage J, Bilodeau L, Maltais F.. Longitudinal comparison of outcomes in patients with smoking-related asthma-COPD overlap and in non-smoking asthmatics with incomplete reversibility of airway obstruction.. Int J Chron Obstruct Pulmon Dis 2019; 14(0):493-498.
Bui KL, Nyberg A, Rabinovich R, Saey D, Maltais F.. The Relevance of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: A Review For Clinicians.. Clin Chest Med 2019; 40(2):367-383.
Viglino D, Martin M, Almeras N, Després JP, Coxson HO, Pépin JL, Vivodtzev I, Maltais F; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators.. Low Liver Density Is Linked to Cardiovascular Comorbidity in COPD: An ECLIPSE Cohort Analysis.. Int J Chron Obstruct Pulmon Dis 2019; 14(0):3053-3061.
Lacasse Y, Krishnan JA, Maltais F, Ekström M. Patient registries for home oxygen research and evaluation.. Int J Chron Obstruct Pulmon Dis 2019; 14(0):1299-1304.
Lavoie KL, Sedeno M, Hamilton A, Li PZ, De Sousa D, Troosters T, Maltais F, Bourbeau J. Behavioural interventions targeting physical activity improve psychocognitive outcomes in COPD.. ERJ Open Res 2019; 5(4):00013-2019.
Maltais F, Bjermer L, Kerwin EM, Jones PW, Watkins ML, Tombs L, Naya IP, Boucot IH, Lipson DA, Compton C, Vahdati-Bolouri M, Vogelmeier CF. Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial.. Respir Res 2019; 20(1):238.
Tan WC, Bourbeau J, Aaron SD, Hogg JC, Maltais F, Hernandez P, Marciniuk DD, Chapman KR, To T, FitzGerald JM, Walker BL, Road J, Zheng L, Zhou G, Yau T, Benedetti A, O'Donnell D, Sin DD. The effects of marijuana smoking on lung function in older people.. Eur Respir J 2019; 54(6):1900826.
Bui KL, Maia N, Saey D, Dechman G, Maltais F, Camp PG, Mathur S.. Reliability of quadriceps muscle power and explosive force, and relationship to physical function in people with chronic obstructive pulmonary disease: an observational prospective multicenter study.. Physiother Theory Pract 2021; 37(8):945-953.
Maltais F, Ferguson GT, Feldman GJ, Deslee G, Bourdin A, Fjällbrant H, Siwek-Pos?uszna A, Jenkins MA, Martin UJ. A Randomized, Double-Blind, Double-Dummy Study of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Relative to Umeclidinium/Vilanterol Dry Powder Inhaler in COPD.. Adv Ther 2019; 36(9):2434-2449.
Shorofsky M, Bourbeau J, Kimoff J, Jen R, Malhotra A, Ayas N, Tan WC, Aaron SD, Sin DD, Road J, Chapman KR, O'Donnell DE, Maltais F, Hernandez P, Walker BL, Marciniuk D, Kaminska M. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.. Chest 2019; 156(5):852-863.
Coats V, Moffet H, Vincent C, Simard S, Tremblay L, Maltais F, Saey D. Feasibility of an eight-week telerehabilitation intervention for patients with unresectable thoracic neoplasia receiving chemotherapy: A pilot study.. Can J Respir Crit Care Sleep Med 2020; 41(1):14-24.
Viglino D, Martin M, Piché ME, Brouillard C, Després JP, Alméras N, Tan WC, Coats V, Bourbeau J, Pépin JL, Maltais F. Metabolic profiles among COPD and controls in the CanCOLD population-based cohort.. PLoS One 2020; 15(4):e0231072.
Gephine S, Bergeron S, Tremblay-Labrecque PF, Mucci P, Saey D, Maltais F. Cardiorespiratory Response during the 1-min Sit-to-Stand Test in Chronic Obstructive Pulmonary Disease.. Med Sci Sports Exerc 2020; 52(7):1441-1448.
Tracey L, Lewthwaite H, Abdallah SJ, Murray S, Wilkinson-Maitland CA, Donovan A, Maltais F, O'Donnell DE, Bourbeau J, Smith BM, Jensen D. Physiological and perceptual responses to exercise according to locus of symptom limitation in COPD.. Respir Physiol Neurobiol 2020; 273(0):103322.
