Domaine de recherche
Étude des mécanismes cellulaires et moléculaires impliqués dans l'inflammation et le remodelage bronchique dans l'asthme.
Description des travaux
Dès les premières manifestations de l'asthme, la muqueuse bronchique présente un infiltrat de cellules inflammatoires (lymphocytes, éosinophiles). Ces cellules sont en état d'activation et produisent un large éventail de cytokines et de médiateurs qui peuvent changer le comportement fonctionnel et phénotypique des cellules résidentes. Ces cellules résidentes (les cellules épithéliales, les fibroblastes et les cellules musculaires lisses), en plus de leur rôle dans la réparation du tissu, sont elles-mêmes une source importante de cytokines et jouent un rôle actif dans l'amplification de la réponse immune ce qui suggère leur implication dans le maintien et la chronicité de l'inflammation. Ces cellules sont aussi impliquées dans les changements structuraux observés dans l'asthme comme la fibrose sous-épithéliale. On s'intéresse aux mécanismes cellulaires et moléculaires qui relient l'inflammation et le remodelage de la muqueuse bronchique. Notre objectif est d'étudier les liens possibles entre les cellules résidentes et les cellules inflammatoires infiltrant la muqueuse bronchique. Plusieurs approches sont utilisées telles que la co-culture entre les cellules inflammatoires et les fibroblastes et les cellules épithéliales bronchiques isolés à partir de sujets sains ou atteints d'asthme; utilisation de modèle de muqueuse bronchique produit par ingénierie tissulaire. Cette dernière technique nous a permis de démonter que les cellules épithéliales d'asthmatiques perdaient la capacité de se différencier comme les cellules de sujets sains. Nous avons également montré que les cellules résidents d'asthmatiques permettaient l'orientation de la réponse inflammatoire vers une réponse Th2. Nous utilisons aussi des biopsies bronchiques pour confirmer ex-vivo nos observations in vitro. Nous pensons qu'à long terme, ces études permettront d'envisager de nouvelles orientations thérapeutiques qui viseront la prévention, le traitement et peut être la correction des anomalies de la structure bronchique.
Mes recherches sont financées par différents organismes dont les IRSC, le FRSQ, le réseau en santé respiratoire.
Prix et distinctions
5- -Chercheur boursier du FRSQ Senior : 2005-2009
- -Chercheur boursier du FRSQ Junior 2 : 2001-2005
- -Prix Armand Frappier de l’Association Pulmonaire du Québec juin 2000
- -Chercheur boursier du FRSQ Junior 1 : 1997-2001
- - Grand prix du comité d’honneur du XVth World Congress of Asthmology avril 1996
Publications
86- Westergren-Thorsson G, Chakir J, Lafrenière-Allard MJ, Boulet LP, Tremblay GM. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. Int J Biochem Cell Biol 2002; 34(10):1256-67.
- Rouabhia M, Ross G, Pagé N, Chakir J. Interleukin-18 and gamma interferon production by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation.. Infect Immun 2002; 70(12):7073-80.
- Dallaire MJ, Ferland C, Lavigne S, Chakir J, Laviolette M. Migration through basement membrane modulates eosinophil expression of CD44.. Clin Exp Allergy 2002; 32(6):898-905.
- Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M. Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions.. J Allergy Clin Immunol 2002; 109(3):463-9.
- Chakir J, Hamid Q, Bossé M, Boulet LP, Laviolette M. Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment. Clin Exp Allergy 2002; 32(4):578-82.
- Westergren-Thorsson G, Chakir J, Lafrenière-Allard MJ, Boulet LP, Tremblay GM. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects.. Int J Biochem Cell Biol 2002; 34(0):1256-67.
- Dallaire MJ, Ferland C, Lavigne S, Chakir J. Migration through basement membrane modulates eosinophil espression of CD44.. Clin Exp Allergy 2002; 32(0):898-905.
- Gauvreau GM, Becker AB, Boulet LP, Chakir J, Fick RB, Greene WL, Killian KJ, O'Byrne PM, Reid JK, Cockcroft DW. The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma.. J Allergy Clin Immunol 2003; 112(2):331-8.
- Boulet LP, Turcotte H, Turcot O, Chakir J. Airway inflammation in asthma with incomplete reversibility of airflow obstruction.. Respir Med 2003; 97(6):739-44.
- Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, Boulet LP, Hamid Q. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression.. J Allergy Clin Immunol 2003; 111(6):1293-8.
