Domaine de recherche
Mécanismes du développement de l'hypertrophie cardiaque excentrique dans l'insuffisance valvulaire aortique et son traitement.
Description des travaux
L'insuffisance ou régurgitation de la valve aortique est une maladie devenue moins fréquente dans les populations plus favorisées de la planète mais qui continue à faire des ravages dans celles plus pauvres ou ayant un accès difficile à des soins de santé modernes. Dans le cas sévères, le coeur se dilate de façon importante pour accommoder le surplus de sang à pomper qui régurgite de l'aorte vers le ventricule gauche.
Outre la chirurgie de remplacement valvulaire par une prothèse lorsque des symptômes commencent à apparaître, aucun traitement médical n'a été reconnu efficace pour retarder l'évolution de cette maladie. Notre équipe cherche à mieux comprendre les mécanismes impliqués dans la dilatation du ventricule gauche et à trouver des moyens pharmacologiques pour la ralentir et aider le myocarde à maintenir sa contractilité.
Chez des modèles animaux de cette maladie, nous étudions plus spécifiquement les systèmes beta-adrénergique et rénine-angiotensine comme cibles thérapeutiques.
Prix et distinctions
3- 2005-2009: Chercheure-boursière-clinicienne senior FRSQ
- 2002-2005: Chercheure-boursière-clinicienne junior II FRSQ
- 2000-2002: Chercheure-boursière-clinicienne junior I FRSQ
Publications
86- Arsenault M, Crète M, Bergeron S. Left ventricular shape assessment: a new simple diagnostic tool in stress echocardiography. J Am Soc Echocardiogr 2002; 15(11):1321-5.
- Arsenault M, Plante E, Drolet MC, Couet J. Experimental aortic regurgitation in rats under echocardiographic guidance. J Heart Valve Dis 2002; 11(1):128-34.
- Bogaty P, Boyer L, Rousseau L, Arsenault M. Is anteroseptal myocardial infarction an appropriate term?. Am J Med 2002; 113(1):37-41.
- Tardif JC, Doré A, Chan KL, Fagan S, Honos G, Marcotte F, Yu E, Siu S, Dumesnil J, Arsenault M, Koilpillai C, D'onofrio F. Economic impact of contrast stress echocardiography on the diagnosis and initial treatment of patients with suspected coronary artery disease. J Am Soc Echocardiogr 2002; 15(11):1335-45.
- Dumesnil JG, Paulin C, Pibarot P, Coulombe D, Arsenault M. Mitral annulus velocities by Doppler tissue imaging: practical implications with regard to preload alterations, sample position, and normal values. J Am Soc Echocardiogr 2002; 15(10):1226-31.
- Drolet MC, Arsenault M, Couet J. Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 2003; 41(7):1211-7.
- Dumont Y, Arsenault M. An alternative to standard continuity equation for the calculation of aortic valve area by echocardiography. J Am Soc Echocardiogr 2003; 16(12):1309-15.
- Bogaty P, Dagenais GR, Poirier P, Boyer L, Auclair L, Pépin G, Jobin J, Arsenault M. Effect of atorvastatin on exercise-induced myocardial ischemia in patients with stable angina pectoris. Am J Cardiol 2003; 92(10):1192-5.
- Hamelin BA, Méthot J, Arsenault M, Pilote S, Poirier P, Plante S, Bogaty P. Influence of the menstrual cycle on the timing of acute coronary events in premenopausal women. Am J Med 2003; 114(7):599-602.
- Plante E, Couet J, Gaudreau M, Dumas MP, Drolet MC, Arsenault M. Left ventricular response to sustained volume overload from chronic aortic valve regurgitation in rats. J Card Fail 2003; 9(2):128-40.
- Plante E, Lachance D, Gaudreau M, Drolet MC, Roussel E, Arsenault M, Couet J. Effectiveness of beta-blockade in experimental chronic aortic regurgitation.. Circulation 2004; 110(11):1477-83.
- Méthot J, Hamelin BA, Bogaty P, Arsenault M, Plante S, Poirier P. Does hormonal status influence the clinical presentation of acute coronary syndromes in women?. J Womens Health (Larchmt) 2004; 13(6):695-702.
- Sharma A, Pilote S, Bélanger PM, Arsenault M, Hamelin BA. A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.. Br J Clin Pharmacol 2004; 58(3):288-97.