Kermelly SB, Côté F, Maltais F. Pulmonary Artery Filling Defects: Beyond Pulmonary Embolism.. Am J Respir Crit Care Med 2020; 201(5):e13-e14.
Vézina FA, Milad D, Godbout K, Bernier M, Maltais F, Nadreau É, Sénéchal M. An unusual cause of exertional dyspnea in a 55 years old man.. Respir Med Case Rep 2020; 29(0):101004.
Bellemare J, Gaudreault N, Valette K, Belmonte I, Nuñez A, Miravitlles M, Maltais F, Bossé Y. The Clinical Utility of Determining the Allelic Background of Mutations Causing Alpha-1 Antitrypsin Deficiency: The Case with the Null Variant Q0(Mattawa)/Q0(ourém).. Chronic Obstr Pulm Dis 2021; 8(1):31-40.
Gupta N, Gaudreault N, Thériault S, Li PZ, Henry C, Kirby M, Maltais F, Tan W, Bourbeau J, Bossé Y. Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD.. Eur Respir J 2020; 56(4):2000958.
Boulet LP, Boulay ME, Coxson HO, Hague CJ, Milot J, Lepage J, Maltais F. Asthma with Irreversible Airway Obstruction in Smokers and Nonsmokers: Links between Airway Inflammation and Structural Changes.. Respiration 2020; 0(0):1-11.
Plante A, Guinde J, Boudreau C, Maltais F, Martel S, Delage A, Fortin M. A Rare Complication: Development of an Aspergilloma after Endobronchial Coil Placement in a COPD Patient.. Respiration 2020; 99(5):423-425.
Tremblay Labrecque PF, Harvey J, Nadreau É, Maltais F, Dion G, Saey D. Validation and Cardiorespiratory Response of the 1-Min Sit-to-Stand Test in Interstitial Lung Disease.. Med Sci Sports Exerc 2020; 52(12):2508-2514.
Lacasse Y, Sériès F, Corbeil F, Baltzan M, Paradis B, Simão P, Abad Fernández A, Esteban C, Guimarães M, Bourbeau J, Aaron SD, Bernard S, Maltais F. Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease.. N Engl J Med 2020; 383(12):1129-1138.
Roy E, Rheault J, Pigeon MA, Ugalde Figueroa PA, Racine C, Simard S, Chouinard G, Lippens A, Lacasse Y, Maltais F. Lung cancer resection and postoperative outcomes in COPD: A single-center experience.. Chron Respir Dis 2020; 17(0):1479973120925430.
Lajoie AC, Sériès F, Bernard S, Bernard E, Santaolalla CJE, Abad Fernández A, Maltais F, Lacasse Y. Reliability of Home Nocturnal Oximetry in the Diagnosis of Overlap Syndrome in COPD.. Respiration 2020; 99(2):132-139.
Viglino D, L'her E, Maltais F, Maignan M, Lellouche F. Evaluation of a new respiratory monitoring tool "Early Warning ScoreO₂" for patients admitted at the emergency department with dyspnea.. Resuscitation 2020; 148(0):59-65.
Ferguson GT, Maltais F, Karpel J, Bothner U, Kloer I, Trampisch M, Buhl R. Long-term safety of tiotropium/olodaterol in older patients with moderate-to-very-severe COPD in the TONADO® studies.. NPJ Prim Care Respir Med 2020; 30(1):53.
Vogelmeier CF, Kerwin EM, Bjermer LH, Tombs L, Jones PW, Boucot IH, Naya IP, Lipson DA, Compton C, Barnes N, Maltais F. Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial.. Ther Adv Respir Dis 2020; 14(0):1753466620968500.
Gephine S, Le Rouzic O, Machuron F, Wallaert B, Chenivesse C, Saey D, Maltais F, Mucci P, Grosbois JM. Long-Term Effectiveness of a Home-Based Pulmonary Rehabilitation in Older People with Chronic Obstructive Pulmonary Disease: A Retrospective Study.. Int J Chron Obstruct Pulmon Dis 2020; 15(0):2505-2514.
