Clinicien(ne) chercheur(e)

Dr Christian Couture

Pneumologie

christian.couture@criucpq.ulaval.ca

Publications

Trier par année :

Coté N, Mahmut A, Bosse Y, Couture C, Pagé S, Trahan S, Boulanger MC, Fournier D, Pibarot P, Mathieu P. Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease.. Inflammation 2013; 36(3):573-81.
Mahmut A, Boulanger MC, Fournier D, Couture C, Trahan S, Pagé S, Arsenault B, Després JP, Pibarot P, Mathieu P. Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling.. Eur J Clin Invest 2013; 43(6):570-8.
Conklin CM, Craddock KJ, Have C, Laskin J, Couture C, Ionescu DN.. Immunohistochemistry is a reliable screening tool for identification of ALK rearrangement in non-small-cell lung carcinoma and is antibody dependent. J Thorac Oncol. Jan 2013;8(1):45-51.(Pneumologie). J Thorac Oncol 2013; 8(1):45-51.
Lamontagne M, Couture C, Postma DS, Timens W, Sin DD, Paré PD, Hogg JC, Nickle D, Laviolette M, Bossé Y.. Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls.. PLoS One 2013; 8(7):e70220.
Lee-Gosselin A, Pascoe CD, Couture C, Pare PD, Bossé Y.. Does the length-dependency of airway smooth muscle force contribute to airway hyperresponsiveness?. J Appl Physiol 2013; 115(9):1304-15.
Clavel MA, Ennezat PV, Maréchaux S, Dumesnil JG, Capoulade R, Hachicha Z, Mathieu P, Bellouin A, Bergeron S, Meimoun P, Arsenault M, Le Tourneau T, Pasquet A, Couture C, Pibarot P. Stress Echocardiography to Assess Stenosis Severity and Predict Outcome in Patients With Paradoxical Low-Flow, Low-Gradient Aortic Stenosis and Preserved LVEF.. JACC Cardiovasc Imaging 2013; 6(2):175-83.
Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.. Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.. PLoS One 2013; 8(8):e72529.
Bérubé JC, Lamontagne M, Couture C, Nickle D, Timens W, Postma DS, Sin DD, Paré PD, Laviolette M, Bossé Y.. Genome-wide genetic ancestry measurements to predict lung function in European populations.. Eur Respir J 2013; 42(4):1144-7.
Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulos S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S. Role for DNA damage signaling in pulmonary arterial hypertension.. Circulation 2013; 0(0):Epub.
Côté N, Mahmut A, Fournier D, Boulanger MC, Couture C, Després JP, Trahan S, Bossé Y, Pagé S, Pibarot P, Mathieu P. Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease.. Pathobiology 2014; 81(1):15-24.
Berthelot-Richer M, O'Connor K, Bernier M, Trahan S, Couture C, Dubois M, Sénéchal M. When Should We Consider the Diagnosis of Giant Cell Myocarditis? Revisiting "Classic" Echocardiographic and Clinical Features of This Rare Pathology.. Exp Clin Transplant 2014; 12(6):565-8.
Morissette MC, Lamontagne M, Bérubé JC, Gaschler G, Williams A, Yauk C, Couture C, Laviolette M, Hogg JC, Timens W, Halappanavar S, Stampfli MR, Bossé Y. Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study.. PLoS One 2014; 9(3):e92498.
Clavel MA, Côté N, Mathieu P, Dumesnil JG, Audet A, Pépin A, Couture C, Fournier D, Trahan S, Pagé S, Pibarot P. Paradoxical low-flow, low-gradient aortic stenosis despite preserved left ventricular ejection fraction: new insights from weights of operatively excised aortic valves.. Eur Heart J 2014; 35(38):2655-62.
Coulombe F, Jaworska J, Verway M, Tzelepis F, Massoud A, Gillard J, Wong G, Kobinger G, Xing Z, Couture C, Joubert P, Fritz JH, Powell WS, Divangahi M. Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages.. Immunity 2014; 40(4):554-68.
Couture C, Brassard A, Brault-Labbé A. [The process of meaning-making in adjustment to multiple sclerosis.]. Rev Neurol (Paris) 2014; 170(6):416-24.