- Drolet MC, Plante E, Battistini B, Couet J, Arsenault M. Early endothelial dysfunction in cholesterol-fed rabbits: a non-invasive in vivo ultrasound study.. Cardiovasc Ultrasound 2004; 2(1):10.
- Plante E, Gaudreau M, Lachance D, Drolet MC, Roussel E, Gauthier C, Lapointe E, Arsenault M, Couet J. Angiotensin-converting enzyme inhibitor captopril prevents volume overload cardiomyopathy in experimental chronic aortic valve regurgitation.. Can J Physiol Pharmacol 2004; 82(3):191-9.
- Bogaty P, Boyer L, Rousseau L, Arsenault M.. Is anteroseptal myoccardial infarction an appropriate term?. Am J Med 2002; 0(0):in press.
- Arsenault M, Bergeron S, Dumesnil JG, Fortin MP, Poirier P. Anginal threshold between stress tests: exercise versus dobutamine stress echocardiography.. Med Sci Sports Exerc 2005; 37(1):18-23.
- Sharma A, Pibarot P, Pilote S, Dumesnil JG, Arsenault M, Bélanger PM, Meibohm B, Hamelin BA. Modulation of metoprolol pharmacokinetics and hemodynamics by diphenhydramine coadministration during exercise testing in healthy premenopausal women.. J Pharmacol Exp Ther 2005; 313(3):1172-81.
- Drolet MC, Roussel E, Deshaies Y, Couet J, Arsenault M. A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice.. J Am Coll Cardiol 2006; 47(4):850-5.
- Méthot J, Hamelin BA, Bogaty P, Arsenault M, Plante S, Poirier P. ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women.. Int J Cardiol 2005; 105(3):308-14.
- Plante E, Lachance D, Drolet MC, Roussel E, Couet J, Arsenault M. Dobutamine stress echocardiography in healthy adult male rats.. Cardiovasc Ultrasound 2005; 3(0):34.
- Sanfilippo AJ, Bewick D, Chan KL, Cujec B, Dumesnil JG, Honos G, Munt B, Sasson Z, Tam J, Tomlinson C, Aboguddah A, Ahmed S, Ali M, Arsenault M, Ascah K, Ashton T, Baird M, Basmadjian A, Beique F, Bla. Guidelines for the provision of echocardiography in Canada: recommendations of a joint Canadian Cardiovascular Society/Canadian Society of Echocardiography Consensus Panel.. Can J Cardiol 2005; 21(9):763-80.
- Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Després JP, Arsenault M, Couet J, Pibarot P. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis.. J Am Coll Cardiol 2006; 47(11):2229-36.
- Méthot J, Hamelin BA, Arsenault M, Bogaty P, Plante S, Poirier P. The ACE-DD genotype is associated with endothelial dysfunction in postmenopausal women.. Menopause 2006; 13(6):959-66.
- Plante E, Lachance D, Roussel E, Drolet MC, Arsenault M, Couet J. Impact of anesthesia on echocardiographic evaluation of systolic and diastolic function in rats.. J Am Soc Echocardiogr 2006; 19(12):1520-5.
- DeBlois J, Bergeron S, LeBlanc MH, Sénéchal M, Gregoire J, Arsenault M. Images in cardiovascular medicine. Directly to the heart.. Circulation 2006; 114(13):e515-6.
- Couet J, Gaudreau M, Lachance D, Plante E, Roussel E, Drolet MC, Arsenault M. Treatment of combined aortic regurgitation and systemic hypertension: Insights from an animal model study.. Am J Hypertens 2006; 19(8):843-50.
- Drolet MC, Lachance D, Plante E, Roussel E, Couet J, Arsenault M. Gender-related differences in left ventricular remodeling in chronic severe aortic valve regurgitation in rats.. J Heart Valve Dis 2006; 15(3):345-51.
- Drolet MC, Couet J, Arsenault M. Development of aortic valve sclerosis or stenosis in rabbits: role of cholesterol and calcium.. J Heart Valve Dis 2008; 17(0):381-387.
- Plante E, Lachance D, Champetier S, Drolet MC, Roussel E, Arsenault M, Couet J. Benefits of long-term beta-blockade in experimental chronic aortic regurgitation.. Am J Physiol Heart Circ Physiol 2008; 294(4):H1888-95.