- Bergeron C, Pagé N, Joubert P, Barbeau B, Hamid Q, Chakir J. Regulation of procollagen I (alpha1) by interleukin-4 in human bronchial fibroblasts: a possible role in airway remodelling in asthma.. Clin Exp Allergy 2003; 33(10):1389-97.
- Gauthier MC, Racine C, Ferland C, Flamand N, Chakir J, Tremblay GM, Laviolette M. Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils. Int J Biochem Cell Biol 2003; 35(12):1667-73.
- Ferland C, Flamand N, Davoine F, Chakir J, Laviolette M. IL-16 activates plasminogen-plasmin system and promotes human eosinophil migration into extracellular matrix via CCR3-chemokine-mediated signaling and by modulating CD4 eosinophil expression.. J Immunol 2004; 173(7):4417-24.
- Sériès F, Chakir J, Boivin D. Influence of weight and sleep apnea status on immunologic and structural features of the uvula.. Am J Respir Crit Care Med 2004; 170(10):1114-9.
- Ludwig MS, Ftouhi-Paquin N, Huang W, Pagé N, Chakir J, Hamid Q. Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects.. Clin Exp Allergy 2004; 34(6):926-30.
- Davoine F, Labonté I, Ferland C, Mazer B, Chakir J, Laviolette M. Role and modulation of CD16 expression on eosinophils by cytokines and immune complexes.. Int Arch Allergy Immunol 2004; 134(2):165-72.
- Bergeron C, Pagé N, Barbeau B, Chakir J. Interleukin-4 promotes airway remodeling in asthma: regulation of procollagen I (alpha1) gene by interleukin-4.. Chest 2003; 123(3):424S.
- Boulay ME, Prince P, Deschesnes F, Chakir J, Boulet LP. Metalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic response.. Respiration 2004; 71(3):216-24.
- Fukakusa M, Bergeron C, Tulic MK, Fiset PO, Al Dewachi O, Laviolette M, Hamid Q, Chakir J. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa.. J Allergy Clin Immunol 2005; 115(2):280-6.
- Joubert P, Lajoie-Kadoch S, Labonté I, Gounni AS, Maghni K, Wellemans V, Chakir J, Laviolette M, Hamid Q, Lamkhioued B. CCR3 expression and function in asthmatic airway smooth muscle cells.. J Immunol 2005; 175(4):2702-8.
- Kelly MM, Chakir J, Vethanayagam D, Boulet LP, Laviolette M, Gauldie J, O'Byrne PM. Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge.. Chest 2006; 130(3):741-53.
- Davoine F, Ferland C, Chakir J, Lee Joo Eun, Adamko DJ, Moqbel R, Laviolette M. Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis.. Int Arch Allergy Appl Immunol 2006; 140(4):277-84.
- Plante S, Semlali A, Joubert P, Bissonnette E, Laviolette M, Hamid Q, Chakir J. Mast cells regulate procollagen I (alpha 1) production by bronchial fibroblasts derived from subjects with asthma through IL-4/IL-4 delta 2 ratio.. J Allergy Clin Immunol 2006; 117(6):1321-7.
- Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemière C, Martin JG, Hamid Q. Increased expression of ADAM33 and ADAM8 with disease progression in asthma.. J Allergy Clin Immunol 2007; 119(4):863-71.
- Bergeron C, Hamid Q, Chakir J. Interleukin-4 and airway remodeling in asthma.. Int Rev Asthma 2005; 7(0):65-73.
- Le Bellego F, Plante S, Chakir J, Hamid Q, Ludwig MS. Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts.. Respir Res 2006; 7(0):68.
- Semlali A, Jacques E, Plante S, Biardel S, Milot J, Laviolette M, Boulet LP, Chakir J. TGF-beta1 alters MAPK activation and bronchial epithelial cell proliferation in asthma.. Am J Respir Cell Mol Biol 2008; 38(2):202-8.
- Darveau ME, Jacques E, Rouabhia M, Hamid Q, Chakir J. Increased T-cell survival by structural bronchial cells derived from asthmatic subjects cultured in an engineered human mucosa.. J Allergy Clin Immunol 2008; 121(3):692-9.
- Semlali A, Jacques E, Chakir J. The Role of Structural Cells on Airway Remodeling and Their Response to Asthma Medication.. Cur Respir Med Rev 2007; 0(0):(sous-presse).
- Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways.. J Allergy Clin Immunol 2009; 123(3):612-8.
- Le Bellego F, Perera H, Plante S, Chakir J, Hamid Q, Ludwig MS. Mechanical strain increases cytokine and chemokine production in bronchial fibroblasts from asthmatic patients.. Allergy 2009; 64(1):32-9.
- Labonté I, Laviolette M, Olivenstein R, Chakir J, Boulet LP, Hamid Q. Quality of bronchial biopsies for morphology study and cell sampling: a comparison of asthmatic and healthy subjects.. Can Respir J 2008; 15(8):431-5.
- Loubaki L, Jacques E, Semlali A, Biardel S, Chakir J, Sériès F. Tumor necrosis factor-alpha expression in uvular tissues differs between snorers and apneic patients.. Chest 2008; 134(5):911-8.
- Morissette MC, Vachon-Beaudoin G, Parent J, Chakir J, Milot J. Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema.. Am J Respir Crit Care Med 2008; 178(3):240-7.
- Chakir J, Loubaki L, Laviolette M, Milot J, Biardel S, Jayaram L, Pizzichini M, Pizzichini E, Hargreave FE, Nair P, Boulet LP. Monitoring sputum eosinophils in mucosal inflammation and remodelling: a pilot study.. Eur Respir J 2010; 35(1):48-53.
- Préfontaine D, Nadigel J, Chouiali F, Audusseau S, Semlali A, Chakir J, Martin JG, Hamid Q. Increased IL-33 expression by epithelial cells in bronchial asthma.. J Allergy Clin Immunol 2010; 125(3):752-4.
- Semlali A, Jacques E, Koussih L, Gounni AS, Chakir J. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway.. J Allergy Clin Immunol 2010; 125(4):844-50.
- Almqvist C, Bradding PB, Chakir J, Ebo D, Grattan C, Kariyawasam HH, Savilahti E, Scadding GK, Vieths S, Wardlaw AJ, Woodfolk J. Developments in the field of allergy in 2008 through the eyes of Clinical & Experimental Allergy.. Clin Exp Allergy 2009; 39(10):1482-98.
- Boulay ME, Duchesneau E, Jacques E, Chakir J, Boulet LP. CysLT1-R expression following allergen provocation in asthma and allergic rhinitis.. Prostaglandins Leukot Essent Fatty Acids 2010; 83(1):15-22.
- Létourneau V, Mériaux A, Goyer N, Chakir J, Cormier Y, Duchaine C. Biological activities of respirable organic dust from Eastern Canadian peat moss factories.. Toxicol In Vitro 2010; 24(4):1273-8.
- Semlali A, Chakir J, Rouabhia M. Effects of whole cigarette smoke on human gingival fibroblast adhesion, growth and migration. J Toxicol Environ Health 2011; 74(13):848-62.
- Chakir J. Rpole de l'épithélium bronchique dans l'asthme. La revue française d'allergologie et d'immunologie clinique 2009; 49(0):211-3.
- Jacques E, Semlali A, Boulet LP, Chakir J. AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects.. Am J Physiol Lung Cell Mol Physiol 2010; 299(2):L281-7.
- Vazquez-Tello A, Semlali A, Chakir J, Martin JG, Leung DY, Eidelman DH, Hamid Q. Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines.. Clin Exp Allergy 2010; 40(9):1312-22.
- Shan L, Redhu NS, Saleh A, Halayko AJ, Chakir J, Gounni AS. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways.. J Immunol 2010; 184(12):7134-43.
- Loubaki L, Semlali A, Boisvert M, Jacques E, Plante S, Aoudjit F, Mourad W, Chakir J. Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction.. Mol Immunol 2010; 47(11):2112-8.
- Semlali A, Jacques E, Rouabhia M, Milot J, Laviolette M, Chakir J. Regulation of epithelial cell proliferation by bronchial fibroblasts obtained from mild asthmatic subjects.. Allergy 2010; 65(11):1438-45.
- Semlali A, Chakir J, Goulet JP, Chmielewski W, Rouabhia M. Whole cigarette smoke promotes human gingival epithelial cell apoptosis and inhibits cell repair processes.. J Periodontal Res 2011; 46(5):533-41.
- Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.. J Allergy Clin Immunol 2011; 127(1):254-61, 261.e1-6.
