Chercheur(e)

Dr Benoit Arsenault

Cardiologie

Y3106

benoit.arsenault@criucpq.ulaval.ca

Domaine de recherche

Métabolisme des lipoprotéines - Fonctionnalité des lipoprotéines de haute densité (HDL) - Cholestérol - Lipoprotéine(a) - PCSK9 - CETP - Nutrition - Activité physique - Génomique - Athérosclérose - Sténose aortique - Statines - Résistance à l'insuline

Description des travaux

Les travaux de notre laboratoire se concentrent sur l'impact de différentes interventions (modification des habitudes de vie, nutrition, activité physique, pharmacothérapie, etc.) sur la fonctionnalité des lipoprotéines de haute densité (HDL) chez l'humain. Nous testons également l'impact de ces différentes interventions sur d'autres biomarqueurs du métabolisme des lipoprotéines tels que PCSK9, la lipoprotéine(a), les phospholipides oxydées, la CETP et d'autres espèces lipidiques. L'association entre ces biomarqueurs, l'athérosclérose et la sténose aortique est également étudiée.

L'étude des déterminants génétiques de la fonctionnalité des HDL et des autres biomarqueurs en émergence du métabolisme des lipoprotéines ainsi que la pharmacogénomique de la réponse aux hypolipémiants se situe également au coeur de nos travaux.

Notre laboratoire s'intéresse également à l'impact des HDL sur la sécrétion d'insuline par les cellules beta du pancréas et aux mécanismes intracellulaires qui sont influencés par les HDL dans la cellule beta.

Prix et distinctions

Août 2011 : Obtention du prix Clinical Science Young Investigator Award, remis par la Société européenne de Cardiologie à Paris.
Novembre 2011 : Nomination pour le prix Council Award for Outstanding Research by an Early Career Investigator de la Société Arteriosclerosis, Thrombosis and Vascular Biology à Orlando, USA.
Mai 2014 : Prix pour la meilleure présentation par affiche au congrès de la Société européenne d’athérosclérose à Madrid.

Publications

125

Trier par année :