- Lacasse Y, Lamontagne R, Martin S, Simard S, Arsenault M. Randomized trial of a smoking cessation intervention in hospitalized patients.. Nicotine Tob Res 2008; 10(7):1215-21.
- Zendaoui A, Lachance D, Drolet MC, Couet J, Arsenault M. Usefulness of spironolactone in the treatment of chronic aortic valve regurgitation.. J Heart Valve Dis 2011; 4(2):207-13.
- Champetier S, Bojmehrani A, Beaudoin J, Lachance D, Plante E, Roussel E, Couet J, Arsenault M. Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems.. Am J Physiol Heart Circ Physiol 2009; 296(3):H669-77.
- Festuccia WT, Laplante M, Brûlé S, Houde VP, Achouba A, Lachance D, Pedrosa ML, Silva ME, Guerra-Sá R, Couet J, Arsenault M, Marette A, Deshaies Y. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.. J Mol Cell Cardiol 2009; 47(1):85-95.
- Lachance D, Champetier S, Plante E, Bouchard-Thomassin AA, Roussel E, Couet J, Arsenault M. Effects of exercise in volume overload: insights from a model of aortic regurgitation.. Med Sci Sports Exerc 2009; 41(6):1230-8.
- Plante E, Lachance D, Beaudoin J, Champetier S, Roussel E, Arsenault M, Couet J. Comparative study of vasodilators in an animal model of chronic volume overload caused by severe aortic regurgitation.. Circ Heart Fail 2009; 2(1):25-32.
- Lachance D, Plante E, Bouchard-Thomassin AA, Champetier S, Roussel E, Drolet MC, Arsenault M, Couet J. Moderate exercise training improves survival and ventricular remodeling in an animal model of left ventricular volume overload.. Circ Heart Fail 2009; 2(5):437-45.
- Bouchard-Martel J, Roussel E, Drolet MC, Arsenault M, Couet J. Interstitial cells from left-sided heart valves display more calcification potential than from right-sided valves: an in-vitro study of porcine valves.. J Heart Valve Dis 2009; 18(4):421-8.
- Sharma A, Pibarot P, Pilote S, Dumesnil JG, Arsenault M, Bélanger PM, Meibohm B, Hamelin BA. Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction.. J Clin Pharmacol 2010; 50(2):214-25.
- Legault S, Sénéchal M, Bergeron S, Arsenault M, Tessier M, Guimond J, Poirier P. Usefulness of an accelerated transoesophageal stress echocardiography in the preoperative evaluation of high risk severely obese subjects awaiting bariatric surgery.. Cardiovasc Ultrasound 2010; 8(0):30.
- Maréchaux S, Hachicha Z, Bellouin A, Dumesnil JG, Meimoun P, Pasquet A, Bergeron S, Arsenault M, Le Tourneau T, Ennezat PV, Pibarot P. Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis.. Eur Heart J 2010; 31(11):1390-7.
- Zendaoui A, Lachance D, Roussel E, Couet J, Arsenault M. Usefulness of carvedilol in the treatment of chronic aortic valve regurgitation.. Circ Heart Fail 2011; 4(2):207-13.
- Bouchard-Thomassin AA, Lachance D, Drolet MC, Couet J, Arsenault M. A high-fructose diet worsens eccentric left ventricular hypertrophy in experimental volume overload.. Am J Physiol Heart Circ Physiol 2011; 300(1):H125-34.
- Arsenault M, Zendaoui A, Roussel E, Drolet MC, Dhahri W, Grenier A, Gascon S, Sarrhini O, Rousseau J, Lecomte R, Couet J.. Angiotensin II Converting Enzyme Inhibition Improves Survival, Ventricular Remodeling and Myocardial Energetics in Experimental Aortic Regurgitation.. Circ Heart Fail 2013; 6(5):1021-8.
- Dhahri W, Couet J, Roussel É, Drolet MC, Arsenault M. Fenofibrate reduces cardiac remodeling and improves cardiac function in a rat model of severe left ventricle volume overload.. Life Sci 2013; 92(1):26-34.