Maltais F, Naya IP, Vogelmeier CF, Boucot IH, Jones PW, Bjermer L, Tombs L, Compton C, Lipson DA, Kerwin EM. Salbutamol use in relation to maintenance bronchodilator efficacy in COPD: a prospective subgroup analysis of the EMAX trial.. Respir Res 2020; 21(1):280.
Maltais F, Schenkenberger I, Wielders PLML, Ortiz de Saracho J, Chinsky K, Watkins M, Millar V, Crim C. Effect of once-daily fluticasone furoate/vilanterol versus vilanterol alone on bone mineral density in patients with COPD: a randomized, controlled trial.. Ther Adv Respir Dis 2020; 14(0):1753466620965145.
Beaulieu J, Jensen D, O'Donnell DE, Brouillard C, Tracey L, Vincent S, Nadreau É, Bernard E, Bernard S, Maltais F. Relieving exertional dyspnea during the 3-min constant speed shuttle test in patients with COPD with indacaterol/glycopyrronium versus tiotropium: the RED trial.. Ther Adv Respir Dis 2020; 14(0):1753466620939507.
Lewthwaite H, Koch EM, Ekström M, Hamilton A, Bourbeau J, Maltais F, Borel B, Jensen D. Predicting the rate of oxygen consumption during the 3-minute constant-rate stair stepping and shuttle tests in people with chronic obstructive pulmonary disease.. J Thorac Dis 2020; 12(5):2489-2498.
Maltais F, O'Donnell DE, Hamilton A, Zhao Y, Casaburi R. Comparative measurement properties of constant work rate cycling and the endurance shuttle walking test in COPD: the TORRACTO^® clinical trial.. Ther Adv Respir Dis 2020; 14(0):1753466620926858.
Kerwin EM, Boucot IH, Vogelmeier CF, Maltais F, Naya IP, Tombs L, Jones PW, Lipson DA, Keeley T, Bjermer L. Early and sustained symptom improvement with umeclidinium/vilanterol versus monotherapy in COPD: a post hoc analysis of the EMAX randomised controlled trial.. Ther Adv Respir Dis 2020; 14(0):1753466620926949.
Vivodtzev I, Maltais F. Cardiovascular Risk in COPD: Searching for a Culprit.. Chest 2020; 157(4):753-754.
Barrecheguren M, Pinto L, Mostafavi-Pour-Manshadi SM, Tan WC, Li PZ, Aaron SD, Benedetti A, Chapman KR, Walker B, Fitzgerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Bourbeau J. Identification and definition of asthma-COPD overlap: The CanCOLD study.. Respirology 2020; 25(8):836-849.
Maltais F, de la Hoz A, Casaburi R, O'Donnell D. Effects of Tiotropium/Olodaterol on Activity-Related Breathlessness, Exercise Endurance and Physical Activity in Patients with COPD: Narrative Review with Meta-/Pooled Analyses.. Adv Ther 2021; 38(2):835-853.
Lewthwaite H, Elsewify O, Niro F, Bourbeau J, Guenette JA, Maltais F, Marciniuk DD, O'Donnell DE, Smith BM, Stickland MK, Tan WC, Jensen D. Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold in Canadian Adults 40 to 80 Years of Age.. Chest 2020; 3692(20):35154-0.
Bourbeau J, Sedeno M, Li PZ, Troosters T, Hamilton A, De Sousa D, Maltais F, Erzen D, Lavoie KL. Mechanisms associated with increased physical activity in patients undergoing self-management behaviour modification in the randomised PHYSACTO trial.. ERJ Open Res 2021; 7(1):00533-2020.
Gephine S, Frykholm E, Nyberg A, Mucci P, Van Hees HWH, Lemson A, Klijn P, Maltais F, Saey D. Specific contribution of quadriceps muscle strength, endurance, and power to functional exercise capacity in people with chronic obstructive pulmonary disease: a multicenter study.. Phys Ther 2021; 101(6):pzab052.
Leung C, Bourbeau J, Sin DD, Aaron SD, FitzGerald JM, Maltais F, Marciniuk DD, O'Donnell D, Hernandez P, Chapman KR, Walker B, Road JD, Zheng L, Zou C, Hogg JC, Tan WC. The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Study.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):305-320.