Sondermeijer BM, Rana JS, Arsenault BJ, Shah PK, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT.. Non-HDL cholesterol vs. Apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study.. Eur J Clin Invest 2013; 43(10):1009-15.
Mahmut A, Boulanger MC, Fournier D, Couture C, Trahan S, Pagé S, Arsenault B, Després JP, Pibarot P, Mathieu P. Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling.. Eur J Clin Invest 2013; 43(6):570-8.
Boekholdt SM, Arsenault BJ, Hovingh GK, Mora S, Pedersen TR, Larosa JC, Welch KM, Amarenco P, Demicco DA, Tonkin AM, Sullivan DR, Kirby A, Colhoun HM, Hitman GA, Betteridge DJ, Durrington PN, Clearfield MB, Downs JR, Gotto AM Jr, Ridker PM, Kastelein JJ.. Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events among Statin-Treated Patients: A Meta-Analysis.. Circulation 2013; 128(14):1504-12.
Arsenault BJ, Larose E.. Appreciating the local and systemic effects of exercise training on vascular health.. Atherosclerosis 2013; 231(1):15-7.
Bouchareb R, Mahmut A, Nsaibia MJ, Boulanger MC, Dahou A, Lépine JL, Laflamme MH, Hadji F, Couture C, Trahan S, Pagé S, Bossé Y, Pibarot P, Scipione CA, Romagnuolo R, Koschinsky ML, Arsenault BJ, Marette A, Mathieu P. Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.. Circulation 2015; 132(8):677-90.
Arsenault BJ, Dubé MP, Brodeur MR, de Oliveira Moraes AB, Lavoie V, Kernaleguen AE, Guauque-Olarte S, Mathieu P, Pibarot P, Messika-Zeitoun D, Bossé Y, Rhainds D, Rhéaume E, Tardif JC. Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.. Arterioscler Thromb Vasc Biol 2014; 34(2):457-62.
Arsenault BJ, Boekholdt SM, Mora S, DeMicco DA, Bao W, Tardif JC, Amarenco P, Pedersen T, Barter P, Waters DD.. Impact of high-dose atorvastatin therapy and clinical risk factors on incident aortic valve stenosis in patients with cardiovascular disease (from TNT, IDEAL, and SPARCL).. Am J Cardiol 2014; 113(8):1378-82.
Arsenault B, Boekholdt SM.. Clinical and biological relevance of statin-mediated changes in HDL metabolism.. Curr Atheroscler Rep 2014; 16(1):379.
Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, LaRosa JC, Waters DD, DeMicco DA, Simes RJ, Keech AC, Colquhoun D, Hitman GA, Betteridge DJ, Clearfield MB, Downs JR, Colhoun HM, Gotto AM Jr, Ridker PM, Grundy SM, Kastelein JJ.. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.. J Am Coll Cardiol 2014; 64(5):485-94.
Arsenault BJ, Boekholdt SM, Dubé MP, Rhéaume E, Wareham NJ, Khaw KT, Sandhu MS, Tardif JC. Lipoprotein(a) levels, genotype and incident aortic valve stenosis: A prospective Mendelian randomization study and replication in a case-control cohort.. Circ Cardiovasc Genet 2014; 7(3):304-10.
Arsenault BJ, Barter P, DeMicco DA, Bao W, Preston GM, LaRosa JC, Grundy SM, Deedwania P, Greten H, Wenger NK, Shepherd J, Waters DD, Kastelein JJ; Treating to New Targets (TNT) Investigators.. Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers.. PLoS One 2014; 9(12):e114519.
Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S; TNT Trial Investigators.. Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy: The TNT Trial.. J Am Coll Cardiol 2015; 65(13):1286-95.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YD, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E; Welcome Trust Case Control Consortium, Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CN, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ.. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.. Nat Commun 2014; 5(0):5068.
Kohli P, Waters DD, Nemr R, Arsenault BJ, Messig M, DeMicco DA, Laskey R, Kastelein JJ.. Risk of new-onset diabetes and cardiovascular risk reduction from high-dose statin therapy in pre-diabetics and non-pre-diabetics: an analysis from TNT and IDEAL.. J Am Coll Cardiol 2015; 65(4):402-4.
Capoulade R, Mahmut A, Tastet L, Arsenault M, Bédard É, Dumesnil JG, Després JP, Larose É, Arsenault BJ, Bossé Y, Mathieu P, Pibarot P. Impact of Plasma Lp-PLA2 Activity on the Progression of Aortic Stenosis: The PROGRESSA Study.. JACC Cardiovasc Imaging 2015; 8(1):26-33.
Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.. J Am Coll Cardiol 2015; 66(11):1236-46.
Guauque-Olarte S, Messika-Zeitoun D, Droit A, Lamontagne M, Tremblay-Marchand J, Lavoie-Charland E, Gaudreault N, Arsenault BJ, Dubé MP, Tardif JC, Body SC, Seidman JG, Boileau C, Mathieu P, Pibarot P, Bossé Y. Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.. Circ Cardiovasc Genet 2015; 8(6):812-22.
