Chercheur(e)
Dr Jean-François Lauzon-Joset
Pneumologie
M0666
Domaine de recherche
Immunité pulmonaire, Microbiote, Infections virales, Stress psychologique, Asthme.
Description des travaux
Mon laboratoire s'intéresse au développement du système immunitaire pulmonaire et l'impact du microbiote sur la réponse antivirale. Récemment, on s'est intéressé à l'impact du stress psychologique en jeune âge sur la maturation du système immunitaire, avec une attention particulière sur les différences entre les hommes et les femmes.
Prix et distinctions
2- Young investigator mentorship program, RSRQ, Quebec, 2019; New Investigator grant - Asthma Foundation of WA (Australia), 2018; Travel award; International Congress of Immunology 2016, Melbourne (Australia), 2016.
Publications
16- Mincham KT, Leffler J, Scott NM, Lauzon-Joset JF, Stumbles PA, Holt PG, Strickland DH.. Quantification of serum ovalbumin-specific immunoglobulin E titre via in vivo passive cutaneous anaphylaxis assay.. Bio Protoc 2019; 9(5):e3184.
- Lauzon-Joset JF, Scott NM, Mincham KT, Stumbles PA, Holt PG, Strickland DH.. Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection: Mechanistic Insight Using Mouse Models.. J Infect Dis 2019; 219(11):1823-1831.
- Mincham KT, Scott NM, Lauzon-Joset JF, Leffler J, Stumbles PA, Holt PG, Strickland DH.. Early life ovalbumin sensitization and aerosol challenge for the induction of allergic airway inflammation in a BALB/c murine model.. Bio Protoc 2019; 9(5):e3181.
- Lauzon-Joset JF, Mincham KT, Abad AP, Short BP, Holt PG, Strickland DH, Leffler J. Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma model.. Clin Exp Allergy 2020; 50(3):391-400.
- Lauzon-Joset JF, Marsolais D, Tardif-Pellerin É, Patoine D, Bissonnette EY. CD200 in asthma.. Int J Biochem Cell Biol 2019; 112(0):141-144.
- Huppé CA, Blais-Lecours P, Bernatchez E, Lauzon-Joset JF, Duchaine C, Rosen H, Dion G, McNagny KM, Blanchet MR, Morissette MC, Marsolais D. S1P1 Contributes to Endotoxin-enhanced B-Cell Functions Involved in Hypersensitivity Pneumonitis.. Am J Respir Cell Mol Biol 2020; 63(2):209-218.
- Bissonnette EY, Lauzon-Joset JF, Debley JS, Ziegler SF. Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis.. Front Immunol 2020; 11(0):583042.
- Granland CM, Scott NM, Lauzon-Joset JF, Langereis JD, de Gier C, Sutherland KMJ, Clark SL, Pickering JL, Thornton RB, Richmond PC, Strickland DH, Kirkham LS. Nasal Delivery of a Commensal Pasteurellaceae Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice.. Infect Immun 2020; 88(4):e00685-19.
- Mincham KT, Jones AC, Bodinier M, Scott NM, Lauzon-Joset JF, Stumbles PA, Bosco A, Holt PG, Strickland DH. Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming.. Front Immunol 2020; 11(0):601494.
- de Jong E, Lauzon-Joset JF, Leffler J, Serralha M, Larcombe AN, Christophersen CT, Holt PG, Strickland DH, Bosco A. IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming.. Front Immunol 2021; 12(0):699633.
- Lauzon-Joset JF, Mincham KT, Scott NM, Khandan Y, Stumbles PA, Holt PG, Strickland DH. Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85.. Clin Transl Immunology 2021; 10(7):e1303.
- Courtemanche O, Huppé CA, Blais Lecours P, Lerdu O, Roy J, Lauzon-Joset JF, Blanchet MR, Morissette MC, Marsolais D. Co-modulation of T cells and B cells enhances the inhibition of inflammation in experimental hypersensitivity pneumonitis.. Respir Res 2022; 23(1):275.
- Patoine D, Bouchard K, Lemay AM, Bissonnette EY, Lauzon-Joset JF. Specificity of CD200/CD200R pathway in LPS-induced lung inflammation.. Front Immunol 2022; 13(0):1092126.
- Patoine D, Bouchard K, Blais-Lecours P, Courtemanche O, Huppé CA, Marsolais D, Bissonnette EY, Lauzon-Joset JF.. CD200Fc limits dendritic cell and B cell activation during chronic allergen exposures.. J Leukoc Biol 2023; 114(1):84-91.
- Bouchard K, Patoine D, Bissonnette EY, Lauzon-Joset JF. OMIP-92: Characterization of rat macrophage subsets, lymphocytes, and granulocytes in bronchoalveolar lavage fluid.. Cytometry A 2023; 103(7):548-550.
- Fonceca AM, Lauzon-Joset JF, Scott NM, Stumbles PA, Strickland DH, Everard ML.. In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection.. Viral Immunol 2023; 36(7):466-474.