Lacasse Y, Sériès F, Maltais F. Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease. Reply.. N Engl J Med 2021; 384(1):86.
Mekov E, Nuñez A, Sin DD, Ichinose M, Rhee CK, Maselli DJ, Coté A, Suppli Ulrik C, Maltais F, Anzueto A, Miravitlles M. Update on Asthma-COPD Overlap (ACO): A Narrative Review.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):1783-1799.
Degois J, Veillette M, Poulin P, Lévesque B, Aubin D, Ouazia B, Brisson M, Maltais F, Duchaine C. Indoor air quality assessment in dwellings with different ventilation strategies in Nunavik and impacts on bacterial and fungal microbiota.. Indoor Air 2021; 31(6):2213-2225.
Bjermer LH, Boucot IH, Vogelmeier CF, Maltais F, Jones PW, Tombs L, Compton C, Lipson DA, Kerwin EM. Efficacy and Safety of Umeclidinium/Vilanterol in Current and Former Smokers with COPD: A Prespecified Analysis of The EMAX Trial.. Adv Ther 2021; 38(9):4815-4835.
Oueslati F, Saey D, Vézina FA, Nadreau É, Martin M, Maltais F. Acute Cardiopulmonary and Muscle Oxygenation Responses to Normocapnic Hyperpnea Exercise in COPD.. Med Sci Sports Exerc 2022; 54(1):47-56.
Bjermer L, Boucot IH, Maltais F, Kerwin EM, Naya IP, Tombs L, Jones PW, Compton C, Lipson DA, Vogelmeier CF. Dual Bronchodilator Therapy as First-Line Treatment in Maintenance-Naïve Patients with Symptomatic COPD: A Pre-Specified Analysis of the EMAX Trial.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):1939-1956.
Begg M, Hamblin JN, Jarvis E, Bradley G, Mark S, Michalovich D, Lennon M, Wajdner HE, Amour A, Wilson R, Saunders K, Tanaka R, Arai S, Tang T, Van Holsbeke C, De Backer J, Vos W, Titlestad IL, FitzGerald JM, Killian K, Bourbeau J, Poirier C, Maltais F, Cahn A, Hessel EM. Exploring PI3K? Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):1621-1636.
Frykholm E, Gephine S, Saey D, Lemson A, Klijn P, Bij de Vaate E, Maltais F, van Hees H, Nyberg A. Isotonic quadriceps endurance is better associated with daily physical activity than quadriceps strength and power in COPD: an international multicentre cross-sectional trial.. Sci Rep 2021; 11(1):11557.
Gephine S, Mucci P, Grosbois JM, Maltais F, Saey D. Physical Frailty in COPD Patients with Chronic Respiratory Failure.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):1381-1392.
Tremblay K, Rousseau S, Zawati MH, Auld D, Chassé M, Coderre D, Falcone EL, Gauthier N, Grandvaux N, Gros-Louis F, Jabet C, Joly Y, Kaufmann DE, Laprise C, Larochelle C, Maltais F, Mes-Masson AM, Montpetit A, Piché A, Richards JB, Tse SM, Turgeon AF, Turecki G, Vinh DC, Wang HT, Mooser V. The Biobanque québécoise de la COVID-19 (BQC19)-A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories.. PLoS One 2021; 16(5):e0245031.
Vogelmeier CF, Naya IP, Maltais F, Bjermer L, Kerwin EM, Tombs L, Jones PW, Compton C, Lipson DA, Boucot IH. Treatment of COPD with Long-Acting Bronchodilators: Association Between Early and Longer-Term Clinically Important Improvement.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):1215-1226.
Cherian M, Jensen D, Tan WC, Mursleen S, Goodall EC, Nadeau GA, Awan AM, Marciniuk DD, Walker BL, Aaron SD, O'Donnell DE, Chapman KR, Maltais F, Hernandez P, Sin DD, Benedetti A, Bourbeau J. Dyspnoea and symptom burden in mild-moderate COPD: the Canadian Cohort Obstructive Lung Disease Study.. ERJ Open Res 2021; 7(2):00960-2020.