Arsenault BJ, Pelletier-Beaumont E, Alméras N, Tremblay A, Poirier P, Bergeron J, Després JP.. PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program.. Atherosclerosis 2014; 236(2):321-6.
Rhéaume C, Arsenault BJ, Després JP, Faha, Boekholdt SM, Wareham NJ, Khaw KT, Chir M. Impact of abdominal obesity and systemic hypertension on risk of coronary heart disease in men and women: the EPIC-Norfolk Population Study.. J Hypertens 2014; 32(11):2224-30; discussio.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Dahou A, Salaun E, Bossé Y, Clavel MA, Arsenault BJ, Pibarot P, Mathieu P. Soluble CD14 is associated with the structural failure of bioprostheses.. Clin Chim Acta 2018; 485(0):173-177.
Mahmut A, Mahjoub H, Boulanger MC, Dahou A, Bouchareb R, Capoulade R, Arsenault BJ, Larose E, Bossé Y, Pibarot P, Mathieu P. Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses.. Clin Chim Acta 2016; 455(0):20-5.
Arsenault BJ, Boyer M, Kastelein JJ.. What does the future hold for cholesteryl ester transfer protein inhibition?. Curr Opin Lipidol 2015; 26(6):526-35.
Salaun E, Mahjoub H, Dahou A, Mathieu P, Larose E, Després JP, Rodés-Cabau J, Arsenault BJ, Puri R, Clavel MA, Pibarot P. Hemodynamic Deterioration of Surgically Implanted Bioprosthetic Aortic Valves.. J Am Coll Cardiol 2018; 72(3):241-251.
Mohamed N, Mahmut A, Boulanger MC, Arsenault BJ, Bouchareb R, Simard S, Witztum JL, Clavel MA, Pibarot P, Bossé Y, Tsimikas S, Mathieu P. Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease.. J Int Med Res 2016; 280(5):509-17.
Boyer M, Mitchell PL, Poirier P, Alméras N, Tremblay A, Bergeron J, Després JP, Arsenault BJ. Impact of a one-year lifestyle modification program on cholesterol efflux capacities in men with abdominal obesity and dyslipidemia.. Am J Physiol Endocrinol Metab 2018; 315(4):E460-E468.
Nsaibia MJ, Mahmut A, Mahjoub H, Dahou A, Bouchareb R, Boulanger MC, Després JP, Bossé Y, Arsenault BJ, Larose E, Pibarot P, Mathieu P. Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration.. Heart 2016; 102(23):1915-1921.
Boyer M, Lévesque V, Poirier P, Marette A, Mathieu P, Després JP, Larose É, Arsenault BJ. Impact of a 1-year lifestyle modification program on plasma lipoprotein and PCSK9 concentrations in patients with coronary artery disease.. J Clin Lipidol 2016; 10(6):1353-1361.
Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial.. Atherosclerosis 2017; 260(0):1-7.
de Oliveira Moraes AB, Stähli BE, Arsenault BJ, Busseuil D, Merlet N, Gebhard C, Fortier A, Rhainds D, Dubé MP, Guertin MC, Asgar A, Rhéaume E, Tardif JC. Resting heart rate as a predictor of aortic valve stenosis progression.. Int J Cardiol 2016; 204(0):149-51.
Waters DD, Arsenault BJ. Predicting Prognosis in Acute Coronary Syndromes: Makeover Time for TIMI and GRACE?. Can J Cardiol 2016; 32(11):1290-3.
van Wijk DF, Boekholdt SM, Arsenault BJ, Ahmadi-Abhari S, Wareham NJ, Stroes ES, Khaw KT. C-Reactive Protein Identifies Low-Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer-Norfolk Prospective Population Study.. J Am Heart Assoc 2016; 5(6):e002823.
Arsenault BJ, Kohli P, Lambert G, DeMicco DA, Laskey R, Messig MM, Kastelein JJ, Waters DD. Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study).. Am J Cardiol 2016; 118(4):494-8.
Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Li X, Psaty BM, Stein CM, Rotter JI, Jukema JW. Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.. Pharmacogenomics 2016; 17(15):1621-8.
Arsenault BJ, Puri R. Reducing exposure to cardiovascular risk factors: the legacy of prevention.. J Thorac Dis 2016; 8(9):2340-3.
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.. J Med Genet 2016; 53(12):835-45.
Verbeek R, Boyer M, Boekholdt SM, Hovingh GK, Kastelein JJ, Wareham N, Khaw KT, Arsenault BJ. Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.. Arterioscler Thromb Vasc Biol 2017; 37(1):43-8.
Perrot N, Verbeek R, Sandhu M, Boekholdt SM, Hovingh GK, Wareham NJ, Khaw KT, Arsenault BJ. Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study.. Atherosclerosis 2017; 256(0):47-52.
Arsenault BJ, Perrot N, Couture P. Does lifestyle contribute to disease severity in patients with inherited lipid disorders?. Curr Opin Lipidol 2017; 28(2):177-85.