Skowronski DM, Hamelin ME, De Serres G, Janjua NZ, Li G, Sabaiduc S, Bouhy X, Couture C, Leung A, Kobasa D, Embury-Hyatt C, de Bruin E, Balshaw R, Lavigne S, Petric M, Koopmans M, Boivin G. Randomized controlled ferret study to assess the direct impact of 2008-09 trivalent inactivated influenza vaccine on A(H1N1)pdm09 disease risk.. PLoS One 2014; 9(1):e86555.
Nguyen JD, Lamontagne M, Couture C, Conti M, Paré PD, Sin DD, Hogg JC, Nickle D, Postma DS, Timens W, Laviolette M, Bossé Y.. Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.. Carcinogenesis 2014; 35(12):2653-9.
Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS.. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.. Thorax 2014; 69(11):997-1004.
Bouchareb R, Mahmut A, Nsaibia MJ, Boulanger MC, Dahou A, Lépine JL, Laflamme MH, Hadji F, Couture C, Trahan S, Pagé S, Bossé Y, Pibarot P, Scipione CA, Romagnuolo R, Koschinsky ML, Arsenault BJ, Marette A, Mathieu P. Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.. Circulation 2015; 132(8):677-90.
Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulos S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S. Role for DNA damage signaling in pulmonary arterial hypertension.. Circulation 2014; 129(7):786-97.
Chapman DG, Pascoe CD, Lee-Gosselin A, Couture C, Seow CY, Paré PD, Salome CM, King GG, Bossé Y. Smooth muscle in the maintenance of increased airway resistance elicited by methacholine in humans.. Am J Respir Crit Care Med 2014; 190(8):879-85.
Cutz JC, Craddock KJ, Torlakovic E, Brandao G, Carter RF, Bigras G, Deschenes J, Izevbaye I, Xu Z, Greer W, Yatabe Y, Ionescu D, Karsan A, Jung S, Fraser RS, Blumenkrantz M, Lavoie J, Fortin F, Bojarski A, Côté GB, van den Berghe JA, Rashid-Kolvear F, Trotter M, Sekhon HS, Albadine R, Tran-Thanh D, Gorska I, Knoll JH, Xu J, Blencowe B, Iafrate AJ, Hwang DM, Pintilie M, Gaspo R, Couture C, Tsao MS. Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer.. J Thorac Oncol 2014; 9(9):1255-63.
Cressman S, Lam S, Tammemagi MC, Evans WK, Leighl NB, Regier DA, Bolbocean C, Shepherd FA, Tsao MS, Manos D, Liu G, Atkar-Khattra S, Cromwell I, Johnston MR, Mayo JR, McWilliams A, Couture C, English JC, Goffin J, Hwang DM, Puksa S, Roberts H, Tremblay A, MacEachern P, Burrowes P, Bhatia R, Finley RJ, Goss GD, Nicholas G, Seely JM, Sekhon HS, Yee J, Amjadi K, Cutz JC, Ionescu DN, Yasufuku K, Martel S, Soghrati K, Sin DD, Tan WC, Urbanski S, Xu Z, Peacock SJ. Resource utilization and costs during the initial years of lung cancer screening with computed tomography in Canada.. J Thorac Oncol 2014; 9(10):1449-58.
Nadeau PL, Kumar A, O'Connor K, Couture CY, Bourgault C, Dubois M, Sénéchal M. Usefulness of cardiac resonance imaging in Churg-Strauss syndrome.. J Cardiovasc Med (Hagerstown) 2014; 0(0):.
Aerts L, Rhéaume C, Carbonneau J, Lavigne S, Couture C, Hamelin MÈ, Boivin G. Adjuvant effect of the human metapneumovirus (HMPV) matrix protein in HMPV subunit vaccines.. J Gen Virol 2015; 96(0):767-74.
Aerts L, Cavanagh MH, Dubois J, Carbonneau J, Rhéaume C, Lavigne S, Couture C, Hamelin MÈ, Boivin G. Effect of in vitro syncytium formation on the severity of human metapneumovirus disease in a murine model.. PLoS One 2015; 10(3):e0120283.
Ferland N, Couture C, Provencher S. Near-fatal haemoptysis as presentation of a giant intralobar pulmonary sequestration.. Eur Respir Rev 2015; 24(135):155-6.