Nyberg A, Martin M, Saey D, Milad N, Patoine D, Morissette MC, Auger D, Stål P, Maltais F. Effects of Low-Load/High-Repetition Resistance Training on Exercise Capacity, Health Status, and Limb Muscle Adaptation in Patients With Severe COPD: A Randomized Controlled Trial.. Chest 2021; 159(5):1821-1832.
Lewthwaite H, Elsewify O, Niro F, Bourbeau J, Guenette JA, Maltais F, Marciniuk DD, O'Donnell DE, Smith BM, Stickland MK, Tan WC, Jensen D. Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold in Canadian Adults 40 to 80 Years of Age.. Chest 2021; 159(5):1922-1933.
Haillot A, Pelland AA, Bossé Y, Carroll TP, Maltais F, Dandurand RJ. IntraIndividual Variability in Serum Alpha-1 Antitrypsin Levels.. Chronic Obstr Pulm Dis 2021; 8(4):464-473.
Soumagne T, Levesque F, Milot J, Godbout K, Lacasse Y, Maltais F. Significance of Stenotrophomonas maltophilia When Detected in Sputum of Ambulatory Patients with COPD.. Int J Chron Obstruct Pulmon Dis 2021; 16(0):2895-2900.
Lacasse Y, Thériault S, St-Pierre B, Bernard S, Sériès F, Bernatchez HJ, Maltais F. Oximetry neither to prescribe long-term oxygen therapy nor to screen for severe hypoxaemia.. ERJ Open Res 2021; 7(4):00272-2021.
Gephine S, Saey D, Grosbois JM, Maltais F, Mucci P. Home-based Pulmonary Rehabilitation is Effective in Frail COPD Patients with Chronic Respiratory Failure.. Chronic Obstr Pulm Dis 2022; 9(1):15-25.
Come JH, Senter TJ, Clark MP, Court JJ, Gale-Day Z, Gu W, Krueger E, Liang J, Morris M, Nanthakumar S, O'Dowd H, Maltais F, Iyer G, Andreassi J, Boucher C, Considine T, Moody CS, Taylor W, Mohanty AK, Huang Y, Zuccola H, Coll J, Bonanno KC, Gagnon KJ, Gan L, Lu F, Gao H, Chakilam A, Engtrakul J, Song B, Crawford D, Doyle E, Kramer T, Vought B, Phillips J, Kemper R, Sanders M, Swett R, Furey B, Winquist R, Bunnage ME, Jackson KL, Charifson PS, Magavi SS. Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.. J Med Chem 2021; 64(24):17753-17776.
Vogelmeier CF, Jones PW, Kerwin EM, Boucot IH, Maltais F, Tombs L, Compton C, Lipson DA, Bjermer LH. Efficacy of umeclidinium/vilanterol according to the degree of reversibility of airflow limitation at screening: a post hoc analysis of the EMAX trial.. Respir Res 2021; 22(1):279.
Vameghestahbanati M, Kirby M, Maltais F, Jensen D, Doiron D, Tan WC, Bourbeau J, Smith BM. Dysanapsis and the Spirometric Response to Inhaled Bronchodilators.. Am J Respir Crit Care Med 2021; 204(8):997-1001.
Kaminska M, Rimmer KP, McKim DA, Monoyama M, Giannouli E, Morisson DL, OConnell C, Petrof BJ, Maltais F.. Long-term non-invasive ventilation in patients with chronic obstructive pulmonary disease (COPD): 2021 Canadian Thoracic Society clinical practice guideline update.. Can J Respir Crit Care Sleep Med 2021; 5(0):160-183.
Bourbeau J, Doiron D, Biswas S, Smith BM, Benedetti A, Brook JR, Aaron SD, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Sin DD, Walker B, Dsilva L, Nadeau G, Coats V, Compton C, Miller BE, Tan WC. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and COPD in the CanCOLD Study.. Am J Respir Crit Care Med 2022; 206(1):44-55.
Grosbois JM, Gephine S, Kyheng M, Henguelle J, Le Rouzic O, Saey D, Maltais F, Chenivesse C. Physical and affective components of dyspnoea are improved by pulmonary rehabilitation in COPD.. BMJ Open Respir Res 2022; 9(1):e001160.