Mathieu P, Arsenault BJ. CAVD: Civilization Aortic Valve Disease.. Eur Heart J 2017; 38(28):2198-200.
de Toro-Martín J, Arsenault BJ, Després JP, Vohl MC. Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome.. Nutrients 2017; 9(8):E913.
Arsenault BJ, Lamarche B, Després JP. Targeting Overconsumption of Sugar-Sweetened Beverages vs. Overall Poor Diet Quality for Cardiometabolic Diseases Risk Prevention: Place Your Bets!. Nutrients 2017; 9(6):E600.
Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Le Quang K, Hadji F, Argaud D, Dahou A, Bossé Y, Koschinsky ML, Pibarot P, Arsenault BJ, Marette A, Mathieu P. OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-KB pathway.. Cardiovasc Res 2017; 113(11):1351-1363.
Jubinville É, Talbot M, Bérubé JC, Hamel-Auger M, Maranda-Robitaille M, Beaulieu MJ, Aubin S, Paré MÈ, Kallend DG, Arsenault B, Bossé Y, Morissette MC. Interplay between cigarette smoking and pulmonary reverse lipid transport.. Eur Respir J 2017; 50(3):1700681.
Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML. Pathobiology of Lp(a) in calcific aortic valve disease.. Expert Rev Cardiovasc Ther 2017; 15(10):797-807.
Poirier P, Marette A, Després JP, Larose E, Arsenault BJ.. Mortality in the Familial Atherosclerosis Treatment Study-Observational Study.. J Clin Lipidol 2017; 11(1):309-10.
Boekholdt SM, Arsenault BJ, Mathieu P. Coronary Artery Disease Affects Symptomatology of Aortic Valve Stenosis.. J Am Coll Cardiol 2017; 70(8):1103-1104.
Brassard D, Arsenault BJ, Boyer M, Bernic D, Tessier-Grenier M, Talbot D, Tremblay A, Levy E, Asztalos B, Jones PJH, Couture P, Lamarche B. Saturated fats from butter but not from cheese increase HDL-mediated cholesterol efflux capacity from J774 macrophages in men and women with abdominal obesity. J Nutr 2018; 148(4):573-80.
Puri R, Ballantyne CM, Hoogeveen RC, Shao M, Barter P, Libby P, Chapman MJ, Erbel R, Arsenault BJ, Raichlen JS, Nissen SE, Nicholls SJ.. Lipoprotein(a) and coronary atheroma progression rates during long-term high-intensity statin therapy: Insights from SATURN.. Atherosclerosis 2017; 263(0):137-44.
Arsenault BJ, Bourgeois R, Mathieu P. Do Oxidized Lipoproteins Cause Atherosclerotic Cardiovascular Diseases?. Can J Cardiol 2017; 33(12):1513-1516.
Arsenault BJ, Després JP.. Cardiovascular disease prevention: lifestyle attenuation of genetic risk.. Nat Rev Cardiol 2017; 14(4):187-8.
Boyer M, Piché ME, Auclair A, Grenier-Larouche T, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Carpentier AC, Poirier P, Arsenault BJ. Acute and Chronic Impact of Bariatric Surgery on Plasma LDL Cholesterol and PCSK9 Levels in Patients With Severe Obesity.. J Clin Endocrinol Metab 2017; 102(11):4023-4030.
Tastet L, Capoulade R, Shen M, Clavel MA, Côté N, Mathieu P, Arsenault M, Bédard É, Tremblay A, Samson M, Bossé Y, Dumesnil JG, Arsenault BJ, Beaudoin J, Bernier M, Després JP, Pibarot P. ApoB/ApoA-I Ratio is Associated With Faster Hemodynamic Progression of Aortic Stenosis: Results From the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) Study.. J Am Heart Assoc 2018; 7(4):e007980.
Piché ME, Laberge AS, Brassard P, Arsenault BJ, Costerousse O, Bertrand OF, Després JP, Poirier P. Rosiglitazone lowers resting and blood pressure response to exercise in men with type 2 diabetes: A 1-year randomized study.. Diabetes Obes Metab 2018; 20(7):1740-1750.
Arsenault BJ, Petrides F, Tabet F, Bao W, Hovingh GK, Boekholdt SM, Ramin-Mangata S, Meilhac O, DeMicco D, Rye KA, Waters DD, Kastelein JJP, Barter P, Lambert G.. Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk. J Clin Lipidol 2018; 12(1):130-136.
Arsenault BJ, Perrot N, Puri R.. Therapeutic agents targeting cardiometabolic risk for preventing and treating atherosclerotic cardiovascular diseases.. Clin Pharmacol Ther 2018; 104(2):257-268.
Boyer M, Lévesque V, Poirier P, Marette A, Mitchell PL, Mora S, Mathieu P, Després JP, Larose E, Arsenault BJ. Longitudinal Changes in Cholesterol Efflux Capacities in Patients With Coronary Artery Disease Undergoing Lifestyle Modification Therapy.. J Am Heart Assoc 2018; 7(11):e008681.
Perrot N, Boekholdt SM, Mathieu P, Wareham NJ, Khaw KT, Arsenault BJ. Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.. Int J Cardiol 2018; 269(0):226-228.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.. Heart 2020; 106(10):738-745.