- Clavel MA, Ennezat PV, Maréchaux S, Dumesnil JG, Capoulade R, Hachicha Z, Mathieu P, Bellouin A, Bergeron S, Meimoun P, Arsenault M, Le Tourneau T, Pasquet A, Couture C, Pibarot P. Stress Echocardiography to Assess Stenosis Severity and Predict Outcome in Patients With Paradoxical Low-Flow, Low-Gradient Aortic Stenosis and Preserved LVEF.. JACC Cardiovasc Imaging 2013; 6(2):175-83.
- Zendaoui A, Lachance D, Roussel E, Couet J, Arsenault M. Effects of spironolactone treatment on an experimental model of chronic aortic valve regurgitation.. J Heart Valve Dis 2012; 21(4):478-86.
- Capoulade R, Larose E, Mathieu P, Clavel MA, Dahou A, Arsenault M, Bédard E, Larue-Grondin S, Le Ven F, Dumesnil JG, Després JP, Pibarot P.. Visceral adiposity and left ventricular mass and function in patients with aortic stenosis: The PROGRESSA Study.. Can J Cardiol 2014; 30(9):1080-7.
- Capoulade R, Mahmut A, Tastet L, Arsenault M, Bédard É, Dumesnil JG, Després JP, Larose É, Arsenault BJ, Bossé Y, Mathieu P, Pibarot P. Impact of Plasma Lp-PLA2 Activity on the Progression of Aortic Stenosis: The PROGRESSA Study.. JACC Cardiovasc Imaging 2015; 8(1):26-33.
- Dhahri W, Drolet MC, Roussel E, Couet J, Arsenault M.. Chronic high-fat diet-induced obesity decreased survival and increased hypertrophy of rats with experimental eccentric hypertrophy from chronic aortic regurgitation.. BMC Cardiovasc Disord 2014; 14(0):123.
- Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP. An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models.. Mol Ther Methods Clin Dev 2014; 1(0):14044.
- Lachance D, Dhahri W, Drolet MC, Roussel É, Gascon S, Sarrhini O, Rousseau JA, Lecomte R, Arsenault M, Couet J.. Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload.. BMC Cardiovasc Disord 2014; 14(0):190.
- Capoulade R, Magne J, Dulgheru R, Hachicha Z, Dumesnil JG, O'Connor K, Arsenault M, Bergeron S, Pierard LA, Lancellotti P, Pibarot P.. Prognostic value of plasma B-type natriuretic peptide levels after exercise in patients with severe asymptomatic aortic stenosis.. Heart 2014; 100(20):1606-12.
- Drolet MC, Desbiens-Brassard V, Roussel E, Tu V, Couet J, Arsenault M. Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation.. Springerplus 2015; 4(0):435.
- Carter S, Capoulade R, Arsenault M, Bédard É, Dumesnil JG, Mathieu P, Pibarot P, Picard F. Relationship Between Insulin-Like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients With Aortic Stenosis.. Can J Cardiol 2015; 31(12):1447-54.
- Roussel E, Drolet MC, Walsh-Wilkinson E, Dhahri W, Lachance D, Gascon S, Sarrhini O, Rousseau JA, Lecomte R, Couet J, Arsenault M. Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism.. Biomed Res Int 2015; 2015(0):949624.
- Tastet L, Capoulade R, Clavel MA, Larose É, Shen M, Dahou A, Arsenault M, Mathieu P, Bédard É, Dumesnil JG, Tremblay A, Bossé Y, Després JP, Pibarot P. Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study.. Eur Heart J Cardiovasc Imaging 2017; 18(1):70-78.
- Capoulade R, Le Ven F, Clavel MA, Dumesnil JG, Dahou A, Thébault C, Arsenault M, O'Connor K, Bédard É, Beaudoin J, Sénéchal M, Bernier M, Pibarot P. Echocardiographic predictors of outcomes in adults with aortic stenosis.. Heart 2016; 102(12):934-42.
- Tastet L, Enriquez-Sarano M, Capoulade R, Malouf J, Araoz PA, Shen M, Michelena HI, Larose E, Arsenault M, Bédard É, Pibarot P, Clavel MA. Impact of Aortic Valve Calcification and Sex on Hemodynamic Progression and Clinical Outcomes in AS.. J Am Coll Cardiol 2017; 69(16):2096-2098.