Gephine S, Mucci P, Bielmann M, Martin M, Bouyer L, Saey D, Maltais F. Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls.. Sci Rep 2022; 12(1):794.
Andreas S, Testa M, Boyer L, Brusselle G, Janssens W, Kerwin E, Papi A, Pek B, Puente-Maestu L, Saralaya D, Watz H, Wilkinson TMA, Casula D, Di Maro G, Lattanzi M, Moraschini L, Schoonbroodt S, Tasciotti A, Arora AK, Maltais F. Non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial.. Lancet Respir Med 2022; 10(5):435-446.
Pelletier É, Desmeules P, Lacasse Y, Tanguay S, Milot J, Morissette MC, Maltais F. Antibody Response to Severe Acute Respiratory Syndrome Coronavirus-2 Vaccination in COPD: A Cohort Study.. Chronic Obstr Pulm Dis 2022; 9(4):591-595.
Chouinard G, Roy P, Blais MC, Lippens A, Pelletier É, Roy E, Marcoux M, Ugalde PA, Rheault J, Pigeon MA, Nicodème F, Lacasse Y, Maltais F. Exercise testing and postoperative complications after minimally invasive lung resection: A cohort study.. Front Physiol 2022; 13(0):951460.
Gaudreault N, Blouin C, Haillot A, Milot J, Maltais F, Bossé Y. The Null Q0_Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency.. Am J Respir Cell Mol Biol 2022; 66(6):700-702.
Soumagne T, Maltais F, Corbeil F, Paradis B, Baltzan M, Simão P, Abad Fernández A, Lecours R, Bernard S, Lacasse Y. Short-Term Oxygen Therapy Outcomes in COPD.. Int J Chron Obstruct Pulmon Dis 2022; 17(0):1685-1693.
Lacasse Y, Casaburi R, Sliwinski P, Chaouat A, Fletcher E, Haidl P, Maltais F. Home oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis.. Lancet Respir Med 2022; 10(11):1029-1037.
Lacasse Y, Bernard S, Maltais F, Nguyen VH. Cost-Effectiveness of an Extended Home Visit Program for Oxygen-Dependent COPD Patients.. Respir Care 2022; 67(9):1082-1090.
Nyberg A, Milad N, Martin M, Patoine D, Morissette MC, Saey D, Maltais F. Role of progression of training volume on intramuscular adaptations in patients with chronic obstructive pulmonary disease.. Front Physiol 2022; 13(0):873465.
Casaburi R, Merrill D, Dolmage T, Garcia-Aymerich J, Fageras M, Goldstein R, Harding G, Kline Leidy N, Maltais F, O'Donnell D, Porszasz J, Puente-Maestu L, Rennard S, Sciurba F, Spruit MA, Tal-Singer R, Tetzlaff K, Van't Hul A, Yu R, Hamilton A. Endurance Time During Constant Work Rate Cycle Ergometry in COPD: Development of an Integrated Database From Interventional Studies.. Chronic Obstr Pulm Dis 2022; 9(4):520-537.
Maltais F, Vogelmeier CF, Kerwin EM, Bjermer LH, Jones PW, Boucot IH, Lipson DA, Tombs L, Compton C, Naya IP. Applying key learnings from the EMAX trial to clinical practice and future trial design in COPD.. Respir Med 2022; 200(0):106918.
Lacasse Y, Casaburi R, Maltais F. When should we treat moderate hypoxaemia in patients with COPD? - Authors' reply.. Lancet Respir Med 2022; 10(11):e98.
Agusti A, Ambrosino N, Blackstock F, Bourbeau J, Casaburi R, Celli B, Crouch R, Negro RD, Dreher M, Garvey C, Gerardi D, Goldstein R, Hanania N, Holland AE, Kaur A, Lareau S, Lindenauer PK, Mannino D, Make B, Maltais F, Marciniuk JD, Meek P, Morgan M, Pepin JL, Reardon JZ, Rochester C, Singh S, Spruit MA, Steiner MC, Troosters T, Vitacca M, Clini E, Jardim J, Nici L, Raskin J, ZuWallack R. COPD: Providing the right treatment for the right patient at the right time.. Respir Med 2022; 207(0):107041.
