Domaine de recherche
Rôle du système nerveux autonome dans le développement des maladies métaboliques
Description des travaux
Étude des mécanismes par lesquels le cerveau contrôle le métabolisme énergétique; développement de stratégies pharmacologiques permettant de traiter les maladies et désordres métaboliques (diabète, résistance à l'insuline, obésité, stéatose hépatique); identification de nouvelles cibles moléculaires et pharmacologiques dans le cerveau et les organes périphériques; définition des mécanismes qui altèrent la communication cerveau-organes dans des situations physiopathologiques; caractérisation des voies de signalisation des récepteurs couplés aux protéines G dans les organes métaboliques (foie, tissus adipeux, reins); développement de combinaisons pharmacologiques efficaces pour améliorer le métabolisme du glucose et des lipides.
Prix et distinctions
2- 2019 : Rolls-Simons Award, The Obesity Society 2019 : Junior Investigator Award, Journal of Lipid Research 2019 : NIDDK/Keystone Symposia Scholarship
Publications
18- Michael NJ, Caron A, Lee CE, Castorena CM, Lee S, Zigman JM, Williams KW, Elmquist JK. Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors.. Mol Metab 2020; 35(0):100956.
- Silva A, Caron A. Pathophysiological mechanisms that alter the autonomic brain-liver communication in metabolic diseases.. Endocrinology 2021; 162(11):bqab164.
- Caron A, Michael NJ. New Horizons: Is Obesity a Disorder of Neurotransmission?. J Clin Endocrinol Metab 2021; 106(12):e4872-e4886.
- Castorena CM, Caron A, Michael NJ, Ahmed NI, Arnold AG, Lee J, Lee C, Limboy C, Tinajero AS, Granier M, Wang S, Horton JD, Holland WL, Lee S, Liu C, Fujikawa T, Elmquist JK. CB1Rs in VMH neurons regulate glucose homeostasis but not body weight.. Am J Physiol Endocrinol Metab 2021; 321(1):E146-E155.
- Srour N, Caron A, Michael NJ. Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance.. Biochimie 2024; 223(0):179-187.
- Martinez-Sanchez N, Sweeney O, Sidarta-Oliveira D, Caron A, Stanley SA, Domingos AI. The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity.. Neuron 2022; 110(21):3597-3626.
- Navarro-Masip È, Caron A, Mulero M, Arola L, Aragonès G. Photoperiodic Remodeling of Adiposity and Energy Metabolism in Non-Human Mammals.. Int J Mol Sci 2023; 24(2):1008.
- Lavoie O, Michael NJ, Caron A. A critical update on the leptin-melanocortin system.. J Neurochem 2023; 165(4):467-486.
- Colas C, Mouchiroud M, Al Dow M, Kolnohuz A, Gélinas Y, Caron A, Laplante M. DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.. Mol Metab 2023; 67(0):101660.
- Srour N, Lavoie O, Khouma A, Minbashi Moeini M, Plamondon J, Kinkead R, Michael NJ, Caron A. Electrophysiological Comparison of Definitive Pro-opiomelanocortin Neurons in the Arcuate Nucleus and the Retrochiasmatic Area of Male and Female Mice.. Neuroscience 2023; 530(0):95-107.
- Khouma A, Moeini MM, Plamondon J, Richard D, Caron A, Michael NJ. Histaminergic regulation of food intake.. Front Endocrinol (Lausanne) 2023; 14(0):1202089.
- Caron A, Carpentier AC, Deshaies Y, Després JP, Picard F, Rivest S, Tchernof A. In Memoriam: Denis Richard 1953-2023.. Neuroendocrinology 2024; 0(0):1-2.
- Samson N, Bosoi CR, Roy C, Turcotte L, Tribouillard L, Mouchiroud M, Berthiaume L, Trottier J, Silva HCG, Guerbette T, Plata-Gómez AB, Besse-Patin A, Montoni A, Ilacqua N, Lamothe J, Citron YR, Gélinas Y, Gobeil S, Zoncu R, Caron A, Morissette M, Pellegrini L, Rochette PJ, Estall JL, Efeyan A, Shum M, Audet-Walsh É, Barbier O, Marette A, Laplante M. HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.. Sci Adv 2024; 10(22):eadk9681.
- Lavoie O, Turmel A, Mattoon P, Desrosiers WJ, Plamondon J, Michael NJ, Caron A. Hypothalamic GABAergic Neurons Expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) Are Sensitive to Metabolic Status and Liraglutide in Male Mice.. Neuroendocrinology 2024; 0(0):1-17.
- Dumont L, Caron A, Richard G, Croteau E, Fortin M, Frisch F, Phoenix S, Dubreuil S, Guérin B, Turcotte ÉE, Carpentier AC, Blondin DP. The effects of the ?(1)-adrenergic receptor antagonist bisoprolol administration on mirabegron-stimulated human brown adipose tissue thermogenesis.. Acta Physiol (Oxf) 2024; 240(5):e14127.
- Lavoie O, Caron A. A sympathetic paradigm shift for the role of NPY in obesity.. Cell Metab 2024; 36(11):2357-2358.
- Silva A, Mouchiroud M, Lavoie O, Beji S, Elmquist JK, Caron A. Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice.. Am J Physiol Endocrinol Metab 2024; 327(5):E626-E635.
- de Ávila C, Gugula A, Trenk A, Intorcia AJ, Suazo C, Nolz J, Plamondon J, Khatri D, Tallant L, Caron A, Blasiak A, Serrano GE, Beach TG, Gundlach AL, Mastroeni DF. Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology.. Biol Res 2024; 57(1):46.