- Capoulade R, Clavel MA, Le Ven F, Dahou A, Thébault C, Tastet L, Shen M, Arsenault M, Bédard É, Beaudoin J, O'Connor K, Bernier M, Dumesnil JG, Pibarot P. Impact of left ventricular remodelling patterns on outcomes in patients with aortic stenosis.. Eur Heart J Cardiovasc Imaging 2017; 18(1):1378-87.
- Shen M, Tastet L, Capoulade R, Larose É, Bédard É, Arsenault M, Chetaille P, Dumesnil JG, Mathieu P, Clavel MA, Pibarot P. Effect of age and aortic valve anatomy on calcification and haemodynamic severity of aortic stenosis.. Heart 2017; 103(1):32-39.
- Beaumont C, Walsh-Wilkinson É, Drolet MC, Roussel É, Arsenault M, Couet J. Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males.. Sci Rep 2017; 7(1):729.
- Dupuis M, Mahjoub H, Clavel MA, Côté N, Toubal O, Tastet L, Dumesnil JG, O'Connor K, Dahou A, Thébault C, Bélanger C, Beaudoin J, Arsenault M, Bernier M, Pibarot P. Forward Left Ventricular Ejection Fraction: A Simple Risk Marker in Patients With Primary Mitral Regurgitation.. J Am Heart Assoc 2017; 6(11):e006309.
- Marsit O, Royer O, Drolet MC, Arsenault M, Couet J, Morin S, Levine RA, Pibarot P, Beaudoin J. Early Activation of Growth Pathways in Mitral Leaflets Exposed to Aortic Regurgitation: New Insights from an Animal Model.. J Heart Valve Dis 2017; 26(3):281-289.
- Pibarot P, Hahn RT, Weissman MD, Arsenault MD, Beaudoin J, Bernier M, Dahou A, Khalique MD, Asch FM, Toubal O, Leipsic J, Blanke P, Zhang F, Parvataneni R, Alu M, Herrmann H, Makkar R, Mack M, Smalling R, Leon M, Vinod H, Thourani MD, Kodali S.. Association of paravalvular regurgitation with 1-year outcomes after transcatheter aortic valve replacement with the SAPIEN 3 valve.. JAMA Cardiol 2017; 2(11):1208-16.
- Tastet L, Capoulade R, Shen M, Clavel MA, Côté N, Mathieu P, Arsenault M, Bédard É, Tremblay A, Samson M, Bossé Y, Dumesnil JG, Arsenault BJ, Beaudoin J, Bernier M, Després JP, Pibarot P. ApoB/ApoA-I Ratio is Associated With Faster Hemodynamic Progression of Aortic Stenosis: Results From the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) Study.. J Am Heart Assoc 2018; 7(4):e007980.
- Shen M, Capoulade R, Tastet L, Guzzetti E, Clavel MA, Salaun E, Bédard É, Arsenault M, Chetaille P, Tizón-Marcos H, Le Ven F, Pibarot P, Larose E.. Prevalence of left ventricle non-compaction criteria in adult patients with bicuspid aortic valve versus healthy control subjects.. Open Heart 2018; 5(2):e000869.
- Roussel E, Drolet MC, Lavigne AM, Arsenault M, Couet J. Multiple short-chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy.. FEBS Open Bio 2018; 8(10):1624-1635.
- Tastet L, Pibarot P, Shen M, Clisson M, Côté N, Salaun E, Arsenault M, Bédard É, Capoulade R, Puri R, Poirier P, Clavel MA.. Oral Anticoagulation Therapy and Progression of Calcific Aortic Valve Stenosis.. J Am Coll Cardiol 2019; 73(14):1869-1871.
- Walsh-Wilkinson É, Drolet MC, Le Houillier C, Roy ÈM, Arsenault M, Couet J. Sex differences in the response to angiotensin II receptor blockade in a rat model of eccentric cardiac hypertrophy.. PeerJ 2019; 7(0):e7461.
- Walsh-Wilkinson E, Beaumont C, Drolet MC, Roy ÈM, Le Houillier C, Beaudoin J, Arsenault M, Couet J. Effects of the loss of estrogen on the heart's hypertrophic response to chronic left ventricle volume overload in rats.. PeerJ 2019; 7(0):e7924.
- Tastet L, Kwiecinski J, Pibarot P, Capoulade R, Everett RJ, Newby DE, Shen M, Guzzetti E, Arsenault M, Bédard É, Larose E, Beaudoin J, Dweck M, Clavel MA. Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis.. JACC Cardiovasc Imaging 2020; 13(3):699-711.