Veilleux SP, O'Connor K, Couture C, Pagé S, Voisine P, Poirier P, Dubois M, Sénéchal M. What the Cardiologist Should Know About Cardiac Involvement in Behçet Disease.. Can J Cardiol 2015; 31(12):1485-8.
Roussel-Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda BR, Zukerberg LR, Figarella-Branger D, Brue T, Drouin J. The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease.. J Clin Endocrinol Metab 2016; 101(2):513-22.
Rheault P, Mohammadi S, O'Connor K, Dagenais F, Voisine P, Bergeron S, Bernier M, Couture C, Poirier P, Cinq-Mars A, Dubois M, Sénéchal M. Clinical Presentation and Value of Echocardiography in the Diagnosis of Freestyle Aortic Bioprosthesis Leaflet Tears: A Retrospective Study.. J Heart Valve Dis 2016; 25(5):628-633.
Bossé Y, Sazonova O, Gaudreault N, Bastien N, Conti M, Pagé S, Trahan S, Couture C, Joubert P. Transcriptomic Microenvironment of Lung Adenocarcinoma.. Cancer Epidemiol Biomarkers Prev 2017; 26(3):389-396.
Gazzola M, Lortie K, Henry C, Mailhot-Larouche S, Chapman DG, Couture C, Seow CY, Paré PD, King GG, Boulet LP, Bossé Y. Airway smooth muscle tone increases airway responsiveness in healthy young adults.. Am J Physiol Lung Cell Mol Physiol 2017; 312(3):L348-L357.
Gazzola M, Henry C, Couture C, Marsolais D, King GG, Fredberg JJ, Bossé Y. Smooth muscle in human bronchi is disposed to resist airway distension.. Respir Physiol Neurobiol 2016; 229(0):51-8.
Tremblay A, Taghizadeh N, McWilliams AM, MacEachern P, Stather DR, Soghrati K, Puksa S, Goffin JR, Yasufuku K, Amjadi K, Nicholas G, Martel S, Laberge F, Johnston M, Shepherd FA, Ionescu DN, Urbanski S, Hwang D, Cutz JC, Sekhon HS, Couture C, Xu Z, Sutedja TG, Atkar-Khattra S, Tammemagi MC, Tsao MS, Lam SC. Low Prevalence of High-Grade Lesions Detected With Autofluorescence Bronchoscopy in the Setting of Lung Cancer Screening in the Pan-Canadian Lung Cancer Screening Study.. Chest 2016; 150(5):1015-1022.
Cressman S, Peacock SJ, Tammemägi MC, Evans WK, Leighl NB, Goffin JR, Tremblay A, Liu G, Manos D, MacEachern P, Bhatia R, Puksa S, Nicholas G, McWilliams A, Mayo JR, Yee J, English JC, Pataky R, McPherson E, Atkar-Khattra S, Johnston MR, Schmidt H, Shepherd FA, Soghrati K, Amjadi K, Burrowes P, Couture C, Sekhon HS, Yasufuku K, Goss G, Ionescu DN, Hwang DM, Martel S, Sin DD, Tan WC, Urbanski S, Xu Z, Tsao MS, Lam S. The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.. J Thorac Oncol 2017; 12(8):1210-1222.
Simard L, Côté N, Dagenais F, Mathieu P, Couture C, Trahan S, Bossé Y, Mohammadi S, Pagé S, Joubert P, Clavel MA. Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?. Circ Res 2017; 120(4):681-691.
Tammemagi MC, Schmidt H, Martel S, McWilliams A, Goffin JR, Johnston MR, Nicholas G, Tremblay A, Bhatia R, Liu G, Soghrati K, Yasufuku K, Hwang DM, Laberge F, Gingras M, Pasian S, Couture C, Mayo JR, Nasute Fauerbach PV, Atkar-Khattra S, Peacock SJ, Cressman S, Ionescu D, English JC, Finley RJ, Yee J, Puksa S, Stewart L, Tsai S, Haider E, Boylan C, Cutz JC, Manos D, Xu Z, Goss GD, Seely JM, Amjadi K, Sekhon HS, Burrowes P, MacEachern P, Urbanski S, Sin DD, Tan WC, Leighl NB, Shepherd FA, Evans WK, Tsao MS, Lam S. Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study.. Lancet Oncol 2017; 18(11):1523-1531.