Oostrik L, Bourbeau J, Doiron D, Ross B, Zhi-Li P, Aaron SD, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Tan WC, Sin DD, Walker B, Janaudis-Ferreira T. Physical Activity and Symptom Burden in COPD: The Canadian Obstructive Lung Disease Study.. Chronic Obstr Pulm Dis 2023; 10(1):89-101.
Quigley N, Couture C, Gervais P, Maltais F.. A 37-Year-Old Man With Right Lung Consolidation.. Chest 2023; 163(3):e111-e114.
Krishnan S, Tan WC, Farias R, Aaron SD, Benedetti A, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Walker B, Bourbeau J; Canadian Cohort Obstructive Lung Disease Collaborative Research Group and the Canadian Respiratory Research Network.. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study. Chest 2023; 164(3):637-649.
Lacasse Y, Maltais F. When and When Not to Prescribe Home Oxygen in COPD.. Arch Bronconeumol 2023; 59(6):350-351.
Ross BA, Doiron D, Benedetti A, Aaron SD, Chapman K, Hernandez P, Maltais F, Marciniuk D, O'Donnell DE, Sin DD, Walker BL, Tan W, Bourbeau J. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort.. Thorax 2023; 78(10):974-982.
Katsuno N, Li PZ, Bourbeau J, Aaron S, Maltais F, Hernandez P, Chapman KR, Walker B, Marciniuk DD, ODonnell DD, Sin DD, Hogg JC, Cheng M, Road J, Tan WC. Factors Associated with Attrition in a Longitudinal Cohort of Older Adults in the Community.. Chronic Obstr Pulm Dis 2023; 10(2):178-189.
Agusti A, Ambrosino N, Blackstock F, Bourbeau J, Casaburi R, Celli B, Crouch R, Negro RD, Dreher M, Garvey C, Gerardi D, Goldstein R, Hanania N, Holland AE, Kaur A, Lareau S, Lindenauer PK, Mannino D, Make B, Maltais F, Marciniuk JD, Meek P, Morgan M, Pepin JL, Reardon JZ, Rochester C, Singh S, Spruit MA, Steiner MC, Troosters T, Vitacca M, Clini E, Jardim J, Nici L, Raskin J, ZuWallack R. COPD: Providing the right treatment for the right patient at the right time.. Respir Med 2023; 207(0):107041.
Vézina FA, Bouchard PA, Breton-Gagnon É, Dion G, Viglino D, Roy P, Bilodeau L, Provencher S, Denault MH, Saey D, Lellouche F, Maltais F. Automated O(2) Titration Alone or With High-Flow Nasal Cannula During Walking Exercise in Chronic Lung Diseases.. Respir Care 2023; 0(0):respcare.10810.
Bourbeau J, Bhutani M, Hernandez P, Aaron SD, Beauchesne MF, Kermelly SB, D'Urzo A, Lal A, Maltais F, Marciniuk JD, Mulpuru S, Penz E, Sin DD, Van Dam A, Wald J, Walker BL, Marciniuk DD. 2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD.. Chest 2023; 164(5):1159-1183.
Tanguay S, Saey D, Marklund S, Nyberg A, Gephine S, Frykholm E, De Brandt J, Burtin C, Maltais F. Reference equations for quadriceps strength, endurance and power: a multicentre study.. ERJ Open Res 2023; 9(4):00313-2023.
Lellouche F, Blais-Lecours P, Maltais F, Sarrazin JF, Rola P, Nguyen T, Châteauvert N, Marsolais D. Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support: A Randomized, Open-Label, Pilot Trial.. Chest 2023; 0(0):Epub.
Kerwin EM, Jones PW, Bjermer LH, Maltais F, Boucot IH, Naya IP, Lipson DA, Compton C, Tombs L, Vogelmeier CF. How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?. Chron Respir Dis 2023; 20(0):14799731231202257.
Flahaut M, Leprohon P, Pham NP, Gingras H, Bourbeau J, Papadopoulou B, Maltais F, Ouellette M. Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis.. Sci Rep 2023; 13(1):16622.

Dr François Maltais

Domaine de recherche

Description des travaux

Prix et distinctions

Publications

Support tomorrow's medicine, now.