- Tastet L, Tribouilloy C, Maréchaux S, Vollema EM, Delgado V, Salaun E, Shen M, Capoulade R, Clavel MA, Arsenault M, Bédard É, Bernier M, Beaudoin J, Narula J, Lancellotti P, Bax JJ, Généreux P, Pibarot P.. Staging Cardiac Damage in Patients With Asymptomatic Aortic Valve Stenosis.. J Am Coll Cardiol 2019; 74(4):550-563.
- Beaumont C, Walsh-Wilkinson É, Drolet MC, Roussel É, Melançon N, Fortier É, Harpin G, Beaudoin J, Arsenault M, Couet J. Testosterone deficiency reduces cardiac hypertrophy in a rat model of severe volume overload.. Physiol Rep 2019; 7(9):e14088.
- Tastet L, Shen M, Capoulade R, Arsenault M, Bédard É, Côté N, Clavel MA, Pibarot P.. Bone Mineral Density and Progression Rate of Calcific Aortic Valve Stenosis.. J Am Coll Cardiol 2020; 75(14):1725-1726.
- Walsh-Wilkinson E, Drolet MC, Arsenault M, Couet J. Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload.. BMC Cardiovasc Disord 2020; 20(1):51.
- Steinberg C, Nadeau-Routhier C, André P, Philippon F, Sarrazin JF, Nault I, O'Hara G, Blier L, Molin F, Plourde B, Roy K, Larose E, Arsenault M, Champagne J. Ventricular Arrhythmia in Septal and Apical Hypertrophic Cardiomyopathy: The French-Canadian Experience.. Front Cardiovasc Med 2020; 7(0):548564.
- Guzzetti E, Capoulade R, Tastet L, Garcia J, Le Ven F, Arsenault M, Bédard É, Larose E, Clavel MA, Pibarot P.. Estimation of Stroke Volume and Aortic Valve Area in Patients With Aortic Stenosis: A Comparison of Echocardiography Versus Cardiovascular Magnetic Resonance.. J Am Soc Echocardiogr 2020; 33(8):953-963.e5.
- Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.. J Am Coll Cardiol 2020; 75(4):395-405.
- Guzzetti E, Tastet L, Annabi MS, Capoulade R, Shen M, Bernard J, García J, Le Ven F, Arsenault M, Bédard É, Larose E, Clavel MA, Pibarot P.. Effect of Regional Upper Septal Hypertrophy on Echocardiographic Assessment of Left Ventricular Mass and Remodeling in Aortic Stenosis.. J Am Soc Echocardiogr 2021; 34(1):62-71.
- Shen M, Tastet L, Capoulade R, Arsenault M, Bédard É, Clavel MA, Pibarot P.. Effect of Bicuspid Aortic Valve Phenotype on Progression of Aortic Stenosis.. Eur Heart J Cardiovasc Imaging 2020; 21(7):727-734.
- Bernard J, Tastet L, Capoulade R, Shen M, Clisson M, Guzzetti E, Larose E, Arsenault M, Bédard É, Côté N, Clavel MA, Pibarot P. Left ventricular asymmetric remodeling and subclinical left ventricular dysfunction in patients with calcific aortic valve stenosis - Results from a subanalysis of the PROGRESSA study.. Int J Cardiol 2021; 332(0):148-156.
- Walsh-Wilkinson E, Arsenault M, Couet J. Segmental analysis by speckle-tracking echocardiography of the left ventricle response to isoproterenol in male and female mice.. PeerJ 2021; 9(0):e11085.
- Tastet L, Shen M, Capoulade R, Arsenault M, Bédard É, Ternacle J, Salaun E, Côté N, Pibarot P, Clavel MA.. Sex Differences in the Progression of Aortic Valve Calcification and Clinical Outcomes: The PROGRESSA Study.. JACC Cardiovasc Imaging 2022; 15(7):1349-1351.
- Walsh-Wilkinson É, Aidara ML, Morin-Grandmont A, Thibodeau SÈ, Gagnon J, Genest M, Arsenault M, Couet J. Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice.. Am J Physiol Heart Circ Physiol 2022; 323(4):H643-H658.
- Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J. Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.. J Am Coll Cardiol 2022; 80(5):500-510.