Bourgeois R, Piché ME, Auclair A, Grenier-Larouche T, Mitchell PL, Poirier P, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Carpentier AC, Arsenault BJ. Acute and chronic effect of bariatric surgery on circulating autotaxin levels.. Physiol Rep 2019; 7(5):e14004.
Bouchareb R, Boulanger MC, Tastet L, Mkannez G, Nsaibia MJ, Hadji F, Dahou A, Messadeq Y, Arsenault BJ, Pibarot P, Bossé Y, Marette A, Mathieu P. Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.. Eur Heart J 2019; 40(17):1362-1373.
Lindman BR, Clavel MA, Abu-Alhayja'a R, Côté N, Dagenais F, Novak E, Voisine P, Poulin A, Arsenault BJ, Desmeules P, Dahou A, Taster L, Aldahoun K, Bossé Y, Mathieu P, Pibarot P. Multimarker Approach to Identify Patients With Higher Mortality and Rehospitalization Rate After Surgical Aortic Valve Replacement for Aortic Stenosis.. JACC Cardiovasc Interv 2018; 11(21):2172-2181.
Perrot N, Thériault S, Dina S, Chen HY, Boekholdt SM, Rigade S, Després MA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert J, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ.. Variation in LPA and calcific aortic valve stenosis in patients undergoing cardiac surgery and familial risk of aortic valve microcalcification.. JAMA Cardiol 2019; 4(7):620-627.
Neeland IJ, Ross R, Després JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH.. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a joint position of the International Atherosclerosis Society and International Chair on Cardiometabolic Risk Working Group on Visceral Obesity.. Lancet Diabetes Endocrinol 2019; 7(9):715-725.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Bourgeois R, Trottier M, Tessier M, Guimont J, Nadeau M, Thériault S, Bossé Y. Witzum JL, Couture P, Mathieu P, Dweck M, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.. Lipoprotein(a), oxidized phospholipids and aortic valve microcalcification assessed by 18-NaF PET/CT.. CJC Open 2019; 1(3):131-140.
Poggio P, Songia P, Cavallotti L, Barbieri SS, Zanotti I, Arsenault BJ, Valerio V, Ferri N, Capoulade R, Camera M.. PCSK9 Involvement in Aortic Valve Calcification.. J Am Coll Cardiol 2018; 72(24):3225-3227.
Zheng K, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Newby DE, Koschinsky ML. Fayad Z, Stroes ESG, Boekholdt SM, Dweck MR.. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol 2019; 73(17):2150-2162.
Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Dubé MP, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dufresne L, Eriksson N, Foco L, Gijsberts CM, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Fitzpatrick N, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Bogaty P, de Borst GJ, Brenner H, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Johnson JA, de Jong PA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Pepinski W, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Scholz M, Siegbahn A, Sinisalo J, Smith JG, Spertus JA, Stewart AFR, Szczeklik W, Szpakowicz A, Ten Berg JM, Thanassoulis G, Thiery J, van der Graaf Y, Visseren FLJ, Waltenberger J, Van der Harst P, Tardif JC, Sattar N, Lang CC, Pare G, Brophy JM, Anderson JL, März W, Wallentin L, Cameron VA, Horne BD, Samani NJ, Hingorani AD, Asselbergs FW. Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.. Circ Genom Precis Med 2019; 12(4):e002471.
Rosa M, Chignon A, Li Z, Boulanger MC, Arsenault BJ, Bossé Y, Thériault S, Mathieu P. A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.. NPJ Genom Med 2019; 4(0):23.
Bastien M, Poirier P, Brassard P, Arsenault BJ, Bertrand OF, Després JP, Costerousse O, Piché ME. Effect of PPAR? agonist on aerobic exercise capacity in relation to body fat distribution in men with type 2 diabetes mellitus and coronary artery disease: a 1-yr randomized study.. Am J Physiol Endocrinol Metab 2019; 317(1):E65-E73.
Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Allayee H, Almgren P, Alver M, Baranova EV, Behloui H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dubé MP, Dufresne L, Eriksson N, Foco L, Scholz M, Gijsberts CM, Glinge C, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kotti S, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Al Ali L, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Engstrøm T, Fitzpatrick N, Fox K, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Boersma EH, Bogaty P, Bots ML, Brenner H, Brugts JJ, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, Danchin N, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Grobbee DE, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Jabbari R, Johnson JA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Niemcunowicz-Janica A, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Siegbahn A, Simon T, Sinisalo J, Smith JG, Spertus JA, Stender S, Stewart AFR, Szczeklik W, Szpakowicz A, Tardif JC, Ten Berg JM, Tfelt-Hansen J, Thanassoulis G, Thiery J, Torp-Pedersen C, van der Graaf Y, Visseren FLJ, Waltenberger J, Weeke PE, Van der Harst P, Lang CC, Sattar N, Cameron VA, Anderson JL, Brophy JM, Pare G, Horne BD, März W, Wallentin L, Samani NJ, Hingorani AD, Asselbergs FW. Subsequent Event Risk in Individuals With Established Coronary Heart Disease.. Circ Genom Precis Med 2019; 12(4):e002470.
Thériault S, Dina C, Messika-Zitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Verhoye JP, Baufreton C, Probst V, Roussel R, the D.E.S.I.R. Study Group, Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ.. Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis. Circ Genom Precis Med 2019; 12(10):e002617.
Zheng KH, Arsenault BJ, Kaiser Y, Khaw KY, Wareham NJ, Stroes ESG, Boekholdt SM.. apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence: Insights From the EPIC-Norfolk Prospective Population Study. J Am Heart Assoc 2019; 8(16):e013020.
Desgagné V, Guérin R, Guay SP, Boyer M, Jutchins E, Picard S, Maréchal A, Corbin F, Van Keuren-Jensen K, Arsenault BJ, Bouchard L.. Human High-Density Lipoprotein Microtranscriptome Is Unique and Suggests an Extended Role in Lipid Metabolism. Epigenomics 2019; 11(8):917-934.
Arsenault BJ.. Exposure to Low Lipoprotein(a) Levels: Key to Healthy Aging?. J Am Coll Cardiol 2019; 74(24):2995-2997.
Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin BA, Zambon A, Barter P, Fruchart JC, Eckel RH, Matsuzawa Y, Després JP. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity.. Nat Rev Endocrinol 2020; 16(3):177-189.
Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ. Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.. JACC Basic Transl Sci 2020; 5(7):649-661.
Perrot N, Thériault S, Rigade S, Chen HY, Dina C, Martinsson A, Boekholdt M, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Engert JC, Wareham NJ, Clavel MA, Pibarot P, Smith G, Schott JJ, Mathieu P, Bossé Y, Thanassoulis G, Arsenault BJ. Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.. Heart 2020; 106(18):1407-1412.
Després AA, Piché ME, Auclair A, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Lescelleur O, Julien F, Martin J, Tchernof A, Mathieu P, Poirier P, Arsenault BJ. Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.. Obes Surg 2020; 30(10):3714-3720.
Li Z, Gaudreault N, Arsenault BJ, Mathieu P, Bossé Y, Thériault S. Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.. Commun Biol 2020; 3(1):477.
Chignon A, Bon-Baret V, Boulanger MC, Li Z, Argaud D, Bossé Y, Thériault S, Arsenault BJ, Mathieu P. Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases.. Commun Biol 2020; 3(1):206.
Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G. Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.. JAMA Cardiol 2020; 5(6):694-702.
Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM. Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.. JAMA Netw Open 2020; 3(2):e200129.
Perazza LR, Mitchell PL, Jensen BAH, Daniel N, Boyer M, Varin TV, Bouchareb R, Nachbar RT, Bouchard M, Blais M, Gagné A, Joubert P, Sweeney G, Roy D, Arsenault BJ, Mathieu P, Marette A. Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr^-/-ApoB^100/100 mice.. Atherosclerosis 2020; 304(0):9-21.
Bourgeois R, Devillers R, Perrot N, Després AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ. Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.. JACC Basic Transl Sci 2020; 5(9):888-897.
Ghodsian N, Gagnon E, Bourgault J, Gobeil É, Manikpurage HD, Perrot N, Girard A, Mitchell PL, Arsenault BJ.. Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study.. Nutrients 2021; 13(12):4208.
Drouin-Chartier JP, Tremblay AJ, Godbout D, Gagnon A, Clavel MA, Clisson M, Arsenault BJ, Pibarot P, Larose E, Couture P. Correlates of Coronary Artery Calcification Prevalence and Severity in Patients With Heterozygous Familial Hypercholesterolemia.. CJC Open 2021; 3(1):62-70.