Lê VB, Riteau B, Alessi MC, Couture C, Jandrot-Perrus M, Rhéaume C, Hamelin MÈ, Boivin G. Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.. Br J Pharmacol 2018; 175(2):388-403.
Melosky B, Blais N, Cheema P, Couture C, Juergens R, Kamel-Reid S, Tsao MS, Wheatley-Price P, Xu Z, Ionescu DN. Standardizing biomarker testing for Canadian patients with advanced lung cancer.. Curr Oncol 2018; 25(1):73-82.
Morin-Thibault LV, Wiseman D, Fortin M, Couture C, Provencher S. Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report.. Pulm Circ 2018; 8(2):2045893218754853.
de La Vega MA, Piret J, Griffin BD, Rhéaume C, Venable MC, Carbonneau J, Couture C, das Neves Almeida R, Tremblay RR, Magalhães KG, Park YK, Roberts CC, Maslow JN, Sardesai NY, Kim JJ, Muthumani K, Weiner DB, Kobinger GP, Boivin G. Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization.. J Infect Dis 2019; 219(3):365-374.
Lê BV, Jandrot-Perrus M, Couture C, Checkmahomed L, Venable MC, Hamelin MÈ, Boivin G. Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice.. J Gen Virol 2018; 99(10):1367-1380.
Gagné A, Racine É, Orain M, Meziou S, Simard S, Couture C, Pagé S, Trahan S, Ugalde Figueroa PA, Lacasse Y, Joubert D, Joubert P. Identification of Grossing Criteria for Intraoperative Evaluation by Frozen Section of Lung Cancer Resection Margins.. Am J Surg Pathol 2018; 42(11):1495-1502.
Massicotte G, Bernier M, Piché ME, Cantin L, Couture C. Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis.. Circ Cardiovasc Imaging 2019; 12(3):e008621.
Delisle V, Perron J, Lafrenière-Bessi V, Côté JM, Drolet C, Couture C, Jacques F.. Neonatal Cardiac Arrest from Left Ventricular Cardiac Hemangioma: A Surprising Presentation.. Can J Cardiol 2019; 35(4):544.e3-544.e5.
Barroso Freitas-Ferraz A, Beaudoin W, Couture C, Perron J, Sénéchal M.. Prosthetic aortic valve thrombosis: To fibrinolyse or not to fibrinolyse? That is the question!. Echocardiography 2019; 36(4):787-790.
Lê VB, Dubois J, Couture C, Cavanagh MH, Uyar O, Pizzorno A, Rosa-Calatrava M, Hamelin MÈ, Boivin G.. Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice.. PLoS Pathog 2019; 15(4):e1007689.
Laflamme P, Vaucher J, Turmel-Roy J, Orain M, Sazonova O, Bertrand OF, Dagenais F, Couture C, Pagé S, Trahan S, Bilodeau S, Joubert P. Coronary artery fixation at iso-arterial pressure: impacts on histologic evaluation and clinical management.. Cardiovasc Pathol 2019; 43(0):107141.
Baz M, M'hamdi Z, Carbonneau J, Lavigne S, Couture C, Abed Y, Boivin G. Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.. Sci Rep 2019; 9(1):16616.
Freitas-Ferraz AB, Beaudoin W, Couture C, Perron J, Sénéchal M. Reply to the Letter to the Editor: Noninvasive diagnostic tools available for discrimination of pannus from thrombus in patients with prosthetic valve dysfunction.. Echocardiography 2019; 36(6):1224-1225.
Gagné A, Wang E, Bastien N, Orain M, Desmeules P, Pagé S, Trahan S, Couture C, Joubert D, Joubert P. Impact of Specimen Characteristics on PD-L1 Testing in Non-Small Cell Lung Cancer: Validation of the IASLC PD-L1 Testing Recommendations.. J Thorac Oncol 2019; 14(12):2062-2070.
Bebb DG, Agulnik J, Albadine R, Banerji S, Bigras G, Butts C, Couture C, Cutz JC, Desmeules P, Ionescu DN, Leighl NB, Melosky B, Morzycki W, Rashid-Kolvear F, Lab C, Sekhon HS, Smith AC, Stockley TL, Torlakovic E, Xu Z, Tsao MS. Crizotinib inhibition of ROS1-positive tumours in advanced non-small-cell lung cancer: a Canadian perspective.. Curr Oncol 2019; 26(4):e551-e557.