- Eap R, Jacques E, Semlali A, Plante S, Chakir J. Cysteinyl leukotrienes regulate TGF-?(1) and collagen production by bronchial fibroblasts obtained from asthmatic subjects.. Prostaglandins Leukot Essent Fatty Acids 2012; 86(3):127-33.
- Schaafsma D, McNeill KD, Mutawe MM, Ghavami S, Unruh H, Jacques E, Laviolette M, Chakir J, Halayko AJ. Simvastatin inhibits TGF?1-induced fibronectin in human airway fibroblasts.. Respir Res 2011; 12(0):113.
- Bougault V, Loubaki L, Joubert P, Turmel J, Couture C, Laviolette M, Chakir J, Boulet LP. Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools.. J Allergy Clin Immunol 2012; 129(2):351-8, 358.e1.
- Boulet LP, Turcotte H, Plante S, Chakir J. Airway function, inflammation and regulatory T cell function in subjects in asthma remission.. Can Respir J 2012; 19(1):19-25.
- Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS.. Pentraxin 3 (PTX3) Expression in Allergic Asthmatic Airways: Role in Airway Smooth Muscle Migration and Chemokine Production.. PLoS One 2012; 7(4):e34965.
- Boucherat O, Chakir J, Jeannotte L. The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.. Biol Open 2012; 1(7):677-91.
- Provost V, Langlois A, Chouinard F, Rola-Pleszczynski M, Chakir J, Flamand N, Laviolette M. Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.. PLoS One 2012; 7(8):e43544.
- Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J. Co-Culture of Human Bronchial Fibroblasts and CD4+ T Cells Increases Th17 Cytokine Signature.. PLoS One 2013; 8(12):e81983.
- Hadj Salem I, Dubé J, Boulet LP, Chakir J. Telomere shortening correlates with accelerated replicative senescence of bronchial fibroblasts in asthma.. Clin Exp Allergy 2015; 45(11):1713-5.
- Movassagh H, Shan L, Halayko AJ, Roth M, Tamm M, Chakir J, Gounni AS.. Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration.. J Allergy Clin Immunol 2014; 133(2):560-7.
- Chakir J, Haj-Salem I, Gras D, Joubert P, Beaudoin ÈL, Biardel S, Lampron N, Martel S, Chanez P, Boulet LP, Laviolette M. Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma.. Ann Am Thorac Soc 2015; 12(11):1612-8.
- Johnson JR, Nishioka M, Chakir J, Risse PA, Almaghlouth I, Bazarbashi AN, Plante S, Martin J, Eidelman D, Hamid Q.. IL-22 contributes to TGF-beta1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells.. Respir Res 2013; 14(1):118.
- Bissonnette EY, Madore AM, Chakir J, Laviolette M, Boulet LP, Hamid Q, Bergeron C, Maghni K, Laprise C.. Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma.. J Asthma 2014; 51(2):119-26.
- El Azreq MA, Boisvert M, Cesaro A, Pagé N, Loubaki L, Allaeys I, Chakir J, Poubelle PE, Tessier PA, Aoudjit F. ?2?1 integrin regulates Th17 cell activity and its neutralization decreases the severity of collagen-induced arthritis.. J Immunol 2013; 191(12):5941-50.
- Haj-Salem I, Fakhfakh R, Bérubé JC, Jacques E, Plante S, Simard MJ, Bossé Y, Chakir J. MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGF?R2 gene in severe asthma.. Allergy 2015; 70(2):212-9.
- Larose MC, Chakir J, Archambault AS, Joubert P, Provost V, Laviolette M, Flamand N.. Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma.. J Allergy Clin Immunol 2015; 136(4):904-13.
- Rouabhia M, Park HJ, Semlali A, Zakrzewski A, Chmielewski W, Chakir J. E-Cigarette Vapor Induces an Apoptotic Response in Human Gingival Epithelial Cells Through the Caspase-3 Pathway.. J Cell Physiol 2017; 232(6):1539-1547.
- Movassagh H, Tatari N, Shan L, Koussih L, Alsubait D, Khattabi M, Redhu NS, Roth M, Tamm M, Chakir J, Gounni AS. Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A.. Oncotarget 2016; 7(49):80238-80251.
- Movassagh H, Shan L, Chakir J, McConville JF, Halayko AJ, Koussih L, Gounni AS. Expression of semaphorin 3E is suppressed in severe asthma.. J Allergy Clin Immunol 2017; 140(4):1176-9.