Bon-Baret V, Chignon A, Boulanger MC, Li Z, Argaud D, Arsenault BJ, Thériault S, Bossé Y, Mathieu P. System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan.. Circ Genom Precis Med 2021; 14(2):e003196.
Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ. Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.. Metabolites 2021; 11(7):459.
Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ. Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.. Circ Genom Precis Med 2021; 14(4):e003271.
Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschinsky ML, Mathieu P, Arsenault BJ. A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.. CJC Open 2020; 3(4):450-459.
Ghodsian N, Abner E, Emdin CA, Gobeil É, Taba N, Haas ME, Perrot N, Manikpurage HD, Gagnon É, Bourgault J, St-Amand A, Couture C, Mitchell PL, Bossé Y, Mathieu P, Vohl MC, Tchernof A, Thériault S, Khera AV, Esko T, Arsenault BJ. Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.. Cell Rep Med 2021; 2(11):100437.
Perrot N, Pelletier W, Bourgault J, Couture C, Li Z, Mitchell PL, Ghodsian N, Bossé Y, Thériault S, Mathieu P, Arsenault BJ. A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.. Aging Cell 2021; 20(11):e13497.
Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S. Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.. Circ Genom Precis Med 2021; 14(6):e003452.
Tremblay M, Perrot N, Ghodsian N, Gobeil É, Couture C, Mitchell PL, Thériault S, Arsenault BJ. Circulating Galectin-3 Levels Are Not Associated With Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study.. J Clin Endocrinol Metab 2021; 106(8):e3178-e3184.
Lindman BR, Sukul D, Dweck MR, Madhavan MV, Arsenault BJ, Coylewright M, Merryman WD, Newby DE, Lewis J, Harrell FE Jr, Mack MJ, Leon MB, Otto CM, Pibarot P. Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review.. J Am Coll Cardiol 2021; 78(23):2354-2376.
Clément AA, Desgagné V, Légaré C, Guay SP, Boyer M, Hutchins E, Corbin F, Van Keuren-Jensen K, Arsenault BJ, Guérin R, Bouchard L.. HDL-enriched miR-30a-5p is associated with HDL-cholesterol levels and glucose metabolism in healthy men and women.. Epigenomics 2021; 13(13):985-994.
Chignon A, Mathieu S, Rufiange A, Argaud D, Voisine P, Bossé Y, Arsenault BJ, Thériault S, Mathieu P. Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease.. Hum Genomics 2022; 16(1):8.
Pérusse L, Jacob R, Drapeau V, Llewellyn C, Arsenault BJ, Bureau A, Labonté MÈ, Tremblay A, Vohl MC. Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation.. Lifestyle Genom 2022; 15(2):67-76.
Yuan S, Chen J, Li X, Fan R, Arsenault B, Gill D, Giovannucci EL, Zheng JS, Larsson SC. Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study.. Eur J Epidemiol 2022; 37(7):723-733.
Mathieu S, Briend M, Abner E, Couture C, Li Z, Bossé Y, Thériault S, Esko T, Arsenault BJ, Mathieu P. Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.. iScience 2022; 25(9):104992.
Moncla LM, Mathieu S, Sylla MS, Bossé Y, Thériault S, Arsenault BJ, Mathieu P. Mendelian randomization of circulating proteome identifies actionable targets in heart failure.. BMC Genomics 2022; 23(1):588.
Gobeil É, Maltais-Payette I, Taba N, Brière F, Ghodsian N, Abner E, Bourgault J, Gagnon E, Manikpurage HD, Couture C, Mitchell PL, Mathieu P, Julien F, Corbeil J, Vohl MC, Thériault S, Esko T, Tchernof A, Arsenault BJ. Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease.. Metabolites 2022; 12(5):440.
Gagnon E, Pelletier W, Gobeil É, Bourgault J, Manikpurage HD, Maltais-Payette I, Abner E, Taba N, Esko T, Mitchell PL, Ghodsian N, Després JP, Vohl MC, Tchernof A, Thériault S, Arsenault BJ. Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases.. Commun Med (Lond) 2022; 2(0):130.
Brassard D, Manikpurage HD, Thériault S, Arsenault BJ, Lamarche B. Greater Adherence to the 2019 Canada's Food Guide Recommendations On Healthy Food Choices Reduces the Risk of Cardiovascular Disease in Adults: a Prospective Analysis of UK Biobank Data.. Am J Clin Nutr 2022; 116(6):1748-1758.
Gagnon E, Mitchell PL, Manikpurage HD, Abner E, Taba N, Esko T, Ghodsian N, Thériault S, Mathieu P, Arsenault BJ. Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study.. J Transl Med 2023; 21(1):60.
Trompet S, Postmus I, Warren E, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault BJ, Chasman D, Hitman GA, Munroe PB, Rotter JI, Psaty BM, Caulfield M, Krauss RM, Cupples A, Jukema JW.. The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction.. Front Pharmacol 2022; 12(0):679857.