Lebel K, Tan S, Parent MC, El-Hamamsy I, Couture C, Laroussi L. An Unusual Presentation of a Cardiac Thrombus.. Can J Cardiol 2019; 35(10):1420.e1-1420.e3.
Cheung CC, Barnes P, Bigras G, Boerner S, Butany J, Calabrese F, Couture C, Deschenes J, El-Zimaity H, Fischer G, Fiset PO, Garratt J, Geldenhuys L, Gilks CB, Ilie M, Ionescu D, Lim HJ, Manning L, Mansoor A, Riddell R, Ross C, Roy-Chowdhuri S, Spatz A, Swanson PE, Tron VA, Tsao MS, Wang H, Xu Z, Torlakovic EE. Fit-For-Purpose PD-L1 Biomarker Testing For Patient Selection in Immuno-Oncology: Guidelines For Clinical Laboratories From the Canadian Association of Pathologists-Association Canadienne Des Pathologistes (CAP-ACP).. Appl Immunohistochem Mol Morphol 2019; 27(10):699-714.
Dubois J, Pizzorno A, Cavanagh MH, Padey B, Nicolas de Lamballerie C, Uyar O, Venable MC, Carbonneau J, Traversier A, Julien T, Lavigne S, Couture C, Lina B, Hamelin MÈ, Terrier O, Rosa-Calatrava M, Boivin G. Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development.. Vaccines (Basel) 2019; 7(4):E164.
Couëtoux du Tertre M, Marques M, Tremblay L, Bouchard N, Diaconescu R, Blais N, Couture C, Pelsser V, Wang H, Higenell V, Izzi L, Gambaro K, Hoffert C, Srivastava A, Spatz A, Rousseau C, McNamara S, Cohen V, Batist G, Agulnik J. Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes.. Mol Cancer Ther 2019; 18(9):1628-1636.
Torlakovic E, Lim HJ, Adam J, Barnes P, Bigras G, Chan AWH, Cheung CC, Chung JH, Couture C, Fiset PO, Fujimoto D, Han G, Hirsch FR, Ilie M, Ionescu D, Li C, Munari E, Okuda K, Ratcliffe MJ, Rimm DL, Ross C, Røge R, Scheel AH, Soo RA, Swanson PE, Tretiakova M, To KF, Vainer GW, Wang H, Xu Z, Zielinski D, Tsao MS. "Interchangeability" of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy.. Mod Pathol 2020; 33(1):4-17.
Guzzetti E, Poulin A, Annabi MA, Zhang B, Kalavrouziotis D, Couture C, Dagenais F, Pibarot P, Clavel MA.. Transvalvular Flow, Sex, and Survival After Valve Replacement Surgery in Patients With Severe Aortic Stenosis.. J Am Coll Cardiol 2020; 75(16):1897-1909.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM. Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.. JAMA Netw Open 2020; 3(2):e200129.
Laflamme P, Mansoori BK, Sazanova O, Orain M, Couture C, Simard S, Trahan S, Manem V, Joubert P. Phospho-histone-H3 immunostaining for pulmonary carcinoids: impact on clinical appraisal, interobserver correlation, and diagnostic processing efficiency.. Hum Pathol 2020; 106(0):74-81.
Torlakovic E, Albadine R, Bigras G, Boag A, Bojarski A, Cabanero M, Camilleri-Broët S, Cheung C, Couture C, Craddock KJ, Cutz JC, Dhamanaskar P, Fiset PO, Hossain M, Hwang DM, Ionescu D, Itani D, Kelly MM, Kwan K, Lim HJ, Nielsen S, Qing G, Sekhon H, Spatz A, Waghray R, Wang H, Xu Z, Tsao MS. Canadian Multicenter Project on Standardization of Programmed Death-Ligand 1 Immunohistochemistry 22C3 Laboratory-Developed Tests for Pembrolizumab Therapy in NSCLC.. J Thorac Oncol 2020; 15(8):1328-1337.
Pilaev M, Shen Y, Carbonneau J, Venable MC, Rhéaume C, Lavigne S, Couture C, Guarné A, Hamelin MÈ, Boivin G. Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice.. Vaccine 2020; 38(9):2122-2127.