- Haj-Salem I, Plante S, Gounni AS, Rouabhia M, Chakir J. Fibroblast-derived exosomes promote epithelial cell proliferation through TGF-?2 signalling pathway in severe asthma.. Allergy 2018; 73(1):178-186.
- Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R. Human Bronchial Epithelial Cell-Derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation.. Am J Respir Cell Mol Biol 2018; 58(1):99-106.
- Movassagh H, Shan L, Duke-Cohan JS, Chakir J, Halayko AJ, Koussih L, Gounni AS. Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma.. Oncotarget 2017; 8(58):98953-98963.
- Gour N, Lajoie S, Smole U, White M, Hu D, Goddard P, Huntsman S, Eng C, Mak A, Oh S, Kim JH, Sharma A, Plante S, Salem IH, Resch Y, Xiao X, Yao N, Singh A, Vrtala S, Chakir J, Burchard EG, Lane AP, Wills-Karp M. Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.. Sci Immunol 2018; 3(20):eaam9841.
- Salem IH, Plante S, Gounni AS, Rouabhia M, Chakir J. A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process.. Cell Signal 2018; 43(0):47-54.
- Larouche M, Gagné-Ouellet V, Boucher-Lafleur AM, Larose MC, Plante S, Madore AM, Laviolette M, Flamand N, Chakir J, Laprise C. Methylation profiles of IL33 and CCL26 in bronchial epithelial cells are associated with asthma.. Epigenomics 2018; 10(12):1555-1568.
- Alanazi H, Park HJ, Chakir J, Semlali A, Rouabhia M. Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis.. Food Chem Toxicol 2018; 118(0):390-398.
- Archambault AS, Turcotte C, Martin C, Provost V, Larose MC, Laprise C, Chakir J, Bissonnette É, Laviolette M, Bossé Y, Flamand N. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils.. PLoS One 2018; 13(8):e0202424.
- Haj Salem I, Gras D, Joubert P, Boulet LP, Lampron N, Martel S, Godbout K, Chanez P, Laviolette M, Chakir J. Persistent Reduction of Mucin Production after Bronchial Thermoplasty in Severe Asthma.. Am J Respir Crit Care Med 2019; 199(4):536-538.
- Ichikawa T, Panariti A, Audusseau S, Mogas AK, Olivenstein R, Chakir J, Laviolette M, Allakhverdi Z, Al Heialy S, Martin JG, Hamid Q. Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma.. Respir Med 2019; 150(0):165-172.
- Rouabhia M, Piché M, Corriveau MN, Chakir J. Effect of e-cigarettes on nasal epithelial cell growth, Ki67 expression, and pro-inflammatory cytokine secretion.. Am J Otolaryngol 2020; 41(6):102686.
- Smole U, Gour N, Phelan J, Hofer G, Köhler C, Kratzer B, Tauber PA, Xiao X, Yao N, Dvorak J, Caraballo L, Puerta L, Rosskopf S, Chakir J, Malle E, Lane AP, Pickl WF, Lajoie S, Wills-Karp M. Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.. Nat Immunol 2020; 21(7):756-765.
- Chakir J, Gagnon PA, Laviolette M.. Bronchial thermoplasty: The heat that reprograms the airways?. J Allergy Clin Immunol 2021; 148(5):1167-1169.
- Côté MÈ, Boulay MÈ, Plante S, Côté A, Chakir J, Boulet LP. Comparison of circulating fibrocytes from non-asthmatic patients with seasonal allergic rhinitis between in and out of pollen season samples.. Allergy Asthma Clin Immunol 2022; 18(1):24.
- Rouabhia M, Piché M, Hazzi C, Corriveau MN, Chakir J.. Effect of cannabis smoke condensate on human nasal epithelial cell adhesion, growth, and migration.. Am J Otolaryngol 2023; 44(4):103890.
- Henry C, Biardel S, Boucher M, Godbout K, Chakir J, Côté A, Laviolette M, Bossé Y. Bronchial thermoplasty attenuates bronchodilator responsiveness.. Respir Med 2023; 217(0):107340.
- Gagnon PA, Côté A, Klein M, Biardel S, Laviolette M, Godbout K, Bossé Y, Chakir J. The reduction of airway smooth muscle by bronchial thermoplasty stands the test of time.. ERJ Open Res 2023; 9(4):00024-2023.
- Gagnon PA, Klein M, De Vos J, Biardel S, Côté A, Godbout K, Laviolette M, Laprise C, Assou S, Chakir J. S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty.. Respir Res 2023; 24(1):294.