Légaré C, Clément AA, Desgagné V, Thibeault K, White F, Guay SP, Arsenault BJ, Scott MS, Jacques PÉ, Perron P, Guérin R, Hivert MF, Bouchard L.. Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy.. Reprod Biol Endocrinol 2022; 20(1):14.
Kaiser Y, Nurmohamed N, Kroon J, Verberne H, Tzolos E, Dweck M, Somsen GA, Arsenault BJ, Stroes ESG, Zheng KH, Boekholdt SM.. Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis.. Heart 2022; 108(1):61-66.
Arsenault BJ.. The promise and challenges of RNA-targeted therapeutics in preventive cardiology.. Eur Heart J 2022; 43(7):550-552.
Arsenault BJ, Kamstrup PR.. Lipoprotein(a) and cardiovascular and valvular diseases: A genetic epidemiological perspective.. Atherosclerosis 2022; 349(0):7-16.
Arsenault BJ.. From the garden to the clinic: how Mendelian randomization is shaping up atherosclerotic cardiovascular disease prevention strategies.. Eur Heart J 2022; 43(42):4447-4449.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky ML, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard B, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JF, Ray KK, Tokgözoglu L, Catapano AL.. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.. Eur Heart J 2022; 43(39):3925-3946.
Gagnon E, Mitchell PL, Arsenault BJ.. Body fat distribution, fasting insulin levels and insulin secretion: A bidirectional Mendelian randomization study.. J Clin Endocrinol Metab 2023; 108(6):1308-1317.
Gagnon E, Girard A, Gobeil E, Bourgault J, Couture C, Mitchell PL, Bouchard C, Tremblay A, Mathieu P, Michaud A, Pérusse L, Arsenault BJ.. Genetic control of body weight by the human brain proteome. iScience 2023; 26(4):106376.
Bourgault J, Abner E, Manikpurage HD, Pujol-Gualdo N, Laisk T, Estonian Biobank Research Team, Gobeil E, Gagnon E, Girard A, Mitchell PL, Thériault S, Esko T, Mathieu P, Arsenault BJ.. Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis.. Gastroenterology 2023; 164(6):953-965.e3.
Gagnon E, Manikpurage HD, Mitchell PL, Girard A, Gobeil É, Bourgault J, Bégin F, Marette A, Thériault S, Arsenault BJ.. Large-scale metabolomic profiling and incident non-alcoholic fatty liver disease.. iScience 2023; 26(7):107127.
Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ.. Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.. Eur Heart J Open 2023; 3(2):oead032.
Arsenault BJ, Després JP. Physical Activity for Type 2 Diabetes Prevention: Some Is Better Than None, More Is Better, and Earliest Is Best.. Diabetes Care 2023; 46(6):1132-1134.
Paulin A, Manikpurage HD, Després JP, Thériault S, Arsenault BJ. Sex-Specific Impact of Body Weight on Atherosclerotic Cardiovascular Disease Incidence in Individuals With and Without Ideal Cardiovascular Health.. J Am Heart Assoc 2023; 12(13):e028502.
Manikpurage HD, Paulin A, Girard A, Eslami A, Mathieu P, Thériault S, Arsenault BJ. Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.. Circ Genom Precis Med 2023; 16(5):470-477.
Després AA, Arsenault BJ.. Lipoprotein(a)It Is Risky, but What Do We Do About It?. Curr Cardiovasc Risk Rep 2018; 12(0):27.
Puri R, Nissen SE, Arsenault BJ, St John J, Riesmeyer JS, Ruotolo G, McErlean E, Menon V, Cho L, Wolski K, Lincoff AM, Nicholls SJ.. Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease: A Prespecified Secondary Analysis of the ACCELERATE Trial.. JAMA Cardiol 2020; 5(10):1136-1143.
Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng QP, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, le Cessie S, Stein CM, Jukema JW; GIST consortium.. Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics J 2020; 20(3):462-470.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky ML, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard B, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JF, Ray KK, Tokgözoglu L, Catapano AL.. Frequent questions and responses on the 2022 lipoprotein(a) consensus statement of the European Atherosclerosis Society.. Atherosclerosis 2023; 374(0):107-120.
Gagnon E, Paulin A, Mitchell PL, Arsenault BJ.. Disentangling the impact of gluteofemoral versus visceral fat accumulation on cardiometabolic health using sex-stratified Mendelian randomization.. Atherosclerosis 2023; 386(0):117371.

Dr Benoit Arsenault

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