Couëtoux du Tertre M, Marques M, McNamara S, Gambaro K, Hoffert C, Tremblay L, Bouchard N, Diaconescu R, Blais N, Couture C, Pelsser V, Wang H, McIntosh L, Hindie V, Parent S, Cortes L, Breton YA, Pottiez G, Croteau P, Higenell V, Izzi L, Spatz A, Cohen V, Batist G, Agulnik J. Discovery of a putative blood-based protein signature associated with response to ALK tyrosine kinase inhibition.. Clin Proteomics 2020; 17(0):5.
Belzile D, Turgeon PY, Leblanc E, Massot M, Bourgault C, Morin J, Dupuis C, Bilodeau M, Laflamme M, Charbonneau E, Trahan S, Pagé S, Joubert P, Couture C, Sénéchal M. Non-invasive diagnostic imaging tests largely underdiagnose cardiac cirrhosis in patients undergoing advanced therapy evaluation: How can we identify the high-risk patient?. Clin Transplant 2021; 35(6):e14277.
Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ. Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.. Circ Genom Precis Med 2021; 14(4):e003271.
Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ. A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.. CJC Open 2020; 3(4):450-459.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ. Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.. Cell Rep Med 2021; 2(11):100437.
Perrot N, Pelletier W, Bourgault J, Couture C, Li Z, Mitchell PL, Ghodsian N, Bossé Y, Thériault S, Mathieu P, Arsenault BJ. A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.. Aging Cell 2021; 20(11):e13497.
Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S. Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.. Circ Genom Precis Med 2021; 14(6):e003452.
Cartlidge TR, Bing R, Kwiecinski J, Guzzetti E, Pawade TA, Doris MK, Adamson PD, Massera D, Lembo M, Peeters FECM, Couture C, Berman DS, Dey D, Slomka P, Pibarot P, Newby DE, Clavel MA, Dweck MR. Contrast-enhanced computed tomography assessment of aortic stenosis.. Heart 2021; 107(23):1905-1911.
Cheung CC, Smith AC, Albadine R, Bigras G, Bojarski A, Couture C, Cutz JC, Huang WY, Ionescu D, Itani D, Izevbaye I, Karsan A, Kelly MM, Knoll J, Kwan K, Nasr MR, Qing G, Rashid-Kolvear F, Sekhon HS, Spatz A, Stockley T, Tran-Thanh D, Tucker T, Waghray R, Wang H, Xu Z, Yatabe Y, Torlakovic EE, Tsao MS. Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer.. Lung Cancer 2021; 160(0):127-135.
Tremblay M, Perrot N, Ghodsian N, Gobeil É, Couture C, Mitchell PL, Thériault S, Arsenault BJ. Circulating Galectin-3 Levels Are Not Associated With Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study.. J Clin Endocrinol Metab 2021; 106(8):e3178-e3184.
Desmeules P, Boudreau DK, Bastien N, Boulanger MC, Bossé Y, Joubert P, Couture C. Performance of an RNA-Based Next-Generation Sequencing Assay for Combined Detection of Clinically Actionable Fusions and Hotspot Mutations in NSCLC.. JTO Clin Res Rep 2022; 3(2):100276.
Quigley N, Lang-Lazdunski L, Boily-Daoust C, Couture C, Fortin M. An unusual isolated anterior mediastinal lesion.. Respirol Case Rep 2022; 10(11):e01059.
Ionescu DN, Stockley TL, Banerji S, Couture C, Mather CA, Xu Z, Blais N, Cheema PK, Chu QS, Melosky B, Leighl NB. Consensus Recommendations to Optimize Testing for New Targetable Alterations in Non-Small Cell Lung Cancer.. Curr Oncol 2022; 29(7):4981-4997.
Ruel LJ, Li Z, Gaudreault N, Henry C, Saavedra Armero V, Boudreau DK, Zhang T, Landi MT, Labbé C, Couture C, Desmeules P, Joubert P, Bossé Y. Tumor Mutational Burden by Whole-Genome Sequencing in Resected NSCLC of Never Smokers.. Cancer Epidemiol Biomarkers Prev 2022; 31(12):2219-2227.

Dr Christian Couture

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